CY1106668T1 - Υποδοριως χορηγουμενες συνθεσεις εμβολιου βασης γαγγλιοζιτη - Google Patents
Υποδοριως χορηγουμενες συνθεσεις εμβολιου βασης γαγγλιοζιτηInfo
- Publication number
- CY1106668T1 CY1106668T1 CY20071100556T CY071100556T CY1106668T1 CY 1106668 T1 CY1106668 T1 CY 1106668T1 CY 20071100556 T CY20071100556 T CY 20071100556T CY 071100556 T CY071100556 T CY 071100556T CY 1106668 T1 CY1106668 T1 CY 1106668T1
- Authority
- CY
- Cyprus
- Prior art keywords
- vssp
- vaccine compositions
- ganglozite
- subscore
- compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 150000002270 gangliosides Chemical class 0.000 abstract 2
- 241000588650 Neisseria meningitidis Species 0.000 abstract 1
- 101710116435 Outer membrane protein Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 108010030416 proteoliposomes Proteins 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Η εφεύρεση σχετίζεται με συνθέσεις εμβολίου που συνδυάζουν γαγγλιοζίτες και το σύμπλοκο πρωτεΐνης εξωτερικής μεμβράνης (OMPC) Ν. meningitidis για να σχηματιστούν πολύ μικρού μεγέθους πρωτεολιποσώματα (VSSP) που στοχεύονται για υποδόρια χορήγηση. Οι εφευρετικές συνθέσεις δεν απαιτούν τη χρήση επιπλέον ανοσοενισχυτικών. Οι προαναφερθείσες συνθέσεις καθιστούν δυνατές τις ανοσολογικές αντιμετωπίσεις με γαγγλιοζίτες, ιδιαίτερα N-AcGM3/VSSP και N-GcGM3/VSSP, που είναι πλεονεκτικοί χάρη στο γεγονός ότι είναι λιγότερο επιθετικοί στο σημείο της ένεσης και μπορούν να χρησιμοποιηθούν ευκολότερα με λιγότερη δυσφορία για τους ασθενείς.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20030047A CU23257A1 (es) | 2003-02-27 | 2003-02-27 | COMPOSICIONES VACUNALES A BASE DE GANGLIOSIDOS PARA LA ADMINISTRACION SUBCUTáNEA |
| PCT/CU2004/000003 WO2004075811A2 (es) | 2003-02-27 | 2004-02-27 | Composiciones vacunales a base de gangliósidos para administración subcutánea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106668T1 true CY1106668T1 (el) | 2012-05-23 |
Family
ID=40091613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071100556T CY1106668T1 (el) | 2003-02-27 | 2007-04-26 | Υποδοριως χορηγουμενες συνθεσεις εμβολιου βασης γαγγλιοζιτη |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US8591917B2 (el) |
| EP (1) | EP1604683B1 (el) |
| JP (1) | JP4729475B2 (el) |
| KR (1) | KR100703570B1 (el) |
| CN (1) | CN100418576C (el) |
| AR (1) | AR043377A1 (el) |
| AT (1) | ATE353668T1 (el) |
| AU (1) | AU2004216554B2 (el) |
| BR (1) | BRPI0407854B1 (el) |
| CA (1) | CA2535214C (el) |
| CL (1) | CL2004000374A1 (el) |
| CR (1) | CR7965A (el) |
| CU (1) | CU23257A1 (el) |
| CY (1) | CY1106668T1 (el) |
| DE (1) | DE602004004768T2 (el) |
| DK (1) | DK1604683T3 (el) |
| EA (1) | EA008905B1 (el) |
| EC (1) | ECSP055978A (el) |
| EG (1) | EG26446A (el) |
| ES (1) | ES2280948T3 (el) |
| GE (1) | GEP20074120B (el) |
| HK (1) | HK1087630A1 (el) |
| HR (1) | HRP20050763A2 (el) |
| IL (1) | IL170355A (el) |
| LT (1) | LT5351B (el) |
| LV (1) | LV13400B (el) |
| MY (1) | MY139811A (el) |
| NZ (1) | NZ541952A (el) |
| PE (1) | PE20040955A1 (el) |
| PT (1) | PT1604683E (el) |
| RS (1) | RS20050664A (el) |
| SI (1) | SI1604683T1 (el) |
| TN (1) | TNSN05209A1 (el) |
| TW (1) | TWI344372B (el) |
| UA (1) | UA80859C2 (el) |
| UY (1) | UY28207A1 (el) |
| WO (1) | WO2004075811A2 (el) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU24534B1 (es) * | 2017-11-06 | 2021-07-02 | Ct Inmunologia Molecular | Adyuvantes nano-particulados que contienen variantes sintéticas del gangliósido gm3 |
| CU20170173A7 (es) | 2017-12-27 | 2019-11-04 | Ct Inmunologia Molecular | Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965198A (en) | 1985-12-24 | 1990-10-23 | Konica Corporation | Monoclonal antibody and method of manufacturing hybridoma producing the same |
| CU22420A1 (es) * | 1993-12-29 | 1996-01-31 | Centro Inmunologia Molecular | Composicion vacunal para el desarrollo de una respuesta contra gangliosidos n glicolilados y su uso para el tratamiento del cancer |
| US6149921A (en) * | 1993-12-29 | 2000-11-21 | Centro De Inmunologia Molecular | Vaccine compositions for eliciting an immune response against N-acetylated gangliosides and their use for cancer treatment |
| PE20020572A1 (es) * | 2000-12-06 | 2002-07-31 | Centro Inmunologia Molecular | Preparaciones para potenciar la inmunogenicidad de antigenos poco inmunogenicos |
| EP1293212A1 (en) * | 2001-08-21 | 2003-03-19 | National Research Council Of Canada | Anti cancer vaccine comprising whole cancer cells with modified sialic acid |
-
2003
- 2003-02-27 CU CU20030047A patent/CU23257A1/es unknown
-
2004
- 2004-02-24 PE PE2004000186A patent/PE20040955A1/es not_active Application Discontinuation
- 2004-02-24 AR ARP040100571A patent/AR043377A1/es not_active Application Discontinuation
- 2004-02-25 TW TW093104808A patent/TWI344372B/zh not_active IP Right Cessation
- 2004-02-26 MY MYPI20040641A patent/MY139811A/en unknown
- 2004-02-26 CL CL200400374A patent/CL2004000374A1/es unknown
- 2004-02-27 UA UAA200508381A patent/UA80859C2/xx unknown
- 2004-02-27 EP EP04715239A patent/EP1604683B1/en not_active Expired - Lifetime
- 2004-02-27 BR BRPI0407854-3A patent/BRPI0407854B1/pt not_active IP Right Cessation
- 2004-02-27 SI SI200430262T patent/SI1604683T1/sl unknown
- 2004-02-27 CA CA2535214A patent/CA2535214C/en not_active Expired - Lifetime
- 2004-02-27 WO PCT/CU2004/000003 patent/WO2004075811A2/es active IP Right Grant
- 2004-02-27 ES ES04715239T patent/ES2280948T3/es not_active Expired - Lifetime
- 2004-02-27 DE DE602004004768T patent/DE602004004768T2/de not_active Expired - Lifetime
- 2004-02-27 AU AU2004216554A patent/AU2004216554B2/en not_active Expired
- 2004-02-27 UY UY28207A patent/UY28207A1/es unknown
- 2004-02-27 CN CNB2004800052015A patent/CN100418576C/zh not_active Expired - Lifetime
- 2004-02-27 GE GEAP20048952A patent/GEP20074120B/en unknown
- 2004-02-27 NZ NZ541952A patent/NZ541952A/en not_active IP Right Cessation
- 2004-02-27 EA EA200501367A patent/EA008905B1/ru not_active IP Right Cessation
- 2004-02-27 DK DK04715239T patent/DK1604683T3/da active
- 2004-02-27 JP JP2006501455A patent/JP4729475B2/ja not_active Expired - Lifetime
- 2004-02-27 US US10/547,164 patent/US8591917B2/en active Active
- 2004-02-27 KR KR1020057015531A patent/KR100703570B1/ko active IP Right Grant
- 2004-02-27 PT PT04715239T patent/PT1604683E/pt unknown
- 2004-02-27 AT AT04715239T patent/ATE353668T1/de active
- 2004-02-27 RS YUP-2005/0664A patent/RS20050664A/sr unknown
-
2005
- 2005-08-18 IL IL170355A patent/IL170355A/en not_active IP Right Cessation
- 2005-08-20 EG EGPCTNA2005000479A patent/EG26446A/en active
- 2005-08-24 EC EC2005005978A patent/ECSP055978A/es unknown
- 2005-08-26 CR CR7965A patent/CR7965A/es unknown
- 2005-08-26 TN TNP2005000209A patent/TNSN05209A1/en unknown
- 2005-08-29 LV LVP-05-110A patent/LV13400B/en unknown
- 2005-09-02 HR HR20050763A patent/HRP20050763A2/hr not_active Application Discontinuation
- 2005-09-21 LT LT2005087A patent/LT5351B/lt not_active IP Right Cessation
-
2006
- 2006-07-14 HK HK06107889.3A patent/HK1087630A1/xx not_active IP Right Cessation
-
2007
- 2007-04-26 CY CY20071100556T patent/CY1106668T1/el unknown
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