CO5680413A2 - Aminoacidos con afinidad por la proteina c2 delta - Google Patents

Aminoacidos con afinidad por la proteina c2 delta

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Publication number
CO5680413A2
CO5680413A2 CO06028475A CO06028475A CO5680413A2 CO 5680413 A2 CO5680413 A2 CO 5680413A2 CO 06028475 A CO06028475 A CO 06028475A CO 06028475 A CO06028475 A CO 06028475A CO 5680413 A2 CO5680413 A2 CO 5680413A2
Authority
CO
Colombia
Prior art keywords
alkyl
phenyl
pyridyl
optionally substituted
fluorine atoms
Prior art date
Application number
CO06028475A
Other languages
English (en)
Inventor
Deur Christopher James
Kolz Christine Nylund
Osuma Augustine Tobi
Mark Stephen Plummer
Schwarz Jacob Bradley
Andrew John Thorpe
Davied Juergen Wustrow
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34396281&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5680413(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CO5680413A2 publication Critical patent/CO5680413A2/es

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    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Abstract

1.- Un compuesto que tiene una estructura representada por la formula III o una sal farmaceuticamente aceptable del mismo, dondeR1 es alquilo (C1-C6) opcionalmente sustituido con uno o cinco átomos de fluor; y R3 es alquilo (C1-C6), cicloalquilo (C3-C6), cicloalquil (C3 - C6) - alquilo (C1 - C3), fenilo, fenil-alquilo (C1- C3), piridilo o piridil- alquilo (C1-C3), donde los restos o sustituyentes alquilo y cicloalquilo están opcionalmente sustituidos con uno a cinco átomos de flúor, y los sustituyentes fenilo y piridilo y los restos fenilo y piridilo de los sustituyentes fenil- alquilo (C1-C3) y piridil- alquilo (C1- C3) están opcionalmente sustituidos con uno a cinco sustituyentes, seleccionados independientemente entre cloro, fluoro, amino, nitro, ciano, hidroxi, alquilamino (C1- C3), alquilo (C1-C3) opcionalmente sustituido con uno a tres átomos de flúor, y alcoxi (C1- C3) opcionalmente sustituido con uno a tres átomos de flúor.
CO06028475A 2003-09-25 2006-03-22 Aminoacidos con afinidad por la proteina c2 delta CO5680413A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50595303P 2003-09-25 2003-09-25
US50744303P 2003-09-30 2003-09-30

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CO5680413A2 true CO5680413A2 (es) 2006-09-29

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US (3) US7179934B2 (es)
EP (1) EP1667957A2 (es)
JP (2) JP4001349B2 (es)
KR (2) KR100768974B1 (es)
AP (1) AP2006003544A0 (es)
AR (1) AR046022A1 (es)
AU (1) AU2004276072A1 (es)
BR (1) BRPI0414781A (es)
CA (1) CA2540208A1 (es)
CO (1) CO5680413A2 (es)
CR (1) CR8290A (es)
EA (1) EA200600467A1 (es)
EC (1) ECSP066450A (es)
IL (1) IL173764A0 (es)
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PE (1) PE20050434A1 (es)
RS (1) RS20060210A (es)
TN (1) TNSN06095A1 (es)
TW (1) TW200528420A (es)
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WO (1) WO2005030700A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505879A (ja) * 2004-07-09 2008-02-28 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー アルファ−２−デルタタンパク質に親和性を有するベータ−アミノ酸の製造
CA2602418A1 (en) * 2005-03-24 2006-09-28 Pharmacia & Upjohn Company Llc Preparation of optically pure beta-amino acids having affinity for the alpha-2-delta protein
JP2009516675A (ja) * 2005-11-17 2009-04-23 ファイザー・リミテッド 疼痛を治療するためのイソシステイン誘導体
BRPI0708671A2 (pt) * 2006-03-06 2011-06-07 Pfizer Prod Inc ligantes alfa-2-delta para sono não restaurador
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US7388023B2 (en) 2008-06-17
CR8290A (es) 2006-10-17
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