ES2145072T3 - Preparacion y usos de proteinas de membranas externas carentes de los de cocos gramnegativos. - Google Patents
Preparacion y usos de proteinas de membranas externas carentes de los de cocos gramnegativos.Info
- Publication number
- ES2145072T3 ES2145072T3 ES94106827T ES94106827T ES2145072T3 ES 2145072 T3 ES2145072 T3 ES 2145072T3 ES 94106827 T ES94106827 T ES 94106827T ES 94106827 T ES94106827 T ES 94106827T ES 2145072 T3 ES2145072 T3 ES 2145072T3
- Authority
- ES
- Spain
- Prior art keywords
- membrane proteins
- gramnegative
- coconuts
- preparation
- external membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010052285 Membrane Proteins Proteins 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000588650 Neisseria meningitidis Species 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000167 toxic agent Toxicity 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
AQUI SE DESCRIBE UN METODO PARA ELIMINAR LIPOOLIGOSACARIDOS (LOS) TOXICOS DE LAS MEMBRANAS EXTERIORES DE COCOS GRAM EGATIVOS, TALES COMO NEISSERIA MENINGITIDIS. PROTEINAS DE MEMBRANAS EXTERIORES VACIADAS DE LOS Y DE MEMBRANAS SOLUBLES EXTERIORES VACIADAS DE LOS PUEDEN SER PREPARADAS, LAS CUALES SON VALIDAS PARA EXTRAER ANTICUERPOS BACTERICIDAS CONTRA CEPAS HOMOLOGAS DE BACTERIA. VACUNAS Y OTROS USOS DE LAS PREPARACIONES SON DESCRITAS ADICIONALMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6158193A | 1993-05-13 | 1993-05-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2145072T3 true ES2145072T3 (es) | 2000-07-01 |
Family
ID=22036711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94106827T Expired - Lifetime ES2145072T3 (es) | 1993-05-13 | 1994-05-02 | Preparacion y usos de proteinas de membranas externas carentes de los de cocos gramnegativos. |
Country Status (11)
Country | Link |
---|---|
US (2) | US6355253B1 (es) |
EP (1) | EP0624376B1 (es) |
JP (1) | JP3711289B2 (es) |
KR (1) | KR100355961B1 (es) |
AT (1) | ATE190502T1 (es) |
CA (1) | CA2123355C (es) |
DE (1) | DE69423383T2 (es) |
DK (1) | DK0624376T3 (es) |
ES (1) | ES2145072T3 (es) |
GR (1) | GR3033469T3 (es) |
PT (1) | PT624376E (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6121427A (en) * | 1994-10-24 | 2000-09-19 | Connaught Laboratories Limited | Major outer membrane protein CD of branhamella |
EP0983342B1 (en) * | 1997-05-28 | 2007-09-05 | Novartis Vaccines and Diagnostics S.r.l. | Culture medium with soy bean extract as aminoacid source and no protein complexes of animal origin |
US20040087020A1 (en) | 1997-05-28 | 2004-05-06 | Chiron S.P.A. | Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin |
DK0991761T3 (da) | 1997-08-21 | 2008-05-19 | Nederlanden Staat | Hidtil ukendte mutaner af gramnegative mucosale bakterier og anvendelse deraf i vacciner |
US20070026021A1 (en) * | 1998-05-01 | 2007-02-01 | Chiron S.R.I. | Neisseria meningitidis antigens and compositions |
EP2261355A3 (en) | 1998-05-01 | 2012-01-11 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
ES2485940T3 (es) | 1998-05-29 | 2014-08-14 | Novartis Vaccines And Diagnostics, Inc. | Combinación de vacunas contra Meningitis B/C |
CN102580072A (zh) | 1999-05-19 | 2012-07-18 | 诺华疫苗和诊断有限公司 | 组合式奈瑟球菌组合物 |
GB9928196D0 (en) * | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
ES2507100T3 (es) * | 2000-01-17 | 2014-10-14 | Novartis Vaccines And Diagnostics S.R.L. | Vacuna OMV suplementada contra meningococo |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
US7785608B2 (en) * | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
US7301554B2 (en) * | 2002-09-20 | 2007-11-27 | Ricoh Company, Ltd. | Light scanning device, scanning line adjusting method, scanning line adjusting control method, image forming apparatus, and image forming method |
JP4697706B2 (ja) | 2002-10-11 | 2011-06-08 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 高毒性髄膜炎菌系統に対する広範な防御のためのポリペプチド−ワクチン |
CA2508912A1 (en) * | 2002-12-06 | 2004-06-24 | Agennix Incorporated | Oral lactoferrin in the treatment of sepsis |
GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
US7608278B2 (en) | 2003-12-30 | 2009-10-27 | Wyeth | Formulations of hydrophobic proteins in an immunogenic composition having improved tolerability |
GB0416120D0 (en) | 2004-07-19 | 2004-08-18 | Health Prot Agency | Stable compositions containing OMV's |
GB0419627D0 (en) * | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
NZ580974A (en) | 2005-02-18 | 2011-05-27 | Novartis Vaccines & Diagnostic | Immunogens from uropathogenic escherichia coli |
LT2351772T (lt) | 2005-02-18 | 2016-10-10 | Glaxosmithkline Biologicals Sa | Baltymai ir nukleorūgštys iš su meningitu/sepsiu susijusių escherichia coli |
KR100612895B1 (ko) * | 2005-05-04 | 2006-08-14 | 삼성전자주식회사 | 화학 물질을 이용한 생물학적 시료로부터 단백질의선택적인 제거 방법 |
WO2008020330A2 (en) | 2006-08-16 | 2008-02-21 | Novartis Ag | Immunogens from uropathogenic escherichia coli |
AR064642A1 (es) * | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
RU2477145C2 (ru) * | 2008-05-30 | 2013-03-10 | ДЗЕ Ю.Эс.Эй., ЭС РЕПРЕЗЕНТЕД БАЙ ДЗЕ СЕКРЕТАРИ ОФ ДЗЕ АРМИ, ОН БЕХАФ ОФ УОЛТЕР РИД АРМИ | Мультивалентная вакцина из нативных везикул наружной мембраны менингококков, способы ее получения и применения |
GB201009861D0 (en) | 2010-06-11 | 2010-07-21 | Novartis Ag | OMV vaccines |
HRP20210242T4 (hr) | 2010-08-23 | 2024-05-10 | Wyeth Llc | Stabilne formulacije antigena iz bakterije neisseria meningitidis rlp2086 |
CN103096920B (zh) | 2010-09-10 | 2016-03-23 | 惠氏有限责任公司 | 脑膜炎奈瑟球菌orf2086抗原的非脂质化变体 |
GB201015132D0 (en) * | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
EP2613805B1 (en) * | 2010-09-10 | 2019-10-23 | GlaxoSmithKline Biologicals SA | Meningococcus overexpressing nada and/or nhba and outer membrane vesicles derived therefrom |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
BR122016004924A2 (pt) | 2012-03-09 | 2019-07-30 | Pfizer Inc. | Polipeptídeo isolado e composições imunogênicas compreendendo os mesmos |
AU2013320313B2 (en) | 2012-09-18 | 2018-07-12 | Glaxosmithkline Biologicals Sa | Outer membrane vesicles |
JP6446377B2 (ja) | 2013-03-08 | 2018-12-26 | ファイザー・インク | 免疫原性融合ポリペプチド |
CA2923129C (en) | 2013-09-08 | 2020-06-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
CN106659717B (zh) | 2014-08-22 | 2019-09-06 | 葛兰素史密斯克莱知识产权发展有限公司 | 用于治疗淋病奈瑟球菌感染的三环含氮化合物 |
AU2016221318B2 (en) | 2015-02-19 | 2020-06-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
CN110568116A (zh) * | 2019-09-17 | 2019-12-13 | 广东医科大学附属医院 | 一种筛选用于诊断阿尔茨海默病的生物标志物的方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4271147A (en) | 1980-01-10 | 1981-06-02 | Behringwerke Aktiengesellschaft | Process for the isolation of membrane proteins from Neisseria meningitidis and vaccines containing same |
US4386066A (en) * | 1981-08-20 | 1983-05-31 | Merck & Co., Inc. | Immunogenic complex from N. gonorrhoeae |
WO1983003354A1 (en) | 1982-03-30 | 1983-10-13 | Us Army | Neisseria gonorrhoeae vaccine |
NL8403195A (nl) | 1984-10-19 | 1986-05-16 | Nederlanden Staat | Immunogene complexen en vaccins die deze bevatten. |
US4601903A (en) | 1985-05-01 | 1986-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease |
DE3516017A1 (de) | 1985-05-02 | 1986-11-27 | Jochen 1000 Berlin Kittel | Verfahren zur herstellung membranstaendiger proteine aus biologischem material zur anwendung im biologischen systemen |
US4707543A (en) | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
JPH01125328A (ja) * | 1987-07-30 | 1989-05-17 | Centro Natl De Biopreparados | 髄膜炎菌ワクチン |
EP0351604B1 (en) * | 1988-06-29 | 1994-09-14 | The Rockefeller University | Neisserial vaccines |
ATE120093T1 (de) | 1988-12-19 | 1995-04-15 | Praxis Biolog Inc | Meningococcales klasse i-aussenmembranprotein- vakzin. |
ES2063965T3 (es) | 1989-03-09 | 1995-01-16 | Praxis Biolog Inc | Vacunas para haemophilus influenzae no tipificable. |
JP2516841B2 (ja) | 1989-04-14 | 1996-07-24 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 抽出方法 |
US5552146A (en) * | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
-
1994
- 1994-05-02 DK DK94106827T patent/DK0624376T3/da active
- 1994-05-02 PT PT94106827T patent/PT624376E/pt unknown
- 1994-05-02 ES ES94106827T patent/ES2145072T3/es not_active Expired - Lifetime
- 1994-05-02 EP EP94106827A patent/EP0624376B1/en not_active Expired - Lifetime
- 1994-05-02 DE DE69423383T patent/DE69423383T2/de not_active Expired - Fee Related
- 1994-05-02 AT AT94106827T patent/ATE190502T1/de not_active IP Right Cessation
- 1994-05-11 CA CA002123355A patent/CA2123355C/en not_active Expired - Fee Related
- 1994-05-12 JP JP12203294A patent/JP3711289B2/ja not_active Expired - Fee Related
- 1994-05-12 KR KR1019940010539A patent/KR100355961B1/ko not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/469,842 patent/US6355253B1/en not_active Expired - Fee Related
-
2000
- 2000-05-22 GR GR20000401165T patent/GR3033469T3/el not_active IP Right Cessation
-
2002
- 2002-03-05 US US10/091,233 patent/US6921537B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR100355961B1 (ko) | 2002-12-26 |
DE69423383D1 (de) | 2000-04-20 |
CA2123355C (en) | 2007-08-28 |
EP0624376A1 (en) | 1994-11-17 |
JPH0819396A (ja) | 1996-01-23 |
US6921537B2 (en) | 2005-07-26 |
DE69423383T2 (de) | 2000-08-24 |
GR3033469T3 (en) | 2000-09-29 |
JP3711289B2 (ja) | 2005-11-02 |
US20020136741A1 (en) | 2002-09-26 |
DK0624376T3 (da) | 2000-07-24 |
PT624376E (pt) | 2000-07-31 |
US6355253B1 (en) | 2002-03-12 |
CA2123355A1 (en) | 1994-11-14 |
ATE190502T1 (de) | 2000-04-15 |
EP0624376B1 (en) | 2000-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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