CN1809380B - 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 - Google Patents
广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Description
n | A | X<sub>1</sub> | L<sub>1</sub> | X<sub>2</sub> | L<sub>2</sub> | B | [SEQID] |
2 | MA | ΔG287 | GSGGGG | 953<sup>(NL)</sup> | - | - | 7 |
2 | M | 936<sup>(NL)</sup> | GSGGGG | ΔG741 | - | - | 8 |
A | 10 | 0 | 0 | 0 | 10 | 5 | 2.5 |
C | 10 | 10 | 5 | 2.5 | 5 | 5 | 2.5 |
W135 | 10 | 10 | 5 | 2.5 | 5 | 5 | 2.5 |
Y | 10 | 10 | 5 | 2.5 | 5 | 5 | 2.5 |
成分 | 量每0.5ml剂量 |
血清组C缀合物 | 10μg糖+12.5-25μg CRM<sub>197</sub> |
血清组W135缀合物 | 10μg糖+6.6-20μg CRM<sub>197</sub> |
血清组Y缀合物 | 10μg糖+6.6-20μg CRM<sub>197</sub> |
ΔG287-953 | 20μg多肽 |
936-ΔG741 | 20μg多肽 |
成分 | 量每0.5ml剂量 |
NadA | 20μg多肽 |
成分 | 量每0.5ml剂量 |
血清组a缀合物 | 5μg糖+6.25-16.5μg CRM<sub>197</sub> |
血清组c缀合物 | 5μg糖+6.25-12.5μg CRM<sub>197</sub> |
血清组W135缀合物 | 5μg糖+3.3-10μg CRM<sub>197</sub> |
血清组Y缀合物 | 5μg糖+3.3-10μg CRM<sub>197</sub> |
肺炎球菌血清型4缀合物 | 2μg糖+2.5μg CRM<sub>197</sub> |
肺炎球菌血清型9V缀合物 | 2μg糖+2.5μg CRM<sub>197</sub> |
肺炎球菌血清型14缀合物 | 2μg糖+2.5μg CRM<sub>197</sub> |
肺炎球菌血清型18C缀合物 | 2μg糖+2.5μg CRM<sub>197</sub> |
肺炎球菌血清型19F缀合物 | 2μg糖+2.5μg CRM<sub>197</sub> |
肺炎球菌血清型23F缀合物 | 2μg糖+2.5μg CRM<sub>197</sub> |
肺炎球菌血清型6B缀合物 | 4μg糖+5μg CRM<sub>197</sub> |
Claims (8)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0223741A GB0223741D0 (en) | 2002-10-11 | 2002-10-11 | Composition with five meningococcal antigens |
GB0223741.0 | 2002-10-11 | ||
GB0305831A GB0305831D0 (en) | 2003-03-13 | 2003-03-13 | Broad protection meningococcal vaccines |
GB0305831.0 | 2003-03-13 | ||
GB0309115.4 | 2003-04-22 | ||
GB0309115A GB0309115D0 (en) | 2003-04-22 | 2003-04-22 | Broad protection meningococcal vaccines |
PCT/IB2003/004848 WO2004032958A1 (en) | 2002-10-11 | 2003-10-02 | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1809380A CN1809380A (zh) | 2006-07-26 |
CN1809380B true CN1809380B (zh) | 2010-05-12 |
Family
ID=32096623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200380105896XA Expired - Lifetime CN1809380B (zh) | 2002-10-11 | 2003-10-02 | 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 |
Country Status (22)
Country | Link |
---|---|
US (2) | US8663656B2 (zh) |
EP (3) | EP1549338B1 (zh) |
JP (4) | JP4697706B2 (zh) |
CN (1) | CN1809380B (zh) |
AT (1) | ATE492288T1 (zh) |
AU (1) | AU2003274511B2 (zh) |
BE (1) | BE2013C042I2 (zh) |
BR (1) | BRPI0315228A8 (zh) |
CA (1) | CA2501812C (zh) |
CY (4) | CY1111341T1 (zh) |
DE (1) | DE60335477D1 (zh) |
DK (3) | DK2351579T3 (zh) |
ES (2) | ES2775098T3 (zh) |
FR (1) | FR13C0040I2 (zh) |
HU (3) | HUE047780T2 (zh) |
LU (1) | LU92241I2 (zh) |
MX (1) | MXPA05003863A (zh) |
NL (1) | NL300604I2 (zh) |
NZ (1) | NZ562998A (zh) |
PT (3) | PT1549338E (zh) |
SI (3) | SI2351579T1 (zh) |
WO (1) | WO2004032958A1 (zh) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
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NZ532665A (en) | 1998-05-01 | 2005-11-25 | Inst Genomic Research | Neisseria meningitidis antigens and compositions |
US20070026021A1 (en) * | 1998-05-01 | 2007-02-01 | Chiron S.R.I. | Neisseria meningitidis antigens and compositions |
US10967045B2 (en) * | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
NZ571167A (en) | 1999-04-30 | 2010-05-28 | Novartis Vaccines & Diagnostic | Fragments from Neisseria protein ORF 953 and their use in medicaments and diagnostic reagents |
CA2373236C (en) | 1999-05-19 | 2014-08-26 | Chiron S.P.A. | Combination neisserial compositions |
EP2975127A1 (en) | 1999-10-29 | 2016-01-20 | GlaxoSmithKline Biologicals SA | Neisserial antigenic peptides |
GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
EP2275129A3 (en) | 2000-01-17 | 2013-11-06 | Novartis Vaccines and Diagnostics S.r.l. | Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins |
WO2001064920A2 (en) | 2000-02-28 | 2001-09-07 | Chiron Spa | Hybrid expression of neisserial proteins |
JP5511117B2 (ja) * | 2000-07-27 | 2014-06-04 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | 髄膜炎菌に起因する疾患に対する広域防御のためのワクチン |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
BR0211494A (pt) * | 2001-07-27 | 2004-08-17 | Chiron Srl | Adesinas de meningococo nada, app e orf 40 |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
WO2003070909A2 (en) * | 2002-02-20 | 2003-08-28 | Chiron Corporation | Microparticles with adsorbed polypeptide-containing molecules |
CA2493124C (en) * | 2002-08-02 | 2014-04-29 | Glaxosmithkline Biologicals S.A. | Vaccine |
ATE492288T1 (de) * | 2002-10-11 | 2011-01-15 | Novartis Vaccines & Diagnostic | Polypeptidimpstoffe zum breiten schutz gegen hypervirulente meningokokken-linien |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
JP4827726B2 (ja) * | 2003-01-30 | 2011-11-30 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 複数の髄膜炎菌血清群に対する注射可能ワクチン |
AU2011224064A1 (en) * | 2003-10-02 | 2011-10-06 | Novartis Vaccines And Diagnostics S.R.L. | Liquid vaccines for multiple meningococcal serogroups |
GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
CN103357002A (zh) * | 2003-10-02 | 2013-10-23 | 诺华疫苗和诊断有限公司 | 多种脑膜炎球菌血清群的液体疫苗 |
GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
RU2379052C2 (ru) | 2004-04-30 | 2010-01-20 | Чирон С.Р.Л. | Вакцинация менингококковыми конъюгатами |
GB0413868D0 (en) * | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
GB0419846D0 (en) * | 2004-09-07 | 2004-10-13 | Chiron Srl | Vaccine adjuvants for saccharides |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
JP4993750B2 (ja) | 2005-01-27 | 2012-08-08 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | 髄膜炎菌に起因する疾患に対する広域防御のための、gna1870を基にした小胞ワクチン |
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EP1858920B1 (en) | 2005-02-18 | 2016-02-03 | GlaxoSmithKline Biologicals SA | Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli |
US8431136B2 (en) | 2005-06-27 | 2013-04-30 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
EP1962902A2 (en) * | 2005-12-06 | 2008-09-03 | Universita Degli Studi di Padova | Methods and compositions relating to adhesins as adjuvants |
EP2586790A3 (en) | 2006-08-16 | 2013-08-14 | Novartis AG | Immunogens from uropathogenic Escherichia coli |
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