DE60330758D1 - Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen - Google Patents

Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen

Info

Publication number
DE60330758D1
DE60330758D1 DE60330758T DE60330758T DE60330758D1 DE 60330758 D1 DE60330758 D1 DE 60330758D1 DE 60330758 T DE60330758 T DE 60330758T DE 60330758 T DE60330758 T DE 60330758T DE 60330758 D1 DE60330758 D1 DE 60330758D1
Authority
DE
Germany
Prior art keywords
substituted amino
amino alkyl
certain pharmaceutically
pharmaceutically valuable
alkyl heterocycles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60330758T
Other languages
English (en)
Inventor
Scott K Thompson
James S Frazee
Lara S Kallander
Chum Ma
Joseph P Marino
Michael J Neeb
Ajita Bhat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of DE60330758D1 publication Critical patent/DE60330758D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
DE60330758T 2002-03-27 2003-03-26 Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen Expired - Lifetime DE60330758D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36841502P 2002-03-27 2002-03-27
PCT/US2003/009039 WO2003082192A2 (en) 2002-03-27 2003-03-26 Certain pharmaceutically useful substituted aminoalkyl heterocycles

Publications (1)

Publication Number Publication Date
DE60330758D1 true DE60330758D1 (de) 2010-02-11

Family

ID=28675483

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60330758T Expired - Lifetime DE60330758D1 (de) 2002-03-27 2003-03-26 Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen

Country Status (8)

Country Link
US (1) US7323494B2 (de)
EP (1) EP1490047B1 (de)
JP (1) JP2005521705A (de)
AT (1) ATE453389T1 (de)
AU (1) AU2003223340A1 (de)
DE (1) DE60330758D1 (de)
ES (1) ES2337037T3 (de)
WO (1) WO2003082192A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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WO2002024632A2 (en) * 2000-09-18 2002-03-28 Glaxo Group Limited Substituted aminopropoxyaryl derivatives useful as agonists for lxr
US7247748B2 (en) 2002-03-27 2007-07-24 Smithkline Corporation Amide compounds and methods of using the same
WO2003082205A2 (en) 2002-03-27 2003-10-09 Smithkline Beecham Corporation Compounds and methods
EP1511483A4 (de) * 2002-03-27 2009-03-18 Smithkline Beecham Corp Verfahren zur behandlung mit lxr-modulatoren
WO2003082802A1 (en) 2002-03-27 2003-10-09 Smithkline Beecham Corporation Acid and ester compounds and methods of using the same
CA2504878A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
FR2869904B1 (fr) 2004-05-07 2006-07-28 Fournier S A Sa Lab Modulateurs des recepteurs lxr
IL166149A0 (en) * 2005-01-05 2006-01-15 Hadasit Med Res Service Use of ezetimibe and amiodarone in protection against beta-amyloid neurotoxicity
JP5159633B2 (ja) 2006-11-30 2013-03-06 興和株式会社 置換カルビノール化合物
WO2009107387A1 (ja) 2008-02-29 2009-09-03 興和株式会社 ２－オキソクロメン誘導体
EP2264029A4 (de) 2008-03-31 2011-08-24 Kowa Co 1,3-dihydroisobenzofuran-derivat
EP2272843A4 (de) 2008-04-30 2011-07-20 Kowa Co Chinolinverbindung
JP5541803B2 (ja) 2008-05-29 2014-07-09 興和株式会社 環状リンカーを有する置換カルビノール化合物
AU2010243044C1 (en) 2009-04-29 2016-08-25 Kowa Company, Ltd. Carbinol compound having heterocyclic linker
WO2012033353A2 (ko) 2010-09-07 2012-03-15 서울대학교 산학협력단 세스터터핀 화합물 및 이들 물질의 용도
AU2018226879B2 (en) 2017-03-03 2023-09-14 Inspirna, Inc. Formulations with improved stability

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
WO1989003819A1 (en) 1987-10-20 1989-05-05 Otsuka Pharmaceutical Co., Ltd. Phenylcarboxylic acid derivatives
US20030153541A1 (en) 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
US6316503B1 (en) 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
WO2001060818A1 (en) 2000-02-14 2001-08-23 Tularik Inc. Lxr modulators
WO2002024632A2 (en) 2000-09-18 2002-03-28 Glaxo Group Limited Substituted aminopropoxyaryl derivatives useful as agonists for lxr
US20030229062A1 (en) 2001-12-07 2003-12-11 The Regents Of The University Of California Treatments for age-related macular degeneration (AMD)
US7470659B2 (en) 2001-12-07 2008-12-30 The Regents Of The University Of California Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
JP2005511713A (ja) 2001-12-07 2005-04-28 ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 加齢性黄斑変性についての処置
EP1511483A4 (de) * 2002-03-27 2009-03-18 Smithkline Beecham Corp Verfahren zur behandlung mit lxr-modulatoren
WO2003082802A1 (en) 2002-03-27 2003-10-09 Smithkline Beecham Corporation Acid and ester compounds and methods of using the same
WO2003082205A2 (en) 2002-03-27 2003-10-09 Smithkline Beecham Corporation Compounds and methods
US7247748B2 (en) 2002-03-27 2007-07-24 Smithkline Corporation Amide compounds and methods of using the same
AU2003301216A1 (en) 2002-12-23 2004-07-22 Irm Llc Novel use of liver x receptor agonists
GB0230177D0 (en) 2002-12-24 2003-02-05 Karobio Ab LXR beta crystal
WO2004110375A2 (en) 2003-06-06 2004-12-23 Merck & Co., Inc. Combination therapy for the treatment of diabetes
WO2004110368A2 (en) 2003-06-06 2004-12-23 Merck & Co., Inc. Combination therapy for the treatment of hypertension
US20060189693A1 (en) 2003-07-22 2006-08-24 Barone Frank C Methods of treatment with lxr agonists
EP1653938A2 (de) 2003-07-28 2006-05-10 Glaxo Group Limited Verfahren zur behandlung von chronisch entzündlichen darmerkrankungen mit lxr-agonisten
WO2005055998A1 (en) 2003-12-04 2005-06-23 Smithkline Beecham Corporation Methods of treatment with lxr agonists
BRPI0417543A (pt) 2003-12-12 2007-03-27 Wyeth Corp quinolinas úteis no tratamento de doença cardiovascular
JP2008503547A (ja) 2004-06-24 2008-02-07 ガラパゴス・ナムローゼ・フェンノートシャップ 骨ホメオスタシスを促進させる方法及び組成物
WO2006004030A1 (ja) 2004-07-02 2006-01-12 Sankyo Company, Limited 組織因子産生抑制剤

Also Published As

Publication number Publication date
US20050165045A1 (en) 2005-07-28
JP2005521705A (ja) 2005-07-21
US7323494B2 (en) 2008-01-29
EP1490047A2 (de) 2004-12-29
AU2003223340A1 (en) 2003-10-13
AU2003223340A8 (en) 2003-10-13
WO2003082192A2 (en) 2003-10-09
EP1490047A4 (de) 2006-01-04
ATE453389T1 (de) 2010-01-15
ES2337037T3 (es) 2010-04-20
EP1490047B1 (de) 2009-12-30
WO2003082192A3 (en) 2003-12-18

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: GLAXOSMITHKLINE LLC, PHILADELPHIA, PA., US

8364 No opposition during term of opposition