CN102164902B - 作为吲哚胺2,3-双加氧酶的抑制剂的1,2,5-噁二唑 - Google Patents

作为吲哚胺2,3-双加氧酶的抑制剂的1,2,5-噁二唑 Download PDF

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Publication number
CN102164902B
CN102164902B CN200980134351.9A CN200980134351A CN102164902B CN 102164902 B CN102164902 B CN 102164902B CN 200980134351 A CN200980134351 A CN 200980134351A CN 102164902 B CN102164902 B CN 102164902B
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amino
compound
formula
oxadiazol
hydroxyl
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Expired - Fee Related
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Chinese (zh)
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CN102164902A (zh
Inventor
A·P·坎布斯
E·W·岳
R·B·斯帕克斯
W·朱
J·周
Q·林
L·翁
T-Y·岳
P·刘
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Incyte Holdings Corp
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Incyte Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Neurology (AREA)
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  • Virology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
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  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • AIDS & HIV (AREA)
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  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200980134351.9A 2008-07-08 2009-07-07 作为吲哚胺2,3-双加氧酶的抑制剂的1,2,5-噁二唑 Expired - Fee Related CN102164902B (zh)

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CN201410287499.9A CN104042611B (zh) 2008-07-08 2009-07-07 作为吲哚胺2，3-双加氧酶的抑制剂的1，2，5-噁二唑

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Application Number Priority Date Filing Date Title
US7887608P 2008-07-08 2008-07-08
US61/078876 2008-07-08
US61/078,876 2008-07-08
US15087309P 2009-02-09 2009-02-09
US61/150,873 2009-02-09
US61/150873 2009-02-09
PCT/US2009/049794 WO2010005958A2 (en) 2008-07-08 2009-07-07 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase

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CN102164902A CN102164902A (zh) 2011-08-24
CN102164902B true CN102164902B (zh) 2014-07-23

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CN201410287499.9A Expired - Fee Related CN104042611B (zh) 2008-07-08 2009-07-07 作为吲哚胺2，3-双加氧酶的抑制剂的1，2，5-噁二唑

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI651311B (zh) 2013-11-08 2019-02-21 英塞特控股公司 用於合成吲哚胺２，３－雙加氧酶抑制劑之方法
CN104042611B (zh) * 2008-07-08 2019-05-14 因塞特控股公司 作为吲哚胺2，3-双加氧酶的抑制剂的1，2，5-噁二唑

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