SG11201709634QA - Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity - Google Patents
Nitrogen-containing tricyclic derivative having hiv replication inhibitory activityInfo
- Publication number
- SG11201709634QA SG11201709634QA SG11201709634QA SG11201709634QA SG11201709634QA SG 11201709634Q A SG11201709634Q A SG 11201709634QA SG 11201709634Q A SG11201709634Q A SG 11201709634QA SG 11201709634Q A SG11201709634Q A SG 11201709634QA SG 11201709634Q A SG11201709634Q A SG 11201709634QA
- Authority
- SG
- Singapore
- Prior art keywords
- nitrogen
- inhibitory activity
- hiv replication
- tricyclic derivative
- containing tricyclic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015109547 | 2015-05-29 | ||
| JP2015170222 | 2015-08-31 | ||
| JP2015223036 | 2015-11-13 | ||
| JP2016054215 | 2016-03-17 | ||
| PCT/JP2016/065702 WO2016194806A1 (en) | 2015-05-29 | 2016-05-27 | Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201709634QA true SG11201709634QA (en) | 2017-12-28 |
Family
ID=57442245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201709634QA SG11201709634QA (en) | 2015-05-29 | 2016-05-27 | Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10494380B2 (en) |
| EP (1) | EP3305789A4 (en) |
| JP (2) | JP6614585B2 (en) |
| KR (1) | KR20180011267A (en) |
| CN (2) | CN111138458A (en) |
| AU (1) | AU2016271762B2 (en) |
| BR (1) | BR112017025367A2 (en) |
| CA (1) | CA2987384A1 (en) |
| HK (1) | HK1253539A1 (en) |
| IL (1) | IL255580B (en) |
| MA (1) | MA43120A (en) |
| MX (1) | MX2017015256A (en) |
| RU (1) | RU2720145C2 (en) |
| SG (1) | SG11201709634QA (en) |
| TW (1) | TWI700284B (en) |
| WO (1) | WO2016194806A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2970282B1 (en) | 2013-03-15 | 2019-08-21 | Incyte Holdings Corporation | Tricyclic heterocycles as bet protein inhibitors |
| WO2015006193A1 (en) | 2013-07-08 | 2015-01-15 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| WO2015095492A1 (en) | 2013-12-19 | 2015-06-25 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| PL3134403T3 (en) | 2014-04-23 | 2020-07-13 | Incyte Corporation | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
| ES2855225T3 (en) | 2014-09-15 | 2021-09-23 | Incyte Corp | Tricyclic heterocycles for use as BET protein inhibitors |
| TW201722966A (en) | 2015-10-29 | 2017-07-01 | 英塞特公司 | Amorphous solid form of a BET protein inhibitor |
| CA3220975A1 (en) | 2016-06-20 | 2017-12-28 | Incyte Corporation | Crystalline solid forms of a bet inhibitor |
| WO2020151232A1 (en) * | 2019-01-23 | 2020-07-30 | 上海和誉生物医药科技有限公司 | 1,2,3,4-tetrahydroquinoxaline derivative, preparation method therefor and application thereof |
| JPWO2021107066A1 (en) | 2019-11-28 | 2021-06-03 | ||
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| CN112409493B (en) * | 2020-08-12 | 2022-09-30 | 浙江工业大学 | Recombinant fusion enzyme and application thereof in synthesis of methyl glyoxylate |
| CN114075212B (en) * | 2020-08-14 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | Fused tricyclic derivatives, preparation method thereof and application thereof in medicines |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU710876B2 (en) | 1996-02-21 | 1999-09-30 | Darwin Discovery Limited | Quinolones and their therapeutic use |
| JP2000505450A (en) * | 1996-02-21 | 2000-05-09 | ダーウィン・ディスカバリー・リミテッド | Quinolones and their therapeutic use |
| US5792774A (en) | 1996-02-21 | 1998-08-11 | Chiroscience Limited | Quinolones and their therapeutic use |
| DE19946289A1 (en) * | 1999-09-28 | 2001-03-29 | Basf Ag | Benzodiazepine derivatives, their production and use |
| SK1582003A3 (en) * | 2000-08-08 | 2003-08-05 | Sanofi Synthelabo | Benzimidazole derivatives, preparation and therapeutic use thereof |
| US7026311B2 (en) * | 2002-01-10 | 2006-04-11 | Abbott Gmbh & Co., Kg | Dibenzodiazepine derivatives, their preparation and use |
| WO2004069834A1 (en) * | 2003-02-07 | 2004-08-19 | Takeda Pharmaceutical Company Limited | Tricyclic compound, process for producing the same, and use |
| JP2004256531A (en) * | 2003-02-07 | 2004-09-16 | Takeda Chem Ind Ltd | Tricyclic ring compound, method for producing the same and use of the same |
| AR056918A1 (en) * | 2005-01-10 | 2007-11-07 | Tibotec Pharm Ltd | 2-OXO-3-CIANO-1,6A-DIAZA-TETRAHIDRO-FLUORANTENOS 1,5,6-REPLACED, PROCESS OF PREPARATION OF THE COMPOUND AND PHARMACEUTICAL COMPOSITION |
| KR20080035576A (en) * | 2005-08-05 | 2008-04-23 | 아스트라제네카 아베 | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators |
| US7939545B2 (en) | 2006-05-16 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| ATE541841T1 (en) | 2007-11-15 | 2012-02-15 | Boehringer Ingelheim Int | INHIBITORS OF REPLICATION OF THE HUMAN IMMUNODEFICIENCY VIRUS |
| CN102124011A (en) | 2007-11-15 | 2011-07-13 | 贝林格尔.英格海姆国际有限公司 | Inhibitors of human immunodeficiency virus replication |
| WO2009062308A1 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| EA201200631A1 (en) | 2007-11-16 | 2012-11-30 | Джилид Сайенсиз, Инк. | Inhibitors of Human Immunodeficiency Virus Replication |
| US8338441B2 (en) * | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| AU2010334958B2 (en) | 2009-12-23 | 2015-02-05 | Katholieke Universiteit Leuven | Novel antiviral compounds |
| CA2802492C (en) | 2010-07-02 | 2018-10-16 | Gilead Sciences, Inc. | 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds |
| CN103140474A (en) * | 2010-07-02 | 2013-06-05 | 吉里德科学公司 | Napht- 2 -ylacetic acid derivatives to treat aids |
| US8633200B2 (en) | 2010-09-08 | 2014-01-21 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| CA2817896A1 (en) | 2010-11-15 | 2012-05-24 | Viiv Healthcare Uk Limited | Inhibitors of hiv replication |
| BR112013011737A2 (en) | 2010-11-15 | 2016-08-09 | Univ Leuven Kath | compound, use of a compound pharmaceutical composition, and method of treating or preventing an HIV infection |
| US9029391B2 (en) | 2011-01-24 | 2015-05-12 | Viiv Healthcare Uk Limited | Isoquinoline compounds and methods for treating HIV |
| EP2508511A1 (en) | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2511273B8 (en) | 2011-04-15 | 2019-06-26 | Hivih | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP3181555B1 (en) | 2011-04-21 | 2018-11-28 | Gilead Sciences, Inc. | Benzothiazole compounds and their pharmaceutical use |
| WO2013002357A1 (en) | 2011-06-30 | 2013-01-03 | 塩野義製薬株式会社 | Hiv replication inhibitor |
| US8609653B2 (en) | 2011-07-15 | 2013-12-17 | Glaxosmithkline Llc | Azaindole compounds and methods for treating HIV |
| US8791108B2 (en) | 2011-08-18 | 2014-07-29 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP2757887B1 (en) | 2011-09-22 | 2017-04-26 | VIIV Healthcare UK Limited | Pyrrolopyridinone compounds and methods for treating hiv |
| US9199959B2 (en) | 2011-10-25 | 2015-12-01 | Shionogi & Co., Ltd. | HIV replication inhibitor |
| KR101467477B1 (en) | 2011-11-15 | 2014-12-02 | 한국화학연구원 | Novel antiviral pyrrolopyridine derivatives and a preparation method thereof |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| WO2013103724A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids |
| US8629276B2 (en) | 2012-02-15 | 2014-01-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9034882B2 (en) | 2012-03-05 | 2015-05-19 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| WO2013157622A1 (en) | 2012-04-19 | 2013-10-24 | 塩野義製薬株式会社 | Hiv replication inhibitor |
| ES2668422T3 (en) | 2012-04-20 | 2018-05-18 | Gilead Sciences, Inc. | Benzothiazol-6-yl acetic acid derivatives and their use to treat an HIV infection |
| WO2014009794A1 (en) * | 2012-07-12 | 2014-01-16 | Viiv Healthcare Uk Limited | Compounds and methods for treating hiv |
| US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| EP2716639A1 (en) | 2012-10-05 | 2014-04-09 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2716632A1 (en) | 2012-10-05 | 2014-04-09 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| EP2719685A1 (en) | 2012-10-11 | 2014-04-16 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| TW201441197A (en) | 2013-01-31 | 2014-11-01 | Shionogi & Co | HIV replication inhibitor |
| ES2623777T3 (en) | 2013-03-13 | 2017-07-12 | VIIV Healthcare UK (No.5) Limited | Human immunodeficiency virus replication inhibitors |
| US9580431B2 (en) | 2013-03-13 | 2017-02-28 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
| CN105189503B (en) | 2013-03-14 | 2017-03-22 | 百时美施贵宝公司 | Inhibitors of human immunodeficiency virus replication |
| EP3107913B1 (en) | 2014-02-19 | 2018-07-04 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
| WO2015147247A1 (en) * | 2014-03-28 | 2015-10-01 | 塩野義製薬株式会社 | Tricyclic derivative having hiv replication inhibitory activity |
| JP6579549B2 (en) * | 2014-05-16 | 2019-09-25 | 塩野義製薬株式会社 | Tricyclic heterocyclic derivatives having HIV replication inhibitory action |
| WO2015179448A1 (en) | 2014-05-21 | 2015-11-26 | Gilead Sciences, Inc. | Therapeutic compounds |
| WO2016005878A1 (en) | 2014-07-08 | 2016-01-14 | Viiv Healthcare Uk Limited | Isoindoline derivatives for use in the treatment of a viral infection |
| ES2703352T3 (en) | 2014-07-22 | 2019-03-08 | Viiv Healthcare Uk Ltd | Isoindoline derivatives useful as antiviral agents |
| RU2017107715A (en) | 2014-08-27 | 2018-09-27 | ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД | Imidazo [1,2-a] pyridine derivatives for use as inhibitors of human immunodeficiency virus replication |
| TW201720798A (en) | 2015-09-17 | 2017-06-16 | Ｖｉｉｖ醫療保健英國有限公司 | Benzoazepine derivatives |
| WO2017093930A1 (en) | 2015-12-04 | 2017-06-08 | Viiv Healthcare Uk Limited | Isoindoline derivatives |
| JP2018536000A (en) | 2015-12-04 | 2018-12-06 | ヴィーブ ヘルスケア ユーケー リミテッド | Isoindoline derivatives |
| JP2018536001A (en) | 2015-12-04 | 2018-12-06 | ヴィーブ ヘルスケア ユーケー リミテッド | Isoindoline derivatives |
| US20180334436A1 (en) | 2015-12-04 | 2018-11-22 | Viiv Healthcare Uk Limited | Tetrahydroisoquinoline derivatives |
-
2016
- 2016-05-27 CA CA2987384A patent/CA2987384A1/en not_active Abandoned
- 2016-05-27 MX MX2017015256A patent/MX2017015256A/en unknown
- 2016-05-27 MA MA043120A patent/MA43120A/en unknown
- 2016-05-27 JP JP2017521897A patent/JP6614585B2/en not_active Expired - Fee Related
- 2016-05-27 CN CN202010066935.5A patent/CN111138458A/en active Pending
- 2016-05-27 RU RU2017145082A patent/RU2720145C2/en active
- 2016-05-27 CN CN201680043904.XA patent/CN107922423B/en not_active Expired - Fee Related
- 2016-05-27 SG SG11201709634QA patent/SG11201709634QA/en unknown
- 2016-05-27 TW TW105116757A patent/TWI700284B/en not_active IP Right Cessation
- 2016-05-27 AU AU2016271762A patent/AU2016271762B2/en not_active Ceased
- 2016-05-27 WO PCT/JP2016/065702 patent/WO2016194806A1/en active Application Filing
- 2016-05-27 KR KR1020177037486A patent/KR20180011267A/en unknown
- 2016-05-27 EP EP16803241.5A patent/EP3305789A4/en not_active Withdrawn
- 2016-05-27 BR BR112017025367-4A patent/BR112017025367A2/en active Search and Examination
- 2016-05-27 US US15/577,795 patent/US10494380B2/en not_active Expired - Fee Related
-
2017
- 2017-11-09 IL IL255580A patent/IL255580B/en active IP Right Grant
-
2018
- 2018-10-05 HK HK18112740.8A patent/HK1253539A1/en unknown
-
2019
- 2019-10-28 US US16/665,231 patent/US10870661B2/en active Active
- 2019-10-29 JP JP2019196066A patent/JP6797464B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2987384A1 (en) | 2016-12-08 |
| HK1253539A1 (en) | 2019-06-21 |
| CN111138458A (en) | 2020-05-12 |
| RU2017145082A (en) | 2019-07-01 |
| CN107922423A (en) | 2018-04-17 |
| EP3305789A4 (en) | 2018-11-21 |
| EP3305789A1 (en) | 2018-04-11 |
| MX2017015256A (en) | 2018-02-19 |
| US10494380B2 (en) | 2019-12-03 |
| JP6797464B2 (en) | 2020-12-09 |
| TW201706275A (en) | 2017-02-16 |
| KR20180011267A (en) | 2018-01-31 |
| BR112017025367A2 (en) | 2018-08-07 |
| TWI700284B (en) | 2020-08-01 |
| JP2020097568A (en) | 2020-06-25 |
| MA43120A (en) | 2018-09-05 |
| IL255580B (en) | 2020-11-30 |
| IL255580A (en) | 2018-01-31 |
| US10870661B2 (en) | 2020-12-22 |
| RU2720145C2 (en) | 2020-04-24 |
| AU2016271762A1 (en) | 2017-11-30 |
| CN107922423B (en) | 2020-10-27 |
| JP6614585B2 (en) | 2019-12-04 |
| RU2017145082A3 (en) | 2019-10-24 |
| JPWO2016194806A1 (en) | 2018-03-22 |
| AU2016271762B2 (en) | 2020-01-23 |
| WO2016194806A1 (en) | 2016-12-08 |
| US20180162876A1 (en) | 2018-06-14 |
| US20200055873A1 (en) | 2020-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1253539A1 (en) | Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity | |
| IL291598A (en) | Cytotoxic benzodiazepine derivatives | |
| HK1245253A1 (en) | Parg inhibitory compounds | |
| EP3193667A4 (en) | Modular shelving | |
| ZA201900019B (en) | Pharmaceutical combinations | |
| PL3310784T3 (en) | Tricyclic compounds and their use as phosphodiesterase inhibitors. | |
| GB2529856B (en) | Modular furniture system | |
| IL257808B (en) | Waterless decarboxylation | |
| HK1253011A1 (en) | Combination hiv therapeutic | |
| EP3144311A4 (en) | Tricyclic heterocyclic derivative having hiv replication-inhibiting effect | |
| PL3531872T3 (en) | Furniture | |
| HK1245796A1 (en) | Xanthine derivative | |
| PT3187071T (en) | Drawer | |
| EP3174864A4 (en) | Vmat inhibitory compounds | |
| GB201612404D0 (en) | Vdu | |
| GB201607978D0 (en) | Inhibitory compounds | |
| AU201613667S (en) | Log splitter | |
| GB201610579D0 (en) | Furniture | |
| AU2015904138A0 (en) | Saddle Shelving | |
| GB201517291D0 (en) | Modular furniture system | |
| GB201509287D0 (en) | Modular furniture system | |
| GB201402369D0 (en) | Pair Pursuit |