CO5210870A1 - Imidazo-3-il-aminas biciclicas procedimiento para su preparacion y medicamentos que las contienen - Google Patents
Imidazo-3-il-aminas biciclicas procedimiento para su preparacion y medicamentos que las contienenInfo
- Publication number
- CO5210870A1 CO5210870A1 CO00074643A CO00074643A CO5210870A1 CO 5210870 A1 CO5210870 A1 CO 5210870A1 CO 00074643 A CO00074643 A CO 00074643A CO 00074643 A CO00074643 A CO 00074643A CO 5210870 A1 CO5210870 A1 CO 5210870A1
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- alkyl
- unbranched
- branched
- phenyl
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052757 nitrogen Chemical group 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- -1 1,1,3,3-tetramethylbutyl Chemical group 0.000 abstract 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
- YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Natural products C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 abstract 1
- 241000347391 Umbrina cirrosa Species 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 1
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Natural products C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 abstract 1
- 150000001454 anthracenes Chemical class 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000002240 furans Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000002987 phenanthrenes Chemical class 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003233 pyrroles Chemical class 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- 150000003577 thiophenes Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Imidazo-3-il-aminas bicíclicas de la fórmula general I <EMI FILE="00074643_1" ID="1" IMF=JPEG > en la cual X representa CR4 o N e Y representa CR5 o N, siempre que X e Y no representan simultáneamente nitrógeno,R1 representa (CH2)nCN con n = 4, 5 ó 6, fenilo, eventualmente sustituido, C4-C8-cicloalquilo, CH2CH2R (R = 4-morfolino), 1,1,3,3-tetrametilbutilo o CH2Ra, representando Ra hidrógeno, OH, C1-C8-alquilo (ramificado o no ramificado) fenilo eventualmente sustituido, CO(OR´) (R´ = C1-C4-alquilo no ramificado o C1-C5 ramificado, PO (OR´)2 (R´ = C1-C4-alquilo no ramificado o C1-C5-alquilo ramificado o Si (RXRYRZ) (en donde RX, RY y RZ representan independientemente entre sí radicales C1-C4-alquilo (ramificados o no ramificados), C4-C8-cicloalquilo o fenilo),R2 representa hidrógeno, CORb, en dondeRb representa C1-C4-alquilo (ramificado, o no ramificado) o C3-C8-cicloalquilo, CH2CH2CO (ORC), en donde RC representa C1-C4-alquilo (ramificado o no ramificado), adamantilo, fenilo eventualmente sustituido, 1-naftilo o 2-naftilo eventualmente sustituidos, o 2-piridilo, 3-piridilo, 4-piridilo, tiazolilo o furoilo eventualmente sustituidos, CH2fenilo, CH2CH2Rd, en donde Rd representa fenilo eventualmente sustituido, o CONHRe en donde Re representa C1-C8-alquilo (ramificado o no ramificado), C3-C8-alquilo o fenilo eventualmente sustituido,R3 representa C1-C8-alquilo (ramificado o no ramificado), C3-C8-cicloalquilo, fenilo eventualmente sustituido, naftilo eventualmente sustituido, pirrol eventualmente sustituido, piridilo eventualmente sustituido, furano eventualmente sustituido, tiofeno eventualmente sustituido, antraceno eventualmente sustituido, fenantreno eventualmente sustituido, o quinolina eventualmente sustituida,R4, R5, R6 y R7 representan independientemente entre sí hidrógeno, C1-C4-alquilo (ramificado o no ramificado), - 2 - NO2, NH2, OH, CF3 Cl, F, Br, CN, COOR, representando R hidrógeno, C1-C4-alquilo (ramificado o no ramificado), OR" en donde R" representa fenilo eventualmente sustituido, bencilo eventualmente sustituido, C1-C4-alquilo (ramificado o no ramificado) o R4 y R5 o R5 y R6 o R6 y R7 representan un puente de carbono de cuatro átomos que eventualmente contiene dobles ligaduras, en el cual eventualmente átomos de carbono individuales están sustituidos por heteroátomos tales como N, O o S, y todos los radicales R4, R5, R6 y R7 que no integran el puente representan hidrógeno,con la salvedad que al menos uno de los radicales R4, R5,R6 o R7 existentes en la molécula es distinto de hidrógeno yque cuando R1 representa metilo, etilo, propilo, n-butilo, isobutilo, CO(Ometilo) o bencilo, R3 es distinto de metilo, y que cuando uno de los radicales R4, R5, R6 y R7 representan O-bencilo o R4 representa OC1-C4-alquilo (ramificado o no ramificado) R1 es distinto de CH2Ra (representando Ra hidrógeno o C1-C5-alquilo (ramificado o no ramificado), en forma de sus bases o sus sales farmacéuticamente aceptables.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19948434A DE19948434A1 (de) | 1999-10-08 | 1999-10-08 | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
| DE1999148437 DE19948437A1 (de) | 1999-10-08 | 1999-10-08 | Am Sechsring substituierte, bicyclische Imidazo-3-aminderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5210870A1 true CO5210870A1 (es) | 2002-10-30 |
Family
ID=26055217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00074643A CO5210870A1 (es) | 1999-10-08 | 2000-10-02 | Imidazo-3-il-aminas biciclicas procedimiento para su preparacion y medicamentos que las contienen |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6849642B2 (es) |
| EP (1) | EP1218380B1 (es) |
| JP (1) | JP2003517466A (es) |
| KR (1) | KR20020038804A (es) |
| CN (1) | CN1222525C (es) |
| AR (1) | AR025961A1 (es) |
| AT (1) | ATE256684T1 (es) |
| AU (1) | AU780823B2 (es) |
| BR (1) | BR0014826A (es) |
| CA (1) | CA2386813C (es) |
| CO (1) | CO5210870A1 (es) |
| CZ (1) | CZ300315B6 (es) |
| DE (1) | DE50004817D1 (es) |
| DK (1) | DK1218380T3 (es) |
| ES (1) | ES2213044T3 (es) |
| HK (1) | HK1047748B (es) |
| HU (1) | HUP0203739A3 (es) |
| IL (2) | IL148998A0 (es) |
| MX (1) | MXPA02003547A (es) |
| NO (1) | NO20021563L (es) |
| NZ (1) | NZ518637A (es) |
| PE (1) | PE20010631A1 (es) |
| PT (1) | PT1218380E (es) |
| RU (1) | RU2002110282A (es) |
| SK (1) | SK286450B6 (es) |
| UY (1) | UY26371A1 (es) |
| WO (1) | WO2001027110A2 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10043845A1 (de) * | 2000-09-06 | 2002-03-14 | Gruenenthal Gmbh | Verfahren zur Messung der Aktivität der NO-Synthase |
| AU2002224927A1 (en) * | 2000-12-13 | 2002-06-24 | Basf Aktiengesellschaft | Use of substituted imidazoazines, novel imidazoazines, methods for the production thereof, and agents containing these compounds |
| US7157460B2 (en) | 2003-02-20 | 2007-01-02 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| US7186832B2 (en) | 2003-02-20 | 2007-03-06 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| DE102004021716A1 (de) * | 2004-04-30 | 2005-12-01 | Grünenthal GmbH | Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen |
| DE102004044884A1 (de) * | 2004-09-14 | 2006-05-24 | Grünenthal GmbH | Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen |
| DE102005016547A1 (de) * | 2005-04-08 | 2006-10-12 | Grünenthal GmbH | Substituierte 5,6,7,8-Tetrahydro-imidazo(1,2-a)pyridin-2-ylamin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| CA2620223A1 (en) | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
| WO2007138072A2 (en) * | 2006-05-31 | 2007-12-06 | Galapagos N.V. | Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases |
| WO2008134553A1 (en) * | 2007-04-26 | 2008-11-06 | Xenon Pharmaceuticals Inc. | Methods of using bicyclic compounds in treating sodium channel-mediated diseases |
| AU2008277628B2 (en) | 2007-07-18 | 2012-03-15 | Novartis Ag | Bicyclic heteroaryl compounds and their use as kinase inhibitors |
| WO2009065131A1 (en) * | 2007-11-16 | 2009-05-22 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| US8129390B2 (en) * | 2007-12-12 | 2012-03-06 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds and methods for using the same |
| CN102007133B (zh) * | 2008-04-15 | 2013-06-12 | 卫材R&D管理有限公司 | 3-苯基吡唑并[5,1-b]噻唑化合物 |
| ES2552549T3 (es) | 2008-04-23 | 2015-11-30 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida para el tratamiento de trastornos metabólicos |
| EP2334675B1 (en) | 2008-09-16 | 2014-03-26 | Csir | Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors |
| WO2010116302A1 (en) * | 2009-04-07 | 2010-10-14 | University Of The Witwatersrand, Johannesburg | Imidaz0[1,2-a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture |
| AR078521A1 (es) * | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
| KR101732212B1 (ko) * | 2010-03-18 | 2017-05-02 | 재단법인 한국파스퇴르연구소 | 항감염성 화합물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489755A (en) | 1966-08-03 | 1970-01-13 | Pfizer & Co C | Imidazo (1,2-b) pyridazines |
| EP0068378B1 (en) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| NZ221996A (en) * | 1986-10-07 | 1989-08-29 | Yamanouchi Pharma Co Ltd | Imidazo-pyridine derivatives and pharmaceutical compositions |
| TW274551B (es) * | 1991-04-16 | 1996-04-21 | Takeda Pharm Industry Co Ltd | |
| AU698867B2 (en) * | 1995-04-21 | 1998-11-12 | Shinnippon Pharmaceutical Inc. | Fused imidazo 1,2-a pyridines |
-
2000
- 2000-09-18 DK DK00964191T patent/DK1218380T3/da active
- 2000-09-18 NZ NZ518637A patent/NZ518637A/xx unknown
- 2000-09-18 WO PCT/EP2000/009095 patent/WO2001027110A2/de active IP Right Grant
- 2000-09-18 IL IL14899800A patent/IL148998A0/xx active IP Right Grant
- 2000-09-18 PT PT00964191T patent/PT1218380E/pt unknown
- 2000-09-18 RU RU2002110282/04A patent/RU2002110282A/ru not_active Application Discontinuation
- 2000-09-18 MX MXPA02003547A patent/MXPA02003547A/es active IP Right Grant
- 2000-09-18 AT AT00964191T patent/ATE256684T1/de active
- 2000-09-18 CZ CZ20021243A patent/CZ300315B6/cs not_active IP Right Cessation
- 2000-09-18 AU AU75199/00A patent/AU780823B2/en not_active Ceased
- 2000-09-18 DE DE50004817T patent/DE50004817D1/de not_active Expired - Lifetime
- 2000-09-18 ES ES00964191T patent/ES2213044T3/es not_active Expired - Lifetime
- 2000-09-18 HU HU0203739A patent/HUP0203739A3/hu unknown
- 2000-09-18 EP EP00964191A patent/EP1218380B1/de not_active Expired - Lifetime
- 2000-09-18 JP JP2001530328A patent/JP2003517466A/ja not_active Withdrawn
- 2000-09-18 KR KR1020027004504A patent/KR20020038804A/ko not_active Application Discontinuation
- 2000-09-18 CA CA002386813A patent/CA2386813C/en not_active Expired - Fee Related
- 2000-09-18 BR BR0014826-1A patent/BR0014826A/pt not_active IP Right Cessation
- 2000-09-18 SK SK461-2002A patent/SK286450B6/sk not_active IP Right Cessation
- 2000-09-18 CN CNB008164304A patent/CN1222525C/zh not_active Expired - Fee Related
- 2000-10-02 CO CO00074643A patent/CO5210870A1/es not_active Application Discontinuation
- 2000-10-05 AR ARP000105253A patent/AR025961A1/es unknown
- 2000-10-05 UY UY26371A patent/UY26371A1/es not_active Application Discontinuation
- 2000-10-06 PE PE2000001065A patent/PE20010631A1/es not_active Application Discontinuation
-
2002
- 2002-04-03 NO NO20021563A patent/NO20021563L/no not_active Application Discontinuation
- 2002-04-04 IL IL148998A patent/IL148998A/en not_active IP Right Cessation
- 2002-04-08 US US10/117,334 patent/US6849642B2/en not_active Expired - Fee Related
- 2002-12-28 HK HK02109383.4A patent/HK1047748B/zh not_active IP Right Cessation
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