CN1809380A - 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 - Google Patents
广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Description
n | A | X1 | L1 | X2 | L2 | B | [SEQID] |
2 | MA | ΔG287 | GSGGGG | 953(NL) | - | - | 7 |
2 | M | 936(NL) | GSGGGG | ΔG741 | - | - | 8 |
A | 10 | 0 | 0 | 0 | 10 | 5 | 2.5 |
C | 10 | 10 | 5 | 2.5 | 5 | 5 | 2.5 |
W135 | 10 | 10 | 5 | 2.5 | 5 | 5 | 2.5 |
Y | 10 | 10 | 5 | 2.5 | 5 | 5 | 2.5 |
血清组 | 铝盐(H=氢氧化物;P=磷酸) | |||||||||||||||
A | P | H | P | H | H | H | P | P | P | H | H | H | P | P | P | H |
C | P | H | H | P | H | H | P | H | H | P | P | H | P | H | P | P |
W135 | P | H | H | H | P | H | H | P | H | H | P | P | P | P | H | P |
Y | P | H | H | H | H | P | H | H | P | P | H | P | H | P | P | P |
血清组 | 铝盐(H=氢氧化物;P=磷酸) | |||||||
C | P | H | H | H | P | P | P | H |
W135 | P | H | H | P | H | P | H | P |
Y | P | H | P | H | H | H | P | P |
脑膜炎球菌菌株(血清组) | ||||||||
2996(B) | MC58(B) | NGH38 | 394/98(B) | H44/76(B) | F6124(A) | BZ133(C) | C11(C) | |
(1) | 32000 | 16000 | 130000 | 16000 | 32000 | 8000 | 16000 | 8000 |
(2) | 256 | 131000 | 128 | 16000 | 32000 | 8000 | 16000 | <4 |
(3) | 32000 | 8000 | - | - | - | 8000 | - | 32000 |
混合物 | 32000 | 32000 | 65000 | 16000 | 260000 | 65000 | >65000 | 8000 |
# | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
2996 | 32768 | 16384 | 65536 | 32768 | 32768 | 65536 | 65536 | 32768 | 65536 | 8192 |
MC58 | 65536 | 32768 | 65536 | 65536 | 65536 | 8192 | 65536 | 32768 | 32768 | 65536 |
394/98 | 65536 | 4096 | 16384 | 4096 | 8192 | 4096 | 32768 | 16384 | 8192 | 16384 |
#菌株 | (a) | (b) | (c) | (d) | (e) | (f) | (g) | (h) | (i) | S-3 | |
A4 | 4 | 50 | 50 | 0 | 100 | 25 | 25 | 25 | 100 | 100 | + |
ET-5 | 8 | 25 | 75 | 88 | 100 | 71 | 14 | 71 | 100 | 100 | + |
谱系3 | 13 | 0 | 75 | 15 | 93 | 8 | 85 | 8 | 92 | 93 | + |
ET-37 | 4 | 11 | 22 | 0 | 33 | 0 | 0 | 0 | 22 | 25 | + |
#菌株 | (a) | (b) | (c) | (d) | (e) | (f) | (g) | (h) | (i) | S-3 | |
A4 | 961-5945 | 128 | 2048 | <8 | 2048 | 262144 | 8192 | 262144 | 262144 | 4096 | 8192 |
ET-5 | 44/76 | <4 | 2048 | 32768 | 131072 | 524288 | 8192 | 524288 | 524288 | 524288 | 16384 |
谱系3 | 394/98 | <4 | 1024 | 32 | 4096 | <4 | 16384 | 256 | 16384 | 16384 | 16384 |
ET-37 | LPN17592 | 2048 | 1024 | 256 | 4096 | <8 | <8 | 512 | 16384 | 65536 | 1024 |
成分 | 量每0.5ml剂量 |
血清组C缀合物 | 10μg糖+12.5-25μg CRM197 |
血清组W135缀合物 | 10μg糖+6.6-20μg CRM197 |
血清组Y缀合物 | 10μg糖+6.6-20μg CRM197 |
ΔG287-953 | 20μg多肽 |
936-ΔG741 | 20μg多肽 |
NadA | 20μg多肽 |
成分 | 量每0.5ml剂量 |
血清组a缀合物 | 5μg糖+6.25-16.5μg CRM197 |
血清组c缀合物 | 5μg糖+6.25-12.5μg CRM197 |
血清组W135缀合物 | 5μg糖+3.3-10μg CRM197 |
血清组Y缀合物 | 5μg糖+3.3-10μg CRM197 |
肺炎球菌血清型4缀合物 | 2μg糖+2.5μg CRM197 |
肺炎球菌血清型9V缀合物 | 2μg糖+2.5μg CRM197 |
肺炎球菌血清型14缀合物 | 2μg糖+2.5μg CRM197 |
肺炎球菌血清型18C缀合物 | 2μg糖+2.5μg CRM197 |
肺炎球菌血清型19F缀合物 | 2μg糖+2.5μg CRM197 |
肺炎球菌血清型23F缀合物 | 2μg糖+2.5μg CRM197 |
肺炎球菌血清型6B缀合物 | 4μg糖+5μg CRM197 |
Claims (31)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0223741A GB0223741D0 (en) | 2002-10-11 | 2002-10-11 | Composition with five meningococcal antigens |
GB0223741.0 | 2002-10-11 | ||
GB0305831A GB0305831D0 (en) | 2003-03-13 | 2003-03-13 | Broad protection meningococcal vaccines |
GB0305831.0 | 2003-03-13 | ||
GB0309115A GB0309115D0 (en) | 2003-04-22 | 2003-04-22 | Broad protection meningococcal vaccines |
GB0309115.4 | 2003-04-22 | ||
PCT/IB2003/004848 WO2004032958A1 (en) | 2002-10-11 | 2003-10-02 | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1809380A true CN1809380A (zh) | 2006-07-26 |
CN1809380B CN1809380B (zh) | 2010-05-12 |
Family
ID=32096623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200380105896XA Expired - Lifetime CN1809380B (zh) | 2002-10-11 | 2003-10-02 | 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 |
Country Status (22)
Country | Link |
---|---|
US (2) | US8663656B2 (zh) |
EP (3) | EP2353608B1 (zh) |
JP (4) | JP4697706B2 (zh) |
CN (1) | CN1809380B (zh) |
AT (1) | ATE492288T1 (zh) |
AU (1) | AU2003274511B2 (zh) |
BE (1) | BE2013C042I2 (zh) |
BR (1) | BRPI0315228A8 (zh) |
CA (1) | CA2501812C (zh) |
CY (4) | CY1111341T1 (zh) |
DE (1) | DE60335477D1 (zh) |
DK (3) | DK2353608T3 (zh) |
ES (2) | ES2608048T3 (zh) |
FR (1) | FR13C0040I2 (zh) |
HU (3) | HUE031886T2 (zh) |
LU (1) | LU92241I2 (zh) |
MX (1) | MXPA05003863A (zh) |
NL (1) | NL300604I2 (zh) |
NZ (1) | NZ562998A (zh) |
PT (3) | PT1549338E (zh) |
SI (3) | SI2351579T1 (zh) |
WO (1) | WO2004032958A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102596240A (zh) * | 2009-08-27 | 2012-07-18 | 诺华有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
CN103298948A (zh) * | 2010-08-11 | 2013-09-11 | 财团法人卫生研究院 | B群脑膜炎球菌次单位疫苗的制造及纯化 |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070026021A1 (en) * | 1998-05-01 | 2007-02-01 | Chiron S.R.I. | Neisseria meningitidis antigens and compositions |
US7576176B1 (en) | 1998-05-01 | 2009-08-18 | Novartis Vaccines And Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
US10967045B2 (en) * | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
CN100392082C (zh) | 1999-04-30 | 2008-06-04 | 启龙股份公司 | 保守的奈瑟球菌抗原 |
NZ536676A (en) | 1999-05-19 | 2006-11-30 | Chiron S | Combination neisserial compositions comprising amino acid sequences |
EP2275553B1 (en) | 1999-10-29 | 2015-05-13 | Novartis Vaccines and Diagnostics S.r.l. | Neisserial antigenic peptides |
GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
EP1897555B1 (en) | 2000-01-17 | 2014-07-16 | Novartis Vaccines and Diagnostics S.r.l. | Supplemented OMV vaccine against meningococcus |
DE60126249T2 (de) | 2000-02-28 | 2008-05-29 | Novartis Vaccines And Diagnostics S.R.L. | Heterologe expression von neisseria-proteinen |
US6936261B2 (en) * | 2000-07-27 | 2005-08-30 | Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
EP1412381B1 (en) | 2001-07-27 | 2010-06-02 | Novartis Vaccines and Diagnostics S.r.l. | Antibodies against meningococcal adhesin app |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102596240A (zh) * | 2009-08-27 | 2012-07-18 | 诺华有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
CN102596240B (zh) * | 2009-08-27 | 2015-02-04 | 诺华股份有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
CN104650241A (zh) * | 2009-08-27 | 2015-05-27 | 诺华股份有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
CN103298948A (zh) * | 2010-08-11 | 2013-09-11 | 财团法人卫生研究院 | B群脑膜炎球菌次单位疫苗的制造及纯化 |
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