CN103204903A - 丙型肝炎抑制剂化合物 - Google Patents

丙型肝炎抑制剂化合物 Download PDF

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Publication number
CN103204903A
CN103204903A CN2013100935669A CN201310093566A CN103204903A CN 103204903 A CN103204903 A CN 103204903A CN 2013100935669 A CN2013100935669 A CN 2013100935669A CN 201310093566 A CN201310093566 A CN 201310093566A CN 103204903 A CN103204903 A CN 103204903A
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CN
China
Prior art keywords
alkyl
cycloalkyl
compound
milliliters
replace
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2013100935669A
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English (en)
Chinese (zh)
Inventor
蒙特斯.利纳斯-布鲁尼特
默里.D.贝利
普尼特.巴德瓦
乔斯.博德利厄
帕斯奎尔.福乔尼
埃莉斯.吉罗
维达.戈里斯
纳撒利.古德里厄
西尔维.古莱特
特迪.哈尔莫斯
让.兰考特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33476973&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN103204903(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CN103204903A publication Critical patent/CN103204903A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2013100935669A 2003-05-21 2004-05-19 丙型肝炎抑制剂化合物 Pending CN103204903A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47270903P 2003-05-21 2003-05-21
US60/472,709 2003-05-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800137831A Division CN1791599A (zh) 2003-05-21 2004-05-19 丙型肝炎抑制剂化合物

Publications (1)

Publication Number Publication Date
CN103204903A true CN103204903A (zh) 2013-07-17

Family

ID=33476973

Family Applications (3)

Application Number Title Priority Date Filing Date
CNA2004800137831A Pending CN1791599A (zh) 2003-05-21 2004-05-19 丙型肝炎抑制剂化合物
CN201310097223XA Pending CN103203010A (zh) 2003-05-21 2004-05-19 包含丙型肝炎抑制剂化合物的药物组合物
CN2013100935669A Pending CN103204903A (zh) 2003-05-21 2004-05-19 丙型肝炎抑制剂化合物

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CNA2004800137831A Pending CN1791599A (zh) 2003-05-21 2004-05-19 丙型肝炎抑制剂化合物
CN201310097223XA Pending CN103203010A (zh) 2003-05-21 2004-05-19 包含丙型肝炎抑制剂化合物的药物组合物

Country Status (33)

Country Link
US (5) US7585845B2 (US08067438-20111129-C00015.png)
EP (1) EP1654261B1 (US08067438-20111129-C00015.png)
JP (2) JP4447603B2 (US08067438-20111129-C00015.png)
KR (1) KR101115294B1 (US08067438-20111129-C00015.png)
CN (3) CN1791599A (US08067438-20111129-C00015.png)
AT (1) ATE378334T1 (US08067438-20111129-C00015.png)
AU (1) AU2004240704B9 (US08067438-20111129-C00015.png)
BR (1) BRPI0410456B8 (US08067438-20111129-C00015.png)
CA (1) CA2522577C (US08067438-20111129-C00015.png)
CL (1) CL2004001161A1 (US08067438-20111129-C00015.png)
CO (1) CO5630024A2 (US08067438-20111129-C00015.png)
CY (1) CY1107200T1 (US08067438-20111129-C00015.png)
DE (1) DE602004010137T2 (US08067438-20111129-C00015.png)
DK (1) DK1654261T3 (US08067438-20111129-C00015.png)
EA (1) EA009295B1 (US08067438-20111129-C00015.png)
EC (1) ECSP056181A (US08067438-20111129-C00015.png)
ES (1) ES2297424T3 (US08067438-20111129-C00015.png)
HR (1) HRP20080014T3 (US08067438-20111129-C00015.png)
IL (1) IL172013A (US08067438-20111129-C00015.png)
ME (1) MEP58308A (US08067438-20111129-C00015.png)
MX (1) MXPA05012545A (US08067438-20111129-C00015.png)
MY (1) MY143076A (US08067438-20111129-C00015.png)
NO (1) NO332056B1 (US08067438-20111129-C00015.png)
NZ (1) NZ544076A (US08067438-20111129-C00015.png)
PE (1) PE20050204A1 (US08067438-20111129-C00015.png)
PL (1) PL1654261T3 (US08067438-20111129-C00015.png)
PT (1) PT1654261E (US08067438-20111129-C00015.png)
RS (1) RS51294B (US08067438-20111129-C00015.png)
TW (1) TWI327145B (US08067438-20111129-C00015.png)
UA (1) UA83046C2 (US08067438-20111129-C00015.png)
UY (1) UY28323A1 (US08067438-20111129-C00015.png)
WO (1) WO2004103996A1 (US08067438-20111129-C00015.png)
ZA (1) ZA200508201B (US08067438-20111129-C00015.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108610301A (zh) * 2016-12-12 2018-10-02 中山大学 一类手性芳杂胺类衍生物及其合成方法和应用

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