DD299067A5 - Verfahren zur herstellung von zwischenprodukten fuer epipodophyllotoxinglucosid-4'-phosphat-derivate - Google Patents

Verfahren zur herstellung von zwischenprodukten fuer epipodophyllotoxinglucosid-4'-phosphat-derivate Download PDF

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Publication number
DD299067A5
DD299067A5 DD88326917A DD32691788A DD299067A5 DD 299067 A5 DD299067 A5 DD 299067A5 DD 88326917 A DD88326917 A DD 88326917A DD 32691788 A DD32691788 A DD 32691788A DD 299067 A5 DD299067 A5 DD 299067A5
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DD
German Democratic Republic
Prior art keywords
etoposide
phosphate
compound
general formula
mmol
Prior art date
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DD88326917A
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German (de)
English (en)
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
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Publication date
Application filed by �������`�����@������@�������k�� filed Critical �������`�����@������@�������k��
Publication of DD299067A5 publication Critical patent/DD299067A5/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
DD88326917A 1987-08-04 1988-08-03 Verfahren zur herstellung von zwischenprodukten fuer epipodophyllotoxinglucosid-4'-phosphat-derivate DD299067A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
DD299067A5 true DD299067A5 (de) 1992-03-26

Family

ID=26765636

Family Applications (2)

Application Number Title Priority Date Filing Date
DD88326917A DD299067A5 (de) 1987-08-04 1988-08-03 Verfahren zur herstellung von zwischenprodukten fuer epipodophyllotoxinglucosid-4'-phosphat-derivate
DD88318652A DD274423A5 (de) 1987-08-04 1988-08-03 Verfahren zur herstellung von epipodophyllotoxinglucosid-4'-phosphat derivaten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DD88318652A DD274423A5 (de) 1987-08-04 1988-08-03 Verfahren zur herstellung von epipodophyllotoxinglucosid-4'-phosphat derivaten

Country Status (34)

Country Link
US (3) US4904768A (ko)
JP (1) JPH0699465B2 (ko)
KR (1) KR900006230B1 (ko)
CN (1) CN1027169C (ko)
AT (1) AT398974B (ko)
BE (1) BE1002982A4 (ko)
CA (1) CA1310637C (ko)
CH (1) CH676716A5 (ko)
CY (1) CY1625A (ko)
CZ (1) CZ286893B6 (ko)
DD (2) DD299067A5 (ko)
DE (1) DE3826562A1 (ko)
DK (2) DK169344B1 (ko)
ES (1) ES2010775A6 (ko)
FI (1) FI87790C (ko)
FR (1) FR2622193B1 (ko)
GB (1) GB2207674B (ko)
GR (1) GR1000490B (ko)
HK (1) HK6392A (ko)
HU (3) HU202547B (ko)
IE (1) IE61040B1 (ko)
IL (1) IL87290A (ko)
IT (1) IT1226825B (ko)
LU (2) LU87290A1 (ko)
MX (1) MX173843B (ko)
MY (1) MY104321A (ko)
NL (2) NL192683C (ko)
NO (4) NO170284C (ko)
NZ (1) NZ225615A (ko)
PT (1) PT88186B (ko)
SE (1) SE502214C2 (ko)
SG (1) SG101291G (ko)
SK (1) SK541288A3 (ko)
YU (3) YU143688A (ko)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
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US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
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US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
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US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
CA2464311A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
DK1537146T3 (da) 2002-07-15 2011-04-04 Univ Texas Antistoffer, der binder til anioniske phospholipider og aminophospholipider, og deres anvendelse til behandling af virusinfektioner
CA2516056C (en) * 2003-01-06 2012-05-29 Angiochem Inc. Aprotinin and analogs as carriers across the blood-brain barrier
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BRPI0613005A8 (pt) * 2005-07-15 2017-12-26 Angiochem Inc uso de polipeptídeos de aprotinina como veículos em conjugados farmacêuticos.
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
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Also Published As

Publication number Publication date
ES2010775A6 (es) 1989-12-01
SE502214C2 (sv) 1995-09-18
CN1027169C (zh) 1994-12-28
YU10490A (en) 1990-06-30
GB8818462D0 (en) 1988-09-07
MX9202851A (es) 1992-06-30
CZ541288A3 (cs) 1999-12-15
NL970042I1 (nl) 1998-03-02
NO172440B (no) 1993-04-13
DE3826562A1 (de) 1989-02-16
SE8802815D0 (sv) 1988-08-03
CN1061225A (zh) 1992-05-20
NL192683B (ko) 1997-08-01
NO172440C (no) 1993-07-21
US5041424A (en) 1991-08-20
NO920277L (no) 1989-02-24
FI87790C (fi) 1993-02-25
NO1998002I1 (no) 1998-01-14
NZ225615A (en) 1991-06-25
YU143688A (en) 1990-04-30
MX173843B (es) 1994-03-30
HUT47303A (en) 1989-02-28
NO883299L (no) 1989-02-24
DK434088A (da) 1989-02-05
SK279325B6 (sk) 1998-10-07
HU208147B (en) 1993-08-30
PT88186A (pt) 1989-06-30
HU905862D0 (en) 1991-03-28
FI883596A (fi) 1989-02-05
FI883596A0 (fi) 1988-08-01
SE8802815L (sv) 1989-02-05
SG101291G (en) 1992-01-17
CH676716A5 (ko) 1991-02-28
NO170284C (no) 1992-09-30
GR1000490B (el) 1992-07-30
ATA195588A (de) 1994-07-15
DK169344B1 (da) 1994-10-10
HK6392A (en) 1992-01-17
GB2207674B (en) 1991-09-11
IE61040B1 (en) 1994-09-07
CZ286893B6 (cs) 2000-07-12
FR2622193A1 (fr) 1989-04-28
IL87290A (en) 1993-01-31
NL8801934A (nl) 1989-03-01
FR2622193B1 (fr) 1993-12-17
KR900006230B1 (ko) 1990-08-27
HU202547B (en) 1991-03-28
AU2030688A (en) 1989-06-08
HU211960A9 (en) 1996-01-29
YU10390A (en) 1990-06-30
PT88186B (pt) 1995-07-03
NL192683C (nl) 1997-12-02
GB2207674A (en) 1989-02-08
SK541288A3 (en) 1998-10-07
NL970042I2 (ko) 2005-06-01
JPH01100188A (ja) 1989-04-18
DK434088D0 (da) 1988-08-03
US4904768A (en) 1990-02-27
AT398974B (de) 1995-02-27
DK11992D0 (da) 1992-01-31
IL87290A0 (en) 1989-01-31
CY1625A (en) 1992-07-10
NO920277D0 (no) 1992-01-22
NO920665L (no) 1989-02-24
DE3826562C2 (ko) 1993-04-08
IT1226825B (it) 1991-02-19
NO170284B (no) 1992-06-22
MY104321A (en) 1994-03-31
IT8821535A0 (it) 1988-07-28
KR890003790A (ko) 1989-04-18
FI87790B (fi) 1992-11-13
JPH0699465B2 (ja) 1994-12-07
IE882378L (en) 1989-02-04
AU610619B2 (en) 1991-05-23
BE1002982A4 (fr) 1991-10-15
DD274423A5 (de) 1989-12-20
NO920665D0 (no) 1992-02-20
GR880100512A (en) 1989-05-25
DK11992A (da) 1992-01-31
USRE35524E (en) 1997-06-03
NO883299D0 (no) 1988-07-26
LU87290A1 (fr) 1990-02-07
CA1310637C (en) 1992-11-24
LU90138I2 (fr) 1997-11-26

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