PA8635201A1 - Uso de derivados quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos - Google Patents
Uso de derivados quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacosInfo
- Publication number
- PA8635201A1 PA8635201A1 PA20058635201A PA8635201A PA8635201A1 PA 8635201 A1 PA8635201 A1 PA 8635201A1 PA 20058635201 A PA20058635201 A PA 20058635201A PA 8635201 A PA8635201 A PA 8635201A PA 8635201 A1 PA8635201 A1 PA 8635201A1
- Authority
- PA
- Panama
- Prior art keywords
- same
- treatment
- micobacterial
- diseases
- drug resistant
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title abstract 3
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- UDPGUMQDCGORJQ-UHFFFAOYSA-N (2-chloroethyl)phosphonic acid Chemical compound OP(O)(=O)CCCl UDPGUMQDCGORJQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004690 coupled electron pair approximation Methods 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE AL USO DE UN DERIVADO QUINOLINA SUSTITUIDO PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE UNA INFECCION CON UNA CEPA DE MICOBACTERIA MULTIRRESISTENTE DONDE EL DERIVADO QUINOLINA SUSTITUIDO ES UN COMPUESTO DE ACUERDO CON LA FORMULA (IA) O FORMULA (IB) LAS SALES DE ADICION DE ACIDO O BASE FARMACEUTICAMENTE ACEPTABLES DEL MISMO, LAS FORMAS ESTEREOQUIMICAMENTE ISOMERICAS DEL MISMO, LAS FORMAS TAUTOMERICAS DEL MISMO O LAS FORMAS DE N-OXIDO DEL MISMO. ASIMISMO SE REIVINDICA UNA COMPOSICION QUE COMPRENDE UN PORTADOR FARMACEUTICAMENTE ACEPTABLE Y COMO INGREDIENTE ACTIVO, UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE LOS COMPUESTOS ANTERIORES Y UNO O MAS DE OTROS AGENTES ANTIMICOBACTERIANOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04102402 | 2004-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8635201A1 true PA8635201A1 (es) | 2006-05-16 |
Family
ID=34929150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20058635201A PA8635201A1 (es) | 2004-05-28 | 2005-05-27 | Uso de derivados quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US20070249667A1 (es) |
| EP (1) | EP1753427B1 (es) |
| JP (2) | JP5081617B2 (es) |
| KR (2) | KR101371653B1 (es) |
| CN (2) | CN102908347A (es) |
| AP (1) | AP2037A (es) |
| AR (1) | AR049127A1 (es) |
| AT (1) | ATE390925T1 (es) |
| AU (1) | AU2005249231B2 (es) |
| BR (1) | BRPI0510414B1 (es) |
| CA (1) | CA2566544C (es) |
| CL (1) | CL2009001980A1 (es) |
| CY (1) | CY1110388T1 (es) |
| DE (1) | DE602005005810T2 (es) |
| DK (1) | DK1753427T3 (es) |
| EA (1) | EA010651B1 (es) |
| ES (1) | ES2306146T3 (es) |
| HK (1) | HK1106136A1 (es) |
| HR (1) | HRP20080307T3 (es) |
| IL (1) | IL179630A (es) |
| JO (1) | JO2524B1 (es) |
| ME (1) | ME01105B (es) |
| MX (1) | MXPA06013888A (es) |
| MY (1) | MY140611A (es) |
| NO (1) | NO338624B1 (es) |
| NZ (1) | NZ550840A (es) |
| PA (1) | PA8635201A1 (es) |
| PL (1) | PL1753427T3 (es) |
| PT (1) | PT1753427E (es) |
| RS (1) | RS50585B (es) |
| SI (1) | SI1753427T1 (es) |
| TW (1) | TWI363625B (es) |
| UA (1) | UA90267C2 (es) |
| WO (1) | WO2005117875A1 (es) |
| ZA (1) | ZA200609899B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908347A (zh) * | 2004-05-28 | 2013-02-06 | 詹森药业有限公司 | 取代的喹啉衍生物在治疗耐药性分枝杆菌性疾病中的用途 |
| KR101301573B1 (ko) * | 2004-12-24 | 2013-09-04 | 얀센 파마슈티카 엔.브이. | 잠재성 튜버큐로시스의 치료법 |
| EE05697B1 (et) * | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
| JP5349730B2 (ja) * | 2005-06-09 | 2013-11-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗バクテリア剤としてのキノリン誘導体 |
| JO2752B1 (en) * | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO3270B1 (ar) * | 2005-06-28 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
| JP5193857B2 (ja) * | 2005-06-28 | 2013-05-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗菌剤としてのキノリン誘導体 |
| WO2007022946A1 (de) | 2005-08-21 | 2007-03-01 | Abbott Gmbh & Co. Kg | Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| UA97813C2 (uk) * | 2006-12-05 | 2012-03-26 | Янссен Фармацевтика Н.В. | Фумаратна сіль (альфа s, бета r)-6-бром-альфа-[2-(диметиламіно)етил]-2-метоксі-альфа-1-нафталеніл-бета-феніл-3-хінолінетанолу |
| JO3271B1 (ar) * | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| JO2685B1 (en) | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| JO2970B1 (en) * | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2725B1 (en) * | 2006-12-06 | 2013-09-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2684B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| MD4009C2 (ro) * | 2008-07-15 | 2010-08-31 | Институт Химии Академии Наук Молдовы | Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos |
| RU2404971C2 (ru) * | 2008-12-02 | 2010-11-27 | ЗАО "Фарм-Синтез" | Новые производные хинолина, способ их получения, их применение для лечения микобактериальных инфекций, фармацевтическая композиция на их основе |
| CN102655865A (zh) * | 2009-09-11 | 2012-09-05 | 沃泰克斯药物股份有限公司 | N-苄基-3-(4-氯苯基)-2-[甲基-[2-氧代-2-(3,4,5-三甲氧基苯基)乙酰基]氨基]-n-[3-(4-吡啶基)-1-[2-(4-吡啶基)乙基]丙酰胺的组合物及其用途 |
| CN102249935B (zh) * | 2010-05-17 | 2015-05-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 芳香2-丁醇类化合物及其医药用途 |
| PL2841425T3 (pl) | 2012-04-27 | 2016-10-31 | Antybakteryjne pochodne chinoliny | |
| EA038350B1 (ru) | 2012-04-27 | 2021-08-12 | Янссен Фармацевтика Нв | Антибактериальные хинолиновые производные |
| CN105330595B (zh) * | 2014-07-14 | 2019-12-10 | 上海嘉坦医药科技有限公司 | 吡啶衍生物及其作为抗分支杆菌的应用 |
| CA2954872C (en) * | 2014-07-14 | 2019-08-13 | Cisen Pharmaceutical Co., Ltd. | Pyridine derivatives and anti-mycobacterial use thereof |
| MX2017009681A (es) * | 2015-01-27 | 2017-10-18 | Janssen Pharmaceutica Nv | Composiciones dispersables. |
| CN106279017A (zh) * | 2015-05-21 | 2017-01-04 | 重庆圣华曦药业股份有限公司 | 贝达喹啉晶型、组合物及其制备方法 |
| WO2017066926A1 (zh) * | 2015-10-20 | 2017-04-27 | 浙江海正药业股份有限公司 | 富马酸贝达喹啉的晶型及其制备方法 |
| WO2017121323A1 (zh) * | 2016-01-13 | 2017-07-20 | 辰欣药业股份有限公司 | 一种吡啶衍生物类化合物的制备方法及其中间体和晶型 |
| ES2934785T3 (es) * | 2016-03-07 | 2023-02-27 | The Global Alliance For Tb Drug Dev Inc | Compuestos antibacterianos y usos de los mismos |
| CN107243008B (zh) * | 2017-04-13 | 2021-03-30 | 中国科学院广州生物医药与健康研究院 | 吡唑并[1,5-a]吡啶类化合物的新应用及一种治疗脓肿分枝杆菌感染的组合物 |
| WO2019044941A1 (ja) * | 2017-09-01 | 2019-03-07 | 学校法人北里研究所 | マイコバクテリウム・アビウム複合感染症に対する治療活性を有する新規化合物及びその製造方法 |
| WO2020047596A1 (en) * | 2018-09-04 | 2020-03-12 | Monash University | Antibacterial compounds and methods of use |
| EP3908269A1 (en) | 2019-01-09 | 2021-11-17 | Janssen Pharmaceutica NV | Combination in the treatment of nontuberculous mycobacterial diseases |
| CN110804016B (zh) * | 2019-12-05 | 2022-11-04 | 福建省微生物研究所 | 抗结核分枝杆菌的二芳基喹啉衍生物 |
| JP2023549605A (ja) | 2020-11-12 | 2023-11-28 | ヤンセン ファーマシューティカ エヌ．ベー． | 非結核性マイコバクテリア疾患の治療におけるベダキリン、エタンブトール、及びマクロライドの組合せ |
| CN117050006A (zh) * | 2022-05-13 | 2023-11-14 | 广州嘉越医药科技有限公司 | 一种吡啶衍生物、中间体、制备方法和应用 |
| WO2023227123A1 (zh) * | 2022-05-27 | 2023-11-30 | 广州嘉越医药科技有限公司 | 吡啶衍生物的用途 |
| WO2023232838A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Pharmaceutica Nv | Bedaquiline for use in the treatment of leprosy |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399558A (en) * | 1993-11-24 | 1995-03-21 | Pathogenesis Corporation | Isoflavonoid antibacterial compounds, compositions and use |
| EP0936866A4 (en) * | 1996-10-28 | 2001-04-11 | Dept Of The Army Us Government | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING ANTIBIOTIC RESIST INFECTIONS |
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| RS52431B (en) * | 2002-07-25 | 2013-02-28 | Janssen Pharmaceutica N.V. | QUINOLINE DERIVATIVES AND THEIR USE AS MYCOBACTERIAL INHIBITORS |
| CN102908347A (zh) * | 2004-05-28 | 2013-02-06 | 詹森药业有限公司 | 取代的喹啉衍生物在治疗耐药性分枝杆菌性疾病中的用途 |
| EE05697B1 (et) * | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
-
2005
- 2005-05-24 CN CN2012103943126A patent/CN102908347A/zh active Pending
- 2005-05-24 KR KR1020067024974A patent/KR101371653B1/ko active Protection Beyond IP Right Term
- 2005-05-24 PL PL05743054T patent/PL1753427T3/pl unknown
- 2005-05-24 JO JO200574A patent/JO2524B1/en active
- 2005-05-24 RS RSP-2008/0291A patent/RS50585B/sr unknown
- 2005-05-24 DK DK05743054T patent/DK1753427T3/da active
- 2005-05-24 ME MEP-2008-89A patent/ME01105B/me unknown
- 2005-05-24 AT AT05743054T patent/ATE390925T1/de active
- 2005-05-24 NZ NZ550840A patent/NZ550840A/en unknown
- 2005-05-24 AU AU2005249231A patent/AU2005249231B2/en active Active
- 2005-05-24 DE DE602005005810T patent/DE602005005810T2/de active Active
- 2005-05-24 KR KR1020137002606A patent/KR20130024969A/ko not_active Application Discontinuation
- 2005-05-24 UA UAA200611048A patent/UA90267C2/ru unknown
- 2005-05-24 SI SI200530294T patent/SI1753427T1/sl unknown
- 2005-05-24 EP EP05743054A patent/EP1753427B1/en active Active
- 2005-05-24 CN CN2005800170162A patent/CN1976704B/zh active Active
- 2005-05-24 EA EA200602260A patent/EA010651B1/ru active Protection Beyond IP Right Term
- 2005-05-24 CA CA2566544A patent/CA2566544C/en active Active
- 2005-05-24 AP AP2006003828A patent/AP2037A/xx active
- 2005-05-24 US US11/569,681 patent/US20070249667A1/en not_active Abandoned
- 2005-05-24 JP JP2007513922A patent/JP5081617B2/ja active Active
- 2005-05-24 WO PCT/EP2005/052371 patent/WO2005117875A1/en active Application Filing
- 2005-05-24 PT PT05743054T patent/PT1753427E/pt unknown
- 2005-05-24 BR BRPI0510414-9A patent/BRPI0510414B1/pt active IP Right Grant
- 2005-05-24 MX MXPA06013888A patent/MXPA06013888A/es active IP Right Grant
- 2005-05-24 ES ES05743054T patent/ES2306146T3/es active Active
- 2005-05-27 TW TW094117334A patent/TWI363625B/zh active
- 2005-05-27 AR ARP050102200A patent/AR049127A1/es unknown
- 2005-05-27 MY MYPI20052432A patent/MY140611A/en unknown
- 2005-05-27 PA PA20058635201A patent/PA8635201A1/es unknown
-
2006
- 2006-11-27 IL IL179630A patent/IL179630A/en active IP Right Grant
- 2006-11-27 ZA ZA200609899A patent/ZA200609899B/xx unknown
- 2006-12-28 NO NO20066041A patent/NO338624B1/no unknown
-
2007
- 2007-10-23 HK HK07111416.6A patent/HK1106136A1/xx unknown
-
2008
- 2008-06-30 HR HR20080307T patent/HRP20080307T3/xx unknown
- 2008-07-02 CY CY20081100696T patent/CY1110388T1/el unknown
-
2009
- 2009-10-20 CL CL2009001980A patent/CL2009001980A1/es unknown
-
2010
- 2010-03-08 US US12/719,221 patent/US20100168133A1/en not_active Abandoned
-
2012
- 2012-07-06 JP JP2012152373A patent/JP5675718B2/ja active Active
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