HUP0203545A2 - Tercier butil-(7-metil-imidazo[1,2-a]piridin-3-il)-amin-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Tercier butil-(7-metil-imidazo[1,2-a]piridin-3-il)-amin-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0203545A2
HUP0203545A2 HU0203545A HUP0203545A HUP0203545A2 HU P0203545 A2 HUP0203545 A2 HU P0203545A2 HU 0203545 A HU0203545 A HU 0203545A HU P0203545 A HUP0203545 A HU P0203545A HU P0203545 A2 HUP0203545 A2 HU P0203545A2
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Hungary
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unsubstituted
substituted
group
singly
unsaturated
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HU0203545A
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English (en)
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Matthias Gerlach
Hagen-Heinrich Hennies
Corinna Maul
Johannes Schneider
Bernd Sundermann
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Grünenthal GmbH
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Publication of HUP0203545A2 publication Critical patent/HUP0203545A2/hu
Publication of HUP0203545A3 publication Critical patent/HUP0203545A3/hu

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A találmány (I) általános képletű tercier butil-(7-metil-imidazo[1,2-a]piridin-3-il)-amin-származékokra[mely képletben R1 jelentésehidrogénatom vagy egyenes- vagy elágazóláncú, helyettesítetlen vagyegyszeresen vagy többszörösen helyettesített alkanilcsoport; és R2jelentése 1-8 szénatomos egyenes- vagy elágazóláncú, telített vagytelítetlen, helyettesítetlen vagy egyszeresen vagy többszörösenhelyettesített alkilcsoport; 3-8 szénatomos telített vagy telítetlen,helyettesített vagy egyszeresen vagy többszörösen helyettesítettcikloalkil-csoport; telített vagy telítetlen, helyettesítetlen vagyegyszeresen vagy többszörösen helyettesített heterociklikus-csoport;helyettesítetlen vagy egyszeresen vagy többszörösen helyettesítettarilcsoport; helyettesítetlen vagy egyszeresen vagy többszörösenhelyettesített heteroaril-csoport; 1-8 szénatomos alkil-(3-8szénatomos cikloalkil)-csoport; 1-8 szénatomos alkil-heterociklikus-csoport; 1-8 szénatomos alkil-aril-csoport vagy 1-8 szénatomos alkil-heteroaril-csoport; mimellet az alkilcsoport egyenes- vagyelágazóláncú, telített vagy telítetlen és helyettesítetlen vagyegyszeresen vagy többszörösen helyettesítve lehet; a cikloalkil-csoport telített vagy telítetlen és helyettesítetlen vagy egyszeresenvagy többszörösen helyettesítve lehet; a heterociklikus-csoporttelített vagy telítetlen és helyettesítetlen vagy egyszeresen vagytöbbszörösen helyettesített lehet; az arilcsoport helyettesítetlenvagy egyszeresen vagy többszörösen helyettesített lehetés aheteroaril-csoport helyettesítetlen vagy egyszeresen vagy többszörösenhelyettesítve lehet] és gyógyászatilag alkalmas sóikra, e vegyületekelőállítására, valamint a fenti vegyületeket tartalmazó gyógyászatikészítményekre vonatkozik. A találmány szerinti vegyületek NO-szintázgátló hatással rendelkeznek és többek között migrén kezelésérealkalmazhatók. Ó
HU0203545A 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridine-3-yl)-amine derivatives, pharmaceutical compositions containing them, process for their preparation and their use HUP0203545A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19948434A DE19948434A1 (de) 1999-10-08 1999-10-08 Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine
PCT/EP2000/009791 WO2001027109A2 (de) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amin-derivate

Publications (2)

Publication Number Publication Date
HUP0203545A2 true HUP0203545A2 (hu) 2003-02-28
HUP0203545A3 HUP0203545A3 (en) 2004-07-28

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HU0203545A HUP0203545A3 (en) 1999-10-08 2000-10-06 Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridine-3-yl)-amine derivatives, pharmaceutical compositions containing them, process for their preparation and their use

Country Status (28)

Country Link
US (1) US6703404B2 (hu)
EP (1) EP1218378B1 (hu)
JP (1) JP2003511450A (hu)
KR (1) KR100793619B1 (hu)
CN (1) CN1208336C (hu)
AR (2) AR025960A1 (hu)
AT (1) ATE238304T1 (hu)
AU (2) AU7419900A (hu)
BR (1) BR0014827A (hu)
CA (1) CA2386804A1 (hu)
CO (2) CO5210861A1 (hu)
CZ (1) CZ20021241A3 (hu)
DE (2) DE19948434A1 (hu)
DK (1) DK1218378T3 (hu)
ES (1) ES2198355T3 (hu)
HK (1) HK1047749B (hu)
HU (1) HUP0203545A3 (hu)
IL (3) IL148997A0 (hu)
MX (1) MXPA02003546A (hu)
NO (1) NO20021564L (hu)
NZ (1) NZ518438A (hu)
PE (2) PE20010706A1 (hu)
PL (1) PL355109A1 (hu)
PT (1) PT1218378E (hu)
RU (1) RU2002110281A (hu)
SK (1) SK4622002A3 (hu)
WO (2) WO2001027119A2 (hu)
ZA (2) ZA200203581B (hu)

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