DK0733046T3 - Benzoylguanidiner, deres fremstilling og anvendelse i medikamenter - Google Patents
Benzoylguanidiner, deres fremstilling og anvendelse i medikamenterInfo
- Publication number
- DK0733046T3 DK0733046T3 DK94931019T DK94931019T DK0733046T3 DK 0733046 T3 DK0733046 T3 DK 0733046T3 DK 94931019 T DK94931019 T DK 94931019T DK 94931019 T DK94931019 T DK 94931019T DK 0733046 T3 DK0733046 T3 DK 0733046T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- benzoylguanidines
- drugs
- preparation
- date
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4337611A DE4337611A1 (de) | 1993-11-04 | 1993-11-04 | Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| PCT/EP1994/003581 WO1995012584A1 (de) | 1993-11-04 | 1994-10-31 | Neue benzoylguanidine, ihre herstellung und ihre verwendung in arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0733046T3 true DK0733046T3 (da) | 2001-09-03 |
Family
ID=6501758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94931019T DK0733046T3 (da) | 1993-11-04 | 1994-10-31 | Benzoylguanidiner, deres fremstilling og anvendelse i medikamenter |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5783576A (da) |
| EP (1) | EP0733046B1 (da) |
| JP (1) | JPH09504535A (da) |
| KR (1) | KR100359676B1 (da) |
| CN (1) | CN1056609C (da) |
| AT (1) | ATE202563T1 (da) |
| AU (1) | AU687911B2 (da) |
| CA (1) | CA2175838A1 (da) |
| CO (1) | CO4290417A1 (da) |
| DE (2) | DE4337611A1 (da) |
| DK (1) | DK0733046T3 (da) |
| ES (1) | ES2157993T3 (da) |
| GR (1) | GR3036642T3 (da) |
| HK (1) | HK1010722A1 (da) |
| NZ (1) | NZ274849A (da) |
| PL (1) | PL180302B1 (da) |
| PT (1) | PT733046E (da) |
| RU (1) | RU2136659C1 (da) |
| TW (1) | TW400319B (da) |
| WO (1) | WO1995012584A1 (da) |
| ZA (1) | ZA948670B (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9610687B (en) * | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| DE69919349T2 (de) * | 1998-03-23 | 2005-01-13 | Aventis Pharmaceuticals Inc. | Piperidinyl- und n-amidinopiperidinyl-derivate |
| US6239279B1 (en) * | 1998-12-16 | 2001-05-29 | Smithkline Beecham Corporation | Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives |
| US6706732B1 (en) | 1999-06-03 | 2004-03-16 | Takeda Chemical Industries, Ltd. | Nasal preparation of guanidinoimino quinoline derivatives |
| US6156758A (en) * | 1999-09-08 | 2000-12-05 | Isis Pharmaceuticals, Inc. | Antibacterial quinazoline compounds |
| WO2003089434A2 (en) * | 2002-04-19 | 2003-10-30 | Cellular Genomics, Inc. | IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES METHOD OF MAKING AND METHOD OF USE THEREOF |
| US7312341B2 (en) * | 2002-09-09 | 2007-12-25 | Cgi Pharmaceuticals, Inc. | 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof |
| WO2004072080A1 (en) * | 2003-02-10 | 2004-08-26 | Cellular Genomics, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity |
| WO2005014599A1 (en) * | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
| US20060183746A1 (en) * | 2003-06-04 | 2006-08-17 | Currie Kevin S | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
| WO2005005429A1 (en) * | 2003-06-30 | 2005-01-20 | Cellular Genomics, Inc. | Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds |
| US7259164B2 (en) * | 2003-08-11 | 2007-08-21 | Cgi Pharmaceuticals, Inc. | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity |
| AU2004276341B2 (en) * | 2003-09-23 | 2011-04-14 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrrole derivatives as protein kinase inhibitors |
| WO2006076593A1 (en) * | 2005-01-14 | 2006-07-20 | Cgi Pharmaceuticals, Inc. | 1,3-diaryl substituted ureas as modulators of kinase activity |
| US7777040B2 (en) * | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| CA2620223A1 (en) | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
| AU2009215191A1 (en) | 2008-02-13 | 2009-08-20 | Gilead Connecticut, Inc. | 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof |
| CA2745871C (en) | 2008-12-08 | 2018-02-20 | Gilead Connecticut, Inc. | Imidazopyrazine syk inhibitors |
| KR20170013414A (ko) | 2008-12-08 | 2017-02-06 | 질레드 코네티컷 인코포레이티드 | 이미다조피라진 ｓｙｋ 억제제 |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| TW201200518A (en) * | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| US9562056B2 (en) | 2010-03-11 | 2017-02-07 | Gilead Connecticut, Inc. | Imidazopyridines Syk inhibitors |
| US9657023B2 (en) | 2013-07-30 | 2017-05-23 | Gilead Connecticut, Inc. | Polymorph of Syk inhibitors |
| MD4684B1 (ro) | 2013-07-30 | 2020-03-31 | Gilead Connecticut INc. | Formulări pe bază de imidazopirazine în calitate de inhibitori SYK |
| EA201690608A1 (ru) | 2013-12-04 | 2016-12-30 | Джилид Сайэнс, Инк. | Способы лечения раковых заболеваний |
| US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
| TWI662037B (zh) | 2013-12-23 | 2019-06-11 | 美商基利科學股份有限公司 | 脾酪胺酸激酶抑制劑 |
| NZ726365A (en) | 2014-07-14 | 2018-06-29 | Gilead Sciences Inc | Combinations for treating cancers |
| KR102399996B1 (ko) | 2017-08-25 | 2022-05-20 | 길리애드 사이언시즈, 인코포레이티드 | Syk 억제제의 다형체 |
| WO2020172431A1 (en) | 2019-02-22 | 2020-08-27 | Gilead Sciences, Inc. | Solid forms of condensed pyrazines as syk inhibitors |
| WO2024086790A1 (en) * | 2022-10-21 | 2024-04-25 | Exelixis, Inc. | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-c]PYRIDINE COMPOUNDS AND DERIVATIVES AS USP1 INHIBITORS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953476A (en) * | 1971-12-27 | 1976-04-27 | Merck & Co., Inc. | 3-Amino-5-sulfonylbenzoic acids |
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| CZ284456B6 (cs) * | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
| DE59305042D1 (de) * | 1992-09-22 | 1997-02-20 | Hoechst Ag | Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika |
| ES2100435T3 (es) * | 1992-12-16 | 1997-06-16 | Hoechst Ag | Aminobenzoilguanidinas 3,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene. |
-
1993
- 1993-11-04 DE DE4337611A patent/DE4337611A1/de not_active Ceased
-
1994
- 1994-10-31 NZ NZ274849A patent/NZ274849A/en unknown
- 1994-10-31 DK DK94931019T patent/DK0733046T3/da active
- 1994-10-31 EP EP94931019A patent/EP0733046B1/de not_active Expired - Lifetime
- 1994-10-31 JP JP7513011A patent/JPH09504535A/ja active Pending
- 1994-10-31 AU AU79937/94A patent/AU687911B2/en not_active Ceased
- 1994-10-31 KR KR1019960702300A patent/KR100359676B1/ko not_active IP Right Cessation
- 1994-10-31 RU RU96112103A patent/RU2136659C1/ru not_active IP Right Cessation
- 1994-10-31 ES ES94931019T patent/ES2157993T3/es not_active Expired - Lifetime
- 1994-10-31 CN CN94194015A patent/CN1056609C/zh not_active Expired - Fee Related
- 1994-10-31 US US08/649,614 patent/US5783576A/en not_active Expired - Lifetime
- 1994-10-31 PL PL94314188A patent/PL180302B1/pl unknown
- 1994-10-31 CA CA002175838A patent/CA2175838A1/en not_active Abandoned
- 1994-10-31 DE DE59409794T patent/DE59409794D1/de not_active Expired - Fee Related
- 1994-10-31 PT PT94931019T patent/PT733046E/pt unknown
- 1994-10-31 AT AT94931019T patent/ATE202563T1/de not_active IP Right Cessation
- 1994-10-31 WO PCT/EP1994/003581 patent/WO1995012584A1/de active IP Right Grant
- 1994-11-02 CO CO94050176A patent/CO4290417A1/es unknown
- 1994-11-03 ZA ZA948670A patent/ZA948670B/xx unknown
- 1994-11-04 TW TW083110205A patent/TW400319B/zh active
-
1998
- 1998-10-21 HK HK98111440A patent/HK1010722A1/xx not_active IP Right Cessation
-
2001
- 2001-09-18 GR GR20010401500T patent/GR3036642T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA948670B (en) | 1995-07-04 |
| EP0733046B1 (de) | 2001-06-27 |
| CN1134146A (zh) | 1996-10-23 |
| AU7993794A (en) | 1995-05-23 |
| PT733046E (pt) | 2001-10-30 |
| JPH09504535A (ja) | 1997-05-06 |
| PL314188A1 (en) | 1996-09-02 |
| NZ274849A (en) | 1998-08-26 |
| CA2175838A1 (en) | 1995-05-11 |
| WO1995012584A1 (de) | 1995-05-11 |
| RU2136659C1 (ru) | 1999-09-10 |
| GR3036642T3 (en) | 2001-12-31 |
| DE4337611A1 (de) | 1995-05-11 |
| HK1010722A1 (en) | 1999-06-25 |
| KR960705789A (ko) | 1996-11-08 |
| KR100359676B1 (ko) | 2003-04-16 |
| CO4290417A1 (es) | 1996-04-17 |
| ATE202563T1 (de) | 2001-07-15 |
| US5783576A (en) | 1998-07-21 |
| TW400319B (en) | 2000-08-01 |
| CN1056609C (zh) | 2000-09-20 |
| DE59409794D1 (de) | 2001-08-02 |
| EP0733046A1 (de) | 1996-09-25 |
| AU687911B2 (en) | 1998-03-05 |
| ES2157993T3 (es) | 2001-09-01 |
| PL180302B1 (pl) | 2001-01-31 |
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