AR025961A1 - Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen - Google Patents

Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen

Info

Publication number
AR025961A1
AR025961A1 ARP000105253A ARP000105253A AR025961A1 AR 025961 A1 AR025961 A1 AR 025961A1 AR P000105253 A ARP000105253 A AR P000105253A AR P000105253 A ARP000105253 A AR P000105253A AR 025961 A1 AR025961 A1 AR 025961A1
Authority
AR
Argentina
Prior art keywords
preparation
imidazo
bicycles
procedure
medicines containing
Prior art date
Application number
ARP000105253A
Other languages
English (en)
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999148437 external-priority patent/DE19948437A1/de
Priority claimed from DE19948434A external-priority patent/DE19948434A1/de
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR025961A1 publication Critical patent/AR025961A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Imidazo-3-il-aminas bicíclicas de la formula general (1) en forma de sus bases o sales farmacéuticamente aceptables, procedimeinto para us preparacion ymedicamento que contiene como sustancia activa al menos una amidazo-3-il-amina bicíclica de la formula general (1) en forma de su base o una salfarmacéuticamente aceptable. Los sustituyentes X, Y, R1, R2, R3, R7, R6 están definidos en la memoria descriptiva. Los compuestos son potentes ligandos delsubtipo alfa2 del receptor alfa-adrenérgico.
ARP000105253A 1999-10-08 2000-10-05 Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen AR025961A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999148437 DE19948437A1 (de) 1999-10-08 1999-10-08 Am Sechsring substituierte, bicyclische Imidazo-3-aminderivate
DE19948434A DE19948434A1 (de) 1999-10-08 1999-10-08 Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine

Publications (1)

Publication Number Publication Date
AR025961A1 true AR025961A1 (es) 2002-12-26

Family

ID=26055217

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000105253A AR025961A1 (es) 1999-10-08 2000-10-05 Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen

Country Status (27)

Country Link
US (1) US6849642B2 (es)
EP (1) EP1218380B1 (es)
JP (1) JP2003517466A (es)
KR (1) KR20020038804A (es)
CN (1) CN1222525C (es)
AR (1) AR025961A1 (es)
AT (1) ATE256684T1 (es)
AU (1) AU780823B2 (es)
BR (1) BR0014826A (es)
CA (1) CA2386813C (es)
CO (1) CO5210870A1 (es)
CZ (1) CZ300315B6 (es)
DE (1) DE50004817D1 (es)
DK (1) DK1218380T3 (es)
ES (1) ES2213044T3 (es)
HK (1) HK1047748B (es)
HU (1) HUP0203739A3 (es)
IL (2) IL148998A0 (es)
MX (1) MXPA02003547A (es)
NO (1) NO20021563L (es)
NZ (1) NZ518637A (es)
PE (1) PE20010631A1 (es)
PT (1) PT1218380E (es)
RU (1) RU2002110282A (es)
SK (1) SK286450B6 (es)
UY (1) UY26371A1 (es)
WO (1) WO2001027110A2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10043845A1 (de) * 2000-09-06 2002-03-14 Gruenenthal Gmbh Verfahren zur Messung der Aktivität der NO-Synthase
EP1343785A2 (de) * 2000-12-13 2003-09-17 Basf Aktiengesellschaft Verwendung von substituierten imidazoazinen, neue imidazoazine, verfahren zu deren herstellung, sowie sie enthaltende mittel
US7186832B2 (en) 2003-02-20 2007-03-06 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
US7157460B2 (en) 2003-02-20 2007-01-02 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
DE102004021716A1 (de) * 2004-04-30 2005-12-01 Grünenthal GmbH Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen
DE102004044884A1 (de) * 2004-09-14 2006-05-24 Grünenthal GmbH Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen
DE102005016547A1 (de) * 2005-04-08 2006-10-12 Grünenthal GmbH Substituierte 5,6,7,8-Tetrahydro-imidazo(1,2-a)pyridin-2-ylamin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
TW200800213A (en) 2005-09-02 2008-01-01 Abbott Lab Novel imidazo based heterocycles
EA200870592A1 (ru) * 2006-05-31 2009-08-28 Галапагос Н.В. Триазолопиразиновые соединения, пригодные для лечения дегенеративных и воспалительных заболеваний
WO2008134553A1 (en) * 2007-04-26 2008-11-06 Xenon Pharmaceuticals Inc. Methods of using bicyclic compounds in treating sodium channel-mediated diseases
CN101801966A (zh) 2007-07-18 2010-08-11 诺瓦提斯公司 双环杂芳基化合物和它们作为激酶抑制剂的用途
NZ585298A (en) 2007-11-16 2012-08-31 Rigel Pharmaceuticals Inc Carboxamide, sulfonamide and amine compounds for metabolic disorders
JP5650540B2 (ja) 2007-12-12 2015-01-07 ライジェル ファーマシューティカルズ， インコーポレイテッド 代謝障害のためのカルボキサミド、スルホンアミド、およびアミン化合物
KR101601994B1 (ko) * 2008-04-15 2016-03-17 에자이 알앤드디 매니지먼트 가부시키가이샤 3-페닐피라졸로[5,1-ｂ]티아졸 화합물
ES2552549T3 (es) 2008-04-23 2015-11-30 Rigel Pharmaceuticals, Inc. Compuestos de carboxamida para el tratamiento de trastornos metabólicos
WO2010032195A1 (en) * 2008-09-16 2010-03-25 Csir Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
US8481740B2 (en) * 2009-04-07 2013-07-09 University Of The Witwatersrand, Johannesburg Imidazo[1,2 a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture
AR078521A1 (es) * 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
US8865734B2 (en) * 2010-03-18 2014-10-21 Institut Pasteur Korea Anti-infective compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3489755A (en) 1966-08-03 1970-01-13 Pfizer & Co C Imidazo (1,2-b) pyridazines
EP0068378B1 (en) 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
NZ221996A (en) * 1986-10-07 1989-08-29 Yamanouchi Pharma Co Ltd Imidazo-pyridine derivatives and pharmaceutical compositions
TW274551B (es) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
EP0822194A4 (en) * 1995-04-21 1998-04-29 Shinnippon Pharmaceutical Inc ANNELLLIED IMIDAZO [1,2-a] PYRIDINE

Also Published As

Publication number Publication date
NZ518637A (en) 2004-12-24
CN1402727A (zh) 2003-03-12
SK4612002A3 (en) 2002-09-10
DE50004817D1 (de) 2004-01-29
AU7519900A (en) 2001-04-23
CZ300315B6 (cs) 2009-04-15
JP2003517466A (ja) 2003-05-27
BR0014826A (pt) 2002-08-27
US20020183327A1 (en) 2002-12-05
KR20020038804A (ko) 2002-05-23
SK286450B6 (sk) 2008-10-07
IL148998A (en) 2006-12-31
CN1222525C (zh) 2005-10-12
HUP0203739A2 (hu) 2003-02-28
EP1218380B1 (de) 2003-12-17
HK1047748A1 (en) 2003-03-07
UY26371A1 (es) 2000-10-31
CA2386813A1 (en) 2001-04-19
CO5210870A1 (es) 2002-10-30
AU780823B2 (en) 2005-04-21
NO20021563D0 (no) 2002-04-03
US6849642B2 (en) 2005-02-01
WO2001027110A2 (de) 2001-04-19
NO20021563L (no) 2002-06-04
ES2213044T3 (es) 2004-08-16
HUP0203739A3 (en) 2004-07-28
RU2002110282A (ru) 2003-12-20
EP1218380A2 (de) 2002-07-03
MXPA02003547A (es) 2002-09-18
ATE256684T1 (de) 2004-01-15
CA2386813C (en) 2008-09-02
PE20010631A1 (es) 2001-07-07
PT1218380E (pt) 2004-05-31
HK1047748B (zh) 2004-10-21
CZ20021243A3 (cs) 2003-12-17
DK1218380T3 (da) 2004-03-15
IL148998A0 (en) 2002-11-10
WO2001027110A3 (de) 2001-09-20
PL364866A1 (en) 2004-12-27

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