PE20081534A1 - Piperidinas sustituidas que tienen actividad inhibidoras de la proteina cinasa - Google Patents

Piperidinas sustituidas que tienen actividad inhibidoras de la proteina cinasa

Info

Publication number
PE20081534A1
PE20081534A1 PE2008000027A PE2008000027A PE20081534A1 PE 20081534 A1 PE20081534 A1 PE 20081534A1 PE 2008000027 A PE2008000027 A PE 2008000027A PE 2008000027 A PE2008000027 A PE 2008000027A PE 20081534 A1 PE20081534 A1 PE 20081534A1
Authority
PE
Peru
Prior art keywords
protein kinase
substituted
piperidins
inhibiting activity
kinase inhibiting
Prior art date
Application number
PE2008000027A
Other languages
English (en)
Inventor
Steven John Woodhead
Martyn Frederickson
Christopher Hamlett
Hannah Fiona Sore
David Winter Walker
Peter Blurton
Ian Collins
Kwai Ming Cheung
John Caldwell
Fonseca Mchary Tatiana Faria Da
Richard William Arthur Luke
Zbigniew Stanley Matusiak
Andrew Leach
Jeffrey James Morris
Original Assignee
Astex Therapeutics Ltd
Cancer Research Technology Ltd Inst Cancer Res Royal Cancer Hospital
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39283821&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081534(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0625668A external-priority patent/GB0625668D0/en
Application filed by Astex Therapeutics Ltd, Cancer Research Technology Ltd Inst Cancer Res Royal Cancer Hospital, Astrazeneca Ab filed Critical Astex Therapeutics Ltd
Publication of PE20081534A1 publication Critical patent/PE20081534A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
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    • A61P17/04—Antipruritics
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    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
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  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE E ES HETEROARILO DE 5 MIEMBROSCON 1-4 HETEROATOMOS SELECCIONADOS DE O, N Y S; q Y r SON CADA UNO 0-1, CON TAL QUE LA SUMA DE q + r SEA 1-2; T ES N, CR5; J1-J2 ES UN GRUPO N=C(R6), (R7)C=N, N=N, ENTRE OTROS; Q3 ES UN ENLACE, ENLAZADOR DE HIDROCARBURO SATURADO QUE CONTIENE1-3 ATOMOS DE CARBONO SUSTITUIDO O NO; G ES NR2R3, CN, OH; R1a Y R1b SON CADA UNO H, R10 O JUNTOS FORMAN ARILO, HETEROARILO, DE 5-6 MIEMBROS SUSTITUIDOS O NO; R3 Y R3 SON CADA UNO H, HIDROCARBILO C1-C4, ACILO C1-C4 SUSTITUIDOS O NO, ENTRE OTROS; R4 Y R6 SON CADA UNO H, HALOGENO, HIDROCARBILO C1-C5 SATURADO, CIANO, CONH2, CF3 Y NH2; R5 Y R7 SON CADA UNO H, HALOGENO, CIANO, ENTRE OTROS. UN COMPUESTO ES 4-(7-(BENCILOXI)-1H-BENZO[d]IMIDAZO-2-LIL)-1-(7H-PIRROLO[2,3-d]PIRIMIDI-4-NIL)PIPERIDI-1-NAMINA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA QUINASA B Y/O LA PROTEINA CINASA A
PE2008000027A 2006-12-21 2008-01-02 Piperidinas sustituidas que tienen actividad inhibidoras de la proteina cinasa PE20081534A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87138606P 2006-12-21 2006-12-21
GB0625668A GB0625668D0 (en) 2006-12-21 2006-12-21 Pharmaceutical compounds
US98263307P 2007-10-25 2007-10-25

Publications (1)

Publication Number Publication Date
PE20081534A1 true PE20081534A1 (es) 2008-12-19

Family

ID=39283821

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000027A PE20081534A1 (es) 2006-12-21 2008-01-02 Piperidinas sustituidas que tienen actividad inhibidoras de la proteina cinasa

Country Status (9)

Country Link
US (1) US20100093748A1 (es)
EP (1) EP2125805A1 (es)
JP (1) JP2010514675A (es)
AR (1) AR064416A1 (es)
CL (1) CL2007003791A1 (es)
PE (1) PE20081534A1 (es)
TW (1) TW200833676A (es)
UY (1) UY30830A1 (es)
WO (1) WO2008075109A1 (es)

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EP3421471B1 (en) 2006-04-25 2021-05-26 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
UA99284C2 (ru) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ
JP4705695B2 (ja) 2007-10-11 2011-06-22 アストラゼネカ アクチボラグ プロテインキナーゼｂ阻害剤としてのピロロ［２，３−ｄ］ピリミジン誘導体
US8193202B2 (en) * 2008-04-21 2012-06-05 Lexicon Pharmaceuticals, Inc. LIMK2 inhibitors, compositions comprising them, and methods of their use
MX2011005002A (es) * 2008-11-11 2011-05-25 Lilly Co Eli Inhibidor de p70 s6 quinasa y terapia de combinacion de inhibidor del receptor de egfr.
JP2012508239A (ja) * 2008-11-11 2012-04-05 イーライ リリー アンド カンパニー Ｐ７０ｓ６キナーゼ阻害剤およびｍｔｏｒ阻害剤の併用療法
AR074072A1 (es) 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
JOP20190231A1 (ar) 2009-01-15 2017-06-16 Incyte Corp طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
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JP2013542202A (ja) 2010-10-01 2013-11-21 ブリストル−マイヤーズ スクイブ カンパニー Ｃｙｐ１７修飾因子として有用である置換ベンゾイミダゾールおよびイミダゾピリジン化合物
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US8778926B2 (en) * 2011-01-21 2014-07-15 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof
HUE047357T2 (hu) 2011-04-01 2020-04-28 Astrazeneca Ab Gyógyászati kezelés
BR112013028895A2 (pt) 2011-05-10 2016-08-09 Bayer Ip Gmbh (tio)carbonilamidinas bicíclicas
JP5964974B2 (ja) * 2011-09-12 2016-08-03 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ キナーゼ活性のモジュレーターとしての新規イミダゾールアミン
US8969586B2 (en) 2011-09-27 2015-03-03 Bristol-Myers Squibb Company Substituted bicyclic heteroaryl compounds
KR102035361B1 (ko) 2011-11-30 2019-11-08 아스트라제네카 아베 암의 병용 치료
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
US9580443B2 (en) 2012-11-16 2017-02-28 Merck Patent Gmbh Heterocyclic derivatives as modulators of kinase activity
EP2920154B1 (en) 2012-11-16 2017-10-11 Merck Patent GmbH Novel imidazol-piperidinyl derivatives as modulators of kinase activity
SG10201900954SA (en) * 2013-03-11 2019-02-27 Merck Patent Gmbh Heterocycles as Modulators of Kinase Activity
US9771369B2 (en) 2014-03-04 2017-09-26 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2015162144A1 (de) * 2014-04-25 2015-10-29 Bayer Cropscience Ag Verfahren zum herstellen von biphenylaminen aus aniliden durch rutheniumkatalyse
CZ306987B6 (cs) * 2015-10-26 2017-11-01 Ústav experimentální botaniky AV ČR, v. v. i. 2,6-disubstituované puriny pro použití jako léčiva a farmaceutické přípravky je obsahující
WO2017201187A1 (en) * 2016-05-18 2017-11-23 Virongy, Llc Lim kinase inhibitors
EP3459953B1 (en) * 2016-05-20 2021-06-30 Taiho Pharmaceutical Co., Ltd. Novel 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one derivative
CA3167999A1 (en) * 2020-03-17 2021-09-23 Xin Li Fused bicyclic derivative, preparation method therefor, and pharmaceutical use thereof
CN113444110B (zh) * 2020-03-25 2023-05-12 江苏恒瑞医药股份有限公司 四氢吡咯并吡唑类衍生物、其制备方法及其在医药上的应用
CN117940410A (zh) 2021-09-17 2024-04-26 江苏恒瑞医药股份有限公司 一种稠合二环类衍生物的可药用盐、晶型及其制备方法
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MY179032A (en) * 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
TW200738709A (en) * 2006-01-19 2007-10-16 Osi Pharm Inc Fused heterobicyclic kinase inhibitors

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Publication number Publication date
AR064416A1 (es) 2009-04-01
CL2007003791A1 (es) 2008-08-22
JP2010514675A (ja) 2010-05-06
UY30830A1 (es) 2008-07-31
WO2008075109A1 (en) 2008-06-26
EP2125805A1 (en) 2009-12-02
TW200833676A (en) 2008-08-16
US20100093748A1 (en) 2010-04-15

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