MX2011012146A - Tieno [2,3-b] piridinas derivados como inhibidores de la replicacion viral novedosos. - Google Patents

Tieno [2,3-b] piridinas derivados como inhibidores de la replicacion viral novedosos.

Info

Publication number
MX2011012146A
MX2011012146A MX2011012146A MX2011012146A MX2011012146A MX 2011012146 A MX2011012146 A MX 2011012146A MX 2011012146 A MX2011012146 A MX 2011012146A MX 2011012146 A MX2011012146 A MX 2011012146A MX 2011012146 A MX2011012146 A MX 2011012146A
Authority
MX
Mexico
Prior art keywords
compounds
relates
thieno
viral replication
pyridine derivatives
Prior art date
Application number
MX2011012146A
Other languages
English (en)
Inventor
Dorothee Bardiot
Patrick Chaltin
Frauke Christ
Zeger Debyser
Marc De Maeyer
Arnaud Marchand
Damien Marchand
Arnout Voet
Original Assignee
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40834066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2011012146(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Leuven Kath filed Critical Univ Leuven Kath
Publication of MX2011012146A publication Critical patent/MX2011012146A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a una serie de compuestos novedosos que tienen actividad antiviral, más específicamente propiedades de inhibición de la replicación del VIH (Virus de la Inmunodeficiencia Humana). La invención también se refiere a procedimientos de preparación de tales compuestos así como a productos intermedios novedosos útiles en una o más etapas de tales síntesis. La invención también se refiere a composiciones farmacéuticas que comprenden una cantidad eficaz de tales compuestos como principios activos. La presente invención se refiere además al uso de tales compuestos como medicinas o en la fabricación de un medicamento útil para el tratamiento de animales que padecen infecciones virales, en particular, infección por VIH. La presente invención se refiere adicionalmente a procedimientos para el tratamiento de infecciones virales en animales mediante la administración de una cantidad terapéutica de tales compuestos, combinados opcionalmente con uno o más fármacos diferentes con actividad antiviral.
MX2011012146A 2009-05-15 2010-05-17 Tieno [2,3-b] piridinas derivados como inhibidores de la replicacion viral novedosos. MX2011012146A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0908394.0A GB0908394D0 (en) 2009-05-15 2009-05-15 Novel viral replication inhibitors
US34380310P 2010-05-03 2010-05-03
PCT/EP2010/056754 WO2010130842A1 (en) 2009-05-15 2010-05-17 Thieno [2, 3-b] pyridine derivatives as viral replication inhibitors

Publications (1)

Publication Number Publication Date
MX2011012146A true MX2011012146A (es) 2012-03-06

Family

ID=40834066

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011012146A MX2011012146A (es) 2009-05-15 2010-05-17 Tieno [2,3-b] piridinas derivados como inhibidores de la replicacion viral novedosos.

Country Status (29)

Country Link
US (2) US8785638B2 (es)
EP (1) EP2430029B1 (es)
JP (2) JP2012526778A (es)
KR (2) KR20120035162A (es)
CN (2) CN102459280B (es)
AP (1) AP2939A (es)
BR (1) BRPI1010833A2 (es)
CA (1) CA2759500A1 (es)
CL (1) CL2011002878A1 (es)
CO (1) CO6460769A2 (es)
CR (1) CR20110601A (es)
CU (1) CU24117B1 (es)
DO (1) DOP2011000343A (es)
EA (1) EA201171376A1 (es)
EC (1) ECSP11011456A (es)
GB (1) GB0908394D0 (es)
GE (1) GEP20146115B (es)
IL (1) IL216357A0 (es)
MA (1) MA33274B1 (es)
MX (1) MX2011012146A (es)
MY (1) MY161085A (es)
NI (1) NI201100194A (es)
NZ (1) NZ596392A (es)
PE (1) PE20120779A1 (es)
SG (1) SG175255A1 (es)
TN (1) TN2012000074A1 (es)
UA (1) UA104021C2 (es)
WO (1) WO2010130842A1 (es)
ZA (1) ZA201107618B (es)

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US20120059028A1 (en) 2012-03-08
IL216357A0 (en) 2012-01-31
CO6460769A2 (es) 2012-06-15
TN2012000074A1 (fr) 2013-09-19
US20140296272A1 (en) 2014-10-02
CU24117B1 (es) 2015-08-27
ZA201107618B (en) 2012-12-27
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JP2016040299A (ja) 2016-03-24
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MY161085A (en) 2017-04-14
UA104021C2 (ru) 2013-12-25
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AU2010247366A1 (en) 2011-11-10
PE20120779A1 (es) 2012-06-20
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