AU2001284645A1 - Quinuclidine-substituted aryl compounds for treatment of disease - Google Patents

Quinuclidine-substituted aryl compounds for treatment of disease

Info

Publication number
AU2001284645A1
AU2001284645A1 AU2001284645A AU8464501A AU2001284645A1 AU 2001284645 A1 AU2001284645 A1 AU 2001284645A1 AU 2001284645 A AU2001284645 A AU 2001284645A AU 8464501 A AU8464501 A AU 8464501A AU 2001284645 A1 AU2001284645 A1 AU 2001284645A1
Authority
AU
Australia
Prior art keywords
quinuclidine
disease
treatment
substituted aryl
aryl compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284645A
Inventor
Vincent E. Groppi Jr.
Jason K. Myers
David W. Piotrowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of AU2001284645A1 publication Critical patent/AU2001284645A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
AU2001284645A 2000-08-18 2001-08-17 Quinuclidine-substituted aryl compounds for treatment of disease Abandoned AU2001284645A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US22616400P 2000-08-18 2000-08-18
US60226164 2000-08-18
US28495601P 2001-04-19 2001-04-19
US28497101P 2001-04-19 2001-04-19
US28496801P 2001-04-19 2001-04-19
US60284971 2001-04-19
US60284956 2001-04-19
US60284968 2001-04-19
PCT/US2001/021136 WO2002016356A2 (en) 2000-08-18 2001-08-17 Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)

Publications (1)

Publication Number Publication Date
AU2001284645A1 true AU2001284645A1 (en) 2002-03-04

Family

ID=27499421

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284645A Abandoned AU2001284645A1 (en) 2000-08-18 2001-08-17 Quinuclidine-substituted aryl compounds for treatment of disease

Country Status (3)

Country Link
US (1) US6492386B2 (en)
AU (1) AU2001284645A1 (en)
WO (1) WO2002016356A2 (en)

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Publication number Priority date Publication date Assignee Title
US7214686B2 (en) 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
SE0000540D0 (en) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
WO2003032897A2 (en) * 2001-10-16 2003-04-24 Astrazeneca Ab Azabicyclic compounds for the treatment of fibromyalgia syndrome
CN100371714C (en) 2001-12-14 2008-02-27 塔加西普特公司 Methods and compositions for treatment of central nervous system disorders
DE10164139A1 (en) 2001-12-27 2003-07-10 Bayer Ag 2-heteroaryl carboxamides
US7659278B2 (en) * 2002-02-21 2010-02-09 Aprea Ab Use of low molecular weight compounds for preparing a medicament useful in treating mutant p53 mediated diseases
WO2004039366A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
ES2293086T3 (en) * 2002-12-06 2008-03-16 The Feinstein Institute For Medical Research INFLAMMATION INHIBITION USING COLINERGIC AGONISTS FROM UNION TO ALFA RECEIVER 7.
US7432280B2 (en) 2003-06-20 2008-10-07 Eli Lilly And Company 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
US7402592B2 (en) 2003-10-15 2008-07-22 Targacept, Inc. Pharmaceutical compositions and methods for relieving pain and treating central nervous system disorders
EP1751150A2 (en) * 2004-05-19 2007-02-14 Neurosearch A/S Novel azabicyclic aryl derivatives
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
JP2009506037A (en) 2005-08-22 2009-02-12 ターガセプト，インコーポレイテッド Heteroaryl-substituted diazatricycloalkanes, methods for their preparation and methods for their use
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
SA08290475B1 (en) 2007-08-02 2013-06-22 Targacept Inc (2S,3R)-N-(2-((3-Pyridinyl)Methyl)-1-Azabicyclo[2.2.2]Oct-3-yl)Benzofuran-2-Carboxamide, Novel Salt forms, and Methods of Use Thereof
CN104193741B (en) 2007-10-01 2016-08-24 阿尔法梅根有限责任公司 Quinuclidine-4-ylmethyl 1H-indole-3-carboxylic acid ester derivant as alpha 7 nicotinic acetylcholine receptor ligands
PT2254598E (en) 2008-02-13 2013-10-16 Targacept Inc Combination of alpha 7 nicotinic agonists and antipsychotics
US20090318520A1 (en) * 2008-06-20 2009-12-24 Afecta Pharmaceuticals Drive Use of isoindoles for the treatment of neurobehavioral disorders
PL2889033T3 (en) 2008-11-19 2018-10-31 Forum Pharmaceuticals Inc. Treatment of negative symptoms of schizophrenia with (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
WO2010132423A1 (en) * 2009-05-11 2010-11-18 Envivo Pharmaceuticals, Inc. Treatment of cognitive disorders with certain alpha-7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors
MX2012013345A (en) 2010-05-17 2013-02-11 Envivo Pharmaceuticals Inc A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]th iophene-2-carboxamide hydrochloride monohydrate.
CN103183625B (en) 2011-12-28 2015-07-08 四川大学 Anti-HIV compound and preparation method and application thereof
CA2872005A1 (en) 2012-05-08 2013-11-14 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
MA37975B2 (en) * 2012-09-11 2021-03-31 Genzyme Corp Glucosylceramide synthase inhibitors
US9434724B2 (en) 2014-07-11 2016-09-06 Alpharmagen, Llc Quinuclidines for modulating alpha 7 activity
US9724340B2 (en) 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods
KR20230043024A (en) 2020-07-24 2023-03-30 젠자임 코포레이션 Pharmaceutical composition comprising benglustat

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5237066A (en) * 1987-02-04 1993-08-17 Delande S.A. Enantiomers of absolute configuration S of amide derivatives of 3-aminoquinuclidine, the process for preparing them and their application in therapy
US4863919A (en) * 1988-02-01 1989-09-05 A. H. Robins Company, Incorporated Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes
EP0353371A1 (en) * 1988-08-04 1990-02-07 Synthelabo Memory enhancing-R-N-(1-azabicyclo[2.2.2] oct-3-yl) benzamides and thiobenzamides
GB9027487D0 (en) * 1990-12-19 1991-02-06 Beecham Group Plc Pharmaceuticals
US5741819A (en) * 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
SE9600683D0 (en) * 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
SE9903760D0 (en) * 1999-10-18 1999-10-18 Astra Ab New compounds
SE9904176D0 (en) * 1999-11-18 1999-11-18 Astra Ab New use
SE0000540D0 (en) * 2000-02-18 2000-02-18 Astrazeneca Ab New compounds

Also Published As

Publication number Publication date
US6492386B2 (en) 2002-12-10
US20020052389A1 (en) 2002-05-02
WO2002016356A3 (en) 2002-05-16
WO2002016356A2 (en) 2002-02-28

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