WO2008000777A3 - Phenyl- pyrazole derivatives, process for their preparation and their pharmaceutical use - Google Patents

Phenyl- pyrazole derivatives, process for their preparation and their pharmaceutical use Download PDF

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Publication number
WO2008000777A3
WO2008000777A3 PCT/EP2007/056448 EP2007056448W WO2008000777A3 WO 2008000777 A3 WO2008000777 A3 WO 2008000777A3 EP 2007056448 W EP2007056448 W EP 2007056448W WO 2008000777 A3 WO2008000777 A3 WO 2008000777A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
phenyl
pharmaceutical use
pyrazole derivatives
compounds
Prior art date
Application number
PCT/EP2007/056448
Other languages
French (fr)
Other versions
WO2008000777A2 (en
Inventor
Heather Anne Barnett
Ian Baxter Campbell
Diane Mary Coe
Anthony William James Cooper
Graham George Adam Inglis
Haydn Terence Jones
Steven Philip Keeling
Simon John Fawcett Macdonald
Iain Mcfarlane Mclay
Philip Alan Skone
Gordon Gad Weingarten
James Michael Woolven
Original Assignee
Glaxo Group Ltd
Heather Anne Barnett
Ian Baxter Campbell
Diane Mary Coe
Anthony William James Cooper
Graham George Adam Inglis
Haydn Terence Jones
Steven Philip Keeling
Simon John Fawcett Macdonald
Iain Mcfarlane Mclay
Philip Alan Skone
Gordon Gad Weingarten
James Michael Woolven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0612942A external-priority patent/GB0612942D0/en
Priority claimed from GB0625458A external-priority patent/GB0625458D0/en
Priority claimed from GB0700077A external-priority patent/GB0700077D0/en
Application filed by Glaxo Group Ltd, Heather Anne Barnett, Ian Baxter Campbell, Diane Mary Coe, Anthony William James Cooper, Graham George Adam Inglis, Haydn Terence Jones, Steven Philip Keeling, Simon John Fawcett Macdonald, Iain Mcfarlane Mclay, Philip Alan Skone, Gordon Gad Weingarten, James Michael Woolven filed Critical Glaxo Group Ltd
Publication of WO2008000777A2 publication Critical patent/WO2008000777A2/en
Publication of WO2008000777A3 publication Critical patent/WO2008000777A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

The present invention provides compounds of formula (I), a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation and/or allergic conditions.
PCT/EP2007/056448 2006-06-29 2007-06-27 Phenyl- pyrazole derivatives, process for their preparation and their pharmaceutical use WO2008000777A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0612942A GB0612942D0 (en) 2006-06-29 2006-06-29 Novel compounds
GB0612942.3 2006-06-29
GB0625458A GB0625458D0 (en) 2006-12-20 2006-12-20 Novel compounds
GB0625458.5 2006-12-20
GB0700077.1 2007-01-03
GB0700077A GB0700077D0 (en) 2007-01-03 2007-01-03 Novel compounds

Publications (2)

Publication Number Publication Date
WO2008000777A2 WO2008000777A2 (en) 2008-01-03
WO2008000777A3 true WO2008000777A3 (en) 2008-02-07

Family

ID=38512590

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/056448 WO2008000777A2 (en) 2006-06-29 2007-06-27 Phenyl- pyrazole derivatives, process for their preparation and their pharmaceutical use

Country Status (1)

Country Link
WO (1) WO2008000777A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0611587D0 (en) * 2006-06-12 2006-07-19 Glaxo Group Ltd Novel compounds
CN107072976A (en) 2014-05-12 2017-08-18 葛兰素史克知识产权第二有限公司 The pharmaceutical composition for including Danirixin for treating communicable disease
WO2021191875A1 (en) 2020-03-26 2021-09-30 Glaxosmithkline Intellectual Property Development Limited Cathepsin inhibitors for preventing or treating viral infections

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999057101A1 (en) * 1998-05-05 1999-11-11 F. Hoffmann-La Roche Ag Pyrazole derivatives as p-38 map kinase inhibitors
WO2000032584A2 (en) * 1998-11-27 2000-06-08 Schering Aktiengesellschaft Nonsteroidal antiinflammatories
WO2004071389A2 (en) * 2003-02-15 2004-08-26 Glaxo Group Limited Non-steroidal infalmmation inhibitors
WO2005030213A1 (en) * 2003-09-24 2005-04-07 Boehringer Ingelheim Pharmaceuticals, Inc. 1,1,1-trifluoro-4-phenyl-4-methyl-2-(1h-pyrrolo
WO2007000334A1 (en) * 2005-06-29 2007-01-04 Glaxo Group Limited Phenyl-pyrazole derivatives as non-steroidal glucocorticoid receptor ligands

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999057101A1 (en) * 1998-05-05 1999-11-11 F. Hoffmann-La Roche Ag Pyrazole derivatives as p-38 map kinase inhibitors
WO2000032584A2 (en) * 1998-11-27 2000-06-08 Schering Aktiengesellschaft Nonsteroidal antiinflammatories
WO2004071389A2 (en) * 2003-02-15 2004-08-26 Glaxo Group Limited Non-steroidal infalmmation inhibitors
WO2005030213A1 (en) * 2003-09-24 2005-04-07 Boehringer Ingelheim Pharmaceuticals, Inc. 1,1,1-trifluoro-4-phenyl-4-methyl-2-(1h-pyrrolo
WO2007000334A1 (en) * 2005-06-29 2007-01-04 Glaxo Group Limited Phenyl-pyrazole derivatives as non-steroidal glucocorticoid receptor ligands

Also Published As

Publication number Publication date
WO2008000777A2 (en) 2008-01-03

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