CN1113675C - 丙酸福地卡松的计定剂量吸入器 - Google Patents

丙酸福地卡松的计定剂量吸入器 Download PDF

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CN1113675C
CN1113675C CN96194635A CN96194635A CN1113675C CN 1113675 C CN1113675 C CN 1113675C CN 96194635 A CN96194635 A CN 96194635A CN 96194635 A CN96194635 A CN 96194635A CN 1113675 C CN1113675 C CN 1113675C
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I·L·布雷托
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Abstract

计量剂量吸入器，该吸入器的内表面由一种或多种氟烃高聚物涂衬，随意与一种或多种非氟烃高聚体组合，用于分散吸入药物制剂，该药物制剂包含丙酸fluticasone或它的生理上可以接受的溶剂化物和氟烃抛射剂基质，随意与一种或多种其它药理活性剂和一种或多种赋型剂组合。

Description

丙酸福地卡松的计定剂量吸入器
发明背景
治疗呼吸道和鼻腔疾患的药物常常以气溶胶制剂由口腔或鼻腔给药。配制这类气溶胶药物制剂的一种广泛应用的方法包括制作药物的悬浮制剂，将药物以分散很好的粉末悬浮在称为抛射剂基质的液化气体中。该悬浮剂储存在封口容器里，该封口容器可以耐受保持抛射剂为液态所需的压力。当安装在容器上的剂量计量阀被触发时，悬浮剂即喷出。
设计剂量阀时是使阀每次触发时一致地释放出固定的、预先确定量的药物制剂。由于悬浮剂经过剂量计量阀通过抛射剂的蒸气高压由容器受力，抛射剂迅速蒸发而留下药物制剂的极细小颗粒的快速运动的云状物。通过渠道形成装置，例如通过园筒或开口的锥形该颗粒云状物射向病人的鼻或口。与气溶胶剂量计量阀触发的同时，病人将药物颗粒吸入肺或鼻腔。按这种方式喷雾药物的系统称为“计定剂量吸入器”(MDI′s)。Peter Byron，Respiratory Drug Delivery，CRCPress，Boca Raton，FL(1990)描述了这种形式治疗的一般背景。
病人常常依赖于MDI′s释放的药物迅速治疗可使人体虚弱，在有些情况下甚至可以危及生命的呼吸道疾病。所以释放给病人的气溶胶药物制剂剂量必须始终满足制药公司声明的规格要求以及必须遵守FDA和别的管理机构的规定。也就是说，罐中的每次剂量在接近的公差范围内必须相同。
一些气溶胶药物趋向于粘附在内表面上，即粘附在MDI的罐阀和帽壁上。这可导致每次触发MDI时病人获得的药量明显少于处方规定的药量。这个问题对于氢氟烷(亦简称“氟烃”)抛射剂基质系统，例如P134a和P227尤其尖锐，该系统是近年开发用于取代氯氟烃例如P11、P114和P12的。
我们发现用氟烃高聚物涂衬MDI′s罐的内部表面，显著减少或基本消除丙酸fluticasone粘附或沉淀在容器壁上的问题从而保证气溶胶中的药物从MDI始终如一地释放。
                  本发明的概述
内表面部分或全部用一种或多种氟烃高聚物作衬的计定剂量吸入器，该高聚物随意与一种或多种非氟烃高聚物组合，该计量剂量吸入器用于喷雾吸入药物制剂，该制剂含丙酸fluticasone或它的生理上可以接受的溶剂化物及氟烃抛射剂基质，并随意地与一种或多种其它药理活性物质或一种或多种赋型剂联用。
                   本发明的详述
术语“计量剂量吸入器”或“MDI”是指一种由一个罐、盖隹罐口的缩边帽和安装在帽上的药物计量阀组成的装置，而术语“MDI系统”还包括适当渠道形成装置。术语“MDI罐”指无帽和无阀的罐。术语“药物计量阀“或”MDI阀”指MDI阀每次触发时从中释放预先决定量药物制剂的阀及它的有关机械。渠道形成装置可以包括例如阀驱动器和园筒或锥样通道，药物可经过该装置从填充的MDI罐经MDI阀释放到病人的鼻或口中，例如唇状驱动器。美国专利5,261,538中描述了典型的MDI部件的关联，该专利这里列为参考文献。
术语“氟烃高聚物”指烃链中一个或多个氢原子被氟原子取代的高聚物。这样，“氟烃高聚物”包括全氟烃-、氢氟烃-、氯氟烃-、氢氯氟烃高聚物或它们的其它卤素取代的衍生物。这类“氟烃高聚物”可以是支链的、均聚物或共聚物。
美国专利NO，4,335,121发明了一种抗炎甾体化合物，化学名称为〔(6a，11b，16a，17a)-6，9-二氟-11-羟基-16-甲基-3-氧代-17-(1-氧代丙氧基)雄甾-1，4-二烯-17-硫代羧酸，S-氟甲基酯，普通名为“丙酸fluticasone”。丙酸fluticasone以气溶胶的形式，已经被医药社会广泛接受用于治疗气喘并以“Flovent”和“Flonase”的商标上市。丙酸fluticasone亦可以生理上可以接受的溶剂化物的形态使用。
术语“药物制剂”指丙酸fluticasone或它的生理上可以接受的溶剂化物随意与一种或多种其它药理活性剂例如抗炎剂，镇痛剂或其它呼吸道药物联合，并随意含一种或多种赋形剂和氟烃抛射剂。这里使用的术语“赋型剂”指有小的药理活性或根本没有药理活性(对用量而言)但可加强药物制剂或完善MDI系统的效能。例如，赋型剂包括表面活性剂，防腐剂、芳香剂、抗氧化剂、抗凝聚剂和助溶剂，例如乙醇和乙醚，但不限于这些。
适宜的表面活性剂为文献已知，例如欧洲专利申请No，0327777中发明的那些表面活性剂。表面活性剂的理想用量范围为相对于药物重量的0.0001％至50％，特别为0.05％至5％。特别有用的表面活性剂为1，2-二〔7-(F-己基)己酰基〕-甘油基-3-磷-N，N，N-三甲基乙醇胺，亦称为3，5，9-三氧杂-4-磷杂二十二碳-1-铵，17，17，18，18，19，19，20，20，21，21，22，22，22-十三氟-7-〔(8，8，9，9，10，10，11，11，12，12，13，13，13-十三氟-1-氧代十三烷基)氧基〕-4-羟基-N，N，N-三甲基-10-氧代-，内盐，4-氧化物。
该药物制剂中能够包括的极性助溶剂有C2-6的脂肪醇和多元醇，例如乙醇、异丙醇和丙二醇，乙醇为优选，这类助溶剂按期待的量使用，或作为唯一的赋型剂使用，或再加上其它赋型剂，例如加上表面活性剂。适当地，该药物制剂可以含极性助溶剂例如含乙醇的量可占抛射剂基质重量的0.01％至5％，优选含0.1％至5％，例如含大约0.1％至1％。
技术人员应当认识到，希望的话本发明中使用的药物制剂可以含丙酸fluticasone(或它的可接受溶剂化物)与一种或多种其它药理活性剂的组合。这类药物可以选自吸入治疗中适宜的任何药物。例如合适的药物可选自镇痛药，例如可待因，二氢吗啡，麦角胺、芬太尼或吗啡；咽类制品，例如diltiazem；抗过敏药，例如色甘酸酯、Ketotifen或nedocromil；抗感染药，例如头孢菌素、青霉素、链霉素、磺胺、四环素和戊烷脒；抗组胺药，例如麦沙非林；抗炎药，例如氯地米松(例如它的二丙酸盐、flunisolide、budesonide、tipredane或去炎松；镇咳药，例如诺斯卡品；支气管扩张剂，例如舒喘灵、Salmeterol、麻黄素、肾上腺素、芬成醇、formoterol、异丙肾上腺素、二羟苯基异丙氨基乙醇、脱羟肾上腺素、去甲麻黄碱、pirbuterol、reproterol、羟哌甲苯二酚、间羟叔丁肾上腺素、新异丙肾上腺素、tulobuterol、间羟异丙肾上腺素、或(-)-4-氨基-3，5-二氯-α-〔〔〔6-〔2-(2-吡啶基)乙氧基〕己基〕氨基〕甲基〕苯甲醇；利尿药，例如氨氯吡啶脒；抗胆碱能药，例如ipratropiun、阿托品或oxitropium；激素，例如可的松、氢化可的松或盘的松龙；黄嘌呤，例如氨荼碱、胆碱荼碱、赖氨酸荼碱、或荼碱；以及治疗用的蛋白和多肽，例如胰岛素或胰高血糖素。技术人员应当明确，适当时这些药物可以以盐的形式使用(例如以碱金属盐、铵盐或酸加合盐的形式使用)，或以酯的形式使用(例如以低级烷基酯的形式使用)，或以溶剂化物的形式使用(例如以水合物的形式使用)，以便优化药物的活性和/或稳定性和/或降低药物在抛射剂基质中的溶解度。
特别优选的药物制剂含丙酸fluticasone(或它的生理上可以接受的溶剂化物)与一种支气管扩张药例如舒喘宁(例如以游离碱或硫酸盐)或Salmeterol(例如Xinafoate)组合。
特别优选的药物组合是丙酸fluticasone和Salmeterol Xinafonate。
这里使用的“抛射剂基质”是指沸点为大约室温(25℃)至大约-25℃的生理惰性液体，室温下该惰性液体单独或以组合的方式产生高蒸气压。MDI系统触发时，MDI中的抛射剂基质的高蒸气压先通过计量阀往外推动计量的药物制剂，然后抛射剂基质迅速蒸发分散药物颗粒。本发明中使用的抛射剂基质为低沸点氟烃；特别是1，1，1，2-四氟乙烷，亦称为“抛射剂基质134a”或“P134a”和1，1，1，2，3，3，3-七氟丙烷，亦称为“抛射剂基质227”或“P227”。
本发明中使用的药物制剂可以不含或基本不含制剂赋型剂，例如不含表面活性剂和助溶剂等。这类药物制剂由于本质上是无味和无臭的，比起含赋型剂的制剂来刺激性和毒性都小，所以是有利的制剂。这样，一种优选的药物制剂主要由丙酸fluticasone或它的生理上可以接受的溶剂化物组成，随意与一种或多种其它药理活性剂特别是与Salmeterol(例如Xinafoate盐形式)以及氟烃抛射剂基质组合。优选的抛射剂基质为1，1，1，2-四氟乙烷、1，1，1，2，3，3，3-七氟正丙烷或它们的混合物，1，1，1，2-四氟乙烷特别优选。
本发明中使用的进一步的药物制剂可以不含或基本不含表面活性剂。这样，进一步优选的药物制剂，包括或主要由舒喘宁(或它的生理上可以接受的溶剂化物)组成，随意与一种或多种其它药理活性剂、一种氟烃抛射剂基质，以及占抛射剂基质重量0.01％至5％的极性助溶剂组合，该制剂本质上不含表面活性剂。优选的抛射剂基质为1，1，1，2-四氟乙烷、1，1，1，2，3，3，3-七氟正丙烷或它们的混合物，特别优选为1，1，1，2-四氟乙烷、或1，1，1，2，3，3，3-七氟正丙烷。
虽然其它不受药物制剂影响的金属，例如不锈钢、铜的合金或锡板都可以使用，但MDI罐和盖最常用铝或铝合金制作。MDI罐亦可用玻璃或塑料制作。不过本发明中MDI罐优选用铝或它的合金制造。有利地可以使用强化铝或铝合金MDI罐。这类强化的MDI罐能够耐受特别高压的加衬和加工处理条件，例如耐受特别的高温，这类条件对一些氟烃高聚物可能是必须的。高温下具有降低变形趋势的加强的MDI罐包括由侧壁和增厚底组成的MDI罐和由本质椭园形底(该形状底增大了侧壁和罐底的角度)构成的MDI罐，而不是标准MDI罐的半球底，具有椭园底的MDI罐为进行加衬工艺提供了进一步的好处。
药物计量阀的构件通常由不锈钢和药理上是惰性并耐气雾剂基质的高聚物构成，这类高聚物有缩醛，聚酰胺(例如尼龙)：聚碳酸酯，聚酯、氟烃高聚物(例如聚四氟乙烯)或这些物料的组合物。另外各种物料(例如氰橡胶、聚脲烷、乙酰树脂、氟烃高聚物)的封条和“0”环，或其它弹性物料都可用于阀内或四周。
本发明中使用的氟烃高聚物体包括由一个或多个下述单体单元的多重复合构成的氟烃：四氟乙烯(PTFE)、氟化的乙烯丙烯(FEP)。全氟烷氧基烷(PFA)、乙烯四氟乙烯(ETFE)、乙烯二烯氟化物(PVDF)，和氯化的乙烯四氟乙烯。具有相对高氟/碳比的氟化高聚物例如全氟烷高聚物PTFE、PFA和FEP为优选。
氟化高聚物可以与非氟高聚物掺合，例如与聚酰胺、聚酰亚胺、聚醚砜、对聚苯硫和胺醛热固树脂掺合。加这些高聚物可改善高聚物衬与罐壁的粘着性能。优选的高聚掺合物为PTFE/FEP/聚酰胺酰亚胺、PTFE/聚醚砜(PES)和FEP-苯并胍胺。
特别优选的衬(涂层)为纯PFA，FEP和PTFE和聚醚砜(PES)的掺合物。
市场销售的氟烃高聚物的商标为聚四氟乙烯、Tefzel、Halar和Hostaflon、Polyflon和Neoflon。高聚物的级别包括FEP杜邦856-200、PFA杜邦857-200、PTFE-PES杜邦3200-100、PTFE-FEP-聚酰胺酰亚胺杜邦856P23485、FEP粉杜邦532和PFA Hoechst6900n。衬厚度的范围为大约1μm至大约1mm。适宜的衬厚度范围为大约1μm至大约100μm，例如1μm至25μm。可以使用一层或多层衬。
优选地本发明中使用的氟烃高聚物衬到金属制作的MDI罐上，特别是衬到铝或铝合金制作的MDI罐上。
特殊的(例如粉碎的)药物的粒度应为在施用气溶胶制剂时允许将基本上所有的药物吸入肺部，因此应小于100微米，理想情况下小于20微米，特别是在1至10微米范围内，例如在1至5微米范围内。
理想情况下气溶胶制剂的药物与制剂总重量的相对比例为0.005％至10％，尤其为0.005％至5％，特别为0.01％至1.0％。
本发明的进一步的方面是计定剂量的吸入器，该吸入器金属内表面部分或全部用一种或多种氟烷高聚体涂衬，随意与一种或多种非氟烷高聚体合用，用于分散由丙酸fluticasone和氟烃抛射剂基质，并随意与一种或多种其它药理活性剂以及一种或多种赋形剂组合的药物制剂。
本发明的特别方面是全部内部金属表面基本都由PFA或FEP，或掺合的氟高聚体树脂系统例如PTFE-PES加衬的MDI，该MDI可有或可无聚酰胺酰亚胺或聚醚砜底衬，用于分散上面定义的药物制剂。
本MDI中使用的优选药物制剂主要含丙酸fluticasone(或它的生理上可以接受的溶剂化物)，随意与一种或多种药理活性剂特别是与Salmeterol如Xinafoate盐形式，和氟烃抛射剂基质，尤其是1，1，1，2-四氟乙烷、1，1，1，2，3，3，3-七氟丙烷或它们的混合物，如特别是1，1，1，2-四氟乙烷的组合。优选的MDI罐由铝或铝合金制作。
本MDI可采用文献已知的金属涂衬方法加衬。例如铝或不锈钢一类的金属在冲压和成形为罐状之前可作为卷盘预涂衬并处理。由于两个原因，该方法很适合高容量生产。首先，卷盘涂衬技术很发达，几家制造商常规地涂金属卷盘可以达到高标准的均匀性和广泛的厚度。第二，预涂的卷盘可以高速和高精度冲压和拉伸，使用的方法与未加衬的卷盘基本相同。
得到涂衬罐的其它技术是静电干粉涂衬或先往制好的MDI罐里侧喷氟化高聚物/高聚物掺合物衬的制剂，然后再处理。制好的MDI罐亦可浸到氟烃高聚物/高聚物掺合物衬制剂中并处理，这样在内侧和外侧均形成涂层。该氟烃高聚物/高聚物掺合物制剂亦可倾到MDI罐内，然后排出来，使内侧留下高聚物衬。为容易制作，适宜地将制好的MDI罐用氟烃高聚物/高聚物掺合物喷涂加衬。
氟烃高聚物/高聚物掺合物亦可采用氟烃单体等离子聚合在罐壁就地生成。氟烃高聚膜可吹入MDI罐内侧以便形成袋。各种氟烃高聚物例如ETFE、FEP和PTFE都可用作膜料买到。
适宜的处理温度取决于选择作衬的氟烃高聚物/高聚物掺合物和使用的涂衬方法。不过，对于卷盘和喷涂加衬来说，典型地需要温度高于高聚物熔点，例如比熔点高大约50℃至多20分钟，例如大约5至10分钟，例如8分钟或所需要的时间。对于上面提到的优选或特别优选的氟烃高聚物/高聚物掺合物，处理温度的范围为大约300℃至大约400℃，例如大约350℃至大约380℃为宜。对于等离子聚合可以使用的典型的温度范围为大约20℃至大约100℃。
这里发明的MDI可按文献方法制造(例如见于上面的Byron和美国专利5,345,980)，其中用常规罐代替用氟化高聚物/高聚物掺合物作衬的罐。也就是说丙酸fluticasone和制剂的其它组分充入用氟化高聚物/高聚物掺合物涂衬的气溶胶罐中。该罐连有在适当的地方打褶的帽装置。药物在液压氟烃抛射剂基质中的悬浮液可以按美国专利5,345,980(本文引作参考文献)中所示通过计量阀引起罐内。
这里发明的内部用氟烃高聚物/高聚物掺合物涂衬的MDI可采用与目前临床用的无衬MDI′S类似的方式用于医疗。不过本发明的MDI′S对于含有和喷施含有氢氟烷氟烃抛射剂基质例如134a和少含或基本不含赋形剂、以及倾向于沉淀或粘着到MDI系统的内壁和部件的药物制剂特别有用。有些情况下调配基本不含赋形剂的吸入药物是有利的，例如当病人对赋型剂过敏或药物与赋形剂反应时就是如此。
含上面描述的制剂的MDI、MDI系统和用这类MDI系统治疗呼吸道疾病，例如治疗哮喘包括本发明的进一步的方面。
对于本领域技术人员来说，修饰这里描述的发明可以在不偏离本发明的精神下容易做到是明确的。寻求的对这里描述的一切题材保护中也包括任何这类修饰。
下面的非限制性实施例解释本发明。
                        实施例
                        实施例1
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)先喷涂衬以(Livingstone Coatings，Charlotte，NC)底漆(杜邦851-204)和按照卖主的标准方法处理，然后再喷涂衬以FEP或PFA(分别为杜邦856-200和857-200)，并按照卖主的标准方法处理。涂层的厚度为大约10mm至50mm。这些罐然后清除空气(见于PCT申请号WO94/22722PCT/EP94/00921)，阀门弯边定位，通过阀门往里充大约20mg丙酸fluticasone和大约12g P134a的悬浮液。
                      实施例2
标准的0.46mm厚的铝片(United Aluminum)喷涂衬以(杜邦，Wilmington，DE)FEP(杜邦856-200)并处理。该片然后深拉成罐(Presspart Inc，Cary，NC)，涂层厚度大约10μm至50μm。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约40mg丙酸fluticasone与大约12g P134A的悬浮液。
                      实施例3
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)啧涂衬以PTFE-PES掺合物(杜邦)为单一衬，并按卖主的标准方法处理。涂层的厚度为大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约41.0mg、21.0mg、8.8mg或4.4mg微粉化的丙酸fluticasone与大约12g P134a的悬浮液。
                      实施例4
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)啧涂衬以PTFE-FEP-聚酰胺酰亚胺掺合物(杜邦)并按卖主的标准方法处理。涂层的厚度在大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约41.0mg、21.0mg、8.8mg或4.4mg微粉化的丙酸fiuticasone与大约12g P134a的悬浮液。
                      实施例5
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)用静电枪喷涂衬以FEP粉(杜邦FEP532)。涂层的厚度在大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约41.0mg、21.0mg、8.8mg或4.4mg微粉化的丙酸fluticasone与大约12g P134a的悬浮液。
                      实施例6
标准的0.46mm厚的铝片(United Aluminum)喷涂衬以FEP-苯并胍胺并处理。该铝片然后深拉成罐。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约41.0mg、21.0mg、8.8mg或4.4mg微粉化的丙酸fluticasone与大约12g P134a的悬浮液。
                      实施例7
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)喷涂衬以PFA的水性分散液(Hoechst PFA-6900n)并处理。涂层的厚度为大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约41.0mg、21.0mg、8.8mg或4.4mg微粉化的丙酸fluticasone与大约12g P134a的悬浮液。
                       实施例8
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)喷涂衬以PTFE-PES掺合物(杜邦)为单一衬，并按卖主的标准方法处理。涂层的厚度在大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充8.8mg、22mg或44mg微粉化的丙酸fluticasone和64mg微粉化的Salmeterol xinafoate与大约12g P134a的悬浮液。
                       实施例9
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)喷涂衬以PTFE-FEP-聚酰胺酰亚胺掺合物(杜邦)并按卖主的标准方法处理。涂层的厚度为大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约8.8mg、22mg或44mg微粉化的丙酸fluticasone和64mg微粉化的Salmeterol xinafoate与大约12g P134a的悬浮液。
                       实施例10
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)用静电枪喷涂衬以FEP粉(杜邦FEP532)。涂层的厚度为大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约8.8mg、22mg或44mg微粉化的丙酸fluticasone和6.4mg微粉化的Salmeterolxinafoate与大约12g P134a的悬浮液。
                       实施例11
标准的0.46mm厚的铝片(United Aluminum)喷涂衬以FEP-苯并胍胺并处理。该铝片然后深拉成罐。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约8.8mg、22mg或44mg微粉化的丙酸fluticasone和6.4mg微粉化的Salmeterol xinafoate与大约12g P134a的悬浮液。
                       实施例12
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)喷涂衬以PFA的水性分散液(Hoechst PFA-6900n)并处理。涂层的厚度为大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约8.8mg、22mg或44mg微粉化的丙酸fluticasone和6.4mg微粉化的Salmeterol xinafoate与大约12g P134a的悬浮液。
                     实施例13
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)喷涂衬以PTFE-PES掺合物(杜邦)为单一衬，并按卖主的标准方法处理。涂层的厚度在大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约5.5mg、13.8mg或27.5mg微粉化的丙酸fluticasone与大约4mg微粉化的Salmeterol xinafoate与大约8gP134a的悬浮液。
                     实施例14
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)喷涂衬以PTFE-FEP-聚酰胺酰亚胺掺合物(杜邦)并按卖主的标准方法处理。涂层的厚度为大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约5.5mg、13.8mg或27.5mg微粉化的丙酸fluticasone与大约4mg微粉化的Salmeterol xinafoate与大约8gP134a的悬浮液。
                     实施例15
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)用静电枪喷涂衬以FEP粉(杜邦FEP532)。涂层的厚度为大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约5.5mg、13.8mg或27.5mg微粉化的丙酸fluticasone与大约4mg微粉化的Salmeterol xinafoate与大约12g P134a的悬浮液。
                     实施例16
标准的0.46mm厚的铝片(United Aluminum)喷涂衬以FEP-苯并胍胺并处理。该铝片然后深拉成罐。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约5.5mg、13.8mg或27.5mg微粉化的丙酸fluticasone与大约4mg微粉化的Salmeterol xinafoate与大约8gP134a的悬浮液。
                     实施例17
标准的12.5ml MDI罐(Presspart Inc，Cary，NC)喷涂衬以PFA的水性分散液(Hoechst PFA-6900n)并处理。涂层的厚度为大约1μm至大约20μm之间。这些罐然后清除空气，阀门弯边定位，通过阀门往里充大约5.5mg、13.8mg或27.5mg微粉化的丙酸fluticasone与大约4mg微粉化的Salmeterol xinafoate与大约8g P134a的悬浮液。
                        实施例18至22
重复实施例3至7，不同的是通过阀门往里通大约13.3mg微粉化的丙酸fluticasone与大约21.4gP227的悬浮液。
                        实施例23至27
重复实施例3至7，不同的是通过阀门往里通66mg或6.6mg粉碎的丙酸fluticasone与大约182mg乙醇及约18.2g P134a的悬浮液。
                        实施例28至52
重复实施例3至27，不同的是使用修饰的底基本为椭园的12.5mlMDI罐(Presspart Inc，Cary，NC)。
在模拟使用的条件下测定发现从MDIs释放的药物剂量是恒定的，而对照的充入未衬的罐中的MDIs在应用中显示明显的剂量释放降低。

Claims (22)

1.计量剂量的吸入器，该吸入器的部分或全部内表面衬有一种聚合物的掺合物，该掺合物包括一种或多种氟烃聚合物，该氟烃聚合物与一种或多种非氟烃聚合物组合，用于喷洒含氟替卡松丙酸酯或它的生理上可以接受的溶剂化物及一种氟烃抛射剂基质、随意与一种或多种其它药理活性剂或一种或多种赋型剂组合的吸入药物制剂。
2.权利要求1的吸入器，含有所述药物制剂。
3.权利要求2的吸入器，其中所说的药物制剂进一步包括一种表面活性剂。
4.权利要求2或3的吸入器，其中所说的药物制剂进一步包括一种极性助溶剂。
5.权利要求2的吸入器，其中所说的药物制剂包括占抛射剂基质重量的0.01％至5％的极性助溶剂，该制剂基本上不含表面活性剂。
6.权利要求2至5中之任一的吸入器，其中所述的药物制剂含有氟替卡松丙酸酯或它的生理上可以接受的盐与一种支气管扩张药或抗过敏药的组合。
7.权利要求6的吸入器，其中所述的药物制剂含有氟替卡松丙酸酯与沙美特罗羟萘酸盐的组合。
8.权利要求2的吸入器，其中所述的药物制剂主要由氟替卡松丙酸酯或它的生理上可以接受的溶剂化物，随意与一种或多种其它药理活性剂及氟烃抛射剂基质组成。
9.权利要求8的吸入器，其中所说的药物制剂主要由氟替卡松丙酸酯或它的生理上可以接受的溶剂化物与一种支气管扩张药或一种抗过敏药组合成。
10.权利要求9的吸入器，其中所说的药物制剂主要由氟替卡松丙酸酯或它的生理上可以接受的溶剂化物与沙美特罗或它的生理上可以接受的盐组合成。
11.权利要求10的吸入器，其中所说的药物制剂主要由氟替卡松丙酸酯和沙美特罗羟萘酸盐组成。
12.权利要求2的吸入器，其中所说药物制剂由氟替卡松丙酸酯或它的生理上可以接受的溶剂化物及氟烃抛射剂基质构成。
13.权利要求2至12中之任一的吸入器，其中氟烃抛射剂基质为1，1，1，2-四氟乙烷或1，1，1，2，3，3，3-七氟正丙烷或它们的混合物。
14.权利要求13的吸入器，其中氟烃抛射剂基质为1，1，1，2-四氟乙烷。
15.权利要求1至14中之任一的吸入器，该吸入器包含一个由金属制作的罐，该罐的内部金属表面一部分或全部加衬。
16.权利要求15的吸入器，其中的金属为铝或它的合金。
17.权利要求1至16中之任一的吸入器，其中所说的氟烃聚合物为全氟烃聚合物。
18.权利要求17的吸入器，其中所说的氟烃聚合物选自PTFE、PFA、FEP和它们的混合物。
19.权利要求1至18中之任一的吸入器，其中所说的氟烃聚合物是与选自聚酰胺、聚酰亚胺、聚酰胺酰亚胺、聚醚砜、聚亚苯基硫醚和氨醛热固性树脂的非氟烃聚合物组合的。
20.权利要求1至19中之任一的吸入器，其中所说氟烃聚合物是与选自聚酰胺酰亚胺和聚醚砜的非氟烃聚合物组合的。
21.权利要求1至20中之任一的吸收器，其中所说聚合物掺合物包括PTFE和聚醚砜。
22.由权利要求1至21中之任一的计量剂量吸入器组成的计量剂量吸入器系统，该系统装有用于经口或鼻吸入药物制剂的适合的管道装置。
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