AU2001282875A1 - Quinuclidine-substituted heteroaryl moieties for treatment of disease - Google Patents

Quinuclidine-substituted heteroaryl moieties for treatment of disease

Info

Publication number
AU2001282875A1
AU2001282875A1 AU2001282875A AU8287501A AU2001282875A1 AU 2001282875 A1 AU2001282875 A1 AU 2001282875A1 AU 2001282875 A AU2001282875 A AU 2001282875A AU 8287501 A AU8287501 A AU 8287501A AU 2001282875 A1 AU2001282875 A1 AU 2001282875A1
Authority
AU
Australia
Prior art keywords
quinuclidine
disease
treatment
substituted heteroaryl
heteroaryl moieties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001282875A
Inventor
Alice L. Bodnar
Jeffrey W. Corbett
Vincent E. Groppi Jr.
Eric Jon Jacobsen
Jason K. Myers
David W. Piotrowski
Bruce N. Rogers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of AU2001282875A1 publication Critical patent/AU2001282875A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
AU2001282875A 2000-08-21 2001-08-17 Quinuclidine-substituted heteroaryl moieties for treatment of disease Abandoned AU2001282875A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US22665200P 2000-08-21 2000-08-21
US60226652 2000-08-21
US28484901P 2001-04-19 2001-04-19
US28485001P 2001-04-19 2001-04-19
US28496701P 2001-04-19 2001-04-19
US60284849 2001-04-19
US60284850 2001-04-19
US60284967 2001-04-19
PCT/US2001/021139 WO2002017358A2 (en) 2000-08-21 2001-08-17 Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)

Publications (1)

Publication Number Publication Date
AU2001282875A1 true AU2001282875A1 (en) 2002-03-04

Family

ID=27499437

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001282875A Abandoned AU2001282875A1 (en) 2000-08-21 2001-08-17 Quinuclidine-substituted heteroaryl moieties for treatment of disease

Country Status (3)

Country Link
US (1) US6500840B2 (en)
AU (1) AU2001282875A1 (en)
WO (1) WO2002017358A2 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214686B2 (en) 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
SE0000540D0 (en) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
NZ533259A (en) 2001-12-14 2007-10-26 Targacept Inc Methods and compositions for treatment of central nervous system disorders
DE10164139A1 (en) 2001-12-27 2003-07-10 Bayer Ag 2-heteroaryl carboxamides
DE60325025D1 (en) 2002-02-15 2009-01-15 Glaxo Group Ltd MODULATORS OF THE VANILLOID RECEPTOR
CN1639166A (en) * 2002-02-28 2005-07-13 马林克罗特公司 Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography
EP1542999A1 (en) * 2002-08-01 2005-06-22 Pharmacia & Upjohn Company LLC 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
SE0202598D0 (en) * 2002-09-02 2002-09-02 Astrazeneca Ab Alpha-7 Nicotinic receptor agonists and statins in combination
KR101129933B1 (en) 2002-09-25 2012-03-23 메모리 파마슈티칼스 코포레이션 Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
US20040138269A1 (en) * 2002-10-11 2004-07-15 Sugen, Inc. Substituted pyrroles as kinase inhibitors
AU2003269413A1 (en) * 2002-11-01 2004-05-25 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
US7273872B2 (en) * 2002-12-06 2007-09-25 The Feinstein Institute For Medical Research Inhibition of inflammation using α 7 receptor-binding cholinergic agonists
AU2003279492A1 (en) * 2002-12-11 2004-06-30 Pharmacia & Upjohn Company Llc Treatment of diseases with combinations of alpha 7 nicotinic acetylcholine receptor agonists and other compounds
CN1764456A (en) * 2003-01-22 2006-04-26 法马西亚和厄普乔恩公司 Treatment of diseases with alpha-7nACh receptor full agonists
AR045651A1 (en) * 2003-09-19 2005-11-02 Solvay Pharm Bv THIAZOL DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS
DK1678172T3 (en) 2003-10-15 2010-04-06 Targacept Inc Azabicyclic compounds for pain relief and treatment of central nervous system disorders
CN1914201A (en) * 2003-12-22 2007-02-14 阿斯利康(瑞典)有限公司 Nicotinic acetylcholine receptor ligands
PL1697378T3 (en) 2003-12-22 2008-04-30 Memory Pharm Corp Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
JP2007515481A (en) * 2003-12-22 2007-06-14 アストラゼネカ・アクチエボラーグ Nicotinic acetylcholine receptor ligand
SE0400708D0 (en) * 2004-03-22 2004-03-22 Aprea Ab New compounds and use thereof
JP4995075B2 (en) 2004-03-25 2012-08-08 メモリー・ファーマシューティカルズ・コーポレイション Indazole, benzothiazole, benzisothiazole, benzisoxazole, and their preparation and use
US7488737B2 (en) * 2004-04-22 2009-02-10 Memory Pharmaceutical Corporation Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
AU2005243147A1 (en) * 2004-05-07 2005-11-24 Memory Pharmaceuticals Corporation 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
EP1751150A2 (en) 2004-05-19 2007-02-14 Neurosearch A/S Novel azabicyclic aryl derivatives
EP1807433B1 (en) * 2004-10-27 2010-03-17 Mallinckrodt, Inc. Method for separation and purification of hydrocodone by preparative chromatography
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
DE602005019094D1 (en) 2004-12-22 2010-03-11 Memory Pharmaceutical Corp NICOTINE ALPHA-7 RECEPTOR LIGANDS AGAINST DISEASES OF THE CNS
MX2007015287A (en) 2005-06-09 2008-02-22 Mallinckrodt Inc Method for separation and purification of naltrexone by preparative chromatography.
EP1917265B1 (en) 2005-08-22 2010-09-29 Targacept, Inc. HETEROARYL-SUBSTiTUTED DIAZATRICYCLOALKANES, METHODS FOR ITS PREPARATION AND USE THEREOF
US8106066B2 (en) * 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
US20090203658A1 (en) * 2007-01-08 2009-08-13 Duke University Neuroactive steroid compositions and methods of use therefor
SA08290475B1 (en) 2007-08-02 2013-06-22 Targacept Inc (2S,3R)-N-(2-((3-Pyridinyl)Methyl)-1-Azabicyclo[2.2.2]Oct-3-yl)Benzofuran-2-Carboxamide, Novel Salt forms, and Methods of Use Thereof
JP5718053B2 (en) 2007-08-27 2015-05-13 ヘリコン・セラピューティクス・インコーポレーテッド Therapeutic isoxazole compounds
MX2010003375A (en) 2007-10-01 2010-05-17 Comentis Inc Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease.
US8784872B2 (en) * 2007-11-19 2014-07-22 Comgenrx, Inc. Formulation for decreasing tobacco, alcohol, drug or food consumption
WO2009102962A2 (en) 2008-02-13 2009-08-20 Targacept, Inc. Combination of alpha 7 nicotinic agonists and antipsychotics
ES2524045T3 (en) * 2008-06-13 2014-12-03 Bayer Cropscience Ag New amides and heteroaromatic thioamides as pesticides
US20100104614A1 (en) * 2008-06-27 2010-04-29 Oronsky Bryan T Providone compositions for wound healing
CN105687190A (en) 2008-11-19 2016-06-22 福拉姆医药股份有限公司 Treatment of cognitive disorders with (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
RU2011150248A (en) * 2009-05-11 2013-06-20 Энвиво Фармасьютикалз, Инк. TREATMENT OF COGNITIVE DISORDERS WITH SPECIFIC ALPHA-7 NICOTIN ACID RECEPTORS IN COMBINATION WITH ACETYLCHOLINESTERASE INHIBITORS
AU2011256287B2 (en) 2010-05-17 2016-11-10 Envivo Pharmaceuticals, Inc. A crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
WO2012007500A2 (en) * 2010-07-15 2012-01-19 Bayer Cropscience Ag New heterocyclic compounds as pesticides
WO2013005153A1 (en) * 2011-07-05 2013-01-10 Lupin Limited Biaryl derivatives as nachr modulators
RU2017136693A (en) 2012-05-08 2019-02-08 Форум Фармасьютикалз, Инк. METHODS FOR MAINTAINING, TREATING OR IMPROVING COGNITIVE FUNCTION
TW201617342A (en) 2014-07-11 2016-05-16 阿法馬根公司 Quinuclidines for modulating alpha 7 activity
US9724340B2 (en) 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3702324A (en) 1970-06-24 1972-11-07 Stanford Research Inst 3,4,5-trimethoxybenzamides of substituted anilines and of alkylpiperidines
FI74707C (en) 1982-06-29 1988-03-10 Sandoz Ag FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ANVAENDBARA ALKYLENOEVERBRYGGADE PIPERIDYLESTRAR ELLER -AMIDER AV BICYKLISKA KARBOXYLSYROR.
FR2529548A1 (en) 1982-07-02 1984-01-06 Delalande Sa NOVEL DERIVATIVES OF AMINO-3 QUINUCLIDINE, THEIR PROCESS AND THEIR THERAPEUTIC APPLICATION
JPS5936675A (en) 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト Cyclic carboxylic acid piperidyl ester and amide derivative
US5175173A (en) 1983-12-22 1992-12-29 Sun Jung Hui Carboxamides useful as antiemetic or antipsychotic agents
US4605652A (en) 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
DE3688296T2 (en) 1985-03-14 1993-11-04 Beecham Group Plc MEDICINES FOR TREATING EMERGENCY.
GB8520616D0 (en) 1985-08-16 1985-09-25 Beecham Group Plc Compounds
DE3782107T2 (en) 1986-07-25 1993-04-01 Beecham Group Plc AZABICYCLIC COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE.
HU202108B (en) 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
US5237066A (en) 1987-02-04 1993-08-17 Delande S.A. Enantiomers of absolute configuration S of amide derivatives of 3-aminoquinuclidine, the process for preparing them and their application in therapy
US4835162A (en) 1987-02-12 1989-05-30 Abood Leo G Agonists and antagonists to nicotine as smoking deterents
DE3822792C2 (en) 1987-07-11 1997-11-27 Sandoz Ag New use of 5HT¶3¶ antagonists
US5364863A (en) 1987-09-08 1994-11-15 Eli Lilly And Company Specific 5-HT3 antagonists
US4921982A (en) 1988-07-21 1990-05-01 Eli Lilly And Company 5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT3 antagonists
US5206246A (en) 1987-10-16 1993-04-27 A. H. Robins Company, Incorporated Anxiolytic-R-n(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides
IE62231B1 (en) 1987-12-24 1995-01-11 Wyeth John & Brother Ltd Heterocyclic compounds
FR2625678B1 (en) 1988-01-13 1991-06-07 Delalande Sa ANOREXIGENAL AGENTS BASED ON N- (QUINUCLIDIN-3-YL) -BENZAMIDES OR THIOBENZAMIDES
US4863919A (en) 1988-02-01 1989-09-05 A. H. Robins Company, Incorporated Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes
DE3810552A1 (en) 1988-03-29 1989-10-19 Sandoz Ag Esters and amides of indole-, benzo[b]thiophene or benzo[b]furancarboxylic acids or 4-amino-2-methoxybenzoic acids with N-heterocyclic or N-heterobicyclic alcohols or amines, processes for their preparation, pharmaceutical compositions containing them and applicator for administration thereof
US5246942A (en) 1988-04-27 1993-09-21 Rhone-Poulenc Rorer Pharmaceuticals Inc. Pharmaceutically useful dibenzofurancarboxamides of specific stereo-configuration
EP0353371A1 (en) 1988-08-04 1990-02-07 Synthelabo Memory enhancing-R-N-(1-azabicyclo[2.2.2] oct-3-yl) benzamides and thiobenzamides
EP0353372B1 (en) 1988-08-04 1993-02-03 Synthelabo Antischizophrenic-S-N-(1-azabicyclo[2.2.2.]oct-3-yl) benzamides and thiobenzamides
IT1228288B (en) 1989-01-09 1991-06-07 Zambon Spa COMPOUNDS WITH ANTI-SEROTONIN ACTIVITY
AU5650890A (en) 1989-05-24 1990-12-18 Nippon Shinyaku Co. Ltd. Indole derivatives and medicine
EP0402056A3 (en) 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
EP0436245A1 (en) 1989-12-27 1991-07-10 Duphar International Research B.V Substituted 3,4-annelated benzimidazol-2(1H)-ones
US5057519A (en) 1990-06-11 1991-10-15 Bristol-Myers Squibb Company 5-HT3 antagonists: use in reducing opiate tolerance
WO1992004347A1 (en) 1990-08-31 1992-03-19 Nippon Shinyaku Co., Ltd. Indole derivative and medicine
US5070095A (en) 1990-12-12 1991-12-03 A. H. Robins Company, Incorporated Substituted 4-(amidino)benzamides of 1-azabicyclo[2.2.2]octan-3- and -4-amine as gastric prokinetic, antiemetic, and anxiolytic agents
GB9027487D0 (en) 1990-12-19 1991-02-06 Beecham Group Plc Pharmaceuticals
JPH04247081A (en) 1991-02-01 1992-09-03 Takeda Chem Ind Ltd 5-membered heterocyclic acid amide
JPH06506467A (en) 1991-03-08 1994-07-21 ローヌ−プーラン　ローラー　インターナショナル（ホウルディングス）　インコーポレイテッド Polycyclic tertiary amine polyaromatic squalene synthetase inhibitor
DE4115215A1 (en) 1991-05-10 1992-11-12 Merck Patent Gmbh INDOLDER DERIVATIVES
US5273972A (en) 1992-03-26 1993-12-28 A. H. Robins Company, Incorporated [(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates
US5236931A (en) 1992-03-26 1993-08-17 A. H. Robins Company, Incorporated 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol
FR2692575B1 (en) 1992-06-23 1995-06-30 Sanofi Elf NOVEL PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5977144A (en) 1992-08-31 1999-11-02 University Of Florida Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines
JP3628691B2 (en) 1993-03-08 2005-03-16 メルク エンド カンパニー インコーポレーテッド Human neuronal nicotinic acetylcholine receptor compositions and methods for their use
US5510478A (en) 1994-11-30 1996-04-23 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
US5712270A (en) 1995-11-06 1998-01-27 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
SE9600683D0 (en) 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
NZ500643A (en) * 1997-05-30 2001-12-21 Neurosearch As Spiro-quinuclidine derivatives and their use in treating conditions responsive to nicotinic ACh receptor modulators
WO2000073431A2 (en) 1999-05-27 2000-12-07 Pharmacia & Upjohn Company Methods and compositions for measuring ion channel conductance
SE9904176D0 (en) 1999-11-18 1999-11-18 Astra Ab New use
SE0000540D0 (en) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds

Also Published As

Publication number Publication date
WO2002017358A3 (en) 2002-05-30
US20020042429A1 (en) 2002-04-11
WO2002017358A2 (en) 2002-02-28
US6500840B2 (en) 2002-12-31

Similar Documents

Publication Publication Date Title
AU2001282875A1 (en) Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2001284646A1 (en) Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2001227837A1 (en) Novel treatment for eye disease
AU2001282873A1 (en) Quinuclidine-substituted aryl compounds for treatment of disease
HUP0203803A3 (en) Pyridopyrimidinone derivatives for treatment of neurodegenerative disease
AU2001284645A1 (en) Quinuclidine-substituted aryl compounds for treatment of disease
IL160884A0 (en) Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
AUPQ893200A0 (en) Medical residue treatment
IL159344A0 (en) Quinuclidines-substituted-multicyclic-heteroaryls for the treatment of disease
AU2001227815A1 (en) Chemically specific imaging of tissue
AU2001282910A1 (en) Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic) acetylcholine receptor ligands
AU2001276860A1 (en) Medicaments for chemotherapeutic treatment of disease
AU2002210385A1 (en) Furazanyl-triazole derivates for the treatment of diseases
AU2000258650A1 (en) 2-piperidone compounds for the treatment of cancer
AU2000265525A1 (en) Medicament for treating intestinal diseases
AU2002217866A1 (en) Geldanamycin derivatives useful for the treatment of cancer
AU2002322481A1 (en) Use of r-nsaid compounds for anti-hiv treatment
AU2002353739A1 (en) Therapeutic compounds
AU2002236781A1 (en) Treatment for snoring
AU2001253568A1 (en) Lipopolysaccharide-conjugate vaccine for sepsis treatment
AUPR610501A0 (en) Treatment of parasitic disease
AU2001245414A1 (en) Treatment of allergies
AU2002214868A1 (en) Therapeutic oligonucleotides of reduced toxicity
AU2001250866A1 (en) Treatment for benign positional vertigo
AU2001257325A1 (en) Cancer treatment