CN114634943A - 使用融合蛋白对tcr重编程的组合物和方法 - Google Patents
使用融合蛋白对tcr重编程的组合物和方法 Download PDFInfo
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- CN114634943A CN114634943A CN202210028922.8A CN202210028922A CN114634943A CN 114634943 A CN114634943 A CN 114634943A CN 202210028922 A CN202210028922 A CN 202210028922A CN 114634943 A CN114634943 A CN 114634943A
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- 108091008874 T cell receptors Proteins 0.000 title claims abstract 50
- 108020001507 fusion proteins Proteins 0.000 title claims abstract 14
- 102000037865 fusion proteins Human genes 0.000 title claims abstract 14
- 239000000203 mixture Substances 0.000 title 1
- 230000008672 reprogramming Effects 0.000 title 1
- 230000009258 tissue cross reactivity Effects 0.000 title 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims abstract 49
- 210000001744 T-lymphocyte Anatomy 0.000 claims abstract 6
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 230000004068 intracellular signaling Effects 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 230000003834 intracellular effect Effects 0.000 claims 6
- 230000004936 stimulating effect Effects 0.000 claims 5
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 230000011748 cell maturation Effects 0.000 claims 1
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- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
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- 206010028980 Neoplasm Diseases 0.000 abstract 1
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- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163342P | 2015-05-18 | 2015-05-18 | |
| US62/163,342 | 2015-05-18 | ||
| PCT/US2016/033146 WO2016187349A1 (en) | 2015-05-18 | 2016-05-18 | Compositions and methods for tcr reprogramming using fusion proteins |
| CN201680032042.0A CN107995913B (zh) | 2015-05-18 | 2016-05-18 | 使用融合蛋白对tcr重编程的组合物和方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680032042.0A Division CN107995913B (zh) | 2015-05-18 | 2016-05-18 | 使用融合蛋白对tcr重编程的组合物和方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114634943A true CN114634943A (zh) | 2022-06-17 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210028922.8A Pending CN114634943A (zh) | 2015-05-18 | 2016-05-18 | 使用融合蛋白对tcr重编程的组合物和方法 |
| CN201680032042.0A Active CN107995913B (zh) | 2015-05-18 | 2016-05-18 | 使用融合蛋白对tcr重编程的组合物和方法 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680032042.0A Active CN107995913B (zh) | 2015-05-18 | 2016-05-18 | 使用融合蛋白对tcr重编程的组合物和方法 |
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| EP (3) | EP3466967A1 (enExample) |
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| CN (2) | CN114634943A (enExample) |
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| PT (1) | PT3298033T (enExample) |
| SG (1) | SG10201914069SA (enExample) |
| WO (1) | WO2016187349A1 (enExample) |
| ZA (1) | ZA201708000B (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9273283B2 (en) * | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| US10611837B2 (en) | 2014-04-10 | 2020-04-07 | Seattle Children's Hospital | Transgene genetic tags and methods of use |
| EP3466967A1 (en) | 2015-05-18 | 2019-04-10 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| US11059880B2 (en) * | 2015-06-30 | 2021-07-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with MHC chimeric receptors and methods of use in immunotherapy |
| US10493139B2 (en) | 2015-07-24 | 2019-12-03 | Innovative Cellular Therapeutics CO., LTD. | Humanized anti-CD19 antibody and use thereof with chimeric antigen receptor |
| US11458167B2 (en) | 2015-08-07 | 2022-10-04 | Seattle Children's Hospital | Bispecific CAR T-cells for solid tumor targeting |
| WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
| WO2017059796A1 (en) * | 2015-10-08 | 2017-04-13 | Shanghai Sidansai Biotechnology Co., Ltd | Activation and expansion of t cells |
| IL295398B2 (en) | 2015-10-23 | 2025-01-01 | Eureka Therapeutics Inc | Antibody/T-cell receptor chimeric constructs and their uses |
| GB201604458D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against cancers |
| WO2017162797A1 (en) * | 2016-03-23 | 2017-09-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
| WO2017192536A1 (en) | 2016-05-02 | 2017-11-09 | University Of Kansas | Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy |
| US10086055B2 (en) * | 2016-06-01 | 2018-10-02 | Promab Biotechnologies, Inc. | Adherent cancer cell line expressing a hematological tumor antigen |
| AU2017306432A1 (en) * | 2016-08-02 | 2019-03-21 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| EP3516068B1 (en) | 2016-09-19 | 2025-04-23 | University of Southern California | Non-radioactive cytotoxicity assays |
| CA3035080A1 (en) | 2016-09-27 | 2018-04-05 | Cero Therapeutics, Inc. | Chimeric engulfment receptor molecules |
| BR112019007100A2 (pt) | 2016-10-07 | 2019-06-25 | Tcr2 Therapeutics Inc | composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| AU2017366739B2 (en) * | 2016-12-02 | 2023-11-23 | Angeles Therapeutics, Inc. | Synthetic immune receptors and methods of use thereof |
| US20210187022A1 (en) * | 2016-12-21 | 2021-06-24 | TCR2 Therapeutics Inc. | Engineered t cells for the treatment of cancer |
| EP3609536B1 (en) * | 2017-01-05 | 2022-03-09 | Innovative Cellular Therapeutics Holdings, Ltd. | Humanized anti-cd19 antibody and use thereof with chimeric antigen receptor |
| JP2020506700A (ja) * | 2017-01-31 | 2020-03-05 | ノバルティス アーゲー | 多重特異性を有するキメラt細胞受容体タンパク質を用いた癌の治療 |
| WO2018166589A1 (en) | 2017-03-15 | 2018-09-20 | Biontech Cell & Gene Therapies Gmbh | Antigen receptors and uses thereof |
| CN110741016A (zh) * | 2017-04-26 | 2020-01-31 | 优瑞科生物技术公司 | 嵌合抗体/t-细胞受体构筑体及其用途 |
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