CN108949772A - 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 - Google Patents

用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 Download PDF

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Publication number
CN108949772A
CN108949772A CN201810507242.8A CN201810507242A CN108949772A CN 108949772 A CN108949772 A CN 108949772A CN 201810507242 A CN201810507242 A CN 201810507242A CN 108949772 A CN108949772 A CN 108949772A
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China
Prior art keywords
polynucleotides
optionally replaced
mmrna
protein
optionally
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Pending
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CN201810507242.8A
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Chinese (zh)
Inventor
斯蒂芬·邦塞尔
提尔塔·柴可拉博提
安东宁·德富热罗勒
S·M·伊巴希尔
马蒂亚斯·约翰
阿坦恩·洛依
苏珊·沃利斯基
K·M·伍德
保罗·哈塔拉
杰森·P·斯洛姆
凯内齐·伊杰贝
杰夫·L·埃尔斯沃思
贾斯汀·基尔德
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Modern Tex Co
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Modern Tex Co
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Publication of CN108949772A publication Critical patent/CN108949772A/zh
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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CN201810507242.8A 2012-04-02 2013-03-09 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 Pending CN108949772A (zh)

Applications Claiming Priority (101)

Application Number Priority Date Filing Date Title
US201261618870P 2012-04-02 2012-04-02
US201261618868P 2012-04-02 2012-04-02
US201261618957P 2012-04-02 2012-04-02
US201261618961P 2012-04-02 2012-04-02
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US201261737174P 2012-12-14 2012-12-14
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CN201380028773.4A CN104411338A (zh) 2012-04-02 2013-03-09 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸

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CN201380028773.4A Pending CN104411338A (zh) 2012-04-02 2013-03-09 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸

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JP (6) JP2015518705A (https=)
CN (2) CN108949772A (https=)
AU (4) AU2013243949A1 (https=)
CA (1) CA2868391A1 (https=)
HK (1) HK1206612A1 (https=)
WO (1) WO2013151666A2 (https=)

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CN109734791A (zh) * 2019-01-17 2019-05-10 武汉明德生物科技股份有限公司 人nf186抗原、人nf186抗体检测试剂盒及其制备方法与应用
CN111744019A (zh) * 2020-07-01 2020-10-09 深圳市瑞吉生物科技有限公司 基于甘露糖的mRNA靶向递送系统及其应用
WO2021139474A1 (zh) * 2020-01-10 2021-07-15 深圳市瑞吉生物科技有限公司 mRNA-GalNAc靶向分子的制备方法及其体内递送系统和应用
WO2023169335A1 (zh) * 2022-03-05 2023-09-14 武汉瑞佶生物科技有限公司 一种mRNA-脂肪酸靶向化合物及其制备方法和应用
US11759532B2 (en) 2019-12-17 2023-09-19 Shenzhen Rhegen Biotechnology Co., Ltd. mRNA targeting molecule comprising N-acetylgalactosamine binding polypeptide and preparation method therefor

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PL2591114T3 (pl) 2010-07-06 2017-08-31 Glaxosmithkline Biologicals Sa Immunizacja dużych ssaków małymi dawkami rna
HUE026646T2 (en) 2010-07-06 2016-07-28 Glaxosmithkline Biologicals Sa Preferred liposomes containing lipids of PKA value for delivery of RNA
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PT3970742T (pt) 2010-08-31 2022-06-27 Glaxosmithkline Biologicals Sa Lipossomas peguilados para entrega de arn codificador de imunogénio
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WO2012075040A2 (en) 2010-11-30 2012-06-07 Shire Human Genetic Therapies, Inc. mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
PL3586861T3 (pl) 2011-06-08 2022-05-23 Translate Bio, Inc. Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna
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RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
CN104114572A (zh) 2011-12-16 2014-10-22 现代治疗公司 经修饰的核苷、核苷酸和核酸组合物
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US10501513B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
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