DD148770A5 - Verfahren zur herstellung von carboxyalkyldipeptiden und ihrer derivate - Google Patents

Verfahren zur herstellung von carboxyalkyldipeptiden und ihrer derivate Download PDF

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Publication number
DD148770A5
DD148770A5 DD79217487A DD21748779A DD148770A5 DD 148770 A5 DD148770 A5 DD 148770A5 DD 79217487 A DD79217487 A DD 79217487A DD 21748779 A DD21748779 A DD 21748779A DD 148770 A5 DD148770 A5 DD 148770A5
Authority
DD
German Democratic Republic
Prior art keywords
proline
alanyl
lower alkyl
carboxy
hydroxy
Prior art date
Application number
DD79217487A
Other languages
German (de)
English (en)
Inventor
Arthur A Patchett
Elbert E Harris
Matthew J Wyvratt
Edward W Tristram
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25513965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD148770(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DD148770A5 publication Critical patent/DD148770A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
DD79217487A 1978-12-11 1979-12-08 Verfahren zur herstellung von carboxyalkyldipeptiden und ihrer derivate DD148770A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96824978A 1978-12-11 1978-12-11

Publications (1)

Publication Number Publication Date
DD148770A5 true DD148770A5 (de) 1981-06-10

Family

ID=25513965

Family Applications (1)

Application Number Title Priority Date Filing Date
DD79217487A DD148770A5 (de) 1978-12-11 1979-12-08 Verfahren zur herstellung von carboxyalkyldipeptiden und ihrer derivate

Country Status (33)

Country Link
US (2) US4374829A (fr)
EP (1) EP0012401B1 (fr)
JP (3) JPS5581845A (fr)
KR (3) KR850000847B1 (fr)
AR (1) AR231971A1 (fr)
AU (1) AU530380B2 (fr)
BG (6) BG39467A3 (fr)
CA (4) CA1302005C (fr)
CS (1) CS237311B2 (fr)
DD (1) DD148770A5 (fr)
DE (2) DE19375005I2 (fr)
DK (1) DK165455C (fr)
EG (1) EG14182A (fr)
ES (2) ES486786A0 (fr)
FI (1) FI68405C (fr)
GR (1) GR72251B (fr)
HK (1) HK27487A (fr)
HU (1) HU182902B (fr)
IE (1) IE48922B1 (fr)
IL (1) IL58849A (fr)
LU (1) LU90173I2 (fr)
MA (1) MA18664A1 (fr)
NL (4) NL930008I2 (fr)
NO (3) NO151622C (fr)
NZ (1) NZ192312A (fr)
PH (1) PH24268A (fr)
PL (2) PL131140B1 (fr)
PT (1) PT70542A (fr)
RO (4) RO85071B (fr)
SU (1) SU1287756A3 (fr)
YU (3) YU42655B (fr)
ZA (1) ZA796688B (fr)
ZW (1) ZW24479A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046289A2 (fr) * 1980-08-18 1982-02-24 Merck & Co. Inc. Dérivés d'oenantholactame substitués comme agents antihypertensifs, leur procédé de préparation, composition pharmaceutique les contenant et produits intermédiaires
EP0046292A1 (fr) * 1980-08-18 1982-02-24 Merck & Co. Inc. Dérivés de caprylolactame substitués comme agents antihypertensifs, procédé de préparation et composition pharmaceutique les contenant
EP0046291A2 (fr) * 1980-08-18 1982-02-24 Merck & Co. Inc. Dérivés de caprolactame substitués utilisables comme agents antihypertensifs, leur procédé de préparation, composition pharmaceutique les contenant et produits intermédiaires

Families Citing this family (384)

* Cited by examiner, † Cited by third party
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IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4595675A (en) * 1979-09-19 1986-06-17 Hoechst Aktiengesellschaft Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4616030A (en) * 1979-12-07 1986-10-07 Adir Perhydroindole-2-carboxylic acids as antihypertensives
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4616031A (en) * 1979-12-07 1986-10-07 Adir Perhydroindole-2-carboxylic acids as antihypertensives
US4644008A (en) * 1979-12-07 1987-02-17 Adir Perhydroindole-2-carboxylic acids as antihypertensives
US4616029A (en) * 1979-12-07 1986-10-07 Adir Perhydromdole-2-carboxylic acids as antihypertensives
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
EP0048159A3 (fr) * 1980-09-17 1982-05-12 University Of Miami Peptides carboxyalcoyliques, thioéthers et éthers de peptides comme agents antihypertensifs
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
GR75775B (fr) * 1980-10-06 1984-08-02 Merck & Co Inc
EP0050800B2 (fr) * 1980-10-23 1995-06-07 Schering Corporation Dipeptides carboxyalcoyliques, procédés pour les préparer et compositions pharmaceutiques les contenant
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
AU543804B2 (en) * 1980-10-31 1985-05-02 Takeda Chemical Industries Ltd. Amides having bicyclic substituents on nitrogen
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
IE53315B1 (en) * 1980-12-18 1988-10-12 Schering Corp Substituted dipeptides,processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4906615A (en) * 1980-12-18 1990-03-06 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
EP0057998B1 (fr) * 1981-01-23 1984-08-08 Takeda Chemical Industries, Ltd. Composés alicycliques, leur préparation et utilisation
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
DE3272505D1 (en) * 1981-03-09 1986-09-18 Merck & Co Inc Substituted thiazolidine carboxylic acid analogs and derivatives as antihypertensives
US4512979A (en) 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
AU556932B2 (en) * 1981-03-30 1986-11-27 Usv Pharmaceutical Corp. Dipetide with heterocyclic groiup
US4510322A (en) * 1981-07-13 1985-04-09 Merck & Co., Inc. Indacrinone having enhanced uricosuric
US4454291A (en) * 1981-07-20 1984-06-12 American Home Products Corporation N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
US4454292A (en) * 1981-07-20 1984-06-12 American Home Products Corporation N-[2-Substituted-1-oxoalkyl]-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
CS226907B1 (en) * 1981-08-07 1984-04-16 Kasafirek Evzen Alkylamides of carboxyalkanoylpeptides
US4766110A (en) * 1981-08-21 1988-08-23 Ryan James W Novel complex amido and imido derivatives of carboxyalkyl peptides
ZA826022B (en) * 1981-08-21 1983-08-31 Univ Miami Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
EP0079522B1 (fr) * 1981-11-09 1986-05-07 Merck & Co. Inc. Agents antihypertendus N-carboxyméthyl(amidino)-lysyl-prolines
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
EP0079521A1 (fr) * 1981-11-09 1983-05-25 Merck & Co. Inc. Procédé pour la préparation de dérivés de carboxyalkyldipeptides
EP0081094A1 (fr) * 1981-11-12 1983-06-15 Merck & Co. Inc. Agents antihypertensifs oméga-aminocarboxyméthyl dipeptidiques
EP0080822A1 (fr) * 1981-11-27 1983-06-08 Beecham Group Plc Peptides issus de prolinol, à activité anti-hypertensive
US4503043A (en) * 1981-12-07 1985-03-05 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
US4555502A (en) * 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
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EP0046289A2 (fr) * 1980-08-18 1982-02-24 Merck & Co. Inc. Dérivés d'oenantholactame substitués comme agents antihypertensifs, leur procédé de préparation, composition pharmaceutique les contenant et produits intermédiaires
EP0046292A1 (fr) * 1980-08-18 1982-02-24 Merck & Co. Inc. Dérivés de caprylolactame substitués comme agents antihypertensifs, procédé de préparation et composition pharmaceutique les contenant
EP0046291A2 (fr) * 1980-08-18 1982-02-24 Merck & Co. Inc. Dérivés de caprolactame substitués utilisables comme agents antihypertensifs, leur procédé de préparation, composition pharmaceutique les contenant et produits intermédiaires
EP0046291A3 (en) * 1980-08-18 1982-04-14 Merck & Co. Inc. Substituted caprolactam derivatives as antihypertensives, process for preparing them, pharmaceutical composition containing them, and intermediates
EP0046289A3 (en) * 1980-08-18 1982-04-28 Merck & Co. Inc. Substituted enantholactam derivatives as antihypertensives, a process for preparing and a pharmaceutical composition containing them, and intermediates

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ES8101540A1 (es) 1980-12-16
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PH24268A (en) 1990-05-29
KR840005084A (ko) 1984-11-03
NL930008I2 (nl) 1997-05-01
DE19375005I2 (de) 2000-07-13
AR231971A1 (es) 1985-04-30
DK523579A (da) 1980-06-12
YU43533B (en) 1989-08-31
KR850000846B1 (ko) 1985-06-17
NL930007I2 (nl) 1997-03-03
AU5346179A (en) 1980-06-19
US4472380A (en) 1984-09-18
ZW24479A1 (en) 1981-07-15
SU1287756A3 (ru) 1987-01-30
NO151622B (no) 1985-01-28
YU300079A (en) 1983-02-28
NL970022I1 (nl) 1997-09-01
IE48922B1 (en) 1985-06-12
NO1995007I1 (no) 1995-08-02
NL930007I1 (nl) 1993-04-01
US4374829A (en) 1983-02-22
HK27487A (en) 1987-04-16
BG39295A3 (en) 1986-05-15
PL126126B1 (en) 1983-07-30
NO151622C (no) 1985-05-08
LU90173I2 (fr) 1998-01-27
NO1996004I1 (no) 1996-02-23
EP0012401B1 (fr) 1984-03-07
YU256682A (en) 1983-02-28
PL131140B1 (en) 1984-10-31
YU256782A (en) 1983-02-28
EG14182A (en) 1983-09-30
KR850000847B1 (ko) 1985-06-17
IL58849A0 (en) 1980-03-31
IL58849A (en) 1983-03-31
IE792382L (en) 1980-06-11
BG39293A3 (en) 1986-05-15
PL220298A1 (fr) 1981-11-13
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CA1275349C (fr) 1990-10-16
ES486786A0 (es) 1980-12-16
RO85071A (fr) 1984-09-24
JPH02131496A (ja) 1990-05-21
RO85071B (ro) 1984-10-30
RO85072B (ro) 1984-09-30
EP0012401A1 (fr) 1980-06-25
YU42655B (en) 1988-10-31
CA1300313C (fr) 1992-05-05
ES494300A0 (es) 1981-07-16
NL930006I1 (nl) 1993-04-01
BG39467A3 (en) 1986-06-16
BG39294A3 (en) 1986-05-15
NZ192312A (en) 1984-07-31
ZA796688B (en) 1981-07-29
NL930006I2 (nl) 1997-03-03
FI68405B (fi) 1985-05-31
JPH032878B2 (fr) 1991-01-17
RO85073B (ro) 1984-10-30
JPH02131430A (ja) 1990-05-21
MA18664A1 (fr) 1980-07-01
ES8106134A1 (es) 1981-07-16
DK165455C (da) 1993-04-13
PT70542A (en) 1980-01-01
GR72251B (fr) 1983-10-05
NL930008I1 (nl) 1993-04-01
DK165455B (da) 1992-11-30
DE2966767D1 (en) 1984-04-12
YU43532B (en) 1989-08-31
CS237311B2 (en) 1985-07-16
FI68405C (fi) 1985-09-10
RO85073A (fr) 1984-09-24
JPH0480009B2 (fr) 1992-12-17
AU530380B2 (en) 1983-07-14
CA1302005C (fr) 1992-05-26
NO794010L (no) 1980-06-12
KR840005083A (ko) 1984-11-03
RO85072A (fr) 1984-08-17
JPH0442400B2 (fr) 1992-07-13
RO80264A (fr) 1982-12-06
BG39466A3 (en) 1986-06-16

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