DE68906183T2 - 2'-desoxy-5-fluoruridinderivate. - Google Patents

2'-desoxy-5-fluoruridinderivate.

Info

Publication number
DE68906183T2
DE68906183T2 DE8989103261T DE68906183T DE68906183T2 DE 68906183 T2 DE68906183 T2 DE 68906183T2 DE 8989103261 T DE8989103261 T DE 8989103261T DE 68906183 T DE68906183 T DE 68906183T DE 68906183 T2 DE68906183 T2 DE 68906183T2
Authority
DE
Germany
Prior art keywords
group
chem
formula
acyl
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989103261T
Other languages
English (en)
Other versions
DE68906183D1 (de
Inventor
Tsutomu Kawai
Fumio Mori
Setsuo Takeda
Hitoshi Saito
Norio Unemi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuraray Co Ltd
Taisho Pharmaceutical Co Ltd
Original Assignee
Kuraray Co Ltd
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuraray Co Ltd, Taisho Pharmaceutical Co Ltd filed Critical Kuraray Co Ltd
Publication of DE68906183D1 publication Critical patent/DE68906183D1/de
Application granted granted Critical
Publication of DE68906183T2 publication Critical patent/DE68906183T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8989103261T 1988-02-29 1989-02-24 2'-desoxy-5-fluoruridinderivate. Expired - Fee Related DE68906183T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4786488 1988-02-29

Publications (2)

Publication Number Publication Date
DE68906183D1 DE68906183D1 (de) 1993-06-03
DE68906183T2 true DE68906183T2 (de) 1993-09-02

Family

ID=12787236

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989103261T Expired - Fee Related DE68906183T2 (de) 1988-02-29 1989-02-24 2'-desoxy-5-fluoruridinderivate.

Country Status (9)

Country Link
US (1) US5032680A (de)
EP (1) EP0331032B1 (de)
KR (1) KR890013009A (de)
CN (1) CN1024349C (de)
AT (1) ATE88714T1 (de)
AU (1) AU610344B2 (de)
CA (1) CA1313661C (de)
DE (1) DE68906183T2 (de)
ES (1) ES2054899T3 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250673A (en) * 1983-05-23 1993-10-05 Taiho Pharmaceutical Company, Ltd. 2'-deoxy-5-substituted uridine derivatives
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
DE4015715A1 (de) * 1990-05-16 1991-11-21 Bayer Ag Neuartige oligophosphate mit antiviraler wirkung
US5627165A (en) * 1990-06-13 1997-05-06 Drug Innovation & Design, Inc. Phosphorous prodrugs and therapeutic delivery systems using same
WO1991019721A1 (en) * 1990-06-13 1991-12-26 Arnold Glazier Phosphorous produgs
US5272152A (en) * 1990-07-02 1993-12-21 E. R. Squibb & Sons, Inc. Purinyl and pyrimidinyl tetrahydrofurans
DE69129650T2 (de) * 1990-09-14 1999-03-25 Acad Of Science Czech Republic Wirkstoffvorläufer von Phosphonaten
US5233031A (en) * 1991-09-23 1993-08-03 University Of Rochester Phosphoramidate analogs of 2'-deoxyuridine
US5314893A (en) * 1993-01-25 1994-05-24 Bristol-Myers Squibb Co. Antiviral tetrahydropyrans
JP2526414B2 (ja) * 1994-05-20 1996-08-21 工業技術院長 制ガン剤エステル化合物及びその製造方法
US5990300A (en) * 1994-09-02 1999-11-23 Andrew C. Hiatt Enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US6214987B1 (en) 1994-09-02 2001-04-10 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
US6232465B1 (en) 1994-09-02 2001-05-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5872244A (en) * 1994-09-02 1999-02-16 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US5808045A (en) * 1994-09-02 1998-09-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5763594A (en) * 1994-09-02 1998-06-09 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US6319908B1 (en) * 1996-07-03 2001-11-20 Inspire Pharmaceuticals, Inc. Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
TW593331B (en) * 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
US6872710B2 (en) * 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
WO2000077014A1 (fr) * 1999-06-11 2000-12-21 Kyowa Hakko Kogyo Co., Ltd. Phosphates d'aryle
DE10313035A1 (de) * 2003-03-24 2004-10-07 Resprotect Gmbh Methode zur Verstärkung der apoptotischen Wirkung von Zytostatika ohne Erhöhung toxischer Nebenwirkungen
EP2136626A4 (de) * 2007-03-19 2011-02-23 Oregon State Wirkstoffe mit n-oxiden aus mannich-basen
US8741858B2 (en) 2007-09-21 2014-06-03 Zhongxu Ren Oligomer-nucleoside phosphate conjugates
CN101440111B (zh) * 2008-12-22 2011-06-22 西安交通大学 一种抗肿瘤化合物及其制备方法
CN104151360B (zh) * 2013-05-14 2019-02-22 北京美倍他药物研究有限公司 磷酸/膦酸衍生物及其医药用途
US20200123190A1 (en) * 2017-04-25 2020-04-23 Ohara Pharmaceutical Co., Ltd. 5'-position dibenzyl monophosphate derivative of nucleoside-based anticancer agent or antivirus agent

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5535057A (en) * 1978-09-05 1980-03-11 Funai Corp 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it
JPS56115799A (en) * 1980-02-15 1981-09-11 Funai Corp 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivative, its preparation, and antitumor agnet containing the same
JPS57128699A (en) * 1981-02-03 1982-08-10 Tokyo Kinzoku Kogyo Kk 5-fluorouracil derivative and its medical composition
DE3263939D1 (en) * 1981-12-09 1985-07-04 Teijin Ltd 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof
JPS5899499A (ja) * 1981-12-09 1983-06-13 Teijin Ltd ５−フルオロ−２′−デオキシウリジン誘導体を有効成分とする抗腫瘍剤
JPS5970699A (ja) * 1982-10-13 1984-04-21 Teijin Ltd ５−フルオロ−２′−デオキシウリジン誘導体及びその製造法
JPS5993096A (ja) * 1982-11-19 1984-05-29 Teijin Ltd ５−フルオロ−２′−デオキシウリジン誘導体及びその製造法
US4684631A (en) * 1984-10-09 1987-08-04 Toyama Chemical Co., Ltd. Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same
JPS6191196A (ja) * 1984-10-09 1986-05-09 Toyama Chem Co Ltd 新規な５―フルオロ―２´―デオキシウリジン―５´―ホスフェート誘導体およびその塩並びにそれらを含有する抗腫瘍剤
JPS6191195A (ja) * 1984-10-12 1986-05-09 Toyama Chem Co Ltd 新規な５−フルオロ−２′−デオキシウリジン−５′−ホスフエ−ト誘導体およびその塩
JPS61152694A (ja) * 1984-12-27 1986-07-11 Toyama Chem Co Ltd 新規な５−フルオロ−２′−デオキシウリジン−５′−ホスフエ−ト誘導体およびその塩
JPS61236793A (ja) * 1985-04-15 1986-10-22 Toyo Jozo Co Ltd 新規リン脂質・ヌクレオシド誘導体

Also Published As

Publication number Publication date
AU610344B2 (en) 1991-05-16
CN1045395A (zh) 1990-09-19
CN1024349C (zh) 1994-04-27
ATE88714T1 (de) 1993-05-15
EP0331032B1 (de) 1993-04-28
KR890013009A (ko) 1989-09-20
EP0331032A1 (de) 1989-09-06
DE68906183D1 (de) 1993-06-03
US5032680A (en) 1991-07-16
CA1313661C (en) 1993-02-16
ES2054899T3 (es) 1994-08-16
AU3015289A (en) 1989-08-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee