SG10202010119TA - NAMPT And Rock Inhibitors - Google Patents

NAMPT And Rock Inhibitors

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Publication number
SG10202010119TA
SG10202010119TA SG10202010119TA SG10202010119TA SG10202010119TA SG 10202010119T A SG10202010119T A SG 10202010119TA SG 10202010119T A SG10202010119T A SG 10202010119TA SG 10202010119T A SG10202010119T A SG 10202010119TA SG 10202010119T A SG10202010119T A SG 10202010119TA
Authority
SG
Singapore
Prior art keywords
nampt
rock inhibitors
rock
inhibitors
Prior art date
Application number
SG10202010119TA
Inventor
Michael L Curtin
Bryan K Sorensen
Howard R Heyman
Richard F Clark
Kevin R Woller
Omar J Shah
Michael MICHAELIDES
Chris Tse
Anil Vasudevan
Helmut Mack
Todd M Hansen
Ramzi Sweis
Marina A Pliushchev
Original Assignee
Abbvie Inc
Abbvie Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45034200&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10202010119T(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc, Abbvie Deutschland filed Critical Abbvie Inc
Publication of SG10202010119TA publication Critical patent/SG10202010119TA/en

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    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
PE20140913A1 (en) * 2010-11-15 2014-08-22 Abbvie Inc NAMPT AND ROCK INHIBITORS
NZ610315A (en) 2010-11-15 2015-08-28 Univ Leuven Kath Antiviral condensed heterocyclic compounds
GB201021103D0 (en) 2010-12-13 2011-01-26 Univ Leuven Kath New compounds for the treatment of neurodegenerative diseases
AU2011367809B2 (en) * 2011-05-09 2017-04-27 Forma Tm, Llc Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
US9199981B2 (en) * 2011-09-01 2015-12-01 Novartis Ag Compounds and compositions as C-kit kinase inhibitors
WO2013033167A1 (en) * 2011-09-01 2013-03-07 Irm Llc Compounds and compositions as c-kit kinase inhibitors
MX348311B (en) * 2011-11-11 2017-06-06 Abbvie Inc Nampt inhibitors.
CN104254330A (en) 2012-01-09 2014-12-31 X-Rx公司 Tryptoline derivatives having kinase inhibitory activity and uses thereof
JP5925723B2 (en) * 2012-04-13 2016-05-25 田辺三菱製薬株式会社 Pharmaceutical use of amide derivatives
EP2882718A4 (en) * 2012-08-10 2015-12-23 Hoffmann La Roche Pyrazole carboxamide compounds, compositions and methods of use
JP6419076B2 (en) 2012-10-05 2018-11-14 カドモン コーポレイション,リミティド ライアビリティ カンパニー RHO kinase inhibitor
WO2014074715A1 (en) * 2012-11-07 2014-05-15 Genentech, Inc. Cyclopropyl amide derivatives
EP3252049A1 (en) 2013-01-18 2017-12-06 Bristol-Myers Squibb Company Phthalazinones and isoquinolinones as rock inhibitors
WO2014141035A2 (en) * 2013-03-11 2014-09-18 Aurigene Discovery Technologies Limited Fused heterocyclyl derivatives as nampt inhibitors
US20160002188A1 (en) 2013-03-13 2016-01-07 Forma Therapeutics, Inc. Novel compounds and compositions for inhibition of fasn
WO2015142001A2 (en) * 2014-03-21 2015-09-24 충남대학교산학협력단 Compound having cardiotonic activity and pharmaceutical composition for preventing or treating heart failure, containing same
US9902702B2 (en) 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
WO2016012958A1 (en) 2014-07-23 2016-01-28 Aurigene Discovery Technologies Limited 4,5-dihydroisoxazole derivatives as nampt inhibitors
US9673344B2 (en) * 2014-08-07 2017-06-06 Lumeta, Llc Apparatus and method for photovoltaic module with tapered edge seal
WO2016028971A1 (en) 2014-08-21 2016-02-25 Bristol-Myers Squibb Company Tied-back benzamide derivatives as potent rock inhibitors
EP3185860A4 (en) 2014-08-29 2018-08-29 The Board of Regents of the University of Texas System Novel capsazepine analogs for the treatment of cancer and other proliferative diseases
US20160108406A1 (en) * 2014-10-08 2016-04-21 University Of Iowa Research Foundation Method of regulating cftr expression and processing
WO2017114275A1 (en) * 2015-12-31 2017-07-06 成都先导药物开发有限公司 Compound for inhibiting rock, preparation method and use of same
TWI730032B (en) 2016-01-13 2021-06-11 美商必治妥美雅史谷比公司 Spiroheptane salicylamides and related compounds as inhibitors of rock
EP3431472B1 (en) * 2016-03-17 2023-05-03 Checkmate Therapeutics Inc. Novel compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same
WO2017170830A1 (en) * 2016-03-31 2017-10-05 武田薬品工業株式会社 Heterocyclic compound
EP3872078A1 (en) * 2016-07-01 2021-09-01 Pfizer Inc. 5,7-dihydro-pyrrolo-pyridine derivatives for use in the treament of depression, anxiety or panic disorders
US10787450B2 (en) 2016-07-07 2020-09-29 Bristol-Myers Squibb Company Spiro-fused cyclic ureas as inhibitors of rock
KR20230144096A (en) 2016-10-18 2023-10-13 씨젠 인크. Targeted delivery of nicotinamide adenine dinucleotide salvage pathway inhibitors
WO2018086703A1 (en) 2016-11-11 2018-05-17 Bayer Pharma Aktiengesellschaft Dihydropyridazinones substituted with phenylureas
WO2018094362A1 (en) * 2016-11-21 2018-05-24 Translational Drug Development, Llc Heterocyclic compounds as kinase inhibitors
EP3610018B1 (en) 2017-04-14 2023-06-07 Arizona Board of Regents on Behalf of the University of Arizona Compositions and methods for treating pulmonary fibrosis
WO2018191747A1 (en) * 2017-04-14 2018-10-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating pulmonary arterial hypertension
CA3060206A1 (en) 2017-04-27 2018-11-01 Seattle Genetics, Inc. Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates
MX2019015371A (en) 2017-06-22 2020-07-20 Pfizer Dihydro-pyrrolo-pyridine derivatives.
CN107118157A (en) * 2017-06-23 2017-09-01 南京大学 The design and synthesis of diphenyl urea analog derivative antitumoral compounds of one class containing pyrazol framework
KR102644889B1 (en) 2017-07-12 2024-03-06 브리스톨-마이어스 스큅 컴퍼니 Spiroheptanyl hydantoin as a ROCK inhibitor
JP7234201B2 (en) 2017-07-12 2023-03-07 ブリストル-マイヤーズ スクイブ カンパニー Inhibitors of 5-membered aminoheterocycles and 5,6- or 6,6-membered bicyclic aminoheterocycles of ROCK for the treatment of heart failure
TW201908293A (en) 2017-07-12 2019-03-01 美商必治妥美雅史谷比公司 5 members of ROCK inhibitor and bicyclic heterocyclic guanamine
US11306081B2 (en) 2017-07-12 2022-04-19 Bristol-Myers Squibb Company Phenylacetamides as inhibitors of rock
EP3694506B1 (en) * 2017-10-09 2023-08-02 Merck Sharp & Dohme LLC Novel substituted phenyloxetane and phenyltetrahydrofuran compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
JP2021512103A (en) 2018-01-31 2021-05-13 バイエル アクチェンゲゼルシャフトBayer Aktiengesellschaft Antibody drug conjugate (ADCS) containing a NAPPT inhibitor
CN113382633A (en) 2018-10-29 2021-09-10 福马治疗股份有限公司 Solid forms of (4- (2-fluoro-4- (1-methyl-1H-benzo [ d ] imidazol-5-yl) benzoyl) piperazin-1-yl) (1-hydroxycyclopropyl) methanone
RU2732297C2 (en) * 2018-11-14 2020-09-15 Общество с ограниченной ответственностью "Гурус БиоФарм" Derivatives of non-steroid anti-inflammatory agents
WO2021013693A1 (en) 2019-07-23 2021-01-28 Bayer Pharma Aktiengesellschaft Antibody drug conjugates (adcs) with nampt inhibitors
EP4211171A2 (en) 2020-09-10 2023-07-19 Precirix N.V. Antibody fragment against fap
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting
WO2023245470A1 (en) * 2022-06-22 2023-12-28 南方医科大学珠江医院 Use of mdp analog in preparing medicament for treating inflammatory bowel disease

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH433312A (en) * 1963-10-18 1967-04-15 Dresden Arzneimittel Process for the preparation of therapeutically valuable amides of isoindoline-2-carboxylic acid
CH443312A (en) * 1963-10-29 1967-09-15 Ajinomoto Kk Process for the preparation of 1-N-oxide of hypoxanthine and 1-N-oxide of inosine, substituted or not, and use of the products obtained by this process for the use of the products obtained by this process for the preparation of 2,6- dichloropurine and 9-BD-ribofuranosyl purine, substituted or not
GB1029326A (en) * 1964-03-18 1966-05-11 Dresden Arzneimittel Isoindoline-2-carboxylic acid amides
BE648616A (en) 1964-05-29 1964-09-16 Dresden Arzneimittel Amides of isoindolin-2-carboxylic acids and their preparation process.
US4419360A (en) 1979-10-31 1983-12-06 Rohm And Haas Company Arthropod repellants
YU183090A (en) 1990-09-27 1992-12-21 Lek NEW N-ACYLDIPEPTIDES, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
US5726197A (en) * 1992-11-02 1998-03-10 Syntex (U.S.A.) Inc. Isoindolinyl derivatives
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
WO1996024587A1 (en) 1995-02-09 1996-08-15 Novo Nordisk A/S Compounds with growth hormone releasing properties
FR2733750B1 (en) 1995-05-03 1997-06-13 Synthelabo DERIVATIVES OF GAMMA-OXO-ALPHA- (PHENYLMETHYL) -5,6- DIHYDRO-4H-THIENO (3,4-C) PYRROLE-5-BUTANOIQUE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
JPH11512429A (en) 1995-09-15 1999-10-26 ファルマシア・アンド・アップジョン・カンパニー Aminoaryloxazolidinone N-oxide
DE19624659A1 (en) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab New pyridylalkene and pyridylalkanoic acid amides
DE19624668A1 (en) 1996-06-20 1998-02-19 Klinge Co Chem Pharm Fab Use of pyridylalkane, pyridylalken or pyridylalkynamides
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
KR20010101675A (en) 1999-01-26 2001-11-14 우에노 도시오 2h-phthalazin-1-one derivatives and drugs comprising these derivatives as the active ingredient
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
EP1343796A4 (en) 2000-10-23 2005-01-12 Smithkline Beecham Corp Compounds and methods
EP1385823B1 (en) 2001-04-09 2006-12-13 Chiron Corporation Guanidino compounds as melanocortin-4 receptor (mc4-r) agonists
AU2002357692A1 (en) 2001-11-09 2003-05-26 Bristol-Myers Squibb Company Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
JP2003277340A (en) 2002-03-22 2003-10-02 Toray Ind Inc Adhesive molecule inhibitor and new amino acid derivative
EP1348434A1 (en) 2002-03-27 2003-10-01 Fujisawa Deutschland GmbH Use of pyridyl amides as inhibitors of angiogenesis
AR042064A1 (en) 2002-11-19 2005-06-08 Takeda Pharmaceutical AMINA COMPOUNDS WITH INHIBITING ACTIVITY OF THE UNION TO THE SOMASTOTINE RECEIVER
PT1595866T (en) 2003-01-31 2016-09-14 Sanwa Kagaku Kenkyusho Co Cyanopyrrolidines useful for the treatment of inter alia metabolic syndrome
GB0310865D0 (en) 2003-05-12 2003-06-18 Black James Foundation Gastrin and cholecystokinin receptor ligands
US7524837B2 (en) 2003-05-12 2009-04-28 Janssen Pharmaceutica N.V. Benzotriazapinone salts and methods for using same
EP1660454A1 (en) 2003-07-07 2006-05-31 Vernalis (R&D) Limited Azacyclic compounds as inhibitors of sensory neurone specific channels
NZ597500A (en) * 2003-08-06 2014-08-29 Senomyx Inc Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
EP1654225A4 (en) 2003-08-13 2007-11-28 Amgen Inc Melanin concentrating hormone receptor antagonists
CA2540858C (en) * 2003-10-14 2009-12-08 Intermune, Inc. Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication
EP1687299A1 (en) 2003-11-20 2006-08-09 Eli Lilly And Company Heterocyclic compounds as modulators of peroxisome proliferator activated receptors, useful for the treamtment and/or prevention of disorders modulated by a ppar
GB0329214D0 (en) * 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
EA012389B1 (en) 2004-03-30 2009-10-30 Интермун, Инк. Macrocyclic compounds as inhibitors of viral replication
EP1737850B1 (en) 2004-04-19 2007-10-03 Symed Labs Limited A novel process for the preparation of linezolid and related compounds
ES2325401T3 (en) 2004-07-20 2009-09-03 Symed Labs Limited NEW INTERMEDIATES FOR LINEZOLID AND RELATED COMPOUNDS.
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
EP1804823A4 (en) 2004-09-29 2010-06-09 Amr Technology Inc Novel cyclosporin analogues and their pharmaceutical uses
CA2590339A1 (en) 2004-12-16 2006-06-22 Matthias Heinrich Nettekoven Piperazinyl pyridine derivatives as anti-obesity agents
EP1833819A1 (en) * 2004-12-30 2007-09-19 Astex Therapeutics Limited Pyrazole compounds that modulate the activity of cdk, gsk and aurora kinases
BRPI0610850A2 (en) * 2005-04-19 2008-12-02 Bayer Pharmaceuticals Corp Aryl alkyl acid derivatives, pharmaceutical composition, medicament as well as use of said derivatives
TW200716636A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
WO2007011290A1 (en) 2005-07-18 2007-01-25 Respiratorius Ab Bronchorelaxing agents based on indol- and isoquinoline derivatives
US8211919B2 (en) * 2005-09-02 2012-07-03 Astellas Pharma Inc. Amide derivatives as rock inhibitors
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
AU2006311101A1 (en) 2005-11-11 2007-05-18 F. Hoffmann-La Roche Ag Carbocyclic fused cyclic amines as inhibitors of the coagulation factor Xa
WO2007076055A2 (en) 2005-12-22 2007-07-05 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
JP4012239B2 (en) * 2006-01-11 2007-11-21 生化学工業株式会社 Oxazolone derivatives
JP4047365B2 (en) 2006-01-11 2008-02-13 生化学工業株式会社 Cycloalkanecarboxamide derivative and method for producing the same
EP1976840A1 (en) * 2006-01-13 2008-10-08 F.Hoffmann-La Roche Ag Cyclohexyl piperazinyl methanone derivatives and their use as histamine h3 receptor modulators
JP4855485B2 (en) * 2006-02-17 2012-01-18 エフ.ホフマン−ラ ロシュ アーゲー Benzoyl-piperidine derivatives as 5HT2 / D3 modulators
BRPI0710153A2 (en) * 2006-04-11 2011-08-02 Novartis Ag organic compounds and their uses
EP2018371B1 (en) 2006-05-18 2015-03-04 Arena Pharmaceuticals, Inc. Primary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
DE602007009221D1 (en) 2006-05-18 2010-10-28 Hoffmann La Roche THIAZOLOPYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ANTAGONISTS ON THE ADENOSINE A2B RECEPTOR
CN101448820A (en) * 2006-05-30 2009-06-03 霍夫曼-拉罗奇有限公司 Piperidinyl pyrimidine derivatives
WO2008027740A2 (en) 2006-08-29 2008-03-06 Office Of Intellectual Property And Technology Catalytic asymmetric synthesis of primary amines via borane reduction of oxime ethers using spiroborate esters
WO2008026018A1 (en) 2006-09-01 2008-03-06 Topotarget Switzerland Sa New method for the treatment of inflammatory diseases
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
CL2007003874A1 (en) * 2007-01-03 2008-05-16 Boehringer Ingelheim Int COMPOUNDS DERIVED FROM BENZAMIDA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT CARDIOVASCULAR DISEASES, HYPERTENSION, ATEROSCLEROSIS, RESTENOSIS, ICTUS, HEART FAILURE, ISCHEMICAL INJURY, HYPERTENSION
MX2009008465A (en) 2007-02-15 2009-08-20 Hoffmann La Roche 2-aminooxazolines as taar1 ligands.
WO2008104077A1 (en) 2007-02-28 2008-09-04 Methylgene Inc. Small molecule inhibitors of protein arginine methyltransferases (prmts)
GB0705882D0 (en) 2007-03-27 2007-05-02 Glaxo Group Ltd Novel compounds
BRPI0810362A2 (en) 2007-04-19 2014-10-29 Concert Pharmaceuticals Inc DEFERRED MORPHOLINYL COMPOUNDS
WO2008130319A2 (en) 2007-04-23 2008-10-30 Astrazeneca Ab Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain
US7531685B2 (en) 2007-06-01 2009-05-12 Protia, Llc Deuterium-enriched oxybutynin
WO2009017838A2 (en) 2007-08-01 2009-02-05 Exelixis, Inc. Combinations of jak-2 inhibitors and other agents
US20090131485A1 (en) 2007-09-10 2009-05-21 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20090118238A1 (en) 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090082471A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched fingolimod
US20090088416A1 (en) 2007-09-26 2009-04-02 Protia, Llc Deuterium-enriched lapaquistat
WO2009045476A1 (en) 2007-10-02 2009-04-09 Concert Pharmaceuticals, Inc. Pyrimidinedione derivatives
ES2378011T3 (en) 2007-10-17 2012-04-04 Sanofi N-phenyl-bipyrrolidin substituted ureas and therapeutic use thereof
US8410124B2 (en) 2007-10-18 2013-04-02 Concert Pharmaceuticals Inc. Deuterated etravirine
US20090105338A1 (en) 2007-10-18 2009-04-23 Protia, Llc Deuterium-enriched gabexate mesylate
AU2008317375B2 (en) 2007-10-26 2013-02-28 Concert Pharmaceuticals, Inc. Deuterated darunavir
GB0721332D0 (en) 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
EP2067771A1 (en) 2007-12-03 2009-06-10 EPFL Ecole Polytechnique Fédérale de Lausanne Derivatives of Dihydroxypyrrolidine as Anti-Cancer Compounds
AU2008333110A1 (en) 2007-12-05 2009-06-11 Astrazeneca Ab (Publ) New compounds III
WO2009086835A1 (en) 2008-01-11 2009-07-16 Topotarget A/S Novel cyanoguanidines
JP2011088826A (en) * 2008-01-31 2011-05-06 Astellas Pharma Inc Aromatic carboxylic acid compound
EP2098231A1 (en) 2008-03-05 2009-09-09 Topotarget Switzerland SA Use of NAD formation inhibitors for the treatment of ischemia-reperfusion injury
WO2009118712A2 (en) 2008-03-27 2009-10-01 Ecole Polytechnique Federale De Lausanne (Epfl) Novel dihydroxypyrrolidine derivatives as anti-cancer agents
EP2318369A1 (en) 2008-06-24 2011-05-11 TopoTarget A/S Squaric acid derivatives as inhibitors of the nicotinamide
RU2011111728A (en) 2008-08-29 2012-10-10 Топотаргет А/С (Dk) NEW DERIVATIVES OF UREA AND THIRE UREA
EP2334181A4 (en) 2008-09-16 2012-03-14 Merck Sharp & Dohme Phthalimide derivative metabotropic glutamate r4 ligands
EP2350048A2 (en) 2008-10-16 2011-08-03 Schering Corporation Azine derivatives and methods of use thereof
WO2010057101A2 (en) 2008-11-17 2010-05-20 Schering Corporation Compounds useful as hiv blockers
WO2010066709A1 (en) * 2008-12-09 2010-06-17 Topotarget A/S Novel pyridinyl acrylamide derivatives
TW201030007A (en) 2009-02-06 2010-08-16 Gruenenthal Gmbh Substituted spiro-amides as b1r modulators
MX2011011178A (en) 2009-04-21 2011-12-06 Astellas Pharma Inc Diacylethylenediamine compound.
WO2011006803A1 (en) 2009-07-14 2011-01-20 Nerviano Medical Sciences S.R.L. 3-0x0-2, 3, -dihydro-lh-isoindole-4-carboxamides with selective parp-1 inhibition
NZ601788A (en) 2010-03-01 2014-11-28 Myrexis Inc Inhibitors of nicotinamide phosphoribosyltransferase and therapeutic uses thereof
WO2012031197A1 (en) * 2010-09-03 2012-03-08 Forma Therapeutics, Inc. Novel compounds and compositions for the inhibition of nampt
RU2593759C2 (en) 2010-09-03 2016-08-10 ФОРМА ТиЭм, ЭлЭлСИ Guanidine compounds and compositions for inhibiting nampt
AR082887A1 (en) 2010-09-03 2013-01-16 Forma Therapeutics Inc DERIVATIVES OF PIRIDIN-3-IL-METIL, AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
PE20140913A1 (en) * 2010-11-15 2014-08-22 Abbvie Inc NAMPT AND ROCK INHIBITORS

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AR083855A1 (en) 2013-03-27
JP6117104B2 (en) 2017-04-19
EP2640698A1 (en) 2013-09-25
CN103313968A (en) 2013-09-18
TW201238950A (en) 2012-10-01
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BR112013012078A2 (en) 2019-09-24

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