CN102439015B - 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途 - Google Patents

1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途 Download PDF

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CN102439015B
CN102439015B CN201080020624.XA CN201080020624A CN102439015B CN 102439015 B CN102439015 B CN 102439015B CN 201080020624 A CN201080020624 A CN 201080020624A CN 102439015 B CN102439015 B CN 102439015B
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alkyl
formula
disorder
compound
compounds
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CN102439015A (zh
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乔斯·玛丽亚·锡德-努涅斯
阿纳·伊莎贝尔·德卢卡斯奥利瓦雷斯
安德烈斯·阿韦利诺·特拉班科-苏亚雷斯
格雷戈尔·詹姆斯·麦克唐纳
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Janssen Pharmaceutica NV
Addex Pharmaceuticals SA
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Janssen Pharmaceutica NV
Addex Pharmaceuticals SA
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CN201080020624.XA 2009-05-12 2010-05-11 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途 Expired - Fee Related CN102439015B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09160067 2009-05-12
EP09160067.6 2009-05-12
PCT/EP2010/002908 WO2010130422A1 (en) 2009-05-12 2010-05-11 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors

Publications (2)

Publication Number Publication Date
CN102439015A CN102439015A (zh) 2012-05-02
CN102439015B true CN102439015B (zh) 2015-05-13

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Country Status (20)

Country Link
US (1) US8946205B2 (https=)
EP (1) EP2430031B1 (https=)
JP (1) JP5707390B2 (https=)
KR (1) KR20120035158A (https=)
CN (1) CN102439015B (https=)
AR (1) AR076859A1 (https=)
AU (1) AU2010246607B2 (https=)
BR (1) BRPI1010831A2 (https=)
CA (1) CA2760259C (https=)
CL (1) CL2011002837A1 (https=)
EA (1) EA020671B1 (https=)
ES (1) ES2409006T3 (https=)
IL (1) IL215910A (https=)
MX (1) MX2011011962A (https=)
MY (1) MY153912A (https=)
NZ (1) NZ596053A (https=)
SG (1) SG176018A1 (https=)
TW (1) TW201100417A (https=)
WO (1) WO2010130422A1 (https=)
ZA (1) ZA201107836B (https=)

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CN101861316B (zh) 2007-11-14 2013-08-21 奥梅-杨森制药有限公司 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
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JP5690277B2 (ja) 2008-11-28 2015-03-25 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
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ES2536433T3 (es) 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
US20130230459A1 (en) 2010-11-08 2013-09-05 Janssen Pharmaceuticals, Inc. RADIOLABELLED mGluR2 PET LIGANDS
US8765767B2 (en) 2012-03-16 2014-07-01 Bristol-Myers Squibb Company Positive allosteric modulators of mGluR2
JO3368B1 (ar) * 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
US9738642B2 (en) 2013-09-19 2017-08-22 Bristol-Myers Squibb Company Triazolopyridine ether derivatives and their use in neurological and pyschiatric disorders
MX386697B (es) 2014-01-21 2025-03-19 Janssen Pharmaceutica Nv Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso
ME03518B (me) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena
JP6678672B2 (ja) 2014-12-11 2020-04-08 ヤンセン ファーマシューティカ エヌ．ベー． １，２，４−トリアゾロ［４，３−ａ］ピリジン化合物およびＭＧＬＵＲ２受容体の正のアロステリック調節因子としてのその使用
JP6953527B2 (ja) * 2016-10-26 2021-10-27 ヤンセン ファーマシューティカ エヌ．ベー． 縮合二環ピリジン化合物、及びａｍｐａ受容体調節因子としてのそれらの使用
WO2019021208A1 (en) * 2017-07-27 2019-01-31 Glaxosmithkline Intellectual Property Development Limited USEFUL INDAZOLE DERIVATIVES AS PERK INHIBITORS
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN111116582B (zh) * 2019-12-18 2022-07-29 大连大学 一种mGluR2拮抗剂

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