PE20020906A1 - Inhibidores de peptido-deformilasa - Google Patents
Inhibidores de peptido-deformilasaInfo
- Publication number
- PE20020906A1 PE20020906A1 PE2002000170A PE2002000170A PE20020906A1 PE 20020906 A1 PE20020906 A1 PE 20020906A1 PE 2002000170 A PE2002000170 A PE 2002000170A PE 2002000170 A PE2002000170 A PE 2002000170A PE 20020906 A1 PE20020906 A1 PE 20020906A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- compounds
- heptanoil
- carbocycle
- hydrazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/34—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/30—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C243/32—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Quinoline Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA IIDONDE R ES ALQUILO C2-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, (CH2)n-CARBOCICLO C3-C6, ENTRE OTROS; R1 ES H, ALQUILO C1-C6, OH, (CH2)n-CARBOCICLO C3-C7; R2 ES H (CON LA CONDICION DE QUE X NO ES O) ALQUILO C1-C3, ALQUENILO C2-C3, ALQUINILO C2-C3, ENTRE OTROS; R3 ES H, ALQUILO C1-C3, FENILO; R2 JUNTO A N FORMAN UN ANILLO HETEROCICLICO QUE PUEDE ESTAR OPCIONALMENTE CONDENSADO A UN ANILLO DE ARILO, HETEROARILO; X ES O, NR3, ENLACE COVALENTE; Y ES O, CH2, ENLACE COVALENTE; n ES 0-2. SON COMPUESTOS PREFERIDOS N-BUTIL-N-(t-BUTOXICARBONILO)-N'-{(2R)-[(FORMILHIDROXIAMINO)METIL]HEPTANOIL}-HIDRAZINA, N-BUTIL-N-FENOXICARBONIL-N'-{(2R)-[(FORMILHIDROXIAMINO)METIL]HEPTANOIL}-HIDRAZINA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE PEPTIDO-DEFORMILASA Y SON UTILES PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27257001P | 2001-03-01 | 2001-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020906A1 true PE20020906A1 (es) | 2002-12-08 |
Family
ID=23040368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000170A PE20020906A1 (es) | 2001-03-01 | 2002-03-01 | Inhibidores de peptido-deformilasa |
Country Status (20)
Country | Link |
---|---|
US (1) | US7019003B2 (es) |
EP (1) | EP1363873B1 (es) |
JP (1) | JP4266638B2 (es) |
KR (1) | KR20030092008A (es) |
CN (1) | CN1505607A (es) |
AR (1) | AR032920A1 (es) |
AU (1) | AU2002335490B2 (es) |
BR (1) | BR0207810A (es) |
CA (1) | CA2439827A1 (es) |
CZ (1) | CZ20032342A3 (es) |
EG (1) | EG24516A (es) |
HU (1) | HUP0303308A2 (es) |
IL (1) | IL157643A0 (es) |
MX (1) | MXPA03007869A (es) |
NO (1) | NO20033828L (es) |
NZ (1) | NZ527728A (es) |
PE (1) | PE20020906A1 (es) |
PL (1) | PL364563A1 (es) |
UY (1) | UY27192A1 (es) |
WO (1) | WO2002070541A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY27813A1 (es) * | 2002-05-31 | 2003-12-31 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
AU2003245423A1 (en) * | 2002-06-06 | 2003-12-22 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
CN100439334C (zh) | 2002-09-19 | 2008-12-03 | 诺瓦提斯公司 | 制备中间体的方法 |
GB0229673D0 (en) * | 2002-12-19 | 2003-01-29 | British Biotech Pharm | Antibacterial agents |
US7332485B2 (en) * | 2003-07-08 | 2008-02-19 | Smithkline Beecham Corp | Peptide deformylase inhibitors |
US7507726B2 (en) * | 2003-08-15 | 2009-03-24 | Smithklinebeecham Corporation | Peptide deformylase inhibitors |
EP1827449A4 (en) * | 2004-11-17 | 2008-01-23 | Smithkline Beecham Corp | USE OF NOVEL ANTIBACTERIAL COMPOUNDS |
ES2435078T3 (es) * | 2005-07-29 | 2013-12-18 | Glaxosmithkline Llc | Inhibidores de la péptido deformilasa |
US7622492B2 (en) | 2005-08-31 | 2009-11-24 | Hoffmann-La Roche Inc. | Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase |
DK1954697T3 (da) * | 2005-10-21 | 2010-06-14 | Glaxo Group Ltd | Peri-kondenserede tricykliske forbindelser, der er anvendelige som antibakterielle midler |
KR100753796B1 (ko) * | 2006-07-28 | 2007-08-31 | 주식회사 프로메디텍 | 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물 |
GB0707706D0 (en) * | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
UA108596C2 (xx) * | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
US8466151B2 (en) | 2007-12-26 | 2013-06-18 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
EP2318406B1 (en) | 2008-07-17 | 2016-01-27 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
WO2011120153A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
WO2013082388A1 (en) * | 2011-12-02 | 2013-06-06 | Glaxosmithkline Intellectual Property (No. 2) Limited | Peptide deformylase inhibitors |
CN116375698B (zh) * | 2023-06-05 | 2023-08-01 | 中国林业科学研究院林产化学工业研究所 | 具有靶向抗肿瘤活性的漆酚基异羟肟酸型hdac抑制剂及其制备方法和应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
US6013792A (en) * | 1993-08-05 | 2000-01-11 | Syntex (U.S.A.), Inc. | Matrix metalloprotease inhibitors |
US6037472A (en) * | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
ATE181055T1 (de) * | 1994-05-28 | 1999-06-15 | British Biotech Pharm | Succinyl hydroxamsäure-, n-formyl-n-hydroxy- aminocarbonsäure- und succinsäureamid-derivate und ihre verwendung als metalloprotease- inhibitoren |
GB9827805D0 (en) | 1998-12-16 | 1999-02-10 | British Biotech Pharm | Antibacterial agents |
WO2001042431A2 (en) | 1999-12-08 | 2001-06-14 | Bayer Aktiengesellschaft | Regulation of human mitochondrial deformylase |
-
2002
- 2002-02-28 UY UY27192A patent/UY27192A1/es not_active Application Discontinuation
- 2002-02-28 AR ARP020100730A patent/AR032920A1/es not_active Application Discontinuation
- 2002-03-01 US US10/469,433 patent/US7019003B2/en not_active Expired - Fee Related
- 2002-03-01 HU HU0303308A patent/HUP0303308A2/hu unknown
- 2002-03-01 BR BRPI0207810-4A patent/BR0207810A/pt not_active IP Right Cessation
- 2002-03-01 PL PL02364563A patent/PL364563A1/xx not_active Application Discontinuation
- 2002-03-01 KR KR10-2003-7011370A patent/KR20030092008A/ko not_active Application Discontinuation
- 2002-03-01 CN CNA028092570A patent/CN1505607A/zh active Pending
- 2002-03-01 WO PCT/US2002/006275 patent/WO2002070541A2/en active IP Right Grant
- 2002-03-01 EP EP02748375.9A patent/EP1363873B1/en not_active Expired - Lifetime
- 2002-03-01 CZ CZ20032342A patent/CZ20032342A3/cs unknown
- 2002-03-01 NZ NZ527728A patent/NZ527728A/en not_active IP Right Cessation
- 2002-03-01 AU AU2002335490A patent/AU2002335490B2/en not_active Ceased
- 2002-03-01 JP JP2002569860A patent/JP4266638B2/ja not_active Expired - Fee Related
- 2002-03-01 IL IL15764302A patent/IL157643A0/xx unknown
- 2002-03-01 PE PE2002000170A patent/PE20020906A1/es not_active Application Discontinuation
- 2002-03-01 CA CA002439827A patent/CA2439827A1/en not_active Abandoned
- 2002-03-01 MX MXPA03007869A patent/MXPA03007869A/es not_active Application Discontinuation
-
2003
- 2003-05-20 EG EG2003050473A patent/EG24516A/xx active
- 2003-08-28 NO NO20033828A patent/NO20033828L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20040087585A1 (en) | 2004-05-06 |
MXPA03007869A (es) | 2003-12-04 |
WO2002070541A2 (en) | 2002-09-12 |
WO2002070541A3 (en) | 2002-12-19 |
HUP0303308A2 (hu) | 2004-01-28 |
EG24516A (en) | 2009-08-19 |
JP2004537507A (ja) | 2004-12-16 |
EP1363873B1 (en) | 2016-04-20 |
CN1505607A (zh) | 2004-06-16 |
PL364563A1 (en) | 2004-12-13 |
UY27192A1 (es) | 2002-09-30 |
BR0207810A (pt) | 2008-04-15 |
AU2002335490B2 (en) | 2005-10-20 |
NO20033828L (no) | 2003-10-06 |
US7019003B2 (en) | 2006-03-28 |
CA2439827A1 (en) | 2002-09-12 |
JP4266638B2 (ja) | 2009-05-20 |
KR20030092008A (ko) | 2003-12-03 |
IL157643A0 (en) | 2004-03-28 |
NZ527728A (en) | 2004-09-24 |
CZ20032342A3 (cs) | 2004-04-14 |
NO20033828D0 (no) | 2003-08-28 |
EP1363873A4 (en) | 2006-01-04 |
AR032920A1 (es) | 2003-12-03 |
EP1363873A2 (en) | 2003-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20020906A1 (es) | Inhibidores de peptido-deformilasa | |
PE20010632A1 (es) | Derivados de ter-butil-(7-metil-imidazol[1,2-a]piridin-3-il)-amina, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen | |
UY26727A1 (es) | Derivados de tropano útiles en terapia | |
AR027518A1 (es) | Inhibidores de girasas y usos de los mismos | |
NO20054195D0 (no) | Isoksazolforbindelser som inhibitorer for varmesjokkproteiner | |
AR038536A1 (es) | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados | |
HUP0400828A2 (hu) | Kondenzált heterociklikus aminopirimidinek, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények | |
BRPI0506817A (pt) | inibidores seletivos de quinase | |
AR049578A1 (es) | Derivados de hidantoina, procesos de obtencion y composiciones farmaceuticas | |
PE20010634A1 (es) | Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen | |
EA200300333A1 (ru) | Новые тиадиазолы и оксадиазолы и их применение в качестве ингибиторов фосфодиэстеразы-7 | |
DK1485377T3 (da) | Pyranoner egnede som ATM-inhibitorer | |
CL2004001167A1 (es) | Compuestos derivados de tiazolidindionas; procedimiento de elaboracion: composicion farmaceutica que los contiene; y su uso en el tratamiento de la diabetes. | |
MY143245A (en) | 4- 2-(cycloalkylamino)pyrimidin-4-yl-(phenyl)-imidazolin-2-one derivatives as p38 map-kinase inhibitors for the treatment of inflammatory diseases | |
CO5680413A2 (es) | Aminoacidos con afinidad por la proteina c2 delta | |
DE69414019T2 (de) | Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren | |
DE60330758D1 (de) | Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen | |
ATE374750T1 (de) | Serotoninwiederaufnahme-inhibitoren | |
PE20050160A1 (es) | 3-aminopirrolidinas como inhibidores de la captacion de monoaminas | |
AR057558A1 (es) | Compuestos de cinolincarboxamida y composicion farmaceutica | |
HU911992D0 (en) | 2-(amino-alkyl)-5-(aryl-alkyl)-1,3-dioxanes, and process for the production of the medical preparations containing them | |
ATE445619T1 (de) | Pyridinylpyrazolopyrimidinon-derivate als pde 7 inhibitoren | |
AR044175A1 (es) | Compuestos de cefemo | |
AR037140A1 (es) | Un compuesto de aminopirrol, su utilizacion, un procedimiento para producirlo y una composicion que lo comprende | |
ATE413174T1 (de) | Nicht-nucleoside revers-transcriptase inhibitoren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |