CY1111341T1 - Πολυπεπτιδιου-εμβολια για ευρεια προστασια εναντι υπερ-λοιμογονων μηνιγγιοκοκκικων γενεαλογικων σειρων - Google Patents
Πολυπεπτιδιου-εμβολια για ευρεια προστασια εναντι υπερ-λοιμογονων μηνιγγιοκοκκικων γενεαλογικων σειρωνInfo
- Publication number
- CY1111341T1 CY1111341T1 CY20111100292T CY111100292T CY1111341T1 CY 1111341 T1 CY1111341 T1 CY 1111341T1 CY 20111100292 T CY20111100292 T CY 20111100292T CY 111100292 T CY111100292 T CY 111100292T CY 1111341 T1 CY1111341 T1 CY 1111341T1
- Authority
- CY
- Cyprus
- Prior art keywords
- protein
- antigens
- protection against
- genealogical
- legislative
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title 1
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 239000000427 antigen Substances 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 230000005875 antibody response Effects 0.000 abstract 2
- 208000034762 Meningococcal Infections Diseases 0.000 abstract 1
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Μικρός αριθμός ορισμένων αντιγόνων μπορεί να παρέχει ευρεία προστασία έναντι μηνιγγιοκοκκικής μόλυνσης και η εφεύρεση παρέχει μία σύνθεση η οποία, μετά την χορήγηση σε ένα υποκείμενο, είναι ικανή να προκαλέσει μία απόκριση αντισώματος σε αυτό το υποκείμενο, όπου η απόκριση αντισώματος είναι βακτηριοκτόνος έναντι δύο ή τριών από υπερ-μολυσματικές γενεαλογικές σειρές Α4, ΕΤ 5 και την γενεαλογική σειρά 3 της Ν.meningitidis οροομάδας Β. Αντί να αποτελείται από ένα απλό αντιγόνο, η σύνθεση περιλαμβάνει ένα μείγμα 10 ή λιγότερων καθαρών αντιγόνων και δεν θα πρέπει να περιλαμβάνει σύμπλεγμα ή απροσδιόριστα μείγματα αντιγόνων όπως φλύκταινες εξωτερικής μεμβράνης. Συγκεκριμένα χρησιμοποιούνται πέντε αντιγόνα πρωτεΐνης: (1) 'NadA' πρωτεΐνη, (2) '741' πρωτεΐνη, (3) '936' πρωτεΐνη, (4) '953' πρωτεΐνη και (5) '287' πρωτεΐνη.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0223741A GB0223741D0 (en) | 2002-10-11 | 2002-10-11 | Composition with five meningococcal antigens |
GB0305831A GB0305831D0 (en) | 2003-03-13 | 2003-03-13 | Broad protection meningococcal vaccines |
GB0309115A GB0309115D0 (en) | 2003-04-22 | 2003-04-22 | Broad protection meningococcal vaccines |
EP03758486A EP1549338B1 (en) | 2002-10-11 | 2003-10-02 | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111341T1 true CY1111341T1 (el) | 2015-08-05 |
Family
ID=32096623
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100292T CY1111341T1 (el) | 2002-10-11 | 2011-03-15 | Πολυπεπτιδιου-εμβολια για ευρεια προστασια εναντι υπερ-λοιμογονων μηνιγγιοκοκκικων γενεαλογικων σειρων |
CY2013026C CY2013026I1 (el) | 2002-10-11 | 2013-07-03 | Πολυπεπτιδιου-εμβολια για ευρεια προστασια εναντι υπερ-λοιμογονων μηνιγγιοκοκκικων γενεαλογικων σειρων |
CY20161101282T CY1118606T1 (el) | 2002-10-11 | 2016-12-13 | Πολυπεπτιδικα εμβολια για ευρεια παραγωγη εναντι υπερμολυσματικων μηνιγγιοκοκκιkων σειρων |
CY20201100227T CY1122869T1 (el) | 2002-10-11 | 2020-03-16 | Πολυπεπτιδικα εμβολια για ευρεια προστασια εναντι υπερλοιμογονων μηνιγγιτιδοκοκκικων γενεαλογικων σειρων |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY2013026C CY2013026I1 (el) | 2002-10-11 | 2013-07-03 | Πολυπεπτιδιου-εμβολια για ευρεια προστασια εναντι υπερ-λοιμογονων μηνιγγιοκοκκικων γενεαλογικων σειρων |
CY20161101282T CY1118606T1 (el) | 2002-10-11 | 2016-12-13 | Πολυπεπτιδικα εμβολια για ευρεια παραγωγη εναντι υπερμολυσματικων μηνιγγιοκοκκιkων σειρων |
CY20201100227T CY1122869T1 (el) | 2002-10-11 | 2020-03-16 | Πολυπεπτιδικα εμβολια για ευρεια προστασια εναντι υπερλοιμογονων μηνιγγιτιδοκοκκικων γενεαλογικων σειρων |
Country Status (22)
Country | Link |
---|---|
US (2) | US8663656B2 (el) |
EP (3) | EP2353608B1 (el) |
JP (4) | JP4697706B2 (el) |
CN (1) | CN1809380B (el) |
AT (1) | ATE492288T1 (el) |
AU (1) | AU2003274511B2 (el) |
BE (1) | BE2013C042I2 (el) |
BR (1) | BRPI0315228A8 (el) |
CA (1) | CA2501812C (el) |
CY (4) | CY1111341T1 (el) |
DE (1) | DE60335477D1 (el) |
DK (3) | DK2353608T3 (el) |
ES (2) | ES2608048T3 (el) |
FR (1) | FR13C0040I2 (el) |
HU (3) | HUE031886T2 (el) |
LU (1) | LU92241I2 (el) |
MX (1) | MXPA05003863A (el) |
NL (1) | NL300604I2 (el) |
NZ (1) | NZ562998A (el) |
PT (3) | PT1549338E (el) |
SI (3) | SI2351579T1 (el) |
WO (1) | WO2004032958A1 (el) |
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GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
EP1897555B1 (en) | 2000-01-17 | 2014-07-16 | Novartis Vaccines and Diagnostics S.r.l. | Supplemented OMV vaccine against meningococcus |
DE60126249T2 (de) | 2000-02-28 | 2008-05-29 | Novartis Vaccines And Diagnostics S.R.L. | Heterologe expression von neisseria-proteinen |
US6936261B2 (en) * | 2000-07-27 | 2005-08-30 | Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
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EP2572707A3 (en) * | 2002-02-20 | 2013-11-06 | Novartis Vaccines and Diagnostics, Inc. | Microparticles with adsorbed polypeptide-containing molecules |
EP1524993B1 (en) * | 2002-08-02 | 2013-03-06 | GlaxoSmithKline Biologicals s.a. | Neisserial vaccine compositions comprising a combination of antigens |
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GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
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GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
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- 2003-10-02 EP EP10181233.7A patent/EP2353608B1/en not_active Expired - Lifetime
- 2003-10-02 ES ES10181277.4T patent/ES2608048T3/es not_active Expired - Lifetime
- 2003-10-02 SI SI200331962T patent/SI1549338T1/sl unknown
- 2003-10-02 AT AT03758486T patent/ATE492288T1/de active
- 2003-10-02 DE DE60335477T patent/DE60335477D1/de not_active Expired - Lifetime
- 2003-10-02 SI SI200332606T patent/SI2353608T1/sl unknown
- 2003-10-02 DK DK10181233.7T patent/DK2353608T3/da active
- 2003-10-02 HU HUE10181277A patent/HUE031886T2/en unknown
- 2003-10-02 BR BRPI0315228A patent/BRPI0315228A8/pt not_active Application Discontinuation
- 2003-10-02 HU HUE10181233A patent/HUE047780T2/hu unknown
- 2003-10-02 DK DK03758486.9T patent/DK1549338T3/da active
- 2003-10-02 PT PT03758486T patent/PT1549338E/pt unknown
- 2003-10-02 EP EP03758486A patent/EP1549338B1/en not_active Expired - Lifetime
- 2003-10-02 PT PT101812774T patent/PT2351579T/pt unknown
- 2003-10-02 JP JP2005501008A patent/JP4697706B2/ja not_active Expired - Lifetime
- 2003-10-02 CN CN200380105896XA patent/CN1809380B/zh not_active Expired - Lifetime
- 2003-10-02 EP EP10181277.4A patent/EP2351579B1/en not_active Expired - Lifetime
- 2003-10-02 DK DK10181277.4T patent/DK2351579T3/en active
- 2003-10-02 PT PT101812337T patent/PT2353608T/pt unknown
- 2003-10-02 ES ES10181233T patent/ES2775098T3/es not_active Expired - Lifetime
- 2003-10-02 WO PCT/IB2003/004848 patent/WO2004032958A1/en active Search and Examination
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2010
- 2010-04-07 JP JP2010089061A patent/JP5705450B2/ja not_active Expired - Lifetime
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2011
- 2011-03-15 CY CY20111100292T patent/CY1111341T1/el unknown
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2012
- 2012-09-21 JP JP2012207826A patent/JP2013006868A/ja not_active Withdrawn
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2013
- 2013-06-27 BE BE2013C042C patent/BE2013C042I2/fr unknown
- 2013-07-03 CY CY2013026C patent/CY2013026I1/el unknown
- 2013-07-04 LU LU92241C patent/LU92241I2/fr unknown
- 2013-07-08 HU HUS1300030C patent/HUS1300030I1/hu unknown
- 2013-07-11 FR FR13C0040C patent/FR13C0040I2/fr active Active
- 2013-07-15 NL NL300604C patent/NL300604I2/nl unknown
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2014
- 2014-02-12 US US14/178,970 patent/US20140212449A1/en not_active Abandoned
- 2014-08-13 JP JP2014164678A patent/JP2014218515A/ja not_active Withdrawn
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2016
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2020
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