UA90267C2 - Применение замещенных хинолиновых производных для лечения заболеваний, вызванных микобактериями, резистентными к лекарственным средствам - Google Patents
Применение замещенных хинолиновых производных для лечения заболеваний, вызванных микобактериями, резистентными к лекарственным средствамInfo
- Publication number
- UA90267C2 UA90267C2 UAA200611048A UAA200611048A UA90267C2 UA 90267 C2 UA90267 C2 UA 90267C2 UA A200611048 A UAA200611048 A UA A200611048A UA A200611048 A UAA200611048 A UA A200611048A UA 90267 C2 UA90267 C2 UA 90267C2
- Authority
- UA
- Ukraine
- Prior art keywords
- substituted quinoline
- treatment
- drug resistant
- quinoline derivatives
- mycobacterial diseases
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000186359 Mycobacterium Species 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003926 antimycobacterial agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Данное изобретение касается применения замещенного хинолинового производного при получении лекарственного средства для лечения инфекции, которую вызывает резистентный к лекарственному средству штамм Mycobacterium, где указанным замещенным хинолиновым производным является соединение формулы (Иа) или формулы (Иb), (Ia), (Ib)ее фармацевтически приемлемые кислотно-аддитивные или основно-аддитивные соли, стереохимически изомерные формы, таутомерные формы и М-оксидные формы.В данном изобретении также заявлена композиция, которая содержит фармацевтически приемлемый носитель и, как активный ингредиент, терапевтически эффективное количество вышеупомянутых соединений и одного или нескольких других антимикобактериальных средств.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04102402 | 2004-05-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA90267C2 true UA90267C2 (ru) | 2010-04-26 |
Family
ID=34929150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200611048A UA90267C2 (ru) | 2004-05-28 | 2005-05-24 | Применение замещенных хинолиновых производных для лечения заболеваний, вызванных микобактериями, резистентными к лекарственным средствам |
Country Status (35)
Country | Link |
---|---|
US (2) | US20070249667A1 (ru) |
EP (1) | EP1753427B1 (ru) |
JP (2) | JP5081617B2 (ru) |
KR (2) | KR20130024969A (ru) |
CN (2) | CN102908347A (ru) |
AP (1) | AP2037A (ru) |
AR (1) | AR049127A1 (ru) |
AT (1) | ATE390925T1 (ru) |
AU (1) | AU2005249231B2 (ru) |
BR (1) | BRPI0510414B1 (ru) |
CA (1) | CA2566544C (ru) |
CL (1) | CL2009001980A1 (ru) |
CY (1) | CY1110388T1 (ru) |
DE (1) | DE602005005810T2 (ru) |
DK (1) | DK1753427T3 (ru) |
EA (1) | EA010651B1 (ru) |
ES (1) | ES2306146T3 (ru) |
HK (1) | HK1106136A1 (ru) |
HR (1) | HRP20080307T3 (ru) |
IL (1) | IL179630A (ru) |
JO (1) | JO2524B1 (ru) |
ME (1) | ME01105B (ru) |
MX (1) | MXPA06013888A (ru) |
MY (1) | MY140611A (ru) |
NO (1) | NO338624B1 (ru) |
NZ (1) | NZ550840A (ru) |
PA (1) | PA8635201A1 (ru) |
PL (1) | PL1753427T3 (ru) |
PT (1) | PT1753427E (ru) |
RS (1) | RS50585B (ru) |
SI (1) | SI1753427T1 (ru) |
TW (1) | TWI363625B (ru) |
UA (1) | UA90267C2 (ru) |
WO (1) | WO2005117875A1 (ru) |
ZA (1) | ZA200609899B (ru) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA06013888A (es) * | 2004-05-28 | 2007-01-26 | Janssen Pharmaceutica Nv | Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos. |
KR101301573B1 (ko) * | 2004-12-24 | 2013-09-04 | 얀센 파마슈티카 엔.브이. | 잠재성 튜버큐로시스의 치료법 |
CA2528849C (en) | 2005-06-08 | 2014-01-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
JP5349730B2 (ja) * | 2005-06-09 | 2013-11-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗バクテリア剤としてのキノリン誘導体 |
JO2752B1 (en) | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
AP2547A (en) * | 2005-06-28 | 2012-12-26 | Janssen Pharmaceutica Nv | Quinoline derivatives as antibacterial agents |
JO3270B1 (ar) * | 2005-06-28 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
WO2007022946A1 (de) | 2005-08-21 | 2007-03-01 | Abbott Gmbh & Co. Kg | Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
UA97813C2 (ru) * | 2006-12-05 | 2012-03-26 | Янссен Фармацевтика Н.В. | Фумаратная соль (альфа s, бета r)-6-бром-альфа-[2-(диметиламино)этил]-2-метокси-альфа-1-нафталенил-бета-фенил-3-хинолинэтанола |
JO2725B1 (en) * | 2006-12-06 | 2013-09-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
JO2970B1 (en) * | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
JO2684B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
JO3271B1 (ar) * | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
JO2685B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
MD4009C2 (ru) * | 2008-07-15 | 2010-08-31 | Институт Химии Академии Наук Молдовы | Использование 1-метил-4-(N-метиламинобутил-4)-β-карболина в качестве противотуберкулезного средства |
RU2404971C2 (ru) * | 2008-12-02 | 2010-11-27 | ЗАО "Фарм-Синтез" | Новые производные хинолина, способ их получения, их применение для лечения микобактериальных инфекций, фармацевтическая композиция на их основе |
WO2011031926A1 (en) * | 2009-09-11 | 2011-03-17 | Vertex Pharmaceuticals Incorporated | Compositions of n-benzyl-3-(4-chlorophenyl)-2-[methyl-[2-oxo-2-(3,4,5-trimethoxyphenyl) acetyl]amino]-n-[3-(4-pyridyl)-1-[2-[4-pyridyl)ethyl]propanamide and uses thereof |
CN102249935B (zh) * | 2010-05-17 | 2015-05-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 芳香2-丁醇类化合物及其医药用途 |
WO2013160431A1 (en) | 2012-04-27 | 2013-10-31 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
DK2841425T3 (en) | 2012-04-27 | 2016-06-27 | Janssen Pharmaceutica Nv | ANTIBACTERIAL QUINOLIN DERIVATIVES |
BR112017000764B1 (pt) * | 2014-07-14 | 2022-07-12 | Shanghai Jia Tan Pharmatech Co. Ltd. | Composto, método para preparar o composto e uso do composto |
CN105330595B (zh) * | 2014-07-14 | 2019-12-10 | 上海嘉坦医药科技有限公司 | 吡啶衍生物及其作为抗分支杆菌的应用 |
US20180000810A1 (en) | 2015-01-27 | 2018-01-04 | Janssen Pharmaceutica Nv | Dispersible compositions |
CN106279017A (zh) * | 2015-05-21 | 2017-01-04 | 重庆圣华曦药业股份有限公司 | 贝达喹啉晶型、组合物及其制备方法 |
RU2018111482A (ru) | 2015-10-20 | 2019-11-21 | Чжэцзян Хисунь Фармасьютикал Ко., Лтд. | Кристаллические формы бедаквилин фумарата и способы их получения |
WO2017121323A1 (zh) * | 2016-01-13 | 2017-07-20 | 辰欣药业股份有限公司 | 一种吡啶衍生物类化合物的制备方法及其中间体和晶型 |
BR112018067922B1 (pt) * | 2016-03-07 | 2024-02-06 | The Global Alliance For Tb Drug Development, Inc | Compostos antibacterianos, usos dos mesmos e composições farmacêuticas |
CN107243008B (zh) * | 2017-04-13 | 2021-03-30 | 中国科学院广州生物医药与健康研究院 | 吡唑并[1,5-a]吡啶类化合物的新应用及一种治疗脓肿分枝杆菌感染的组合物 |
US11407742B2 (en) * | 2017-09-01 | 2022-08-09 | The Kitasato Institute | Compound having therapeutic activity against mycobacterium avium complex infection, and method for producing same |
WO2020047596A1 (en) * | 2018-09-04 | 2020-03-12 | Monash University | Antibacterial compounds and methods of use |
KR20210113628A (ko) | 2019-01-09 | 2021-09-16 | 얀센 파마슈티카 엔.브이. | 비결핵성 마이코박테리아 질환의 치료에서의 조합물 |
WO2021107876A1 (en) * | 2019-11-26 | 2021-06-03 | Nanyang Technological University | Compounds for treating tuberculosis |
CN110804016B (zh) * | 2019-12-05 | 2022-11-04 | 福建省微生物研究所 | 抗结核分枝杆菌的二芳基喹啉衍生物 |
KR20230107275A (ko) | 2020-11-12 | 2023-07-14 | 얀센 파마슈티카 엔.브이. | 비결핵성 마이코박테리아 질환의 치료에서 베다퀼린, 에탐부톨 및 마크롤라이드의 조합물 |
WO2023217279A1 (zh) * | 2022-05-13 | 2023-11-16 | 广州嘉越医药科技有限公司 | 一种吡啶衍生物、中间体、制备方法和应用 |
CN117122595A (zh) * | 2022-05-27 | 2023-11-28 | 广州嘉越医药科技有限公司 | 吡啶衍生物的用途 |
WO2023232838A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Pharmaceutica Nv | Bedaquiline for use in the treatment of leprosy |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399558A (en) * | 1993-11-24 | 1995-03-21 | Pathogenesis Corporation | Isoflavonoid antibacterial compounds, compositions and use |
EP0936866A4 (en) * | 1996-10-28 | 2001-04-11 | Dept Of The Army Us Government | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING ANTIBIOTIC RESIST INFECTIONS |
US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
SI2301544T1 (sl) * | 2002-07-25 | 2013-01-31 | Janssen Pharmaceutica, N.V. | Derivati kinolina kot vmesne spojine za mikobakterijske inhibitorje |
MXPA06013888A (es) * | 2004-05-28 | 2007-01-26 | Janssen Pharmaceutica Nv | Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos. |
CA2528849C (en) * | 2005-06-08 | 2014-01-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
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2005
- 2005-05-24 MX MXPA06013888A patent/MXPA06013888A/es active IP Right Grant
- 2005-05-24 RS RSP-2008/0291A patent/RS50585B/sr unknown
- 2005-05-24 US US11/569,681 patent/US20070249667A1/en not_active Abandoned
- 2005-05-24 BR BRPI0510414-9A patent/BRPI0510414B1/pt active IP Right Grant
- 2005-05-24 DK DK05743054T patent/DK1753427T3/da active
- 2005-05-24 KR KR1020137002606A patent/KR20130024969A/ko not_active Application Discontinuation
- 2005-05-24 PL PL05743054T patent/PL1753427T3/pl unknown
- 2005-05-24 EA EA200602260A patent/EA010651B1/ru active Protection Beyond IP Right Term
- 2005-05-24 UA UAA200611048A patent/UA90267C2/ru unknown
- 2005-05-24 AU AU2005249231A patent/AU2005249231B2/en active Active
- 2005-05-24 CN CN2012103943126A patent/CN102908347A/zh active Pending
- 2005-05-24 CA CA2566544A patent/CA2566544C/en active Active
- 2005-05-24 PT PT05743054T patent/PT1753427E/pt unknown
- 2005-05-24 DE DE602005005810T patent/DE602005005810T2/de active Active
- 2005-05-24 ME MEP-2008-89A patent/ME01105B/me unknown
- 2005-05-24 CN CN2005800170162A patent/CN1976704B/zh active Active
- 2005-05-24 JO JO200574A patent/JO2524B1/en active
- 2005-05-24 JP JP2007513922A patent/JP5081617B2/ja active Active
- 2005-05-24 SI SI200530294T patent/SI1753427T1/sl unknown
- 2005-05-24 AP AP2006003828A patent/AP2037A/xx active
- 2005-05-24 NZ NZ550840A patent/NZ550840A/en unknown
- 2005-05-24 EP EP05743054A patent/EP1753427B1/en active Active
- 2005-05-24 ES ES05743054T patent/ES2306146T3/es active Active
- 2005-05-24 WO PCT/EP2005/052371 patent/WO2005117875A1/en active Application Filing
- 2005-05-24 AT AT05743054T patent/ATE390925T1/de active
- 2005-05-24 KR KR1020067024974A patent/KR101371653B1/ko active Protection Beyond IP Right Term
- 2005-05-27 AR ARP050102200A patent/AR049127A1/es unknown
- 2005-05-27 MY MYPI20052432A patent/MY140611A/en unknown
- 2005-05-27 TW TW094117334A patent/TWI363625B/zh active
- 2005-05-27 PA PA20058635201A patent/PA8635201A1/es unknown
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2006
- 2006-11-27 IL IL179630A patent/IL179630A/en active IP Right Grant
- 2006-11-27 ZA ZA200609899A patent/ZA200609899B/xx unknown
- 2006-12-28 NO NO20066041A patent/NO338624B1/no unknown
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2007
- 2007-10-23 HK HK07111416.6A patent/HK1106136A1/xx unknown
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2008
- 2008-06-30 HR HR20080307T patent/HRP20080307T3/xx unknown
- 2008-07-02 CY CY20081100696T patent/CY1110388T1/el unknown
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2009
- 2009-10-20 CL CL2009001980A patent/CL2009001980A1/es unknown
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2010
- 2010-03-08 US US12/719,221 patent/US20100168133A1/en not_active Abandoned
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2012
- 2012-07-06 JP JP2012152373A patent/JP5675718B2/ja active Active
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