HK1010722A1 - Benzoyl guanidines, their production and their use in medicaments - Google Patents
Benzoyl guanidines, their production and their use in medicamentsInfo
- Publication number
- HK1010722A1 HK1010722A1 HK98111440A HK98111440A HK1010722A1 HK 1010722 A1 HK1010722 A1 HK 1010722A1 HK 98111440 A HK98111440 A HK 98111440A HK 98111440 A HK98111440 A HK 98111440A HK 1010722 A1 HK1010722 A1 HK 1010722A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pct
- medicaments
- production
- date
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4337611A DE4337611A1 (de) | 1993-11-04 | 1993-11-04 | Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln |
PCT/EP1994/003581 WO1995012584A1 (de) | 1993-11-04 | 1994-10-31 | Neue benzoylguanidine, ihre herstellung und ihre verwendung in arzneimitteln |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1010722A1 true HK1010722A1 (en) | 1999-06-25 |
Family
ID=6501758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98111440A HK1010722A1 (en) | 1993-11-04 | 1998-10-21 | Benzoyl guanidines, their production and their use in medicaments |
Country Status (21)
Country | Link |
---|---|
US (1) | US5783576A (xx) |
EP (1) | EP0733046B1 (xx) |
JP (1) | JPH09504535A (xx) |
KR (1) | KR100359676B1 (xx) |
CN (1) | CN1056609C (xx) |
AT (1) | ATE202563T1 (xx) |
AU (1) | AU687911B2 (xx) |
CA (1) | CA2175838A1 (xx) |
CO (1) | CO4290417A1 (xx) |
DE (2) | DE4337611A1 (xx) |
DK (1) | DK0733046T3 (xx) |
ES (1) | ES2157993T3 (xx) |
GR (1) | GR3036642T3 (xx) |
HK (1) | HK1010722A1 (xx) |
NZ (1) | NZ274849A (xx) |
PL (1) | PL180302B1 (xx) |
PT (1) | PT733046E (xx) |
RU (1) | RU2136659C1 (xx) |
TW (1) | TW400319B (xx) |
WO (1) | WO1995012584A1 (xx) |
ZA (1) | ZA948670B (xx) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA9610687B (en) * | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
CA2325471C (en) * | 1998-03-23 | 2010-08-17 | Aventis Pharmaceuticals Products Inc. | Piperididinyl and n-amidinopiperidinyl derivatives |
US6239279B1 (en) * | 1998-12-16 | 2001-05-29 | Smithkline Beecham Corporation | Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives |
EP1182194A4 (en) | 1999-06-03 | 2004-02-11 | Takeda Chemical Industries Ltd | PERNASAL COMPOSITIONS |
US6156758A (en) * | 1999-09-08 | 2000-12-05 | Isis Pharmaceuticals, Inc. | Antibacterial quinazoline compounds |
KR20050008691A (ko) * | 2002-04-19 | 2005-01-21 | 셀룰러 지노믹스 아이엔씨 | 이미다조[1,2-a]피라진-8-일 아민, 그의 제조방법 및사용방법 |
AU2003270489A1 (en) * | 2002-09-09 | 2004-03-29 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
WO2004072081A1 (en) * | 2003-02-10 | 2004-08-26 | Cellular Genomics, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity |
US7405295B2 (en) * | 2003-06-04 | 2008-07-29 | Cgi Pharmaceuticals, Inc. | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
US20060183746A1 (en) * | 2003-06-04 | 2006-08-17 | Currie Kevin S | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
WO2005005429A1 (en) * | 2003-06-30 | 2005-01-20 | Cellular Genomics, Inc. | Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds |
WO2005019220A2 (en) * | 2003-08-11 | 2005-03-03 | Cellular Genomics Inc. | Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity |
EP1668013B1 (en) | 2003-09-23 | 2012-02-22 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrrole derivatives as protein kinase inhibitors |
EP2397478A1 (en) * | 2005-01-14 | 2011-12-21 | CGI Pharmaceuticals, Inc. | 1,3-diaryl substituted ureas as modulators of kinase activity. |
US7777040B2 (en) * | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
US7709468B2 (en) | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
JP5496915B2 (ja) | 2008-02-13 | 2014-05-21 | シージーアイ ファーマシューティカルズ,インコーポレーテッド | 6−アリール−イミダゾ[1,2−a]ピラジン誘導体、その製造方法、及びその使用方法 |
JP5696052B2 (ja) | 2008-12-08 | 2015-04-08 | ギリアード コネチカット, インコーポレイテッド | イミダゾピラジンsyk阻害剤 |
US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
HUE030427T2 (en) | 2008-12-08 | 2017-05-29 | Gilead Connecticut Inc | Imidazopyrazine Syk inhibitors |
TW201200518A (en) * | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
NZ602362A (en) | 2010-03-11 | 2014-11-28 | Gilead Connecticut Inc | Imidazopyridines syk inhibitors |
AP2016009007A0 (en) | 2013-07-30 | 2016-01-31 | Gilead Connecticut Inc | Formulation of syk inhibitors |
TW201602108A (zh) | 2013-07-30 | 2016-01-16 | 吉李德康乃狄克公司 | 脾酪胺酸激酶(Syk)抑制劑之多晶型 |
PT3076976T (pt) | 2013-12-04 | 2020-12-07 | Kronos Bio Inc | Métodos para tratar cancros |
US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
UY35898A (es) | 2013-12-23 | 2015-07-31 | Gilead Sciences Inc | ?compuestos inhibidores de syk y composiciones que los comprenden?. |
KR20170029580A (ko) | 2014-07-14 | 2017-03-15 | 길리애드 사이언시즈, 인코포레이티드 | 암을 치료하기 위한 조합물 |
KR102399996B1 (ko) | 2017-08-25 | 2022-05-20 | 길리애드 사이언시즈, 인코포레이티드 | Syk 억제제의 다형체 |
JP2022521413A (ja) | 2019-02-22 | 2022-04-07 | クロノス バイオ インコーポレイテッド | Syk阻害剤としての縮合ピラジンの固体形態 |
WO2024086790A1 (en) * | 2022-10-21 | 2024-04-25 | Exelixis, Inc. | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-c]PYRIDINE COMPOUNDS AND DERIVATIVES AS USP1 INHIBITORS |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3953476A (en) * | 1971-12-27 | 1976-04-27 | Merck & Co., Inc. | 3-Amino-5-sulfonylbenzoic acids |
DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
CZ284456B6 (cs) * | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
ES2097409T3 (es) * | 1992-09-22 | 1997-04-01 | Hoechst Ag | Benzoilguanidinas, procedimiento para su preparacion, asi como su empleo como antiarritmicos. |
DK0603650T3 (da) * | 1992-12-16 | 1997-10-20 | Hoechst Ag | 3,5-Substituerede aminobenzoylguanidiner, fremgangsmåde til deres freemstilling, deres anvendelse som lægemiddel eller diagnostikum samt lægemiddel med indhold deraf. |
-
1993
- 1993-11-04 DE DE4337611A patent/DE4337611A1/de not_active Ceased
-
1994
- 1994-10-31 CN CN94194015A patent/CN1056609C/zh not_active Expired - Fee Related
- 1994-10-31 AT AT94931019T patent/ATE202563T1/de not_active IP Right Cessation
- 1994-10-31 KR KR1019960702300A patent/KR100359676B1/ko not_active IP Right Cessation
- 1994-10-31 RU RU96112103A patent/RU2136659C1/ru not_active IP Right Cessation
- 1994-10-31 PL PL94314188A patent/PL180302B1/pl unknown
- 1994-10-31 WO PCT/EP1994/003581 patent/WO1995012584A1/de active IP Right Grant
- 1994-10-31 PT PT94931019T patent/PT733046E/pt unknown
- 1994-10-31 JP JP7513011A patent/JPH09504535A/ja active Pending
- 1994-10-31 CA CA002175838A patent/CA2175838A1/en not_active Abandoned
- 1994-10-31 DE DE59409794T patent/DE59409794D1/de not_active Expired - Fee Related
- 1994-10-31 DK DK94931019T patent/DK0733046T3/da active
- 1994-10-31 US US08/649,614 patent/US5783576A/en not_active Expired - Lifetime
- 1994-10-31 AU AU79937/94A patent/AU687911B2/en not_active Ceased
- 1994-10-31 ES ES94931019T patent/ES2157993T3/es not_active Expired - Lifetime
- 1994-10-31 NZ NZ274849A patent/NZ274849A/en unknown
- 1994-10-31 EP EP94931019A patent/EP0733046B1/de not_active Expired - Lifetime
- 1994-11-02 CO CO94050176A patent/CO4290417A1/es unknown
- 1994-11-03 ZA ZA948670A patent/ZA948670B/xx unknown
- 1994-11-04 TW TW083110205A patent/TW400319B/zh active
-
1998
- 1998-10-21 HK HK98111440A patent/HK1010722A1/xx not_active IP Right Cessation
-
2001
- 2001-09-18 GR GR20010401500T patent/GR3036642T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL180302B1 (pl) | 2001-01-31 |
KR960705789A (ko) | 1996-11-08 |
PL314188A1 (en) | 1996-09-02 |
DE59409794D1 (de) | 2001-08-02 |
WO1995012584A1 (de) | 1995-05-11 |
EP0733046A1 (de) | 1996-09-25 |
CA2175838A1 (en) | 1995-05-11 |
DE4337611A1 (de) | 1995-05-11 |
PT733046E (pt) | 2001-10-30 |
TW400319B (en) | 2000-08-01 |
US5783576A (en) | 1998-07-21 |
NZ274849A (en) | 1998-08-26 |
CO4290417A1 (es) | 1996-04-17 |
ATE202563T1 (de) | 2001-07-15 |
RU2136659C1 (ru) | 1999-09-10 |
DK0733046T3 (da) | 2001-09-03 |
JPH09504535A (ja) | 1997-05-06 |
CN1134146A (zh) | 1996-10-23 |
GR3036642T3 (en) | 2001-12-31 |
KR100359676B1 (ko) | 2003-04-16 |
EP0733046B1 (de) | 2001-06-27 |
AU687911B2 (en) | 1998-03-05 |
CN1056609C (zh) | 2000-09-20 |
ES2157993T3 (es) | 2001-09-01 |
AU7993794A (en) | 1995-05-23 |
ZA948670B (en) | 1995-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20051031 |