CN105367583A - 作为病毒复制抑制剂的噻吩并[2,3-b]吡啶衍生物 - Google Patents

作为病毒复制抑制剂的噻吩并[2,3-b]吡啶衍生物 Download PDF

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Publication number
CN105367583A
CN105367583A CN201510574332.5A CN201510574332A CN105367583A CN 105367583 A CN105367583 A CN 105367583A CN 201510574332 A CN201510574332 A CN 201510574332A CN 105367583 A CN105367583 A CN 105367583A
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China
Prior art keywords
methyl
heterocycle
pyridin
tetrahydrochysene
alkynyl
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Pending
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CN201510574332.5A
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English (en)
Chinese (zh)
Inventor
D.巴迪奥特
P.查尔丁
F.克里斯特
Z.德拜泽
M.德梅耶
A.马钱德
D.马钱德
A.沃特
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Katholieke Universiteit Leuven
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Katholieke Universiteit Leuven
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40834066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN105367583(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Katholieke Universiteit Leuven filed Critical Katholieke Universiteit Leuven
Publication of CN105367583A publication Critical patent/CN105367583A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201510574332.5A 2009-05-15 2010-05-17 作为病毒复制抑制剂的噻吩并[2,3-b]吡啶衍生物 Pending CN105367583A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0908394.0A GB0908394D0 (en) 2009-05-15 2009-05-15 Novel viral replication inhibitors
GB0908394.0 2009-05-15
US34380310P 2010-05-03 2010-05-03
US61/343,803 2010-05-03
CN201080031813.7A CN102459280B (zh) 2009-05-15 2010-05-17 作为病毒复制抑制剂的噻吩并[2,3-b]吡啶衍生物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201080031813.7A Division CN102459280B (zh) 2009-05-15 2010-05-17 作为病毒复制抑制剂的噻吩并[2,3-b]吡啶衍生物

Publications (1)

Publication Number Publication Date
CN105367583A true CN105367583A (zh) 2016-03-02

Family

ID=40834066

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201510574332.5A Pending CN105367583A (zh) 2009-05-15 2010-05-17 作为病毒复制抑制剂的噻吩并[2,3-b]吡啶衍生物
CN201080031813.7A Expired - Fee Related CN102459280B (zh) 2009-05-15 2010-05-17 作为病毒复制抑制剂的噻吩并[2,3-b]吡啶衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201080031813.7A Expired - Fee Related CN102459280B (zh) 2009-05-15 2010-05-17 作为病毒复制抑制剂的噻吩并[2,3-b]吡啶衍生物

Country Status (29)

Country Link
US (2) US8785638B2 (fr)
EP (1) EP2430029B1 (fr)
JP (2) JP2012526778A (fr)
KR (2) KR20120035162A (fr)
CN (2) CN105367583A (fr)
AP (1) AP2939A (fr)
BR (1) BRPI1010833A2 (fr)
CA (1) CA2759500A1 (fr)
CL (1) CL2011002878A1 (fr)
CO (1) CO6460769A2 (fr)
CR (1) CR20110601A (fr)
CU (1) CU24117B1 (fr)
DO (1) DOP2011000343A (fr)
EA (1) EA201171376A1 (fr)
EC (1) ECSP11011456A (fr)
GB (1) GB0908394D0 (fr)
GE (1) GEP20146115B (fr)
IL (1) IL216357A0 (fr)
MA (1) MA33274B1 (fr)
MX (1) MX2011012146A (fr)
MY (1) MY161085A (fr)
NI (1) NI201100194A (fr)
NZ (1) NZ596392A (fr)
PE (1) PE20120779A1 (fr)
SG (1) SG175255A1 (fr)
TN (1) TN2012000074A1 (fr)
UA (1) UA104021C2 (fr)
WO (1) WO2010130842A1 (fr)
ZA (1) ZA201107618B (fr)

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AR105653A1 (es) 2015-08-11 2017-10-25 VIIV HEALTHCARE UK (Nº 5) LTD Derivados del ácido 5-(n-bencil-tetrahidroisoquinolin-6-il)-piridin-3-il acético como inhibidores de la replicación del virus de la inmunodeficiencia humana
TW201718537A (zh) 2015-08-12 2017-06-01 Ｖｉｉｖ醫療保健英國（Ｎｏ．５）有限公司 做為人類免疫缺陷病毒複製抑制劑之吡啶－３－基乙酸衍生物
CN108137552A (zh) 2015-08-12 2018-06-08 Viiv保健英国第五有限公司 作为人免疫缺陷病毒复制的抑制剂的5-(n-稠合三环芳基四氢异喹啉-6-基)吡啶-3-基乙酸衍生物
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JP2018536001A (ja) 2015-12-04 2018-12-06 ヴィーブ ヘルスケア ユーケー リミテッド イソインドリン誘導体
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JP2020503348A (ja) 2017-01-03 2020-01-30 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド ヒト免疫不全ウイルス複製の阻害剤としてのピリジン−３−イル酢酸誘導体
US20200016136A1 (en) 2017-01-03 2020-01-16 Viiv Healthcare Uk (No. 5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
WO2019244066A2 (fr) 2018-06-19 2019-12-26 VIIV Healthcare UK (No.5) Limited Dérivés d'acide pyridin-3-yl-acétique en tant qu'inhibiteurs de la réplication du virus de l'immunodéficience humaine
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CN113286792B (zh) * 2018-12-14 2023-12-05 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的含n色烯-4-酮衍生物
EP4355750A1 (fr) * 2021-06-15 2024-04-24 GlaxoSmithKline Intellectual Property Development Limited Composé pharmaceutique
CN113603655B (zh) * 2021-07-14 2022-12-16 上海应用技术大学 一种4-羟基-2-甲基-3-(苯磺酰基)噻唑烷-2-羧酸甲酯化合物的制备方法
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