PE20010632A1 - Derivados de ter-butil-(7-metil-imidazol[1,2-a]piridin-3-il)-amina, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen - Google Patents

Derivados de ter-butil-(7-metil-imidazol[1,2-a]piridin-3-il)-amina, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen

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Publication number
PE20010632A1
PE20010632A1 PE2000001063A PE0010632000A PE20010632A1 PE 20010632 A1 PE20010632 A1 PE 20010632A1 PE 2000001063 A PE2000001063 A PE 2000001063A PE 0010632000 A PE0010632000 A PE 0010632000A PE 20010632 A1 PE20010632 A1 PE 20010632A1
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Peru
Prior art keywords
pyridin
methyl
imidazol
procedure
preparation
Prior art date
Application number
PE2000001063A
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English (en)
Inventor
Johannes Schneider
Bernd Sundermann
Hagen-Heinrich Hennies
Matthias Gerlach
Corinna Maul
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20010632A1 publication Critical patent/PE20010632A1/es

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    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07ORGANIC CHEMISTRY
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
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    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
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    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

SE REFIERE A DERIVADOS DE TERBUTIL-(7-METIL-IMIDAZOL[1,2-a]PIRIDIN-3-IL)-AMINA DE FORMULA I, DONDE R1 ES H, ALCANILO C1-C4; R2 ES ALQUILO C1-C8, CICLOALQUILO C3-C8, HETEROCICLO, ARILO, HETEROARILO, ENTRE OTROS; EXCEPTO COMPUESTOS CUANDO R1 ES METILO; R2 ES FENILO. SON COMPUESTOS PREFERIDOS TERBUTIL-(7-METIL-2-PIRIDIN-3-IL-IMIDAZOL[1,2-a]PIRIDIN-3-IL)AMINA, TERBUTIL-[2-(2,3-DIMETOXI-FENIL)-5,7-DIMETIL-IMIDAZO[1,2-a]PIRIDIN-3-IL]AMINA, 3-(3-TERBUTILAMINO-5,7-DIMETIL-IMIDAZO[1,2-a]PIRIDIN-2-IL)-FENOL, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN INHIBIDOR DE MONOXIDO DE NITROGENO SINTASA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE SHOCK SEPTICO, ESCLEROSIS MULTIPLE, PARKINSON, ALZHEIMER, HUNTINGTON, INFLAMACIONES, DOLORES INFLAMATORIOS, ISQUEMIA CEREBRAL, DIABETES, MENINGITIS, ARTERIOSCLEROSIS, CURACION DE HERIDAS
PE2000001063A 1999-10-08 2000-10-06 Derivados de ter-butil-(7-metil-imidazol[1,2-a]piridin-3-il)-amina, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen PE20010632A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19948434A DE19948434A1 (de) 1999-10-08 1999-10-08 Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine

Publications (1)

Publication Number Publication Date
PE20010632A1 true PE20010632A1 (es) 2001-07-07

Family

ID=7924888

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2000001062A PE20010706A1 (es) 1999-10-08 2000-10-06 Biblioteca de sustancias que contiene imidazo-5-il-aminas biciclicas y/o imidazo-3-il-aminas biciclicas, procedimiento para la preparacion de esta biblioteca de sustancias, y uso de sustancias de esta biblioteca para la preparacion de medicamentos pa
PE2000001063A PE20010632A1 (es) 1999-10-08 2000-10-06 Derivados de ter-butil-(7-metil-imidazol[1,2-a]piridin-3-il)-amina, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen

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PE2000001062A PE20010706A1 (es) 1999-10-08 2000-10-06 Biblioteca de sustancias que contiene imidazo-5-il-aminas biciclicas y/o imidazo-3-il-aminas biciclicas, procedimiento para la preparacion de esta biblioteca de sustancias, y uso de sustancias de esta biblioteca para la preparacion de medicamentos pa

Country Status (28)

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US (1) US6703404B2 (es)
EP (1) EP1218378B1 (es)
JP (1) JP2003511450A (es)
KR (1) KR100793619B1 (es)
CN (1) CN1208336C (es)
AR (2) AR025959A1 (es)
AT (1) ATE238304T1 (es)
AU (2) AU7419900A (es)
BR (1) BR0014827A (es)
CA (1) CA2386804A1 (es)
CO (2) CO5210861A1 (es)
CZ (1) CZ20021241A3 (es)
DE (2) DE19948434A1 (es)
DK (1) DK1218378T3 (es)
ES (1) ES2198355T3 (es)
HK (1) HK1047749B (es)
HU (1) HUP0203545A3 (es)
IL (3) IL148997A0 (es)
MX (1) MXPA02003546A (es)
NO (1) NO20021564L (es)
NZ (1) NZ518438A (es)
PE (2) PE20010706A1 (es)
PL (1) PL355109A1 (es)
PT (1) PT1218378E (es)
RU (1) RU2002110281A (es)
SK (1) SK4622002A3 (es)
WO (2) WO2001027119A2 (es)
ZA (2) ZA200203581B (es)

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