DK172475B1 - Analogifremgangsmåde til fremstilling af benzoesyrepiperidylesterderivater - Google Patents

Analogifremgangsmåde til fremstilling af benzoesyrepiperidylesterderivater Download PDF

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Publication number
DK172475B1
DK172475B1 DK198302951A DK295183A DK172475B1 DK 172475 B1 DK172475 B1 DK 172475B1 DK 198302951 A DK198302951 A DK 198302951A DK 295183 A DK295183 A DK 295183A DK 172475 B1 DK172475 B1 DK 172475B1
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DK
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Prior art keywords
general formula
compound
endo
methyl
indol
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DK198302951A
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Danish (da)
English (en)
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DK295183A (da
DK295183D0 (da
Inventor
Peter Donatsch
Bruno Huegi
Brian Peter Richardson
Paul Stadler
Guenter Engel
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Novartis Ag
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Publication of DK295183D0 publication Critical patent/DK295183D0/da
Publication of DK295183A publication Critical patent/DK295183A/da
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Publication of DK172475B1 publication Critical patent/DK172475B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
DK198302951A 1982-06-29 1983-06-27 Analogifremgangsmåde til fremstilling af benzoesyrepiperidylesterderivater DK172475B1 (da)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
CH397982 1982-06-29
CH397982 1982-06-29
CH426782 1982-07-13
CH426782 1982-07-13
CH695182 1982-11-30
CH695082 1982-11-30
CH695182 1982-11-30
CH695082 1982-11-30
CH749582 1982-12-22
CH749482 1982-12-22
CH749582 1982-12-22
CH749482 1982-12-22
CH125683 1983-03-09
CH125683 1983-03-09

Publications (3)

Publication Number Publication Date
DK295183D0 DK295183D0 (da) 1983-06-27
DK295183A DK295183A (da) 1983-12-30
DK172475B1 true DK172475B1 (da) 1998-09-14

Family

ID=27561049

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198302951A DK172475B1 (da) 1982-06-29 1983-06-27 Analogifremgangsmåde til fremstilling af benzoesyrepiperidylesterderivater

Country Status (20)

Country Link
US (3) US4803199A (de)
AT (1) AT391136B (de)
AU (2) AU570002B2 (de)
CH (2) CH669792A5 (de)
CY (1) CY1500A (de)
DE (6) DE3348334C2 (de)
DK (1) DK172475B1 (de)
FI (1) FI74707C (de)
FR (1) FR2531083B1 (de)
GB (4) GB2125398B (de)
HK (1) HK60690A (de)
HU (1) HU191053B (de)
IL (1) IL69081A (de)
IT (1) IT1173724B (de)
NL (2) NL191991C (de)
NZ (1) NZ204714A (de)
PT (1) PT76937B (de)
SE (1) SE463210B (de)
SG (1) SG53789G (de)
WO (1) WO1984000166A1 (de)

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HK60690A (en) 1990-08-17
DE3348333C2 (de) 1992-08-27
IT1173724B (it) 1987-06-24
AU1628683A (en) 1984-01-05
IL69081A (en) 1987-02-27
CH669792A5 (de) 1989-04-14
PT76937A (en) 1983-07-01
NL191991C (nl) 1996-12-03
DE3322574A1 (de) 1983-12-29
DE3348331C2 (de) 1992-08-06
AU603399B2 (en) 1990-11-15
HU191053B (en) 1986-12-28
GB2166728A (en) 1986-05-14
ATA235883A (de) 1990-02-15
IT8348580A0 (it) 1983-06-27
AU8243487A (en) 1988-04-28
FR2531083B1 (fr) 1986-11-28
DK295183A (da) 1983-12-30
SE8303651D0 (sv) 1983-06-27
US5017582A (en) 1991-05-21
IL69081A0 (en) 1983-10-31
DE19475004I2 (de) 2003-06-12
FI74707C (fi) 1988-03-10
GB2166728B (en) 1986-11-26
NL191991B (nl) 1996-08-01
FI832293L (fi) 1983-12-30
GB8520188D0 (en) 1985-09-18
DE3348332C2 (de) 1992-08-06
DK295183D0 (da) 1983-06-27
NL970021I2 (nl) 1998-01-05
GB2125398A (en) 1984-03-07
GB2166727A (en) 1986-05-14
SE463210B (sv) 1990-10-22
CY1500A (en) 1990-08-03
US4803199A (en) 1989-02-07
GB8317365D0 (en) 1983-07-27
CH669954A5 (en) 1989-04-28
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SE8303651L (sv) 1983-12-30
AT391136B (de) 1990-08-27
FR2531083A1 (fr) 1984-02-03
GB8520186D0 (en) 1985-09-18
GB2166726B (en) 1986-11-26
PT76937B (en) 1986-03-11
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SG53789G (en) 1989-12-08
US4910207A (en) 1990-03-20
DE3322574C2 (de) 1992-07-30
DE3348334C2 (de) 1992-08-06
FI74707B (fi) 1987-11-30
NZ204714A (en) 1986-08-08
WO1984000166A1 (en) 1984-01-19
FI832293A0 (fi) 1983-06-22
GB2166726A (en) 1986-05-14
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