DE19948434A1 - Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine - Google Patents

Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine

Info

Publication number
DE19948434A1
DE19948434A1 DE19948434A DE19948434A DE19948434A1 DE 19948434 A1 DE19948434 A1 DE 19948434A1 DE 19948434 A DE19948434 A DE 19948434A DE 19948434 A DE19948434 A DE 19948434A DE 19948434 A1 DE19948434 A1 DE 19948434A1
Authority
DE
Germany
Prior art keywords
phenyl
imidazo
pyridin
amine
fluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19948434A
Other languages
German (de)
English (en)
Inventor
Matthias Gerlach
Corinna Maul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE19948434A priority Critical patent/DE19948434A1/de
Priority to ES00967692T priority patent/ES2213611T3/es
Priority to HK02109383.4A priority patent/HK1047748B/zh
Priority to CZ20021243A priority patent/CZ300315B6/cs
Priority to HK02109382.5A priority patent/HK1047747B/zh
Priority to DK00967693T priority patent/DK1218383T3/da
Priority to SK461-2002A priority patent/SK286450B6/sk
Priority to AT00964191T priority patent/ATE256684T1/de
Priority to JP2001530336A priority patent/JP2003511456A/ja
Priority to CA002386813A priority patent/CA2386813C/en
Priority to NZ518390A priority patent/NZ518390A/en
Priority to PT00967692T priority patent/PT1218382E/pt
Priority to PCT/EP2000/009096 priority patent/WO2001027111A2/de
Priority to DK00964191T priority patent/DK1218380T3/da
Priority to DK00967692T priority patent/DK1218382T3/da
Priority to RU2002110282/04A priority patent/RU2002110282A/ru
Priority to PL00355206A priority patent/PL355206A1/xx
Priority to SI200030303T priority patent/SI1218382T1/xx
Priority to PCT/EP2000/009097 priority patent/WO2001027118A2/de
Priority to PT00964191T priority patent/PT1218380E/pt
Priority to ES00967693T priority patent/ES2316388T3/es
Priority to PCT/EP2000/009098 priority patent/WO2001027119A2/de
Priority to BR0014826-1A priority patent/BR0014826A/pt
Priority to HU0203739A priority patent/HUP0203739A3/hu
Priority to BR0014818-0A priority patent/BR0014818A/pt
Priority to CNB008159866A priority patent/CN1257169C/zh
Priority to CZ20021242A priority patent/CZ20021242A3/cs
Priority to IL14899700A priority patent/IL148997A0/xx
Priority to AU77771/00A priority patent/AU779197B2/en
Priority to HK02109381.6A priority patent/HK1047746B/xx
Priority to EP00967692A priority patent/EP1218382B1/de
Priority to SI200031017T priority patent/SI1218383T1/sl
Priority to PL364866A priority patent/PL203534B1/pl
Priority to KR1020027004442A priority patent/KR20020068515A/ko
Priority to RU2002110112/04A priority patent/RU2002110112A/ru
Priority to EP00967693A priority patent/EP1218383B1/de
Priority to CNB008164304A priority patent/CN1222525C/zh
Priority to AU77772/00A priority patent/AU781227B2/en
Priority to DE50004817T priority patent/DE50004817D1/de
Priority to SK464-2002A priority patent/SK4642002A3/sk
Priority to NZ518637A priority patent/NZ518637A/xx
Priority to SI200030298T priority patent/SI1218380T1/xx
Priority to SK436-2002A priority patent/SK286788B6/sk
Priority to HU0203140A priority patent/HUP0203140A3/hu
Priority to EP00964191A priority patent/EP1218380B1/de
Priority to NZ518439A priority patent/NZ518439A/en
Priority to DE50005155T priority patent/DE50005155D1/de
Priority to AT00967692T priority patent/ATE258554T1/de
Priority to KR1020027004516A priority patent/KR100756592B1/ko
Priority to RU2002110102/04A priority patent/RU2264402C2/ru
Priority to MXPA02003547A priority patent/MXPA02003547A/es
Priority to DE50015443T priority patent/DE50015443D1/de
Priority to AU74199/00A priority patent/AU7419900A/en
Priority to KR1020027004504A priority patent/KR20020038804A/ko
Priority to PT00967693T priority patent/PT1218383E/pt
Priority to PL00355019A priority patent/PL355019A1/xx
Priority to CA002388476A priority patent/CA2388476C/en
Priority to CA002382919A priority patent/CA2382919C/en
Priority to PCT/EP2000/009095 priority patent/WO2001027110A2/de
Priority to JP2001530329A priority patent/JP2003511451A/ja
Priority to BR0014817-2A priority patent/BR0014817A/pt
Priority to JP2001530328A priority patent/JP2003517466A/ja
Priority to MXPA02002837A priority patent/MXPA02002837A/es
Priority to HU0203052A priority patent/HUP0203052A3/hu
Priority to CZ20021210A priority patent/CZ20021210A3/cs
Priority to AT00967693T priority patent/ATE413403T1/de
Priority to IL14899800A priority patent/IL148998A0/xx
Priority to AU75199/00A priority patent/AU780823B2/en
Priority to CNB008163650A priority patent/CN1211385C/zh
Priority to IL14901000A priority patent/IL149010A0/xx
Priority to ES00964191T priority patent/ES2213044T3/es
Priority to CO00074640A priority patent/CO5210861A1/es
Priority to CO00074644A priority patent/CO5200851A1/es
Priority to CO00074643A priority patent/CO5210870A1/es
Priority to ARP000105232 priority patent/AR025950A1/es
Priority to UY26371A priority patent/UY26371A1/es
Priority to ARP000105254A priority patent/AR025962A1/es
Priority to ARP000105252A priority patent/AR030030A1/es
Priority to ARP000105253A priority patent/AR025961A1/es
Priority to UY26370A priority patent/UY26370A1/es
Priority to UY26372A priority patent/UY26372A1/es
Priority to ARP000105250A priority patent/AR025959A1/es
Priority to CO00075814A priority patent/CO5251378A1/es
Priority to ARP000105251A priority patent/AR025960A1/es
Priority to MXPA02003546A priority patent/MXPA02003546A/es
Priority to PE2000001063A priority patent/PE20010632A1/es
Priority to RU2002110281/04A priority patent/RU2002110281A/ru
Priority to NZ518438A priority patent/NZ518438A/en
Priority to JP2001530327A priority patent/JP2003511450A/ja
Priority to CA002386804A priority patent/CA2386804A1/en
Priority to PT00969439T priority patent/PT1218378E/pt
Priority to AT00969439T priority patent/ATE238304T1/de
Priority to SI200030069T priority patent/SI1218378T1/xx
Priority to HK02109385.2A priority patent/HK1047749B/zh
Priority to EP00969439A priority patent/EP1218378B1/de
Priority to PL00355109A priority patent/PL355109A1/xx
Priority to ES00969439T priority patent/ES2198355T3/es
Priority to PE2000001062A priority patent/PE20010706A1/es
Priority to CO00076179A priority patent/CO5251429A1/es
Priority to CZ20021241A priority patent/CZ20021241A3/cs
Priority to SK462-2002A priority patent/SK4622002A3/sk
Priority to IL14899900A priority patent/IL148999A0/xx
Priority to DE50001911T priority patent/DE50001911D1/de
Priority to AU79153/00A priority patent/AU780526B2/en
Priority to KR1020027004518A priority patent/KR100793619B1/ko
Priority to PE2000001064A priority patent/PE20010634A1/es
Priority to BR0014827-0A priority patent/BR0014827A/pt
Priority to DK00969439T priority patent/DK1218378T3/da
Priority to HU0203545A priority patent/HUP0203545A3/hu
Priority to PCT/EP2000/009791 priority patent/WO2001027109A2/de
Priority to PE2000001066A priority patent/PE20010638A1/es
Priority to PE2000001065A priority patent/PE20010631A1/es
Priority to CNB008167079A priority patent/CN1208336C/zh
Publication of DE19948434A1 publication Critical patent/DE19948434A1/de
Priority to NO20021563A priority patent/NO20021563L/no
Priority to NO20021564A priority patent/NO20021564L/no
Priority to NO20021566A priority patent/NO20021566L/no
Priority to NO20021565A priority patent/NO322754B1/no
Priority to IL149010A priority patent/IL149010A/en
Priority to IL148999A priority patent/IL148999A/en
Priority to IL148998A priority patent/IL148998A/en
Priority to US10/117,334 priority patent/US6849642B2/en
Priority to US10/117,333 priority patent/US6638933B2/en
Priority to US10/117,339 priority patent/US6703404B2/en
Priority to US10/117,335 priority patent/US6657064B2/en
Priority to ZA200203581A priority patent/ZA200203581B/xx
Priority to ZA200203579A priority patent/ZA200203579B/xx
Priority to US10/633,579 priority patent/US6936631B2/en
Priority to CY20091100104T priority patent/CY1110416T1/el
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE19948434A 1999-10-08 1999-10-08 Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine Withdrawn DE19948434A1 (de)

Priority Applications (128)

Application Number Priority Date Filing Date Title
DE19948434A DE19948434A1 (de) 1999-10-08 1999-10-08 Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine
ES00967692T ES2213611T3 (es) 1999-10-08 2000-09-18 Derivados biciclicos de imidazo-3-il-amina.
HK02109383.4A HK1047748B (zh) 1999-10-08 2000-09-18 在第六环上取代的二环咪唑并-3-基-胺的衍生物
CZ20021243A CZ300315B6 (cs) 1999-10-08 2000-09-18 Na šesticlenném kruhu substituované bicyklické deriváty imidazo-3-yl-aminu, zpusob jejich výroby, jejich použití a léciva tyto látky obsahující
HK02109382.5A HK1047747B (zh) 1999-10-08 2000-09-18 二环咪唑并-3-基-胺的衍生物
DK00967693T DK1218383T3 (da) 1999-10-08 2000-09-18 Biocykliske imidazo-5-yl-aminoderivater
SK461-2002A SK286450B6 (sk) 1999-10-08 2000-09-18 Bicyklické imidazo-3-yl-amíny, spôsob ich výroby,ich použitie a liečivá obsahujúce tieto látky
AT00964191T ATE256684T1 (de) 1999-10-08 2000-09-18 Am sechsring substituierte, bicyclische imidazo-3-yl-aminderivate
JP2001530336A JP2003511456A (ja) 1999-10-08 2000-09-18 二環状イミダゾ−５−イル−アミン誘導体
CA002386813A CA2386813C (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl amine derivatives substituted on the 6-membered ring
NZ518390A NZ518390A (en) 1999-10-08 2000-09-18 Bicyclic imidazo-5-yl-amine derivatives
PT00967692T PT1218382E (pt) 1999-10-08 2000-09-18 Derivados de imidazo-3-il-amina biciclica
PCT/EP2000/009096 WO2001027111A2 (de) 1999-10-08 2000-09-18 Bicyclische imidazo-3-yl-aminderivate
DK00964191T DK1218380T3 (da) 1999-10-08 2000-09-18 Bicykliske imidazo-3-yl-aminoderivater substitueret i seksledsringen
DK00967692T DK1218382T3 (da) 1999-10-08 2000-09-18 Bicykliske imidazo-3-ylaminderivater
RU2002110282/04A RU2002110282A (ru) 1999-10-08 2000-09-18 Замещенные в 6-членном кольце бициклические производные имидазо-3-иламина
PL00355206A PL355206A1 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives
SI200030303T SI1218382T1 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives
PCT/EP2000/009097 WO2001027118A2 (de) 1999-10-08 2000-09-18 Bicyclische imidazo-5-yl-aminderivate
PT00964191T PT1218380E (pt) 1999-10-08 2000-09-18 Derivados de imidazo-3-il-amina biciclicos substituidos no anel de seis membros
ES00967693T ES2316388T3 (es) 1999-10-08 2000-09-18 Derivados biciclicos de imidazo-5-ilamima.
PCT/EP2000/009098 WO2001027119A2 (de) 1999-10-08 2000-09-18 Substanzbibliothek enthaltend bicyclische imidazo-5-yl-amine und/oder bicyclische imidazo-3-yl-amine
BR0014826-1A BR0014826A (pt) 1999-10-08 2000-09-18 Imidazo-3-il-aminas bicìclicas, procedimento de sua preparação e medicamentos que as contêm
HU0203739A HUP0203739A3 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives which are substituted on the sixth ring, process for their preparation and pharmaceutical compositions containing them
BR0014818-0A BR0014818A (pt) 1999-10-08 2000-09-18 Imidazo-3-il-aminas bicìclicas procedimento de preparação e medicamentos que contém como substância ativa pelo menos uma imidazo-3-il-amina bicìclica
CNB008159866A CN1257169C (zh) 1999-10-08 2000-09-18 双环咪唑－3－基－胺衍生物
CZ20021242A CZ20021242A3 (cs) 1999-10-08 2000-09-18 Bicyklické deriváty imidazo-5-yl-aminu, způsob jejich výroby, jejich pouľití a léčiva tyto látky obsahující
IL14899700A IL148997A0 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives
AU77771/00A AU779197B2 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives
HK02109381.6A HK1047746B (en) 1999-10-08 2000-09-18 Bicyclic imidazo-5-yl-amine derivatives
EP00967692A EP1218382B1 (de) 1999-10-08 2000-09-18 Bicyclische imidazo-3-yl-aminderivate
SI200031017T SI1218383T1 (sl) 1999-10-08 2000-09-18 Biciklični imidazo-5-il-aminski derivati
PL364866A PL203534B1 (pl) 1999-10-08 2000-09-18 Bicykliczne imidazo-3-ylo-aminy, srodek leczniczy zawieraj acy te nowe zwi azki, zastosowanie tych zwi azków i sposób ich wytwarzania
KR1020027004442A KR20020068515A (ko) 1999-10-08 2000-09-18 비사이클릭 이미다조-5-일-아민 유도체
RU2002110112/04A RU2002110112A (ru) 1999-10-08 2000-09-18 Бициклические производные имидазо-5-иламина
EP00967693A EP1218383B1 (de) 1999-10-08 2000-09-18 Bicyclische imidazo-5-yl-aminderivate
CNB008164304A CN1222525C (zh) 1999-10-08 2000-09-18 在六元环上被取代的双环咪唑－3－基胺衍生物
AU77772/00A AU781227B2 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-5-yl-amine derivatives
DE50004817T DE50004817D1 (de) 1999-10-08 2000-09-18 Am sechsring substituierte, bicyclische imidazo-3-yl-aminderivate
SK464-2002A SK4642002A3 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-5-yl-amine derivatives method for producing thereof, use thereof and pharmaceutical compositions containing said compounds
NZ518637A NZ518637A (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl amine derivatives substituted on the 6-membered ring
SI200030298T SI1218380T1 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives which are substituted on the sixth ring
SK436-2002A SK286788B6 (sk) 1999-10-08 2000-09-18 Bicyklické deriváty imidazo-3-yl-amínu, spôsob ich výroby, ich použitie a liečivá obsahujúce tieto látky
HU0203140A HUP0203140A3 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-5-yl-amine derivatives, process for their preparation and pharmaceutical compositions containing them
EP00964191A EP1218380B1 (de) 1999-10-08 2000-09-18 Am sechsring substituierte, bicyclische imidazo-3-yl-aminderivate
NZ518439A NZ518439A (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives
DE50005155T DE50005155D1 (de) 1999-10-08 2000-09-18 Bicyclische imidazo-3-yl-aminderivate
AT00967692T ATE258554T1 (de) 1999-10-08 2000-09-18 Bicyclische imidazo-3-yl-aminderivate
KR1020027004516A KR100756592B1 (ko) 1999-10-08 2000-09-18 비사이클릭 이미다조-3-일-아민 유도체, 이의 제조방법 및 이를 포함하는 진통제
RU2002110102/04A RU2264402C2 (ru) 1999-10-08 2000-09-18 Бициклические производные имидазо-3-иламина, способ их получения и лекарственное средство на их основе
MXPA02003547A MXPA02003547A (es) 1999-10-08 2000-09-18 Derivados biciclos de imidazo-3-il-amina substituidos en el sexto anillo.
DE50015443T DE50015443D1 (de) 1999-10-08 2000-09-18 Bicyclische imidazo-5-yl-aminderivate
AU74199/00A AU7419900A (en) 1999-10-08 2000-09-18 Substance library containing bicyclic imidazo-5-yl-amines and/or bicyclic imidazo-3-yl-amines
KR1020027004504A KR20020038804A (ko) 1999-10-08 2000-09-18 6원 환이 치환되어 있는 2환식 이미다조-3-일-아민 유도체
PT00967693T PT1218383E (pt) 1999-10-08 2000-09-18 Derivados bicíclicos de imidazo-5-il-amina
PL00355019A PL355019A1 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-5-yl-amine derivatives
CA002388476A CA2388476C (en) 1999-10-08 2000-09-18 Bicyclic imidazo-5-yl-amine derivatives
CA002382919A CA2382919C (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives
PCT/EP2000/009095 WO2001027110A2 (de) 1999-10-08 2000-09-18 Am sechsring substituierte, bicyclische imidazo-3-yl-aminderivate
JP2001530329A JP2003511451A (ja) 1999-10-08 2000-09-18 二環状イミダゾ−３−イル−アミン誘導体
BR0014817-2A BR0014817A (pt) 1999-10-08 2000-09-18 Imidazo-5-il-aminas bicìclicas, medicamentos que as contém, seu emprego para a preparação de medicamentos e procedimento para sua preparação
JP2001530328A JP2003517466A (ja) 1999-10-08 2000-09-18 ６員環が置換された二環状イミダゾ−３−イル−アミン誘導体
MXPA02002837A MXPA02002837A (es) 1999-10-08 2000-09-18 Derivados biciclicos de imidazo-5-il-amina.
HU0203052A HUP0203052A3 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives, process for their preparation, pharmaceutical compositions containing them and their use
CZ20021210A CZ20021210A3 (cs) 1999-10-08 2000-09-18 Bicyklické deriváty imidazo-3-yl-aminu, způsob jejich výroby, jejich pouľití a léčiva tyto látky obsahující
AT00967693T ATE413403T1 (de) 1999-10-08 2000-09-18 Bicyclische imidazo-5-yl-aminderivate
IL14899800A IL148998A0 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives which are substituted on the sixth ring
AU75199/00A AU780823B2 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-3-yl-amine derivatives which are substituted on the sixth ring
CNB008163650A CN1211385C (zh) 1999-10-08 2000-09-18 双环咪唑－5－基胺衍生物
IL14901000A IL149010A0 (en) 1999-10-08 2000-09-18 Bicyclic imidazo-5-yl-amine derivatives
ES00964191T ES2213044T3 (es) 1999-10-08 2000-09-18 Nuevas imidazo-3-il-aminas biciclicas.
CO00074640A CO5210861A1 (es) 1999-10-08 2000-10-02 Biblioteca de sustancias que contienen imidazo-5-il-aminas biciclicas y/o imidazo 3-il-aminas biciclicas, procedimiento para la prepraracion de esta biblioteca de sustancias y uso de sustancias de esta biblioteca para la preparacion de medicamentos p
CO00074644A CO5200851A1 (es) 1999-10-08 2000-10-02 Imidazo-5-il-aminas biciclicas, medicamentos que las contienen, su uso para la preparacion de medicamentos y procedimiento para su preparacion
CO00074643A CO5210870A1 (es) 1999-10-08 2000-10-02 Imidazo-3-il-aminas biciclicas procedimiento para su preparacion y medicamentos que las contienen
ARP000105232 AR025950A1 (es) 1999-10-08 2000-10-04 Nuevos compuestos.
UY26371A UY26371A1 (es) 1999-10-08 2000-10-05 Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen
ARP000105254A AR025962A1 (es) 1999-10-08 2000-10-05 Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que los contienen
ARP000105252A AR030030A1 (es) 1999-10-08 2000-10-05 Imidazo-5-il-aminas biciclicas, medicamentos que las contienen, su uso para la preparacion de medicamentos y procedimiento para su preparacion
ARP000105253A AR025961A1 (es) 1999-10-08 2000-10-05 Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen
UY26370A UY26370A1 (es) 1999-10-08 2000-10-05 "imidazo-5-il-aminas bicíclicas, medicamentos que las contienen, su uso para la preparación de medicamentos y procedimiento para su preparación".
UY26372A UY26372A1 (es) 1999-10-08 2000-10-05 "imidazo-3-il-aminas bicíclicas procedimiento para su preparación y medicamentos que las contienen "
ARP000105250A AR025959A1 (es) 1999-10-08 2000-10-05 DERIVADOS DE TER.-BUTIL-(7-METIL-IMIDAZO[1,2,a]PIRIDIN-3-IL)-AMINA, PROCEDIMIENTO PARA SU PREPARACION, MEDICAMENTOS QUE LOS CONTIENEN, SU USO PARA LAPREPARACION DE UN MEDICAMENTO PARA LA INHIBICION DE NO-SINTASA Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN
CO00075814A CO5251378A1 (es) 1999-10-08 2000-10-05 Imidazo-3-il-aminas biciclicas, procedimientos para su preparacion y medicamentos que las contienen
ARP000105251A AR025960A1 (es) 1999-10-08 2000-10-05 Biblioteca de sustancias que contiene imidazo-5-il-aminas biciclicas y/o imidazo 3-il-aminas biciclicas, procedimiento para la preparacion de estabiblioteca de sustancias, y uso de sustancias de esta biblioteca para la preparacion de medicamentos para el tratamiento del dolor
MXPA02003546A MXPA02003546A (es) 1999-10-08 2000-10-06 Derivados de tert-butil-(7-metil-imidazo(1.2-a)piridin-3-il)-amina.
PE2000001063A PE20010632A1 (es) 1999-10-08 2000-10-06 Derivados de ter-butil-(7-metil-imidazol[1,2-a]piridin-3-il)-amina, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen
RU2002110281/04A RU2002110281A (ru) 1999-10-08 2000-10-06 Производные трет-бутил(7-метилимидазол[1,2-а]пиридин-3-ил)амина
NZ518438A NZ518438A (en) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo[1,2-A]pyridine-3-yl)-amine derivatives
JP2001530327A JP2003511450A (ja) 1999-10-08 2000-10-06 ｔ−ブチル−（７−メチル−イミダゾ［１，２−ａ］ピリジン−３−イル）−アミン誘導体
CA002386804A CA2386804A1 (en) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridine-3-yl)-amine derivatives
PT00969439T PT1218378E (pt) 1999-10-08 2000-10-06 Derivados de terc-butil-(7-metil-imidazo-¬1,2-a|-piridin-3-il)-amina
AT00969439T ATE238304T1 (de) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo(1,2-a)pyridin-3-y )-amin-derivate
SI200030069T SI1218378T1 (en) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo(1,2-a)pyridine-3-yl)-amine derivatives
HK02109385.2A HK1047749B (zh) 1999-10-08 2000-10-06 叔丁基-(7-甲基-咪唑[1，2-a]吡啶-3-基)-胺衍生物
EP00969439A EP1218378B1 (de) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amin-derivate
PL00355109A PL355109A1 (en) 1999-10-08 2000-10-06 Tert.
ES00969439T ES2198355T3 (es) 1999-10-08 2000-10-06 Nuevos derivados de t-butil-(7-metil-imidazo-(1,2-a)-piridin-3-il)-amina, procedimiento para su preparacion y las composiciones farmaceuticas que los contienen.
PE2000001062A PE20010706A1 (es) 1999-10-08 2000-10-06 Biblioteca de sustancias que contiene imidazo-5-il-aminas biciclicas y/o imidazo-3-il-aminas biciclicas, procedimiento para la preparacion de esta biblioteca de sustancias, y uso de sustancias de esta biblioteca para la preparacion de medicamentos pa
CO00076179A CO5251429A1 (es) 1999-10-08 2000-10-06 Derivados de ter-butil-(7-metil-imidazo(1,2-a)piridin-3- il)-amina procedimiento para su preparacion, medicamentos que los contienen, su uso para la preparacion de un medicamento para la inhibicion de la no-sintasa y composiciones farmaceuticas que l
CZ20021241A CZ20021241A3 (cs) 1999-10-08 2000-10-06 Deriváty terc.-butyl-(7-methyl-imidazo[1.2-a]pyridin-3-yl)-aminu, způsob jejich výroby, jejich pouľití a léčiva tyto látky obsahující
SK462-2002A SK4622002A3 (en) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridine-3-yl)-amine derivatives, method for producing thereof and medicaments comprising said compounds
IL14899900A IL148999A0 (en) 1999-10-08 2000-10-06 Tert-butyl-(7-methyl-imidazo [1, 2-a] pyridine-3-yl)-amine derivatives
DE50001911T DE50001911D1 (de) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amin-derivate
AU79153/00A AU780526B2 (en) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo(1,2-a)pyridine-3-yl)-amine derivatives
KR1020027004518A KR100793619B1 (ko) 1999-10-08 2000-10-06 3급-부틸-(7-메틸-이미다조[1,2-ａ]피리딘-3-일)-아민 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
PE2000001064A PE20010634A1 (es) 1999-10-08 2000-10-06 Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen
BR0014827-0A BR0014827A (pt) 1999-10-08 2000-10-06 Derivados de terc-butil-(7-metil-imidazo (1,2-a) piridin-3-il) amina, procedimento de sua preparação, medicamentos que os contém, sua utilização para a preparação de medicamento para inibição de no-sintase e composições farmacêuticas que os contém
DK00969439T DK1218378T3 (da) 1999-10-08 2000-10-06 Tert.-butyl-(7-methylimidazo[1,2-a]pyridin-3-yl) aminderivater
HU0203545A HUP0203545A3 (en) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridine-3-yl)-amine derivatives, pharmaceutical compositions containing them, process for their preparation and their use
PCT/EP2000/009791 WO2001027109A2 (de) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amin-derivate
PE2000001066A PE20010638A1 (es) 1999-10-08 2000-10-06 Imidazo-5-il-aminas biciclicas, medicamentos que las contienen, su uso para la preparacion de medicamentos y procedimiento para su preparacion
PE2000001065A PE20010631A1 (es) 1999-10-08 2000-10-06 Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen
CNB008167079A CN1208336C (zh) 1999-10-08 2000-10-06 叔丁基－(7－甲基咪唑并[1,2－a]吡啶－3－基)胺衍生物
NO20021563A NO20021563L (no) 1999-10-08 2002-04-03 På seksringen substituerte, bisykliske imidazo-3-yl- aminderivater
NO20021564A NO20021564L (no) 1999-10-08 2002-04-03 Tert.-butyl-(7-metyl-imidazo[1,2-a]pyridin-3-yl)-amin- derivater
NO20021566A NO20021566L (no) 1999-10-08 2002-04-03 Bicykliske imidazo-5-yl-aminderivater
NO20021565A NO322754B1 (no) 1999-10-08 2002-04-03 Bicykliske imidazo-3-yl-aminderivater, legemiddel inneholdende disse, deres anvendelse for fremstilling av et legemiddel samt en fremgangsmate for fremstilling av derivatene.
IL149010A IL149010A (en) 1999-10-08 2002-04-04 Imidazo-5-Il-Amin derivatives in cyclics, their preparation and pharmaceutical preparations containing them
IL148999A IL148999A (en) 1999-10-08 2002-04-04 Pharmaceutical preparations containing a history of tart butyl - (7 - methyl – imidazo [a – 1,2] pyridine - 3 - ile) - reliable, several such histories and their preparation
IL148998A IL148998A (en) 1999-10-08 2002-04-04 2 - SUBSTITUTED - 3 - (SUBSTITUTED AMIDO) IMIDAZO [1,2 -a] PYRIDINES AND SIMILAR COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US10/117,334 US6849642B2 (en) 1999-10-08 2002-04-08 Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring
US10/117,333 US6638933B2 (en) 1999-10-08 2002-04-08 Bicyclic imidazo-3-yl-amine derivatives
US10/117,339 US6703404B2 (en) 1999-10-08 2002-04-08 Tert -butyl-(7-methyl-imidazol [1,2-a]pyridin-3-yl)-amine derivatives
US10/117,335 US6657064B2 (en) 1999-10-08 2002-04-08 Bicyclic imidazo-5-yl-amine derivatives
ZA200203581A ZA200203581B (en) 1999-10-08 2002-05-06 Bicyclic imidazo-3-yl-amine derivatives.
ZA200203579A ZA200203579B (en) 1999-10-08 2002-05-06 Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amine derivatives.
US10/633,579 US6936631B2 (en) 1999-10-08 2003-08-05 Bicyclic imidazo-5-yl-amine derivatives
CY20091100104T CY1110416T1 (el) 1999-10-08 2009-01-28 Δικυκλικα παραγωγα ιμιδαζ-5-υλ-αμινης

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10117184A1 (de) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
CN1585639A (zh) 1998-09-21 2005-02-23 佛罗里达大学研究基金会 抗疟疾制剂
WO2001076694A1 (en) 2000-04-10 2001-10-18 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
DE10043845A1 (de) * 2000-09-06 2002-03-14 Gruenenthal Gmbh Verfahren zur Messung der Aktivität der NO-Synthase
DE10050663A1 (de) * 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
AU2002224927A1 (en) * 2000-12-13 2002-06-24 Basf Aktiengesellschaft Use of substituted imidazoazines, novel imidazoazines, methods for the production thereof, and agents containing these compounds
DE10117183A1 (de) * 2001-04-05 2002-10-10 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel
DE10132726A1 (de) 2001-07-05 2003-02-27 Gruenenthal Gmbh Verwendung von substituierten gamma-Lactonverbindungen als Arzneimittel
DK1483247T3 (da) 2002-03-13 2009-08-17 Euro Celtique Sa Arylsubstituerede pyrimidiner og anvendelsen deraf
CA2482991A1 (en) 2002-04-19 2003-10-30 Cellular Genomics, Inc. Imidazo[1,2-a]pyrazin-8-ylamines method of making and method of use thereof
US20050197435A1 (en) * 2002-06-14 2005-09-08 Dotson Darin L. Polymer additive compositions for bimolecular nucleation in thermoplastics
US7312341B2 (en) 2002-09-09 2007-12-25 Cgi Pharmaceuticals, Inc. 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof
DE10246890A1 (de) 2002-10-08 2004-04-22 Grünenthal GmbH Substituierte C-Imidazo[1,2-alpyridin-3-yl-methylamine
AU2003290333A1 (en) * 2002-12-24 2004-07-22 Biofocus Plc Compound libraries of imidazo(1,5-a)pyridin-3-yl derivatives and related heterobicycles for targetting compounds capable of binding to g-protein coupled receptors
WO2004072081A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
WO2005034949A1 (en) 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
DE102004021716A1 (de) * 2004-04-30 2005-12-01 Grünenthal GmbH Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen
DE102004044884A1 (de) 2004-09-14 2006-05-24 Grünenthal GmbH Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen
US7820654B2 (en) 2004-09-23 2010-10-26 Dr. Reddy's Laboratories Ltd. Pyrimidine compounds, process for their preparation and compositions containing them
TR201910900T4 (tr) 2005-04-04 2019-08-21 Univ Florida Desferritiyokin polieter analogları.
DE102005016547A1 (de) * 2005-04-08 2006-10-12 Grünenthal GmbH Substituierte 5,6,7,8-Tetrahydro-imidazo(1,2-a)pyridin-2-ylamin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
WO2007024294A2 (en) 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
EP1902056A2 (en) 2005-05-20 2008-03-26 Array Biopharma, Inc. Raf inhibitor compounds and methods of use thereof
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
EP1910385B1 (en) 2005-08-04 2013-07-24 Sirtris Pharmaceuticals, Inc. Benzothiazoles and thiazolopyridines as sirtuin modulators
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7709468B2 (en) 2005-09-02 2010-05-04 Abbott Laboratories Imidazo based heterocycles
SI2495016T1 (sl) 2005-12-23 2020-04-30 Ariad Pharmaceuticals, Inc. Biciklične heteroarilne spojine
DE102006011574A1 (de) 2006-03-10 2007-10-31 Grünenthal GmbH Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
ES2422890T3 (es) 2006-03-17 2013-09-16 Ambit Biosciences Corporation Compuestos de imidazolotiazol para el tratamiento de enfermedades proliferativas
WO2008115433A1 (en) 2007-03-15 2008-09-25 University Of Florida Desferrithiocin polyether analogues
WO2008134553A1 (en) * 2007-04-26 2008-11-06 Xenon Pharmaceuticals Inc. Methods of using bicyclic compounds in treating sodium channel-mediated diseases
GB0708188D0 (en) * 2007-04-27 2007-06-06 Merck Sharp & Dohme Therapeutic compounds
CL2008001821A1 (es) 2007-06-20 2009-03-13 Sirtris Pharmaceuticals Inc Compuestos derivados de imidazo[2,1-b]-tiazol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de diabetes, sindrome metabolico, resistencia a la insulina, entre otras.
TW200916472A (en) 2007-06-20 2009-04-16 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
DE102007040336A1 (de) * 2007-08-27 2009-03-05 Johann Wolfgang Goethe-Universität Frankfurt am Main Neue Inhibitoren der 5-Lipoxygenase und deren Verwendungen
CA2696776C (en) 2007-09-19 2015-12-15 Ambit Biosciences Corporation Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith
JP5496915B2 (ja) 2008-02-13 2014-05-21 シージーアイ ファーマシューティカルズ，インコーポレーテッド ６−アリール−イミダゾ［１，２−ａ］ピラジン誘導体、その製造方法、及びその使用方法
RS52561B (sr) * 2008-04-15 2013-04-30 Eisai R&D Management Co., Ltd. Jedinjenje 3-fenilpirazolo[5,1-b]tiazol
WO2010032195A1 (en) 2008-09-16 2010-03-25 Csir Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
EA021293B1 (ru) 2008-12-08 2015-05-29 Джилид Коннектикут, Инк. ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
CN102307474B (zh) 2008-12-08 2015-04-01 吉利德康涅狄格股份有限公司 咪唑并吡嗪syk抑制剂
EP2376502B1 (en) 2008-12-19 2015-06-17 GlaxoSmithKline LLC Thiazolopyridine sirtuin modulating compounds
AR078521A1 (es) * 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
CN103168039B (zh) 2010-03-11 2016-08-03 吉利德康涅狄格公司 咪唑并吡啶类syk抑制剂
EP3620161A1 (en) 2011-12-16 2020-03-11 University of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
BR112014026651A8 (pt) 2012-04-26 2018-01-16 Bristol Myers Squibb Co derivados de imidazotiadiazol e de imidazopiridazina como inibidores do receptor ativado por proteases 4 (par4) para o tratamento de agregação plaquetária
WO2013163244A1 (en) 2012-04-26 2013-10-31 Bristol-Myers Squibb Company Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation
LT2841437T (lt) 2012-04-26 2017-09-11 Bristol-Myers Squibb Company Imidazotiadiazolo ir imidazopirazino dariniai, kaip proteazės aktyvuotų receptorių 4 (par4) inhibitoriai, skirti trombocitų agregacijos gydymui
WO2014076021A1 (en) * 2012-11-14 2014-05-22 F. Hoffmann-La Roche Ag Imidazopyridine derivatives
EA029281B1 (ru) 2013-07-30 2018-03-30 Джилид Коннектикут, Инк. Полиморф ингибиторов syk
CA2919522C (en) 2013-07-30 2019-02-26 Gilead Connecticut, Inc. Formulation of syk inhibitors
AU2014352780A1 (en) 2013-11-22 2016-06-09 University Of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
CN105764516A (zh) 2013-12-04 2016-07-13 吉利德科学公司 治疗癌症的方法
TWI662037B (zh) 2013-12-23 2019-06-11 美商基利科學股份有限公司 脾酪胺酸激酶抑制劑
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
MX373103B (es) 2014-02-13 2020-04-17 Incyte Holdings Corp Ciclopropilaminas como inhibidores de desmetilasa específica de lisina 1 (lsd1).
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
SI3105218T1 (sl) 2014-02-13 2019-11-29 Incyte Corp Ciklopropilamini kot inhibitorji LSD1
EP3105219B9 (en) 2014-02-13 2018-10-03 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
US9617279B1 (en) 2014-06-24 2017-04-11 Bristol-Myers Squibb Company Imidazooxadiazole compounds
US9598419B1 (en) 2014-06-24 2017-03-21 Universite De Montreal Imidazotriazine and imidazodiazine compounds
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
WO2016007727A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
BR112016028641A2 (pt) 2014-07-14 2017-08-22 Gilead Sciences Inc ?método para tratar câncer?
EP3277689B1 (en) 2015-04-03 2019-09-04 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
KR20170140306A (ko) 2015-04-27 2017-12-20 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도
LT3334709T (lt) 2015-08-12 2025-03-10 Incyte Holdings Corporation Lsd1 inhibitoriaus druskos
JP6999574B2 (ja) 2016-04-22 2022-01-18 インサイト・コーポレイション Ｌｓｄ１阻害剤の製剤
US11098043B2 (en) * 2017-07-14 2021-08-24 University Of Massachusetts Certain imidazopyridines as cyclic AMP response element binding (CREB) binding protein (CBP) inhibitors and uses thereof
CA3073871A1 (en) 2017-08-25 2019-02-28 Gilead Sciences, Inc. Polymorphs of syk inhibitors
JP2020536853A (ja) * 2017-10-04 2020-12-17 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 転写因子ｓａｌｌ４の小分子阻害およびその使用
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
CN113950479A (zh) 2019-02-22 2022-01-18 克洛诺斯生物股份有限公司 作为syk抑制剂的缩合吡嗪的固体形式
WO2024220541A1 (en) * 2023-04-18 2024-10-24 Kallyope, Inc. Nk3 modulators and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3030982A1 (de) * 1979-08-21 1981-03-12 Yamanouchi Pharmaceutical Co., Ltd., Tokyo 2-phenylimidazo(2,1-b)benzothiazolderivate
EP0068378A1 (en) * 1981-06-26 1983-01-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
EP0266890A1 (en) * 1986-10-07 1988-05-11 Yamanouchi Pharmaceutical Co. Ltd. Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them
FR2638161A1 (fr) * 1988-10-24 1990-04-27 Centre Nat Rech Scient Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
WO1998006724A1 (en) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3489755A (en) * 1966-08-03 1970-01-13 Pfizer & Co C Imidazo (1,2-b) pyridazines
JPH08333258A (ja) * 1994-12-14 1996-12-17 Japan Tobacco Inc チアジン又はチアゼピン誘導体及びそれら化合物を含有してなる一酸化窒素合成酵素阻害剤
GB9506188D0 (en) * 1995-03-27 1995-05-17 Fujisawa Pharmaceutical Co Amidine derivatives
US5908842A (en) * 1995-12-08 1999-06-01 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
AUPP278498A0 (en) * 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3030982A1 (de) * 1979-08-21 1981-03-12 Yamanouchi Pharmaceutical Co., Ltd., Tokyo 2-phenylimidazo(2,1-b)benzothiazolderivate
EP0068378A1 (en) * 1981-06-26 1983-01-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
EP0266890A1 (en) * 1986-10-07 1988-05-11 Yamanouchi Pharmaceutical Co. Ltd. Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them
FR2638161A1 (fr) * 1988-10-24 1990-04-27 Centre Nat Rech Scient Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
WO1998006724A1 (en) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
L.Almirante, A.Mugnaini, P.Rugarli, A.Gamba, E. Zefelippo, N.Da Toma, W. Murmann, J. Med. Chem. 1969, 12, 122-126 *
R.C.Varma, D.Kumar, Tetrhedron letters 1999, 40, 7665-7669. Es wird daraufhingewiesen, daß die In- ternetpublikation dieses Artikel in Tetrahedron Alert ca. 4-6 Wochen vor dem Erscheinen des Hefteswar. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10117184A1 (de) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen

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