CN1139592C - 喜树碱衍生物，其制备用途以及中间体 - Google Patents

喜树碱衍生物，其制备用途以及中间体 Download PDF

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Publication number
CN1139592C
CN1139592C CNB008047804A CN00804780A CN1139592C CN 1139592 C CN1139592 C CN 1139592C CN B008047804 A CNB008047804 A CN B008047804A CN 00804780 A CN00804780 A CN 00804780A CN 1139592 C CN1139592 C CN 1139592C
Authority
CN
China
Prior art keywords
compound
group
formula
camptothecin
iminomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008047804A
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English (en)
Chinese (zh)
Other versions
CN1343209A (zh
Inventor
S
S·潘科
L·默里尼
��˹��ŵ��
F·祖尼诺
�����ɵ�
P·卡米纳迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori, Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Publication of CN1343209A publication Critical patent/CN1343209A/zh
Application granted granted Critical
Publication of CN1139592C publication Critical patent/CN1139592C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB008047804A 1999-03-09 2000-03-08 喜树碱衍生物，其制备用途以及中间体 Expired - Fee Related CN1139592C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity
EP99830124.6 1999-03-09

Publications (2)

Publication Number Publication Date
CN1343209A CN1343209A (zh) 2002-04-03
CN1139592C true CN1139592C (zh) 2004-02-25

Family

ID=8243303

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008047804A Expired - Fee Related CN1139592C (zh) 1999-03-09 2000-03-08 喜树碱衍生物，其制备用途以及中间体

Country Status (38)

Country Link
US (2) US6242457B1 (https=)
EP (1) EP1044977B1 (https=)
JP (1) JP4610743B2 (https=)
KR (1) KR100702085B1 (https=)
CN (1) CN1139592C (https=)
AR (1) AR022860A1 (https=)
AT (1) ATE216998T1 (https=)
AU (1) AU774174B2 (https=)
BG (1) BG65032B1 (https=)
BR (1) BR0008840B1 (https=)
CA (1) CA2362760C (https=)
CO (1) CO5180590A1 (https=)
CZ (1) CZ304465B6 (https=)
DE (1) DE69901379T2 (https=)
DK (1) DK1044977T3 (https=)
EA (1) EA003605B1 (https=)
EE (1) EE04679B1 (https=)
EG (1) EG23999A (https=)
ES (1) ES2175919T3 (https=)
HR (1) HRP20010667B1 (https=)
HU (1) HU229506B1 (https=)
IL (2) IL144958A0 (https=)
IS (1) IS2003B (https=)
ME (2) ME00017B (https=)
MX (1) MXPA01009081A (https=)
NO (1) NO328363B1 (https=)
NZ (1) NZ513393A (https=)
PE (1) PE20001485A1 (https=)
PL (1) PL222208B1 (https=)
PT (1) PT1044977E (https=)
RS (1) RS50405B (https=)
SI (1) SI1044977T1 (https=)
SK (1) SK287561B6 (https=)
TN (1) TNSN00045A1 (https=)
TR (1) TR200102603T2 (https=)
TW (1) TWI272272B (https=)
WO (1) WO2000053607A1 (https=)
ZA (1) ZA200107408B (https=)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1041209A1 (zh) 1999-01-13 2002-07-05 Meditech Research Limited 加強藥物療效的成份及方法
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
CA2458856C (en) * 2001-08-27 2011-02-15 Meditech Research Limited Improved therapeutic protocols
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
BRPI0509240A (pt) * 2004-03-26 2007-09-04 Novartis Ag regime de tratamento para derivados de camptotecina
US20070207149A1 (en) 2004-04-27 2007-09-06 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
CN101080227B (zh) * 2004-12-15 2011-08-31 诺瓦提斯公司 用于治疗癌症的治疗剂的组合
PL1828196T3 (pl) 2004-12-21 2013-02-28 Sigma Tau Ind Farmaceuti Stereoselektywny sposób wytwarzania i krystaliczne formy kamptotecyny
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
US7767200B2 (en) 2005-07-14 2010-08-03 Wellstat Biologics Corporation Cancer treatment using viruses, fluoropyrimidines and camptothecins
CA2616607C (en) * 2005-07-27 2015-06-02 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
US20080213385A1 (en) * 2005-08-10 2008-09-04 Oskar Kalb Formulations for 7- (T-Butoxy) Iminomethyl Camptothecin
EA013877B1 (ru) * 2005-09-07 2010-08-30 Алкемиа Онколоджи Пти Лимитед Терапевтические композиции, содержащие гиалуроновую кислоту и терапевтические антитела, а также способы лечения
PL1962850T3 (pl) * 2005-12-21 2012-07-31 Sigma Tau Ind Farmaceuti Leczenie lekoopornych nowotworów
WO2007098091A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
AU2007232206B2 (en) 2006-03-30 2013-04-04 Drais Pharmaceuticals, Inc. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
KR20090115856A (ko) * 2007-02-01 2009-11-09 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. 캄포테신 유도체를 함유하는 약학적 조성물
US8853233B2 (en) * 2007-02-13 2014-10-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
WO2009015981A2 (en) * 2007-08-01 2009-02-05 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Treatment of pediatric tumors
EP2096113A1 (en) 2008-02-05 2009-09-02 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 9-substituted camptothecin derivatives as antitumor compounds
TWI482621B (zh) 2009-12-23 2015-05-01 Sigma Tau Ind Farmaceuti 青蒿素基藥物與其他化學治療劑的抗癌組合物
AU2016326747A1 (en) 2015-09-25 2018-03-01 Zy Therapeutics Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
WO2025252101A1 (zh) * 2024-06-05 2025-12-11 荣昌生物制药(烟台)股份有限公司 一种喜树碱类化合物及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
ATE247471T1 (de) * 1991-11-15 2003-09-15 Smithkline Beecham Corp Cisplatin und topotecan enthaltende zusammensetzung als antitumor.
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
KR100516593B1 (ko) * 1996-08-19 2005-09-22 바이오누머릭 파마슈티칼스, 인코포레이티드 고 친유성 캠프토테신 유도체

Also Published As

Publication number Publication date
MEP4008A (xx) 2010-02-10
HUP0200210A3 (en) 2004-03-29
CN1343209A (zh) 2002-04-03
PL222208B1 (pl) 2016-07-29
SI1044977T1 (en) 2002-08-31
EE04679B1 (et) 2006-08-15
PL355094A1 (en) 2004-03-22
TWI272272B (en) 2007-02-01
NO328363B1 (no) 2010-02-01
PT1044977E (pt) 2002-09-30
BG65032B1 (bg) 2006-12-29
US6242457B1 (en) 2001-06-05
BG105810A (en) 2002-06-28
IS2003B (is) 2005-04-15
RS50405B (sr) 2009-12-31
EA003605B1 (ru) 2003-06-26
HRP20010667B1 (en) 2003-06-30
AU774174B2 (en) 2004-06-17
ATE216998T1 (de) 2002-05-15
TNSN00045A1 (fr) 2005-11-10
ES2175919T3 (es) 2002-11-16
ME00017B (me) 2010-06-10
CZ20013077A3 (cs) 2002-01-16
IL144958A0 (en) 2002-06-30
HUP0200210A2 (hu) 2002-05-29
DE69901379D1 (de) 2002-06-06
CO5180590A1 (es) 2002-07-30
MXPA01009081A (es) 2002-08-30
NO20014128L (no) 2001-08-24
SK11642001A3 (sk) 2002-01-07
AR022860A1 (es) 2002-09-04
IL144958A (en) 2009-08-03
HU229506B1 (en) 2014-01-28
BR0008840B1 (pt) 2011-12-27
CA2362760A1 (en) 2000-09-14
CA2362760C (en) 2009-08-18
EE200100466A (et) 2002-12-16
AU3160400A (en) 2000-09-28
WO2000053607A1 (en) 2000-09-14
JP2002539128A (ja) 2002-11-19
NZ513393A (en) 2003-04-29
CZ304465B6 (cs) 2014-05-21
KR100702085B1 (ko) 2007-04-02
YU64301A (sh) 2005-07-19
PE20001485A1 (es) 2000-12-07
BR0008840A (pt) 2002-01-08
KR20010102519A (ko) 2001-11-15
HRP20010667A2 (en) 2002-08-31
EA200100954A1 (ru) 2002-04-25
US6589939B2 (en) 2003-07-08
SK287561B6 (sk) 2011-02-04
HK1031222A1 (en) 2001-06-08
US20010008939A1 (en) 2001-07-19
DK1044977T3 (da) 2002-07-08
EP1044977B1 (en) 2002-05-02
EG23999A (en) 2008-03-19
ZA200107408B (en) 2002-05-29
TR200102603T2 (tr) 2002-01-21
NO20014128D0 (no) 2001-08-24
JP4610743B2 (ja) 2011-01-12
IS6031A (is) 2001-07-31
DE69901379T2 (de) 2002-11-07
EP1044977A1 (en) 2000-10-18

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Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CI01 Publication of corrected invention patent application

Correction item: Denomination of Invention

Correct: Camptothecin derivatives, process for their preparation and their use and intermediates

False: Camptothecin derivatives, their preparation, use and intermediates

Number: 8

Page: 381

Volume: 20

CI03 Correction of invention patent

Correction item: Denomination of Invention

Correct: Camptothecin derivatives, process for their preparation and their use and intermediates

False: Camptothecin derivatives, their preparation, use and intermediates

Number: 8

Page: The title page

Volume: 20

COR Change of bibliographic data

Free format text: CORRECT: INVENTION NAME; FROM: CAMPTOTHECIN DERIVATIVES, PREPARING USE AND INTERMEDIATE BODY TO: CAMPTOTHECIN DERIVATIVES, PREPARATION METHOD AND THE USE AND INTERMEDIATE BODY

ERR Gazette correction

Free format text: CORRECT: INVENTION NAME; FROM: CAMPTOTHECIN DERIVATIVES, PREPARING USE AND INTERMEDIATE BODY TO: CAMPTOTHECIN DERIVATIVES, PREPARATION METHOD AND THE USE AND INTERMEDIATE BODY

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20040225

Termination date: 20180308