CU20110208A7 - Derivados de la piridina de tieno (2,3-b) como inhibidores virales de la réplica - Google Patents

Derivados de la piridina de tieno (2,3-b) como inhibidores virales de la réplica

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Publication number
CU20110208A7
CU20110208A7 CU20110208A CU20110208A CU20110208A7 CU 20110208 A7 CU20110208 A7 CU 20110208A7 CU 20110208 A CU20110208 A CU 20110208A CU 20110208 A CU20110208 A CU 20110208A CU 20110208 A7 CU20110208 A7 CU 20110208A7
Authority
CU
Cuba
Prior art keywords
compounds
relates
tieno
piridine
replica
Prior art date
Application number
CU20110208A
Other languages
English (en)
Other versions
CU24117B1 (es
Inventor
Arnout Voet
Damien Marchand
Arnaud Marchand
Maeyer Marc De
Zeger Debyser
Frauke Christ
Patrick Chaltin
Dorothee Bardiot
Original Assignee
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40834066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20110208(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Leuven Kath filed Critical Univ Leuven Kath
Publication of CU20110208A7 publication Critical patent/CU20110208A7/es
Publication of CU24117B1 publication Critical patent/CU24117B1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Abstract

La presente invención se refiere a una serie de compuestos novedosos que tienen actividad antiviral, más específicamente propiedades de inhibición de la replicación del VIH (Virus de la Inmunodeficiencia Humana). La invención también se refiere a procedimientos de preparación de tales compuestos así como a productos intermedios novedosos útiles en una o más etapas de tales síntesis. La invención también se refiere a composiciones farmacéuticas que comprenden una cantidad eficaz de tales compuestos como medicinas o en la fabricación de un medicamnto útil para el tratamiento de animales que padecen infecciones virales, en particular, infección por VIH. La presente invención se refiere adicionalmente a procedimientos para el tratamiento de infecciones virales en animales mediante la administración de una cantidad terapéutica de tales compuestos, combinados opcionalmente con uno o más fármacos diferentes con actividad antiviral.
CUP2011000208A 2009-05-15 2010-05-17 Derivados de la piridina de tieno (2,3-b) como inhibidores virales de la réplica CU24117B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0908394.0A GB0908394D0 (en) 2009-05-15 2009-05-15 Novel viral replication inhibitors
US34380310P 2010-05-03 2010-05-03

Publications (2)

Publication Number Publication Date
CU20110208A7 true CU20110208A7 (es) 2012-02-15
CU24117B1 CU24117B1 (es) 2015-08-27

Family

ID=40834066

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2011000208A CU24117B1 (es) 2009-05-15 2010-05-17 Derivados de la piridina de tieno (2,3-b) como inhibidores virales de la réplica

Country Status (29)

Country Link
US (2) US8785638B2 (es)
EP (1) EP2430029B1 (es)
JP (2) JP2012526778A (es)
KR (2) KR20120035162A (es)
CN (2) CN105367583A (es)
AP (1) AP2939A (es)
BR (1) BRPI1010833A2 (es)
CA (1) CA2759500A1 (es)
CL (1) CL2011002878A1 (es)
CO (1) CO6460769A2 (es)
CR (1) CR20110601A (es)
CU (1) CU24117B1 (es)
DO (1) DOP2011000343A (es)
EA (1) EA201171376A1 (es)
EC (1) ECSP11011456A (es)
GB (1) GB0908394D0 (es)
GE (1) GEP20146115B (es)
IL (1) IL216357A0 (es)
MA (1) MA33274B1 (es)
MX (1) MX2011012146A (es)
MY (1) MY161085A (es)
NI (1) NI201100194A (es)
NZ (1) NZ596392A (es)
PE (1) PE20120779A1 (es)
SG (1) SG175255A1 (es)
TN (1) TN2012000074A1 (es)
UA (1) UA104021C2 (es)
WO (1) WO2010130842A1 (es)
ZA (1) ZA201107618B (es)

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CA2759500A1 (en) 2010-11-18
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GB0908394D0 (en) 2009-06-24
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US8785638B2 (en) 2014-07-22
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