AR037140A1 - Un compuesto de aminopirrol, su utilizacion, un procedimiento para producirlo y una composicion que lo comprende - Google Patents
Un compuesto de aminopirrol, su utilizacion, un procedimiento para producirlo y una composicion que lo comprendeInfo
- Publication number
- AR037140A1 AR037140A1 ARP020103226A ARP020103226A AR037140A1 AR 037140 A1 AR037140 A1 AR 037140A1 AR P020103226 A ARP020103226 A AR P020103226A AR P020103226 A ARP020103226 A AR P020103226A AR 037140 A1 AR037140 A1 AR 037140A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- procedure
- produce
- formula
- composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de aminopirrol de fórmula (1), un profármaco, isómero individual, una mezcla de isómeros o una sal farmacéuticamente aceptable de los mismos, donde cada uno de Ar1 y Ar2 es independientemente arilo opcionalmente sustituido; y cada uno de R1 y R2 es independientemente un grupo protector de nitrógeno, hidrógeno, o alquilo. Su utilización, un procedimiento para producirlo y una composición que lo comprende. El compuesto de fórmula (1) es útil en el tratamiento de enfermedades. Especialmente el compuesto de fórmula (1) es inhibidor de la p38 MAP quinasa y, por lo tanto, es útil para el tratamiento de enfermedades inflamatorias, particularmente artritis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31616901P | 2001-08-30 | 2001-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037140A1 true AR037140A1 (es) | 2004-10-27 |
Family
ID=23227809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103226A AR037140A1 (es) | 2001-08-30 | 2002-08-28 | Un compuesto de aminopirrol, su utilizacion, un procedimiento para producirlo y una composicion que lo comprende |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6696471B2 (es) |
| EP (1) | EP1423378B1 (es) |
| JP (1) | JP2005506324A (es) |
| KR (1) | KR20040029075A (es) |
| CN (1) | CN1281603C (es) |
| AR (1) | AR037140A1 (es) |
| AT (1) | ATE309239T1 (es) |
| AU (1) | AU2002331179B2 (es) |
| BR (1) | BR0212077A (es) |
| CA (1) | CA2458808A1 (es) |
| DE (1) | DE60207273T2 (es) |
| ES (1) | ES2252509T3 (es) |
| MX (1) | MXPA04001810A (es) |
| PL (1) | PL373115A1 (es) |
| RU (1) | RU2315045C2 (es) |
| WO (1) | WO2003020715A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| WO2006020365A2 (en) * | 2004-07-26 | 2006-02-23 | The Regents Of The University Of California | Method for prevention or treatment of inflamatory disease |
| US20100104536A1 (en) * | 2007-03-20 | 2010-04-29 | Indravadan Ambalal Modi | P38 inhibitors |
| US20180325947A1 (en) | 2015-10-27 | 2018-11-15 | Children's Hospital Medical Center | Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| AU2018346709A1 (en) | 2017-10-05 | 2020-04-16 | Fulcrum Therapeutics, Inc. | Use of p38 inhibitors to reduce expression of DUX4 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9710352A (pt) | 1996-07-11 | 1999-08-17 | Pfizer | Compostos piridilpirrole |
| WO1998007425A1 (en) * | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| US5776954A (en) * | 1996-10-30 | 1998-07-07 | Merck & Co., Inc. | Substituted pyridyl pyrroles, compositions containing such compounds and methods of use |
| PL344004A1 (en) | 1998-05-05 | 2001-09-10 | Hoffmann La Roche | Pyrazole derivatives as p-38 map kinase inhibitors |
| AU3859999A (en) * | 1998-05-14 | 1999-11-29 | G.D. Searle & Co. | 1,5-diaryl substituted pyrazoles as p38 kinase inhibitors |
-
2002
- 2002-08-26 DE DE60207273T patent/DE60207273T2/de not_active Expired - Fee Related
- 2002-08-26 RU RU2004109817/04A patent/RU2315045C2/ru not_active IP Right Cessation
- 2002-08-26 WO PCT/EP2002/009505 patent/WO2003020715A1/en active IP Right Grant
- 2002-08-26 EP EP02767427A patent/EP1423378B1/en not_active Expired - Lifetime
- 2002-08-26 CA CA002458808A patent/CA2458808A1/en not_active Abandoned
- 2002-08-26 MX MXPA04001810A patent/MXPA04001810A/es active IP Right Grant
- 2002-08-26 PL PL02373115A patent/PL373115A1/xx not_active Application Discontinuation
- 2002-08-26 JP JP2003524985A patent/JP2005506324A/ja active Pending
- 2002-08-26 AU AU2002331179A patent/AU2002331179B2/en not_active Ceased
- 2002-08-26 BR BR0212077-1A patent/BR0212077A/pt not_active IP Right Cessation
- 2002-08-26 KR KR10-2004-7002895A patent/KR20040029075A/ko active IP Right Grant
- 2002-08-26 ES ES02767427T patent/ES2252509T3/es not_active Expired - Lifetime
- 2002-08-26 CN CNB028166310A patent/CN1281603C/zh not_active Expired - Fee Related
- 2002-08-26 AT AT02767427T patent/ATE309239T1/de not_active IP Right Cessation
- 2002-08-28 AR ARP020103226A patent/AR037140A1/es unknown
- 2002-08-29 US US10/231,792 patent/US6696471B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1423378A1 (en) | 2004-06-02 |
| US6696471B2 (en) | 2004-02-24 |
| AU2002331179B2 (en) | 2008-04-17 |
| PL373115A1 (en) | 2005-08-08 |
| RU2315045C2 (ru) | 2008-01-20 |
| DE60207273D1 (de) | 2005-12-15 |
| RU2004109817A (ru) | 2005-10-20 |
| ES2252509T3 (es) | 2006-05-16 |
| WO2003020715A1 (en) | 2003-03-13 |
| CA2458808A1 (en) | 2003-03-13 |
| DE60207273T2 (de) | 2006-07-20 |
| CN1547578A (zh) | 2004-11-17 |
| US20030130319A1 (en) | 2003-07-10 |
| KR20040029075A (ko) | 2004-04-03 |
| ATE309239T1 (de) | 2005-11-15 |
| JP2005506324A (ja) | 2005-03-03 |
| BR0212077A (pt) | 2004-09-28 |
| CN1281603C (zh) | 2006-10-25 |
| MXPA04001810A (es) | 2004-07-08 |
| EP1423378B1 (en) | 2005-11-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |