UA104021C2 - ПРОИЗВОДНЫЕ ТИЕНО[2,3-b]ПИРИДИНА КАК ИНГИБИТОРЫ РЕПЛИКАЦИИ ВИРУСА - Google Patents
ПРОИЗВОДНЫЕ ТИЕНО[2,3-b]ПИРИДИНА КАК ИНГИБИТОРЫ РЕПЛИКАЦИИ ВИРУСАInfo
- Publication number
- UA104021C2 UA104021C2 UAA201113390A UAA201113390A UA104021C2 UA 104021 C2 UA104021 C2 UA 104021C2 UA A201113390 A UAA201113390 A UA A201113390A UA A201113390 A UAA201113390 A UA A201113390A UA 104021 C2 UA104021 C2 UA 104021C2
- Authority
- UA
- Ukraine
- Prior art keywords
- heading
- compounds
- relates
- thieno
- normal
- Prior art date
Links
- 229940123627 Viral replication inhibitor Drugs 0.000 title 1
- PWSBNTOBQBTNEJ-UHFFFAOYSA-N thieno[2,3-b]pyridine Chemical class C1=C[CH]C2=C=CSC2=N1 PWSBNTOBQBTNEJ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 3
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Представленное изобретение касается ряда новых соединений, которые имеют противовирусную активность, более особенно способность ингибировать репликацию ВИЧ (вирус иммунодефицита человека).Изобретение также касается способов получения таких соединений, также как и новых промежуточных соединений, полезных на одной или более стадиях таких синтезов.Изобретение также касается фармацевтических композиций, содержащих эффективное количество таких соединений в качестве активных ингредиентов.Это изобретение также касается применения таких соединений как медикаментов или при приготовлении медикамента, полезного для лечения животных, страдающих вирусными инфекциями, в частности ВИЧ.Это изобретение также касается способов лечения вирусных инфекций у ж�
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0908394.0A GB0908394D0 (en) | 2009-05-15 | 2009-05-15 | Novel viral replication inhibitors |
PCT/EP2010/056754 WO2010130842A1 (en) | 2009-05-15 | 2010-05-17 | Thieno [2, 3-b] pyridine derivatives as viral replication inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
UA104021C2 true UA104021C2 (ru) | 2013-12-25 |
Family
ID=40834066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201113390A UA104021C2 (ru) | 2009-05-15 | 2010-05-17 | ПРОИЗВОДНЫЕ ТИЕНО[2,3-b]ПИРИДИНА КАК ИНГИБИТОРЫ РЕПЛИКАЦИИ ВИРУСА |
Country Status (29)
Country | Link |
---|---|
US (2) | US8785638B2 (ru) |
EP (1) | EP2430029B1 (ru) |
JP (2) | JP2012526778A (ru) |
KR (2) | KR20140127905A (ru) |
CN (2) | CN105367583A (ru) |
AP (1) | AP2939A (ru) |
BR (1) | BRPI1010833A2 (ru) |
CA (1) | CA2759500A1 (ru) |
CL (1) | CL2011002878A1 (ru) |
CO (1) | CO6460769A2 (ru) |
CR (1) | CR20110601A (ru) |
CU (1) | CU24117B1 (ru) |
DO (1) | DOP2011000343A (ru) |
EA (1) | EA201171376A1 (ru) |
EC (1) | ECSP11011456A (ru) |
GB (1) | GB0908394D0 (ru) |
GE (1) | GEP20146115B (ru) |
IL (1) | IL216357A0 (ru) |
MA (1) | MA33274B1 (ru) |
MX (1) | MX2011012146A (ru) |
MY (1) | MY161085A (ru) |
NI (1) | NI201100194A (ru) |
NZ (1) | NZ596392A (ru) |
PE (1) | PE20120779A1 (ru) |
SG (1) | SG175255A1 (ru) |
TN (1) | TN2012000074A1 (ru) |
UA (1) | UA104021C2 (ru) |
WO (1) | WO2010130842A1 (ru) |
ZA (1) | ZA201107618B (ru) |
Families Citing this family (67)
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GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
US8338441B2 (en) | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
US9102614B2 (en) | 2010-07-02 | 2015-08-11 | Gilead Sciences, Inc. | Naphth-2-ylacetic acid derivatives to treat AIDS |
JP5806735B2 (ja) | 2010-07-02 | 2015-11-10 | ギリアード サイエンシーズ, インコーポレイテッド | Hiv抗ウイルス化合物としての2−キノリニル−酢酸誘導体 |
AU2011331301A1 (en) * | 2010-11-15 | 2013-05-23 | Katholieke Universiteit Leuven | Antiviral condensed heterocyclic compounds |
WO2012066442A1 (en) * | 2010-11-15 | 2012-05-24 | Pfizer Limited | Inhibitors of hiv replication |
EP2508511A1 (en) | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
EP2511273B8 (en) | 2011-04-15 | 2019-06-26 | Hivih | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
AP2015008931A0 (en) | 2011-04-21 | 2015-12-31 | Gilead Sciences Inc | Benzothiazole compounds and their pharmaceutical use |
US8791108B2 (en) | 2011-08-18 | 2014-07-29 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
JP6099149B2 (ja) | 2011-10-25 | 2017-03-22 | 塩野義製薬株式会社 | Hiv複製阻害剤 |
PL2781519T3 (pl) * | 2011-11-15 | 2020-06-29 | St Pharm Co., Ltd. | Nowa przeciwwirusowa pochodna pirolopirydyny i sposób jej wytwarzania |
WO2013103724A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids |
US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
KR101390616B1 (ko) | 2012-03-28 | 2014-04-29 | 주식회사 두산 | 신규 화합물 및 이를 포함하는 유기 전계 발광 소자 |
UY34750A (es) | 2012-04-20 | 2013-11-29 | Gilead Sciences Inc | ?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?. |
US9163023B2 (en) * | 2012-07-12 | 2015-10-20 | Viiv Healthcare Uk Limited | Compounds and methods for treating HIV |
US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
EP2716632A1 (en) | 2012-10-05 | 2014-04-09 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
EP2716639A1 (en) | 2012-10-05 | 2014-04-09 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
EP2719685A1 (en) | 2012-10-11 | 2014-04-16 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
TW201441197A (zh) | 2013-01-31 | 2014-11-01 | Shionogi & Co | Hiv複製抑制劑 |
EP2970273B1 (en) | 2013-03-13 | 2017-03-01 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
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US9580431B2 (en) | 2013-03-13 | 2017-02-28 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
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ES2623904T3 (es) | 2013-03-14 | 2017-07-12 | VIIV Healthcare UK (No.5) Limited | Inhibidores de la replicación del virus de la inmunodeficiencia humana |
EA201690089A1 (ru) | 2013-06-11 | 2017-04-28 | Латвийский Институт Органического Синтеза | ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ |
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US9932353B2 (en) | 2014-02-18 | 2018-04-03 | Viiv Healthcare Uk (No. 5) Limited | Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
WO2015126743A1 (en) | 2014-02-18 | 2015-08-27 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
US9409922B2 (en) | 2014-02-18 | 2016-08-09 | Bristol-Myers Squibb Company | Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication |
PT3107913T (pt) | 2014-02-19 | 2018-09-28 | Viiv Healthcare Uk No 5 Ltd | Inibidores da replicação do vírus da imunodeficiência humana |
US9273067B2 (en) | 2014-02-19 | 2016-03-01 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
US9193720B2 (en) | 2014-02-20 | 2015-11-24 | Bristol-Myers Squibb Company | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
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JP6579549B2 (ja) | 2014-05-16 | 2019-09-25 | 塩野義製薬株式会社 | Hiv複製阻害作用を有する3環性複素環誘導体 |
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CN107922423B (zh) | 2015-05-29 | 2020-10-27 | 盐野义制药株式会社 | 具有hiv复制抑制作用的含氮三环性衍生物 |
JP2018520162A (ja) | 2015-07-06 | 2018-07-26 | ヴィーブ ヘルスケア ユーケー(ナンバー5)リミテッド | ヒト免疫不全ウイルス複製の阻害剤としてのピリジン−3−イル酢酸誘導体 |
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AU2016290986A1 (en) | 2015-07-09 | 2018-01-18 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
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CA2995042A1 (en) | 2015-08-12 | 2017-02-16 | VIIV Healthcare UK (No.5) Limited | 5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
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EP3455217A1 (en) | 2016-05-11 | 2019-03-20 | ViiV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
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2009
- 2009-05-15 GB GBGB0908394.0A patent/GB0908394D0/en not_active Ceased
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2010
- 2010-05-17 SG SG2011075900A patent/SG175255A1/en unknown
- 2010-05-17 KR KR1020147026826A patent/KR20140127905A/ko not_active Application Discontinuation
- 2010-05-17 MA MA34351A patent/MA33274B1/fr unknown
- 2010-05-17 US US13/320,519 patent/US8785638B2/en not_active Expired - Fee Related
- 2010-05-17 EP EP10721773.9A patent/EP2430029B1/en not_active Not-in-force
- 2010-05-17 AP AP2011005975A patent/AP2939A/xx active
- 2010-05-17 PE PE2011001928A patent/PE20120779A1/es not_active Application Discontinuation
- 2010-05-17 BR BRPI1010833A patent/BRPI1010833A2/pt not_active IP Right Cessation
- 2010-05-17 EA EA201171376A patent/EA201171376A1/ru unknown
- 2010-05-17 NZ NZ596392A patent/NZ596392A/en not_active IP Right Cessation
- 2010-05-17 CN CN201510574332.5A patent/CN105367583A/zh active Pending
- 2010-05-17 UA UAA201113390A patent/UA104021C2/ru unknown
- 2010-05-17 GE GEAP201012454A patent/GEP20146115B/en unknown
- 2010-05-17 JP JP2012510317A patent/JP2012526778A/ja active Pending
- 2010-05-17 CU CUP2011000208A patent/CU24117B1/es active IP Right Grant
- 2010-05-17 CA CA2759500A patent/CA2759500A1/en not_active Abandoned
- 2010-05-17 MX MX2011012146A patent/MX2011012146A/es active IP Right Grant
- 2010-05-17 CN CN201080031813.7A patent/CN102459280B/zh not_active Expired - Fee Related
- 2010-05-17 KR KR1020117029989A patent/KR20120035162A/ko active IP Right Grant
- 2010-05-17 WO PCT/EP2010/056754 patent/WO2010130842A1/en active Application Filing
- 2010-05-17 MY MYPI2011005465A patent/MY161085A/en unknown
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- 2011-10-18 ZA ZA2011/07618A patent/ZA201107618B/en unknown
- 2011-11-09 DO DO2011000343A patent/DOP2011000343A/es unknown
- 2011-11-11 NI NI201100194A patent/NI201100194A/es unknown
- 2011-11-14 IL IL216357A patent/IL216357A0/en unknown
- 2011-11-14 EC EC2011011456A patent/ECSP11011456A/es unknown
- 2011-11-15 CR CR20110601A patent/CR20110601A/es unknown
- 2011-11-15 CO CO11155179A patent/CO6460769A2/es active IP Right Grant
- 2011-11-15 CL CL2011002878A patent/CL2011002878A1/es unknown
-
2012
- 2012-02-16 TN TNP2012000074A patent/TN2012000074A1/fr unknown
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- 2014-06-17 US US14/306,614 patent/US9499563B2/en active Active
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