CN101415813B - 微流体装置 - Google Patents

微流体装置 Download PDF

Info

Publication number
CN101415813B
CN101415813B CN2007800117954A CN200780011795A CN101415813B CN 101415813 B CN101415813 B CN 101415813B CN 2007800117954 A CN2007800117954 A CN 2007800117954A CN 200780011795 A CN200780011795 A CN 200780011795A CN 101415813 B CN101415813 B CN 101415813B
Authority
CN
China
Prior art keywords
microchip
sample
beads
samples
chip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800117954A
Other languages
English (en)
Chinese (zh)
Other versions
CN101415813A (zh
Inventor
S·B·乔瓦诺维齐
I·I·布拉加
D·兰克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Integenx Inc
Original Assignee
Microchip Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchip Biotechnologies Inc filed Critical Microchip Biotechnologies Inc
Publication of CN101415813A publication Critical patent/CN101415813A/zh
Application granted granted Critical
Publication of CN101415813B publication Critical patent/CN101415813B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00514—Stationary mixing elements
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/16—Phosphorus containing
    • Y10T436/163333—Organic [e.g., chemical warfare agents, insecticides, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25875—Gaseous sample or with change of physical state

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Mechanical Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
CN2007800117954A 2006-02-03 2007-02-02 微流体装置 Expired - Fee Related CN101415813B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76498006P 2006-02-03 2006-02-03
US60/764,980 2006-02-03
PCT/US2007/061573 WO2008030631A2 (en) 2006-02-03 2007-02-02 Microfluidic devices

Publications (2)

Publication Number Publication Date
CN101415813A CN101415813A (zh) 2009-04-22
CN101415813B true CN101415813B (zh) 2013-04-10

Family

ID=39157909

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800117954A Expired - Fee Related CN101415813B (zh) 2006-02-03 2007-02-02 微流体装置

Country Status (7)

Country Link
US (4) US7745207B2 (enExample)
EP (1) EP1979079A4 (enExample)
JP (1) JP5063616B2 (enExample)
KR (1) KR20080096567A (enExample)
CN (1) CN101415813B (enExample)
CA (1) CA2641271A1 (enExample)
WO (1) WO2008030631A2 (enExample)

Families Citing this family (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2290731A1 (en) * 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
DK1432786T3 (da) 2001-09-06 2009-10-26 Rapid Micro Biosystems Inc Hurtig detektion af replikerede celler
US20030108664A1 (en) * 2001-10-05 2003-06-12 Kodas Toivo T. Methods and compositions for the formation of recessed electrical features on a substrate
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US7445926B2 (en) * 2002-12-30 2008-11-04 The Regents Of The University Of California Fluid control structures in microfluidic devices
US7799553B2 (en) * 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
CN101073002B (zh) 2004-09-15 2012-08-08 英特基因有限公司 微流体装置
GB0421529D0 (en) 2004-09-28 2004-10-27 Landegren Gene Technology Ab Microfluidic structure
WO2007038478A2 (en) * 2005-09-26 2007-04-05 Rapid Micro Biosystems, Inc Cassette containing growth medium
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
JP5063616B2 (ja) 2006-02-03 2012-10-31 インテジェニックス インコーポレイテッド マイクロ流体デバイス
US7766033B2 (en) * 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
WO2007123908A2 (en) 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
KR20100028526A (ko) * 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 및 나노유체 장치, 시스템 및 응용
US20100151465A1 (en) * 2008-03-27 2010-06-17 Jingyue Ju Selective Capture and Release of Analytes
US8454906B2 (en) 2007-07-24 2013-06-04 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
WO2009049268A1 (en) 2007-10-12 2009-04-16 Rheonix, Inc. Integrated microfluidic device and methods
US20090253181A1 (en) 2008-01-22 2009-10-08 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
US8585916B2 (en) * 2008-01-24 2013-11-19 Sandia Corporation Micropores and methods of making and using thereof
EP2133149A1 (en) * 2008-06-13 2009-12-16 F.Hoffmann-La Roche Ag Lab-on-disc device
US10718909B2 (en) 2008-07-29 2020-07-21 Glenair, Inc. Expanded beam fiber optic connection system
US20110263044A1 (en) * 2008-07-31 2011-10-27 Eads Deutschland Gmbh Device and method for the automatic detection of biological particles
JP5492207B2 (ja) * 2008-08-27 2014-05-14 ライフ テクノロジーズ コーポレーション 生物学的サンプルの処理装置および処理方法
US11235323B2 (en) 2008-08-27 2022-02-01 Life Technologies Corporation Apparatus for and method of processing biological samples
EP2340300B1 (en) * 2008-09-24 2013-12-18 Straus Holdings Inc. Method for detecting analytes
WO2010048631A2 (en) * 2008-10-24 2010-04-29 Biomicro, Inc. Modular system for performing laboratory protocols and associated methods
GB2478449B (en) * 2008-12-23 2013-01-30 Optimize Tech Inc Assembly for placing an insert into communication with an analytical chemical instrument
KR20110111449A (ko) * 2008-12-31 2011-10-11 인터젠엑스 인크. 미세유체 칩을 갖는 기구
US9012208B2 (en) * 2009-02-03 2015-04-21 Netbio, Inc. Nucleic acid purification
WO2010101926A2 (en) * 2009-03-02 2010-09-10 The Johns Hopkins University Microfluidic system for high-throughput, droplet-based single molecule analysis with low reagent consumption
US9090663B2 (en) * 2009-04-21 2015-07-28 The Trustees Of Columbia University In The City Of New York Systems and methods for the capture and separation of microparticles
GB2473868A (en) 2009-09-28 2011-03-30 Invitrogen Dynal As Apparatus and method of automated processing of biological samples
US8388908B2 (en) * 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
GB2483402B (en) 2009-06-04 2014-04-09 Lockheed Corp Multiple-sample microfluidic chip for DNA analysis
EP2438016B1 (en) 2009-06-05 2021-06-02 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
GB0913228D0 (en) * 2009-07-29 2009-09-02 Iti Scotland Ltd Loading element
KR101122124B1 (ko) * 2009-11-17 2012-03-16 주식회사 아모그린텍 분석물질의 검출 방법 및 장치
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
WO2013134744A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc Microfluidic assay assemblies and methods of manufacture
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
JP5701894B2 (ja) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド アッセイを行う方法及び装置
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US9321051B2 (en) 2009-12-22 2016-04-26 Samsung Electronics Co., Ltd. Microfluidic device and method of manufacturing the same
KR20110072275A (ko) * 2009-12-22 2011-06-29 삼성전자주식회사 미세 유체 소자 및 그 제조방법
DK2526119T3 (en) 2010-01-19 2018-07-30 Harvard College Manipulated opsonin for pathogen detection and treatment
US9689792B1 (en) * 2010-01-21 2017-06-27 The United States Of America As Represented By The Secretary Of The Army Biological material detection apparatus
US9651520B2 (en) * 2010-02-25 2017-05-16 Mettler-Toledo Thornton, Inc. Microfluidic interface for a microchip
JP5585138B2 (ja) * 2010-03-17 2014-09-10 オムロン株式会社 流路チップ及び治具
US20110240127A1 (en) * 2010-04-02 2011-10-06 Integenx Inc. Fluidic Article Fabricated In One Piece
USD673286S1 (en) 2010-04-29 2012-12-25 Sony Corporation Micro flow channel chip
USD869308S1 (en) 2010-04-29 2019-12-10 Sony Corporation Micro flow channel chip
USD673287S1 (en) * 2010-11-24 2012-12-25 Sony Corporation Micro flow channel chip
WO2011139888A2 (en) 2010-04-29 2011-11-10 Statspin, Inc. Analytical system for performing laboratory protocols and associated methods
US8475738B2 (en) * 2010-05-04 2013-07-02 Electronics And Telecommunications Research Institute Photocatalytic apparatus and method for injecting microfluidic volumes
WO2011137533A1 (en) 2010-05-05 2011-11-10 The Governing Council Of The University Of Toronto Method of processing dried samples using digital microfluidic device
CN105803534A (zh) * 2010-05-06 2016-07-27 艾比斯生物科学公司 集成样品制备系统和稳定的酶混合物
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
EP2606242A4 (en) 2010-08-20 2016-07-20 Integenx Inc MICROFLUIDIC DEVICES WITH MECHANICALLY SEALED MEMBRANE VALVES
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
US9114399B2 (en) * 2010-08-31 2015-08-25 Canon U.S. Life Sciences, Inc. System and method for serial processing of multiple nucleic acid assays
CA2813090C (en) 2010-10-01 2019-11-12 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods incorporating a solid phase
WO2012051529A1 (en) 2010-10-15 2012-04-19 Lockheed Martin Corporation Micro fluidic optic design
US8895297B2 (en) 2010-10-29 2014-11-25 Samsung Electronics Co., Ltd. Micro-device and methods for disrupting cells
CN102465110B (zh) * 2010-10-29 2015-08-19 三星电子株式会社 细胞裂解装置和使细胞或病毒裂解的方法
KR101776215B1 (ko) 2010-10-29 2017-09-08 삼성전자 주식회사 세포 파쇄용 마이크로 디바이스 및 이를 이용한 세포 파쇄 방법
WO2012067985A2 (en) * 2010-11-18 2012-05-24 The Regents Of The University Of California Method and device for high-throughput solution exchange for cell and particle suspensions
US9815060B2 (en) 2010-11-18 2017-11-14 The Regents Of The University Of California Method and device for high-throughput solution exchange for cell and particle suspensions
KR101889100B1 (ko) * 2011-04-12 2018-08-16 엘지전자 주식회사 진단용 카트리지 및 진단용 카트리지 제어 방법
WO2012096480A2 (en) * 2011-01-10 2012-07-19 Lg Electronics Inc. Diagnostic cartridge and control method for diagnostic cartridge
US9377422B2 (en) 2011-01-14 2016-06-28 The Charles Stark Draper Laboratory, Inc. System and method for a microfluidic calorimeter
JP5978287B2 (ja) 2011-03-22 2016-08-24 サイヴェク・インコーポレイテッド マイクロ流体装置並びに製造及び使用の方法
WO2013066418A1 (en) * 2011-06-14 2013-05-10 Corning Incorporated Hybrid microfluidic assemblies
US9593160B2 (en) 2011-07-18 2017-03-14 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
WO2013019714A1 (en) 2011-07-29 2013-02-07 The Trustees Of Columbia University In The City Of New York Mems affinity sensor for continuous monitoring of analytes
TWM426766U (en) * 2011-10-13 2012-04-11 Chin-Feng Wan Microfluidic chip
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US8894946B2 (en) 2011-10-21 2014-11-25 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
DK2776550T3 (en) 2011-11-07 2018-02-19 Rapid Micro Biosystems Inc Cartridge for sterility testing
CN104145014A (zh) * 2011-11-11 2014-11-12 爱库倍特公司 用于进行扩增子挽救多重聚合酶链式反应(pcr)的系统和方法
US9475025B2 (en) 2011-12-29 2016-10-25 General Electric Company Microfluidic handling system
US9382569B1 (en) * 2012-01-17 2016-07-05 Elemental Scientific, Inc. Fast detection of the presence of a target microbe in a liquid sample
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
CA2866854C (en) 2012-03-09 2020-08-18 Leica Biosystems Richmond, Inc. Device and method for controlling the temperature in a moving fluid in a laboratory sample processing system
CA3138752C (en) 2012-04-03 2024-02-06 Illumina, Inc. Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
KR101959447B1 (ko) * 2012-04-06 2019-03-18 삼성전자주식회사 시료 중의 표적물질을 효율적으로 처리하는 방법
WO2013158666A1 (en) 2012-04-16 2013-10-24 Rapid Micro Biosystems, Inc. Cell culturing device
JP2013255447A (ja) * 2012-06-12 2013-12-26 Nippon Koden Corp 細胞単離装置
CN103571824B (zh) 2012-08-09 2016-04-13 财团法人工业技术研究院 用于分离核酸的组合物及方法
EP4480582A1 (en) 2013-01-18 2024-12-25 Biomeme, Inc. Analytic device
US9169521B1 (en) * 2013-03-14 2015-10-27 The Boeing Company Point-of-collection sample preparation device and method
EP2976642A4 (en) 2013-03-15 2016-09-21 Harvard College METHOD AND COMPOSITIONS FOR IMPROVING THE DETECTION AND / OR RECORDING OF A TARGET UNIT
KR101653701B1 (ko) 2013-03-15 2016-09-02 지멘스 헬쓰케어 다이아그노스틱스 인크. 미세유체 분배 장치
WO2014143658A1 (en) * 2013-03-15 2014-09-18 The Charles Stark Draper Laboratory, Inc. System and method for a microfluidic calorimeter
SE537452C2 (sv) * 2013-04-02 2015-05-05 Btg Instr Ab Provtagnings-och analysanordning
EP3848045A1 (en) 2013-05-21 2021-07-14 President and Fellows of Harvard College Engineered heme-binding compositions and uses thereof
ES2817425T3 (es) * 2013-05-24 2021-04-07 Illumina Cambridge Ltd Secuenciado pirofosforolítico usando nanoporos
CN103540672B (zh) * 2013-10-29 2015-04-08 中国科学技术大学 一种亲和核酸分子的快速鉴定和分离方法
CA2928843C (en) * 2013-11-01 2021-11-23 Marc Dominic Dejohn Sample extraction and preparation device
EP3068536A4 (en) * 2013-11-13 2017-07-26 Canon U.S. Life Sciences, Inc. Thermal control systems and methods using thermally guarded multiplexed sensors
CN118287167A (zh) 2013-11-18 2024-07-05 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
EP2878375A1 (en) * 2013-11-29 2015-06-03 Genewave Microfluidic cartridge for molecular diagnosis, docking station using such a microfluidic cartridge, and process for analyzing a biological sample
WO2015084748A1 (en) * 2013-12-03 2015-06-11 Perfinity Biosciences, Inc A single reactor for simplified sample preparation workflows
EP3546474B1 (en) 2013-12-18 2021-07-07 President and Fellows of Harvard College Crp capture/detection of gram positive bacteria
US20150166326A1 (en) * 2013-12-18 2015-06-18 Berkeley Lights, Inc. Capturing Specific Nucleic Acid Materials From Individual Biological Cells In A Micro-Fluidic Device
GB201401584D0 (en) * 2014-01-29 2014-03-19 Bg Res Ltd Intelligent detection of biological entities
GB2523825A (en) 2014-03-07 2015-09-09 Ibm Fabrication of annular microfluidic probe heads
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
JP6500349B2 (ja) * 2014-06-03 2019-04-17 株式会社島津製作所 培地用バルブ及びこれを備えた培地供給システム
MY182488A (en) * 2014-08-05 2021-01-25 Sanwa Biotech Ltd On-site diagnostic system and the method therof
WO2016022696A1 (en) 2014-08-05 2016-02-11 The Trustees Of Columbia University In The City Of New York Method of isolating aptamers for minimal residual disease detection
EP3552690B1 (en) 2014-10-22 2024-09-25 IntegenX Inc. Systems and methods for sample preparation, processing and analysis
US10210410B2 (en) 2014-10-22 2019-02-19 Integenx Inc. Systems and methods for biometric data collections
US10357780B2 (en) 2014-10-27 2019-07-23 President And Fellows Of Harvard College Magnetic capture of a target from a fluid
CN113943773A (zh) * 2014-11-05 2022-01-18 加州理工学院 生物体对药物的响应的微流体测量
US9970437B2 (en) * 2014-11-25 2018-05-15 Genia Technologies, Inc. Two-way pump selectable valve and bypass waste channel
WO2016116790A1 (en) * 2015-01-22 2016-07-28 Kwazulu-Natal Research Institute For Tb-Hiv (K-Rith) Npc Microdialysis device
US9702793B2 (en) 2015-03-16 2017-07-11 Todd A Balisky Variable volume sample capture device
US10471428B2 (en) 2015-05-11 2019-11-12 The University Of North Carolina At Chapel Hill Fluidic devices with nanoscale manifolds for molecular transport, related systems and methods of analysis
WO2016197106A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Evaporation management in digital microfluidic devices
EP3303547A4 (en) 2015-06-05 2018-12-19 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
CN113791203B (zh) 2015-06-12 2024-05-17 芯易诊有限公司 用于分析生物样品的方法
CN107922941A (zh) * 2015-06-15 2018-04-17 塞弗德公司 在自动化反应盒中DNA甲基化的整合的纯化和测量以及突变和/或mRNA表达水平的共同测量
US10233491B2 (en) 2015-06-19 2019-03-19 IntegenX, Inc. Valved cartridge and system
JP6409971B2 (ja) * 2015-07-06 2018-10-24 株式会社島津製作所 オートサンプラ及び液体クロマトグラフ
WO2017011554A1 (en) 2015-07-14 2017-01-19 Cytochip Inc. Volume sensing in fluidic cartridge
EP3763378A1 (en) 2015-08-06 2021-01-13 President and Fellows of Harvard College Improved microbe-binding molecules and uses thereof
JP6714603B2 (ja) * 2015-10-09 2020-07-01 シスメックス株式会社 検体処理チップ、検体処理装置および検体処理方法
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
CN108431199B (zh) * 2016-01-05 2022-04-08 日本板硝子株式会社 反应处理装置和反应处理方法
EP3478409A1 (en) * 2016-06-29 2019-05-08 Miltenyi Biotec GmbH Multilevel disposable cartridge for biological specimens
EP3500660A4 (en) 2016-08-22 2020-03-04 Miroculus Inc. FEEDBACK SYSTEM FOR CONTROLLING PARALLEL DROPLETS IN A DIGITAL MICROFLUIDIC DEVICE
WO2018058078A1 (en) 2016-09-23 2018-03-29 California Institute Of Technology Digital quantification of dna replication and/or chromosome segregation based determination of antimicrobial susceptibility
DE102016222032A1 (de) * 2016-11-10 2018-05-17 Robert Bosch Gmbh Mikrofluidische Vorrichtung und Verfahren zur Analyse von Nukleinsäuren
CA3046636A1 (en) 2016-12-12 2018-06-21 Cepheid Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge
US20210072255A1 (en) 2016-12-16 2021-03-11 The Brigham And Women's Hospital, Inc. System and method for protein corona sensor array for early detection of diseases
JP2020515815A (ja) 2016-12-28 2020-05-28 ミロキュラス インコーポレイテッド デジタルマイクロ流体デバイスおよび方法
GB201704758D0 (en) 2017-01-05 2017-05-10 Illumina Inc Reagent channel mixing systema and method
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
US10170392B2 (en) * 2017-04-05 2019-01-01 International Business Machines Corporation Wafer level integration for embedded cooling
EP3401013A1 (en) * 2017-05-12 2018-11-14 Universitat de Barcelona Devices and methods for multiplexing liquid in biosensor micro-chambers
CN109201128A (zh) * 2017-07-05 2019-01-15 京东方科技集团股份有限公司 微流控芯片、化学发光免疫分析系统和分析方法
WO2019023133A1 (en) 2017-07-24 2019-01-31 Miroculus Inc. DIGITAL MICROFLUIDIC SYSTEMS AND METHODS WITH INTEGRATED PLASMA COLLECTION DEVICE
CN115582155B (zh) 2017-09-01 2025-08-26 因特格拉生物科学股份公司 数字微流控设备及其使用方法
WO2019055875A2 (en) 2017-09-15 2019-03-21 Biomeme, Inc. METHODS AND SYSTEMS FOR AUTOMATIC SAMPLE PROCESSING
US12448655B2 (en) 2017-10-11 2025-10-21 California Institute Of Technology Antibiotic susceptibility of microorganisms and related methods and systems
US11827944B2 (en) 2017-10-11 2023-11-28 California Institute Of Technology Antibiotic susceptibility of microorganisms and related compositions, methods and systems
WO2019083844A1 (en) 2017-10-23 2019-05-02 Cytochip Inc. DEVICES AND METHOD FOR MEASURING TARGET ANALYTES AND PARTICLES
KR102245674B1 (ko) * 2017-11-17 2021-04-27 주식회사 엘지화학 고상 추출용 마이크로 디바이스
JP7524061B2 (ja) 2017-12-15 2024-07-29 バイオミーム インコーポレイテッド サンプルを分析するためのポータブル装置及び方法
AU2019255388B2 (en) 2018-04-19 2025-01-30 First Light Diagnostics, Inc. Detection of targets
US10809818B2 (en) 2018-05-21 2020-10-20 International Business Machines Corporation Digital pen with dynamically formed microfluidic buttons
EP3796999A4 (en) 2018-05-23 2022-03-09 Miroculus Inc. Control of evaporation in digital microfluidics
CN108760661B (zh) * 2018-09-08 2023-06-09 重庆科技学院 一种石油废水重金属离子多通道检测芯片
EP3853602A1 (en) * 2018-09-20 2021-07-28 Fluidic Analytics Limited Improvements in or relating to profiling of particles using microfluidic devices
EP3861357A4 (en) 2018-10-04 2022-11-09 First Light Diagnostics, Inc. Test cartridges
CN109576345A (zh) * 2018-10-17 2019-04-05 西人马（厦门）科技有限公司 一种用于dna提取的微流控芯片及其检测方法
WO2020078952A1 (de) * 2018-10-17 2020-04-23 Hte Gmbh The High Throughput Experimentation Company Vorrichtung und verfahren zur untersuchung von reaktionen
AU2019374692B2 (en) 2018-11-07 2025-08-28 Seer, Inc. Compositions, methods and systems for protein corona analysis and uses thereof
CN109490058B (zh) * 2018-11-16 2021-04-20 南京爱思唯志生物科技有限公司 一种适于液体混合的微流控系统及方法
US10824772B2 (en) 2018-11-28 2020-11-03 International Business Machines Corporation Dynamically adjusting grip panel
MY209720A (en) 2018-11-30 2025-07-31 Illumina Inc The temperature controllable reagent cartridge and temperature control system
EP3917670A4 (en) 2019-01-31 2022-11-02 Miroculus Inc. ANTIFOULING COMPOSITIONS AND METHODS FOR HANDLING AND TREATING ENCAPSULATED DROPLET
WO2020185200A1 (en) 2019-03-08 2020-09-17 Hewlett-Packard Development Company, L.P. Disposable microfluidic cassettes
CN113874708A (zh) 2019-03-21 2021-12-31 生米公司 多功能分析装置
WO2020198209A1 (en) 2019-03-26 2020-10-01 Seer, Inc. Compositions, methods and systems for protein corona analysis from biofluids and uses thereof
WO2020206326A1 (en) * 2019-04-05 2020-10-08 Cornell University System and methods for generating dynamic materials having artificial metabolism
CA3133124A1 (en) 2019-04-08 2020-10-15 Miroculus Inc. Multi-cartridge digital microfluidics apparatuses and methods of use
KR102788544B1 (ko) * 2019-04-16 2025-03-31 (주)얼라인드제네틱스 애널라이트 수집 장치, 이를 이용한 애널라이트 수집 방법 및 애널라이트 검사 시스템
CN111844215B (zh) * 2019-04-25 2021-10-08 旭泰精密机械股份有限公司 超音波刀柄
US20220212192A1 (en) * 2019-06-01 2022-07-07 Northeastern University Microfluidic Device for High-Throughput Screening of Tumor Cell Adhesion and Motility
CN110186742A (zh) * 2019-07-08 2019-08-30 苏州新海生物科技股份有限公司 Poct检测装置及样本混匀装置
WO2021016614A1 (en) 2019-07-25 2021-01-28 Miroculus Inc. Digital microfluidics devices and methods of use thereof
US11123734B2 (en) 2019-07-31 2021-09-21 CytoVale Inc. System and method for immune activity determination
US12220652B2 (en) 2019-08-01 2025-02-11 Georgia Tech Research Corporation Microfluidic platform for refrigeration induced phase separation of aqueous-acetonitrile solutions
CA3146525A1 (en) 2019-08-05 2021-02-11 William Manning Systems and methods for sample preparation, data generation, and protein corona analysis
KR102298299B1 (ko) * 2019-08-08 2021-09-07 광운대학교 산학협력단 원심분리와 자기분리가 가능한 통합형 세포분리장치
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
CN112940061B (zh) * 2019-12-10 2024-05-03 财团法人工业技术研究院 核酸萃取装置
CN112708532B (zh) * 2020-05-19 2022-03-15 中国科学院微生物研究所 一种可持续工作的核酸检测设备
KR20230079044A (ko) 2020-08-25 2023-06-05 시어 인코퍼레이티드 단백질 및 핵산 검정을 위한 조성물 및 방법
EP3967674A1 (en) 2020-09-11 2022-03-16 Precirix N.V. Reactions of radioactive compounds facilitated by a solid phase
CA3192080A1 (en) 2020-09-18 2022-03-24 Marc DEJOHN Portable devices and methods for analyzing samples
WO2022226412A2 (en) * 2021-04-23 2022-10-27 Poppy Health, Inc. System and method for characterizing, monitoring, & detecting bioaerosol presence & movement in an indoor environment
US11597980B2 (en) * 2021-07-08 2023-03-07 Poppy Health, Inc. System and method for detecting pathogens in an environment via an electrostatic air sampler
US12181401B2 (en) 2021-12-07 2024-12-31 Poppy Health, Inc. Tracer detection system and method for characterizing effectiveness of air removal in an aerosol zone
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation
CN114487401B (zh) * 2022-04-18 2022-06-21 中国农业大学 一种微生物检测的双适配体功能核酸恒温微流控芯片传感器
EP4563687A1 (en) * 2022-08-02 2025-06-04 Terumo Kabushiki Kaisha Separating device and separating method
DE102023126573A1 (de) * 2023-09-28 2025-04-03 Bürkert Werke GmbH & Co. KG Einweg-Fluidführungsbaugruppe, Verfahren zur Herstellung der Einweg-Fluidführungsbaugruppe, mikrofluidische Vorrichtung mit Einweg-Fluidführungsbaugruppe sowie Proteindefektdiagnosevorrichtung

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922591A (en) * 1995-06-29 1999-07-13 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US20040063217A1 (en) * 2002-09-27 2004-04-01 Webster James Russell Miniaturized fluid delivery and analysis system
US20040209354A1 (en) * 2002-12-30 2004-10-21 The Regents Of The University Of California Fluid control structures in microfluidic devices

Family Cites Families (474)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075740A (en) 1960-06-02 1963-01-29 Dow Chemical Co Diaphragm valve
US3190310A (en) * 1960-12-16 1965-06-22 American Radiator & Standard Gang valve arrangement
US3352643A (en) 1964-09-02 1967-11-14 Hitachi Ltd Liquid chromatography and chromatographs
US3433257A (en) 1966-02-01 1969-03-18 Ibm Diaphragm type fluid logic latch
US3568692A (en) 1967-11-27 1971-03-09 Bowles Eng Corp Optical machining process
US3610274A (en) 1969-10-08 1971-10-05 Brown & Sharpe Mfg Fluid logic circuit
US3662517A (en) 1970-04-08 1972-05-16 Sherwood Medical Ind Inc Syringe filling apparatus
US4011357A (en) 1974-03-07 1977-03-08 Mobil Oil Corporation Laminate of biaxially oriented polystyrene film and polystyrene foam
US4113665A (en) 1977-02-03 1978-09-12 Ameron, Inc. Coatings prepared from trialkoxysilanes
EP0024207B1 (en) * 1979-08-17 1983-04-13 Alan Ralston Rice Pile-driving apparatus
US4703913A (en) 1982-09-22 1987-11-03 California Institute Of Technology Diaphragm valve
US4558845A (en) 1982-09-22 1985-12-17 Hunkapiller Michael W Zero dead volume valve
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
GB8523166D0 (en) 1985-09-19 1985-10-23 Yarsley Technical Centre Ltd Scratch resistant coatings
US5085757A (en) * 1987-11-25 1992-02-04 Northeastern University Integrated temperature control/alignment system for high performance capillary electrophoretic apparatus
US5523231A (en) 1990-02-13 1996-06-04 Amersham International Plc Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5935401A (en) * 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
US6176962B1 (en) 1990-02-28 2001-01-23 Aclara Biosciences, Inc. Methods for fabricating enclosed microchannel structures
US5387505A (en) * 1990-05-04 1995-02-07 Eastman Kodak Company Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage
SE470347B (sv) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
DE69104775T2 (de) 1990-05-29 1995-06-01 Waters Investments Ltd Verfahren und Vorrichtung zum Durchführen der Kapillarelektroforese.
US5364759B2 (en) 1991-01-31 1999-07-20 Baylor College Medicine Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
JPH07209251A (ja) 1994-01-14 1995-08-11 Hitachi Ltd 電気泳動装置
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
DE69303898T3 (de) 1992-05-01 2007-01-18 Trustees Of The University Of Pennsylvania Fluessigkeitsbehandlung in mikrofabrizierten analytischen vorrichtungen
US5275645A (en) * 1992-11-24 1994-01-04 Ameron, Inc. Polysiloxane coating
US5482836A (en) * 1993-01-14 1996-01-09 The Regents Of The University Of California DNA purification by triplex-affinity capture and affinity capture electrophoresis
US5338427A (en) 1993-02-26 1994-08-16 Biometric Imaging Inc. Single use separation cartridge for a capillary electrophoresis instrument
EP0620432B1 (en) 1993-04-15 2004-08-25 Zeptosens AG Method for controlling sample introduction in microcolumn separation techniques and sampling device
JP3563140B2 (ja) 1995-01-19 2004-09-08 株式会社日立製作所 キャピラリーアレイ電気泳動装置
US5482845A (en) 1993-09-24 1996-01-09 The Trustees Of Columbia University In The City Of New York Method for construction of normalized cDNA libraries
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
US5453163A (en) 1993-10-29 1995-09-26 Yan; Chao Electrokinetic packing of capillary columns
US6129828A (en) 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US6358385B1 (en) * 1993-12-17 2002-03-19 The Perkin-Elmer Corporation Polymers for separation of biomolecules by capillary electrophoresis
US20070269799A9 (en) 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US5639428A (en) * 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5705628A (en) * 1994-09-20 1998-01-06 Whitehead Institute For Biomedical Research DNA purification and isolation using magnetic particles
CA2118048C (en) * 1994-09-30 2003-04-08 James W. Schumm Multiplex amplification of short tandem repeat loci
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
DE69533159T2 (de) 1994-11-14 2005-07-21 Trustees Of The University Of Pennsylvania Miniaturisierte probenvorbereitungsvorrichtungen sowie systeme zur feststellung und behandlung von analyten
US5775371A (en) 1995-03-08 1998-07-07 Abbott Laboratories Valve control
US5741462A (en) 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US5675155A (en) 1995-04-26 1997-10-07 Beckman Instruments, Inc. Multicapillary fluorescent detection system
JP3477918B2 (ja) 1995-05-29 2003-12-10 株式会社島津製作所 キャピラリ電気泳動チップ
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US20020022261A1 (en) 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US20020068357A1 (en) 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
US5705813A (en) 1995-11-01 1998-01-06 Hewlett-Packard Company Integrated planar liquid handling system for maldi-TOF MS
DE69523610T2 (de) 1995-12-14 2003-04-03 Agilent Technologies, Inc. (N.D.Ges.D.Staates Delaware) Säule für kapillarchromatographische Trennverfahren
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5948684A (en) 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5994064A (en) 1996-04-24 1999-11-30 Identigene, Inc. Simple and complex tandem repeats with DNA typing method
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
EP0910474B1 (en) 1996-06-14 2004-03-24 University of Washington Absorption-enhanced differential extraction method
JP3788519B2 (ja) 1996-06-28 2006-06-21 カリパー・ライフ・サイエンシズ・インコーポレーテッド 微小スケール流体装置の高処理能力スクリーニングアッセイシステム
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6136212A (en) 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
US6110343A (en) 1996-10-04 2000-08-29 Lockheed Martin Energy Research Corporation Material transport method and apparatus
US6379929B1 (en) 1996-11-20 2002-04-30 The Regents Of The University Of Michigan Chip-based isothermal amplification devices and methods
JPH10206384A (ja) 1997-01-16 1998-08-07 Kagaku Gijutsu Shinko Jigyodan マルチキャピラリー電気泳動装置
US6306588B1 (en) * 1997-02-07 2001-10-23 Invitrogen Corporation Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
US6117634A (en) 1997-03-05 2000-09-12 The Reagents Of The University Of Michigan Nucleic acid sequencing and mapping
WO1998045684A1 (en) 1997-04-04 1998-10-15 Biosite Diagnostics, Inc. Methods for concentrating ligands using magnetic particles
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6872527B2 (en) * 1997-04-16 2005-03-29 Xtrana, Inc. Nucleic acid archiving
US5951262A (en) * 1997-04-18 1999-09-14 Centriflow Llc Mechanism for providing motive force and for pumping applications
CA2286601A1 (en) 1997-05-16 1998-11-26 Alberta Research Council Microfluidic system and methods of use
US6632619B1 (en) 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
JP4294740B2 (ja) 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
US5900130A (en) * 1997-06-18 1999-05-04 Alcara Biosciences, Inc. Method for sample injection in microchannel device
GB9713597D0 (en) 1997-06-28 1997-09-03 Sec Dep Of The Home Department Improvements in and relating to forensic identification
US6073482A (en) 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
JP3481828B2 (ja) 1997-08-26 2003-12-22 株式会社日立製作所 電気泳動分析装置，電気泳動分析方法及びそれに用いる試料容器
US6190616B1 (en) 1997-09-11 2001-02-20 Molecular Dynamics, Inc. Capillary valve, connector, and router
US6207031B1 (en) 1997-09-15 2001-03-27 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
US6007775A (en) 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
WO1999019717A1 (en) 1997-10-15 1999-04-22 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US6120985A (en) 1997-10-31 2000-09-19 Bbi Bioseq, Inc. Pressure-enhanced extraction and purification
EP1042061A1 (en) 1997-12-24 2000-10-11 Cepheid Integrated fluid manipulation cartridge
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6200814B1 (en) 1998-01-20 2001-03-13 Biacore Ab Method and device for laminar flow on a sensing surface
US6685809B1 (en) * 1999-02-04 2004-02-03 Ut-Battelle, Llc Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels
WO1999041599A1 (en) 1998-02-16 1999-08-19 The Institute Of Physical And Chemical Research Capillary cassette and method of producing the same
US6251343B1 (en) * 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
EP1062510A2 (en) 1998-03-10 2000-12-27 Strategic Diagnostics Inc. Integrated assay device and methods of production and use
US6979424B2 (en) 1998-03-17 2005-12-27 Cepheid Integrated sample analysis device
US6534262B1 (en) * 1998-05-14 2003-03-18 Whitehead Institute For Biomedical Research Solid phase technique for selectively isolating nucleic acids
US6787111B2 (en) 1998-07-02 2004-09-07 Amersham Biosciences (Sv) Corp. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
US6627446B1 (en) 1998-07-02 2003-09-30 Amersham Biosciences (Sv) Corp Robotic microchannel bioanalytical instrument
US6787308B2 (en) * 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6387234B1 (en) * 1998-08-31 2002-05-14 Iowa State University Research Foundation, Inc. Integrated multiplexed capillary electrophoresis system
US6103199A (en) 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
EP0999443A3 (en) 1998-11-02 2002-09-18 The Institute of Physical and Chemical Research Capillary electrophoretic apparatus, sample plate and sample injection method
EP1006355A3 (en) 1998-11-30 2000-11-08 The Institute of Physical and Chemical Research Capillary electrophoretic apparatus
AU772281B2 (en) 1998-12-14 2004-04-22 Li-Cor Inc. A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
CA2359901A1 (en) 1999-02-16 2000-08-24 Pe Corporation (Ny) Bead dispensing system
US6153389A (en) 1999-02-22 2000-11-28 Haarer; Brian K. DNA additives as a mechanism for unambiguously marking biological samples
DE60044490D1 (de) 1999-02-23 2010-07-15 Caliper Life Sciences Inc Manipulation von mikroteilchen in mikrofluiden systemen
EP1411340A3 (en) 1999-02-26 2004-05-19 EXACT Sciences Corporation Biochemical purification devices with immobilized capture probes and their uses
JP2002537781A (ja) 1999-02-26 2002-11-12 モザイク テクノロジーズ 固定化捕捉プローブを有する生化学的精製装置およびその使用
US6319476B1 (en) 1999-03-02 2001-11-20 Perseptive Biosystems, Inc. Microfluidic connector
US7150994B2 (en) 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
US6048100A (en) 1999-03-10 2000-04-11 Industrial Label Corp. Resealable closure for a bag
US6994986B2 (en) * 1999-03-17 2006-02-07 The Board Of Trustees Of The Leland Stanford University In vitro synthesis of polypeptides by optimizing amino acid metabolism
WO2000060362A1 (en) 1999-04-08 2000-10-12 Chung Chang Young Apparatus for fast preparation and analysis of nucleic acids
JP3746658B2 (ja) 1999-04-12 2006-02-15 株式会社日立製作所 微粒子を用いたプローブアレーの作製方法及び装置
US6322683B1 (en) 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US20040053290A1 (en) 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
WO2002043864A2 (en) 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6620584B1 (en) 1999-05-20 2003-09-16 Illumina Combinatorial decoding of random nucleic acid arrays
DE60014676T2 (de) 1999-05-28 2005-11-17 Cepheid, Sunnyvale Vorrichtung und verfahren zur analyse flüssiger proben
GB9913561D0 (en) 1999-06-10 1999-08-11 Cortecs Diagnostics Limited Apparatus, instrument & device for conducting an assay
JP2003510017A (ja) * 1999-06-22 2003-03-18 インビトロジェン コーポレイション 核酸の検出および識別のために改良されたプライマーおよび方法
US6878540B2 (en) 1999-06-25 2005-04-12 Cepheid Device for lysing cells, spores, or microorganisms
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
DE60031540T2 (de) 1999-06-28 2007-05-16 California Institute Of Technology, Pasadena Mikromechanische pump- und ventilsysteme
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6533914B1 (en) 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
US7015030B1 (en) 1999-07-28 2006-03-21 Genset S.A. Microfluidic devices and uses thereof in biochemical processes
US6977145B2 (en) 1999-07-28 2005-12-20 Serono Genetics Institute S.A. Method for carrying out a biochemical protocol in continuous flow in a microreactor
US6423536B1 (en) 1999-08-02 2002-07-23 Molecular Dynamics, Inc. Low volume chemical and biochemical reaction system
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
US6824663B1 (en) 1999-08-27 2004-11-30 Aclara Biosciences, Inc. Efficient compound distribution in microfluidic devices
US6846626B1 (en) * 1999-09-01 2005-01-25 Genome Technologies, Llc Method for amplifying sequences from unknown DNA
US20020151089A1 (en) 1999-09-15 2002-10-17 Chapman William H. Separating components of biological samples
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6623945B1 (en) 1999-09-16 2003-09-23 Motorola, Inc. System and method for microwave cell lysing of small samples
AU7537200A (en) 1999-09-29 2001-04-30 Solexa Ltd. Polynucleotide sequencing
US6623613B1 (en) 1999-10-01 2003-09-23 The Regents Of The University Of California Microfabricated liquid sample loading system
JP3896739B2 (ja) * 1999-10-29 2007-03-22 株式会社日立製作所 キャピラリー電気泳動装置
JP2003516129A (ja) 1999-11-04 2003-05-13 カリフォルニア・インスティテュート・オブ・テクノロジー ポリヌクレオチド配列を解析する方法および装置
US6326068B1 (en) 1999-11-08 2001-12-04 Exxonmobil Oil Corporation Multi-layer hermetically sealable film
US7329388B2 (en) 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6705345B1 (en) * 1999-11-08 2004-03-16 The Trustees Of Boston University Micro valve arrays for fluid flow control
US6120184A (en) 1999-11-17 2000-09-19 Stone Container Corporation Bag apparatus with reclosable pour spout
CA2290731A1 (en) 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
EP1257664A4 (en) 2000-01-28 2006-04-05 Althea Technologies Inc METHOD FOR THE ANALYSIS OF GENE EXPRESSION
SE0000300D0 (sv) * 2000-01-30 2000-01-30 Amersham Pharm Biotech Ab Microfluidic assembly, covering method for the manufacture of the assembly and the use of the assembly
US6807490B1 (en) 2000-02-15 2004-10-19 Mark W. Perlin Method for DNA mixture analysis
US7922984B2 (en) 2000-02-18 2011-04-12 Selective Micro Technologies, Llc Apparatus and method for controlled delivery of a gas
WO2001062887A1 (en) 2000-02-23 2001-08-30 Zyomyx, Inc. Chips having elevated sample surfaces
JP3389547B2 (ja) 2000-02-28 2003-03-24 株式会社日立製作所 電気泳動装置
US6432191B2 (en) 2000-02-28 2002-08-13 John B. Schutt Silane-based, coating compositions, coated articles obtained therefrom and methods of using same
US6929731B2 (en) 2000-03-07 2005-08-16 Northeastern University Parallel array of independent thermostats for column separations
CA2403384C (en) 2000-03-22 2007-04-10 Docusys, Inc. A drug delivery and monitoring system
AU2001242184A1 (en) 2000-03-28 2001-10-08 Queen:S University At Kingston Methods for effecting neuroprotection using a potassium channel modulator
JP2001283190A (ja) 2000-03-30 2001-10-12 Fuji Photo Film Co Ltd 画像処理装置
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
SE0001768D0 (sv) 2000-05-12 2000-05-12 Helen Andersson Mikrofluidisk flödescell för manipulering av partiklar
JP3918403B2 (ja) 2000-05-15 2007-05-23 株式会社日立製作所 キャピラリアレイ
US6531282B1 (en) * 2000-05-30 2003-03-11 Oligotrail, Llc Multiplex amplification and analysis of selected STR loci
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
WO2002001184A1 (en) * 2000-06-23 2002-01-03 Micronics, Inc. Fluid mixing on (partially) covered sample slides
US6885982B2 (en) 2000-06-27 2005-04-26 Fluidigm Corporation Object oriented microfluidic design method and system
US6829753B2 (en) 2000-06-27 2004-12-07 Fluidigm Corporation Microfluidic design automation method and system
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6531041B1 (en) * 2000-07-20 2003-03-11 Symyx Technologies, Inc. Multiplexed capillary electrophoresis system with rotatable photodetector
US7004184B2 (en) * 2000-07-24 2006-02-28 The Reagents Of The University Of Michigan Compositions and methods for liquid metering in microchannels
US20020048534A1 (en) 2000-08-24 2002-04-25 David Storek Sample preparing arrangement and a method relating to such an arrangement
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
US7011943B2 (en) 2000-09-06 2006-03-14 Transnetyx, Inc. Method for detecting a designated genetic sequence in murine genomic DNA
WO2002023163A1 (en) 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
US7790368B1 (en) 2000-09-22 2010-09-07 Hitachi, Ltd. Method for analyzing nucleic acid
US7097809B2 (en) 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
AU2002211389A1 (en) 2000-10-03 2002-04-15 California Institute Of Technology Microfluidic devices and methods of use
CA2422325A1 (en) 2000-10-06 2002-04-11 Gradipore Limited Multi-port separation apparatus and method
US6782746B1 (en) 2000-10-24 2004-08-31 Sandia National Laboratories Mobile monolithic polymer elements for flow control in microfluidic devices
EP1202054B1 (en) 2000-10-25 2003-01-08 Bruker BioSpin GmbH LC-NMR system, comprising a device for trapping at least one component of a chromatography flow
EP1205294A3 (en) 2000-11-13 2003-05-21 Arkmount Systems Inc. Heat sealing and cutting mechanism and container forming apparatus incorporating the same
AU2002248149A1 (en) 2000-11-16 2002-08-12 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
US6521188B1 (en) 2000-11-22 2003-02-18 Industrial Technology Research Institute Microfluidic actuator
US6527003B1 (en) * 2000-11-22 2003-03-04 Industrial Technology Research Micro valve actuator
GB0028647D0 (en) 2000-11-24 2001-01-10 Nextgen Sciences Ltd Apparatus for chemical assays
SE0004351D0 (sv) 2000-11-27 2000-11-27 Helen Andersson System och metod för tidstyrd vätskehantering för reaktioner och processer i ett mikrofluidiskt flödescellsystem
US20020137039A1 (en) 2000-12-22 2002-09-26 Baxter Aktiengesellschaft 5' Nuclease nucleic acid amplification assay having an improved internal control
US20020123538A1 (en) * 2000-12-29 2002-09-05 Peiguang Zhou Hot-melt adhesive based on blend of amorphous and crystalline polymers for multilayer bonding
US6767194B2 (en) * 2001-01-08 2004-07-27 President And Fellows Of Harvard College Valves and pumps for microfluidic systems and method for making microfluidic systems
US20020098097A1 (en) 2001-01-22 2002-07-25 Angad Singh Magnetically-actuated micropump
CA2450676C (en) 2001-03-09 2010-03-30 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US20020148992A1 (en) 2001-04-03 2002-10-17 Hayenga Jon W. Pneumatic valve interface for use in microfluidic structures
US6802342B2 (en) 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
DE60239328D1 (de) 2001-04-06 2011-04-14 Fluidigm Corp Polymeroberflächenmodifikation
WO2002081729A2 (en) 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
US7288405B2 (en) 2001-04-25 2007-10-30 Cornell Research Foundation, Inc. Devices and methods for pharmacokinetic-based cell culture system
US7318912B2 (en) * 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
JP2002370200A (ja) 2001-06-12 2002-12-24 Kawamura Inst Of Chem Res 微小バルブ機構の製造方法
US6629820B2 (en) 2001-06-26 2003-10-07 Micralyne Inc. Microfluidic flow control device
GB0119959D0 (en) * 2001-08-16 2001-10-10 Sec Dep Of The Home Department Improvements in and relating to analysis
US20030095897A1 (en) 2001-08-31 2003-05-22 Grate Jay W. Flow-controlled magnetic particle manipulation
US20040013536A1 (en) * 2001-08-31 2004-01-22 Hower Robert W Micro-fluidic pump
JP2003074462A (ja) 2001-09-03 2003-03-12 Fukuoka Institute Of Technology 磁性流体ポンプ
JP3685119B2 (ja) * 2001-10-18 2005-08-17 株式会社日立製作所 生体分子回収方法
JP4381670B2 (ja) * 2001-10-30 2009-12-09 株式会社日立製作所 反応装置
US20030087425A1 (en) 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier
US7142987B2 (en) 2001-11-07 2006-11-28 Genvault Corporation Apparatus, system, and method of archival and retrieval of samples
US7584240B2 (en) 2001-11-07 2009-09-01 Genvault Corporation Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients
US20030129755A1 (en) 2001-11-07 2003-07-10 Genvault Corporation System and method of storing and retrieving storage elements
US20030087455A1 (en) 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
JP2005508196A (ja) * 2001-11-07 2005-03-31 アプレラ コーポレイション 核酸分析の汎用ヌクレオチド
JP4355210B2 (ja) 2001-11-30 2009-10-28 フルイディグム コーポレイション 微小流体デバイスおよび微小流体デバイスの使用方法
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US6864480B2 (en) * 2001-12-19 2005-03-08 Sau Lan Tang Staats Interface members and holders for microfluidic array devices
US6532997B1 (en) 2001-12-28 2003-03-18 3M Innovative Properties Company Sample processing device with integral electrophoresis channels
CA2473376A1 (en) * 2002-01-16 2003-07-31 Dynal Biotech Asa Method for isolating nucleic acids and protein from a single sample
US7081191B2 (en) 2002-01-18 2006-07-25 Hitachi High-Technologies Corporation Capillary electrophoresis device
WO2003065019A1 (en) 2002-01-25 2003-08-07 Illumina, Inc. Sensor arrays for detecting analytes in fluids
US6581441B1 (en) 2002-02-01 2003-06-24 Perseptive Biosystems, Inc. Capillary column chromatography process and system
EP1474236B1 (en) 2002-02-13 2006-01-04 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
JP3922039B2 (ja) 2002-02-15 2007-05-30 株式会社日立製作所 電磁波吸収材料及びそれを用いた各種製品
US6685442B2 (en) 2002-02-20 2004-02-03 Sandia National Laboratories Actuator device utilizing a conductive polymer gel
EP1488365A4 (en) 2002-03-11 2007-05-09 Athenix Corp INTEGRATED SYSTEM FOR GENETIC DIVERSITY COLLECTION WITH HIGH THROUGHPUT
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
CA2480728A1 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
EP1508044B1 (en) * 2002-05-09 2010-09-01 The University of Chicago Device and method for pressure-driven plug transport and reaction
US20030215369A1 (en) 2002-05-17 2003-11-20 Eggers Mitchell D. Sample carrier receiver
US20030217923A1 (en) 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US20040101444A1 (en) 2002-07-15 2004-05-27 Xeotron Corporation Apparatus and method for fluid delivery to a hybridization station
US6786708B2 (en) 2002-07-18 2004-09-07 The Regents Of The University Of Michigan Laminated devices and methods of making same
US20040018611A1 (en) * 2002-07-23 2004-01-29 Ward Michael Dennis Microfluidic devices for high gradient magnetic separation
CA2492450A1 (en) 2002-07-26 2004-02-05 Applera Corporation Microfluidic device including purification column with excess diluent, and method
US7198759B2 (en) 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
US7244961B2 (en) 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
WO2004012862A2 (en) 2002-08-02 2004-02-12 Amersham Biosciences (Sv) Corp Integrated microchip design
US20040038385A1 (en) * 2002-08-26 2004-02-26 Langlois Richard G. System for autonomous monitoring of bioagents
US20040197845A1 (en) 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
DK1545780T3 (da) 2002-09-06 2007-06-04 Epigem Ltd Modulært mikrofluidsystem
US7157228B2 (en) * 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
JP3725109B2 (ja) 2002-09-19 2005-12-07 財団法人生産技術研究奨励会 マイクロ流体デバイス
US8871446B2 (en) 2002-10-02 2014-10-28 California Institute Of Technology Microfluidic nucleic acid analysis
US6883774B2 (en) 2002-10-21 2005-04-26 Lockheed Martin Corporation Microelectromechanical high pressure gas microvalve
US7932098B2 (en) 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
US20040086872A1 (en) 2002-10-31 2004-05-06 Childers Winthrop D. Microfluidic system for analysis of nucleic acids
US7217542B2 (en) 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
US7718442B2 (en) 2002-11-22 2010-05-18 Genvault Corporation Sealed sample storage element system and method
JP2004180594A (ja) * 2002-12-04 2004-07-02 Shimadzu Corp 細胞培養装置
AU2003298938A1 (en) * 2002-12-05 2004-06-30 Protasis Corporation Configurable microfluidic substrate assembly
EP1579013A4 (en) * 2002-12-13 2007-02-28 Gene Codes Forensics Inc PROCEDURE FOR CREATING PROILES AND IDENTIFYING PERSONS USING PROBED DATA
US20050266582A1 (en) 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
KR101048831B1 (ko) 2002-12-27 2011-07-13 신에쯔 한도타이 가부시키가이샤 단결정 제조용 흑연 히터 및 단결정 제조장치와 단결정 제조방법
US7122153B2 (en) 2003-01-08 2006-10-17 Ho Winston Z Self-contained microfluidic biochip and apparatus
US7049558B2 (en) * 2003-01-27 2006-05-23 Arcturas Bioscience, Inc. Apparatus and method for heating microfluidic volumes and moving fluids
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
AU2004209426B2 (en) 2003-01-29 2008-04-17 454 Life Sciences Corporation Method for preparing single-stranded DNA libraries
WO2004067162A2 (en) * 2003-01-30 2004-08-12 Ciphergen Biosystems Inc. Apparatus for microfluidic processing and reading of biochip arrays
US7338637B2 (en) 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
EP2574400B1 (en) 2003-02-05 2016-09-28 Iquum, Inc. Sample processing
JP4119275B2 (ja) 2003-02-18 2008-07-16 忠弘 大見 真空排気系用のダイヤフラム弁
DE602004021239D1 (de) 2003-03-10 2009-07-09 Univ Michigan Intergrierte mikrofluidische kontrollvorrichtung mit programmierbaren taktilen stellgliedern
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US7745116B2 (en) * 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
US7419578B2 (en) 2003-04-11 2008-09-02 Hitachi High-Technologies Corporation Capillary electrophoresis apparatus
EP1685282A2 (en) 2003-04-17 2006-08-02 Fluidigm Corporation Crystal growth devices and systems, and methods for using same
US20050026181A1 (en) 2003-04-29 2005-02-03 Genvault Corporation Bio bar-code
US20100075858A1 (en) 2003-04-29 2010-03-25 Genvault Corporation Biological bar code
US20040219533A1 (en) 2003-04-29 2004-11-04 Jim Davis Biological bar code
WO2004098757A2 (en) 2003-05-06 2004-11-18 New Jersey Institute Of Technology Microfluidic mixing using flow pulsing
FR2855076B1 (fr) 2003-05-21 2006-09-08 Inst Curie Dispositif microfluidique
US20050181394A1 (en) 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
DE10330804A1 (de) 2003-07-08 2005-04-28 Fresenius Medical Care De Gmbh Einwegkassette
EP1641944B1 (en) 2003-07-09 2011-06-29 Genvault Corporation Room temperature elution of nucleic acids
US7063304B2 (en) * 2003-07-11 2006-06-20 Entegris, Inc. Extended stroke valve and diaphragm
US7943393B2 (en) 2003-07-14 2011-05-17 Phynexus, Inc. Method and device for extracting an analyte
US7357898B2 (en) * 2003-07-31 2008-04-15 Agency For Science, Technology And Research Microfluidics packages and methods of using same
US20050047967A1 (en) 2003-09-03 2005-03-03 Industrial Technology Research Institute Microfluidic component providing multi-directional fluid movement
US20050064490A1 (en) 2003-09-23 2005-03-24 University Of Missouri Methods of synthesizing polynucleotides using thermostable enzymes
KR20060105787A (ko) 2003-11-21 2006-10-11 가부시키가이샤 에바라 세이사꾸쇼 액체를 이용한 마이크로칩 장치
US7939249B2 (en) * 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
JP5028091B2 (ja) 2004-01-25 2012-09-19 フルイディグム コーポレイション 結晶形成デバイスならびに結晶形成デバイスを作製および使用するためのシステムおよび方法
ES2439225T3 (es) 2004-01-26 2014-01-22 President And Fellows Of Harvard College Sistema y método para el suministro de fluidos
WO2005075081A1 (en) 2004-02-02 2005-08-18 Silicon Valley Scientific, Inc. Integrated system with modular microfluidi components
US8043849B2 (en) 2004-02-24 2011-10-25 Thermal Gradient Thermal cycling device
WO2005091820A2 (en) 2004-03-05 2005-10-06 Alumina Micro Llc Selective bonding for forming a microvalve
US7077175B2 (en) 2004-04-09 2006-07-18 Hongfeng Yin Particle packing of microdevice
CA2565572C (en) 2004-05-03 2018-03-06 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
JP4683538B2 (ja) * 2004-05-06 2011-05-18 セイコーインスツル株式会社 分析用マイクロチップを含む分析システムと分析方法
JP3952036B2 (ja) 2004-05-13 2007-08-01 コニカミノルタセンシング株式会社 マイクロ流体デバイス並びに試液の試験方法および試験システム
PT1773978E (pt) 2004-05-19 2014-05-29 Massachusetts Inst Technology Modelo de doença com células/tecidos tri-dimensionais perfundidos
WO2005116081A2 (en) 2004-05-24 2005-12-08 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form
JP4372616B2 (ja) * 2004-05-28 2009-11-25 アイダエンジニアリング株式会社 マイクロバルブ、マイクロポンプ及びこれらを内蔵するマイクロチップ
US7799553B2 (en) * 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US20050272144A1 (en) * 2004-06-08 2005-12-08 Konica Minolta Medical & Graphic, Inc. Micro-reactor for improving efficiency of liquid mixing and reaction
US20060057209A1 (en) 2004-09-16 2006-03-16 Predicant Biosciences, Inc. Methods, compositions and devices, including microfluidic devices, comprising coated hydrophobic surfaces
WO2006020617A1 (en) 2004-08-09 2006-02-23 Generation Biotech, Llc Method for nucleic acid isolation and amplification
US7585663B2 (en) 2004-08-26 2009-09-08 Applied Biosystems, Llc Thermal device, system, and method, for fluid processing device
CN101073002B (zh) * 2004-09-15 2012-08-08 英特基因有限公司 微流体装置
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
JP2006090386A (ja) * 2004-09-22 2006-04-06 Kitz Sct:Kk ダイヤフラムバルブ
GB0421529D0 (en) 2004-09-28 2004-10-27 Landegren Gene Technology Ab Microfluidic structure
WO2006044458A2 (en) 2004-10-13 2006-04-27 University Of Virginia Patent Foundation Electrostatic actuation for management of flow
US7832429B2 (en) 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
US7608160B2 (en) 2004-10-13 2009-10-27 Rheonix, Inc. Laminated microfluidic structures and method for making
WO2006053588A1 (en) 2004-11-17 2006-05-26 Agilent Technologies, Inc. Supply arrangement with supply reservoir element and fluidic device
JP4850072B2 (ja) * 2004-11-22 2012-01-11 日水製薬株式会社 マイクロチップ
KR100634525B1 (ko) * 2004-11-23 2006-10-16 삼성전자주식회사 복수 개의 전자석이 배치되어 있는 마이크로채널을포함하는 미세유동 장치, 그를 이용하여 시료를 혼합하는방법 및 세포를 용해하는 방법
WO2006071470A2 (en) 2004-12-03 2006-07-06 California Institute Of Technology Microfluidic devices with chemical reaction circuits
EP2418018B1 (en) 2004-12-23 2013-05-22 Abbott Point of Care Inc. Methods for the separation nucleic acids
JP5165381B2 (ja) 2004-12-24 2013-03-21 コリン パテント ホールディングス ピーティーワイ リミテッド 安全注射器
US20060163143A1 (en) 2005-01-26 2006-07-27 Chirica Gabriela S Microliter scale solid phase extraction devices
IL166716A0 (en) 2005-02-07 2006-01-15 Gene Bio Applic Ltd Double chamber tank for electrophoresis
CA2496481A1 (en) 2005-02-08 2006-08-09 Mds Inc., Doing Business Through It's Mds Sciex Division Method and apparatus for sample deposition
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
JP3921233B2 (ja) 2005-02-10 2007-05-30 松下電器産業株式会社 流体チップ、それを用いた流体移動制御方法、および化学反応装置
US20060210994A1 (en) 2005-03-15 2006-09-21 Joyce Timothy H Microfluidic systems and methods for using microfluidic devices
US20060210998A1 (en) 2005-03-18 2006-09-21 Christiane Kettlitz Determination of antibiotic resistance in staphylococcus aureus
US20070017812A1 (en) 2005-03-30 2007-01-25 Luc Bousse Optimized Sample Injection Structures in Microfluidic Separations
JP4431518B2 (ja) 2005-04-05 2010-03-17 株式会社日立ハイテクノロジーズ 電気泳動装置、及びキャピラリアレイ
US20070015179A1 (en) * 2005-04-26 2007-01-18 Trustees Of Boston University Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples
US20070020654A1 (en) 2005-05-19 2007-01-25 Affymetrix, Inc. Methods and kits for preparing nucleic acid samples
US8206974B2 (en) 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
US20060263789A1 (en) 2005-05-19 2006-11-23 Robert Kincaid Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using
US7316766B2 (en) 2005-05-27 2008-01-08 Taidoc Technology Corporation Electrochemical biosensor strip
WO2007002579A2 (en) 2005-06-23 2007-01-04 Bioveris Corporation Assay cartridges and methods for point of care instruments
US7817273B2 (en) 2005-06-30 2010-10-19 Life Technologies Corporation Two-dimensional spectral imaging system
US20070031865A1 (en) * 2005-07-07 2007-02-08 David Willoughby Novel Process for Construction of a DNA Library
US7428848B2 (en) * 2005-08-09 2008-09-30 Cfd Research Corporation Electrostatic sampler and method
CN101273258A (zh) 2005-09-30 2008-09-24 卡钳生命科学股份有限公司 利用磁性珠纯化生物学组分的微流体装置
US20070184547A1 (en) 2005-10-11 2007-08-09 Kalyan Handique Polynucleotide sample preparation device
US7709544B2 (en) 2005-10-25 2010-05-04 Massachusetts Institute Of Technology Microstructure synthesis by flow lithography and polymerization
US20080311585A1 (en) 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
US20070113908A1 (en) * 2005-11-18 2007-05-24 The Ohio State University And Bioloc, Inc. Valve for microfluidic chips
US20070122819A1 (en) * 2005-11-25 2007-05-31 Industrial Technology Research Institute Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US20080179255A1 (en) 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic devices
JP4593451B2 (ja) 2005-12-05 2010-12-08 セイコーインスツル株式会社 マイクロリアクターシステム及び送液方法
US7976795B2 (en) 2006-01-19 2011-07-12 Rheonix, Inc. Microfluidic systems
CN101004423B (zh) 2006-01-19 2011-12-28 博奥生物有限公司 流体样品分析用卡盒系统
JP2007198765A (ja) 2006-01-24 2007-08-09 Toray Ind Inc 分析チップおよび分析方法
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
JP5063616B2 (ja) 2006-02-03 2012-10-31 インテジェニックス インコーポレイテッド マイクロ流体デバイス
WO2007106580A2 (en) 2006-03-15 2007-09-20 Micronics, Inc. Rapid magnetic flow assays
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
ES2587007T3 (es) 2006-03-24 2016-10-20 Handylab, Inc. Sistema integrado para procesar muestras microfluídicas, y métodos de uso del mismo
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US9063132B2 (en) * 2006-03-29 2015-06-23 Inverness Medical Switzerland Gmbh Assay device and method
KR100785010B1 (ko) 2006-04-06 2007-12-11 삼성전자주식회사 수소 결합을 이용하여 고체 지지체의 친수성 표면 상에서핵산 정제 방법 및 장치
EP4190448A3 (en) * 2006-05-11 2023-09-20 Bio-Rad Laboratories, Inc. Microfluidic devices
WO2007136840A2 (en) * 2006-05-20 2007-11-29 Codon Devices, Inc. Nucleic acid library design and assembly
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
JP2009539411A (ja) 2006-06-12 2009-11-19 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド 分析反応を行うための基板
US8137912B2 (en) * 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2041573B1 (en) 2006-06-23 2019-09-04 PerkinElmer Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
US8337777B2 (en) 2006-06-28 2012-12-25 Applied Biosystems, Llc Sample distribution devices and methods
US7629124B2 (en) * 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
CA2658533C (en) 2006-07-28 2016-03-15 Qiagen Gmbh Device for processing samples
WO2008024319A2 (en) 2006-08-20 2008-02-28 Codon Devices, Inc. Microfluidic devices for nucleic acid assembly
US8244866B2 (en) 2006-09-27 2012-08-14 International Business Machines Corporation Matching an autonomic manager with a manageable resource
WO2008147382A1 (en) 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US20080131327A1 (en) 2006-09-28 2008-06-05 California Institute Of Technology System and method for interfacing with a microfluidic chip
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
US20080242560A1 (en) 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
US20080145898A1 (en) 2006-12-14 2008-06-19 Applera Corporation Sequencing methods
WO2008076395A2 (en) 2006-12-14 2008-06-26 The Trustees Of The University Of Pennsylvania Mechanically actuated diagnostic device
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2008076406A2 (en) 2006-12-14 2008-06-26 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
US8409877B2 (en) 2006-12-29 2013-04-02 Intel Corporation Enzymatic signal generation and detection of binding complexes in stationary fluidic chip
GB2445739A (en) 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
EP2126766A2 (en) 2007-01-26 2009-12-02 Illumina Inc. Image data efficient genetic sequencing method and system
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
KR20100028526A (ko) 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 및 나노유체 장치, 시스템 및 응용
WO2008098094A1 (en) 2007-02-06 2008-08-14 Network Biosystems, Inc. Devices and methods for the performance of miniaturized in vitro assays
WO2008130463A2 (en) * 2007-02-06 2008-10-30 The Trustees Of The University Of Pennsylvania Multiplexed nanoscale electrochemical sensors for multi-analyte detection
WO2008124046A1 (en) 2007-04-04 2008-10-16 Micropoint Bioscience Inc.. Micromachined electrowetting microfluidic valve
EP2137523A1 (en) 2007-04-04 2009-12-30 Network Biosystems, Inc. Plastic microfluidic separation and detection platforms
US8221990B2 (en) 2007-04-06 2012-07-17 Teijin Pharma Limited Screening GPR12 receptor for substances having Nesfatin-1-like action, or which regulate Nesfatin-1 action
US8702976B2 (en) 2007-04-18 2014-04-22 Ondavia, Inc. Hand-held microfluidic testing device
EP2150350B1 (en) 2007-05-24 2012-04-25 The Regents of the University of California Integrated fluidics devices with magnetic sorting
US20100111770A1 (en) * 2007-06-07 2010-05-06 Samsung Electronics Co., Ltd. Microfluidic Chip and Method of Fabricating The Same
ATE555836T1 (de) 2007-06-29 2012-05-15 Harvard College Materialtrennungsverfahren auf dichtebasis, überwachung feststoffunterstützter reaktionen und messung der dichte kleiner flüssigkeitsvolumina und feststoffe
JPWO2009008236A1 (ja) 2007-07-10 2010-09-02 コニカミノルタエムジー株式会社 マイクロ検査チップの液体混合方法および検査装置
US9618139B2 (en) * 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8454906B2 (en) 2007-07-24 2013-06-04 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
US7744737B1 (en) 2007-07-26 2010-06-29 Sandia Corporation Microfluidic device for the assembly and transport of microparticles
DE102007035721B4 (de) 2007-07-30 2019-02-07 Robert Bosch Gmbh Mikroventil, Verfahren zum Herstellen eines Mikroventils sowie Mikropumpe
JP2010535502A (ja) * 2007-08-07 2010-11-25 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 遺伝子合成のための一体型マイクロ流体デバイス
CN101842161A (zh) * 2007-08-23 2010-09-22 辛温尼奥生物系统公司 用于目标物质的俘获磁性拣选系统
US8268263B2 (en) 2007-09-06 2012-09-18 Siemens Healthcare Diagnostics Inc. Reagent cartridge
US8398642B2 (en) 2007-09-20 2013-03-19 Symmetry Medical, Inc. Dual reamer driver
US7960116B2 (en) 2007-09-28 2011-06-14 Pacific Biosciences Of California, Inc. Nucleic acid sequencing methods and systems
JP2011504592A (ja) * 2007-11-26 2011-02-10 アトノミックス アクティーゼルスカブ 双峰性サイズ分布を有する磁気粒子を備える、統合型分離および検出カートリッジ
US20090253181A1 (en) 2008-01-22 2009-10-08 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
JP4937934B2 (ja) 2008-01-22 2012-05-23 株式会社日立ハイテクノロジーズ キャピラリアレイユニット及びキャピラリ電気泳動装置
WO2009117611A2 (en) 2008-03-19 2009-09-24 Cynvenio Biosystems, Llc Trapping magnetic cell sorting system
US20110137018A1 (en) 2008-04-16 2011-06-09 Cynvenio Biosystems, Inc. Magnetic separation system with pre and post processing modules
US7867713B2 (en) * 2008-04-21 2011-01-11 Lawrence Livermore National Security, Llc Polymerase chain reaction system using magnetic beads for analyzing a sample that includes nucleic acid
US20090269504A1 (en) 2008-04-24 2009-10-29 Momentive Performance Materials Inc. Flexible hardcoats and substrates coated therewith
KR100960066B1 (ko) 2008-05-14 2010-05-31 삼성전자주식회사 동결건조시약이 저장된 미세유동장치 및 이를 이용한시료분석방법
US8323568B2 (en) 2008-06-13 2012-12-04 Honeywell International Inc. Magnetic bead assisted sample conditioning system
WO2009152952A1 (en) 2008-06-19 2009-12-23 Boehringer Ingelheim Microparts Gmbh Fluid metering container
US20100209957A1 (en) 2008-06-20 2010-08-19 Genvault Corporation Biosample storage devices and methods of use thereof
US8092761B2 (en) 2008-06-20 2012-01-10 Silverbrook Research Pty Ltd Mechanically-actuated microfluidic diaphragm valve
US7892496B2 (en) 2008-06-20 2011-02-22 Silverbrook Research Pty Ltd Mechanically-actuated microfluidic pinch valve
US7976789B2 (en) 2008-07-22 2011-07-12 The Board Of Trustees Of The University Of Illinois Microfluidic device for preparing mixtures
US8617488B2 (en) 2008-08-07 2013-12-31 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
US20100035252A1 (en) 2008-08-08 2010-02-11 Ion Torrent Systems Incorporated Methods for sequencing individual nucleic acids under tension
CN102159726A (zh) * 2008-09-05 2011-08-17 生命科技公司 用于核酸测序验证、校准和标准化的方法和系统
WO2010031007A2 (en) 2008-09-12 2010-03-18 Genvault Corporation Matrices and media for storage and stabilization of biomolecules
CN102170971B (zh) 2008-10-06 2013-12-11 皇家飞利浦电子股份有限公司 微流体装置
JP2012504956A (ja) 2008-10-10 2012-03-01 セントレ ナショナル デ ラ レシェルシェ サイエンティフィーク−ディーエーイー 細胞ソート・デバイス
US9422409B2 (en) 2008-10-10 2016-08-23 Massachusetts Institute Of Technology Method of hydrolytically stable bonding of elastomers to substrates
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20120028822A1 (en) 2008-11-04 2012-02-02 Helicos Biosciences Corporation Methods, flow cells and systems for single cell analysis
KR20110111449A (ko) 2008-12-31 2011-10-11 인터젠엑스 인크. 미세유체 칩을 갖는 기구
US9012208B2 (en) 2009-02-03 2015-04-21 Netbio, Inc. Nucleic acid purification
US20100221726A1 (en) 2009-02-09 2010-09-02 Frederic Zenhausern Relating to devices
US9410948B2 (en) 2009-03-23 2016-08-09 Koninklijke Philips N.V. Manipulation of magnetic particles in a biological sample
US20100243916A1 (en) 2009-03-30 2010-09-30 Lockheed Martin Corporation Modular optical diagnostic platform for chemical and biological target diagnosis and detection
WO2010129937A2 (en) * 2009-05-08 2010-11-11 Life Technologies Corporation Methods for detecting genetic variations in dna samples
GB2473868A (en) 2009-09-28 2011-03-30 Invitrogen Dynal As Apparatus and method of automated processing of biological samples
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
GB2483402B (en) 2009-06-04 2014-04-09 Lockheed Corp Multiple-sample microfluidic chip for DNA analysis
EP2438016B1 (en) 2009-06-05 2021-06-02 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
EP2443254A2 (en) 2009-06-15 2012-04-25 NetBio, Inc. Improved methods for forensic dna quantitation
WO2011003941A1 (en) 2009-07-07 2011-01-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for detection of biological agents
US20120164036A1 (en) 2009-07-21 2012-06-28 Seth Stern Microfluidic devices and uses thereof
US8551787B2 (en) 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
GB2472236A (en) 2009-07-29 2011-02-02 Iti Scotland Ltd Apparatus for analysing microfluidic devices
CN105969761B (zh) 2009-09-21 2020-04-07 阿科尼生物系统公司 磁力裂解方法和装置
TWI421495B (zh) 2009-10-30 2014-01-01 Univ Nat Cheng Kung 微流體晶片
US20130084565A1 (en) 2009-11-03 2013-04-04 University Of Virginia Patent Foundation Versatile, visible method for detecting polymeric analytes
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
EP2516669B1 (en) 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Enzyme assays on a droplet actuator
CA2786569C (en) 2010-01-29 2019-04-09 Micronics, Inc. Sample-to-answer microfluidic cartridge
US8580505B2 (en) 2010-02-26 2013-11-12 Life Technologies Corporation Fast PCR for STR genotyping
US8720036B2 (en) 2010-03-09 2014-05-13 Netbio, Inc. Unitary biochip providing sample-in to results-out processing and methods of manufacture
EP3690433B9 (en) 2010-03-09 2022-12-21 ANDE Corporation Biochip with reagent storage
US20110240127A1 (en) 2010-04-02 2011-10-06 Integenx Inc. Fluidic Article Fabricated In One Piece
CN102947082B (zh) 2010-04-06 2016-03-30 金沃特公司 生物材料的稳定化的化学脱水
WO2011130280A1 (en) 2010-04-12 2011-10-20 Genvault Corporation Products and methods for tissue preservation
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
EP2606242A4 (en) 2010-08-20 2016-07-20 Integenx Inc MICROFLUIDIC DEVICES WITH MECHANICALLY SEALED MEMBRANE VALVES
US9522520B2 (en) 2010-09-01 2016-12-20 Boehringer Ingelheim Microparts Gmbh Process for producing a microfluidic apparatus and related laminating devices
EP2635706B1 (en) 2010-11-05 2015-04-01 Centre Hospitalier Universitaire Vaudois Method for detecting the presence of a dna minor contributor in a dna mixture
US20120181460A1 (en) 2011-01-14 2012-07-19 Integenx Inc. Valves with Hydraulic Actuation System
WO2012129242A2 (en) 2011-03-23 2012-09-27 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
EP2694288A2 (en) 2011-04-07 2014-02-12 4titude Ltd. Heat weldable film for labelling plastic polymer reaction tubes
US8661151B2 (en) 2011-05-09 2014-02-25 Google Inc. Dynamic playlist for mobile computing device
EP3447147A1 (en) 2011-05-12 2019-02-27 NetBio, Inc. Methods and compositions for rapid multiplex amplification of str loci
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
WO2013049071A1 (en) 2011-09-26 2013-04-04 Integenx Inc. Methods and apparatuses for releasably fastening pins
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US8894946B2 (en) 2011-10-21 2014-11-25 Integenx Inc. Sample preparation, processing and analysis systems
WO2013130910A1 (en) 2012-02-29 2013-09-06 Integenx Inc. Sample preparation, processing and analysis systems
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
CA2874870C (en) 2012-07-16 2020-07-07 Sharath Chandra MAHAVADI Capillary electrophoresis for reservoir fluid analysis at wellsite and laboratory
US20140065628A1 (en) 2012-08-28 2014-03-06 Integenx Inc. Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis
WO2014055936A1 (en) 2012-10-04 2014-04-10 Integenx Inc. Preservation of biological materials in non-aqueous fluid media
US20140161686A1 (en) 2012-12-10 2014-06-12 Advanced Liquid Logic, Inc. System and method of dispensing liquids in a microfluidic device
CN118287167A (zh) 2013-11-18 2024-07-05 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
EP3552690B1 (en) 2014-10-22 2024-09-25 IntegenX Inc. Systems and methods for sample preparation, processing and analysis
US10233491B2 (en) 2015-06-19 2019-03-19 IntegenX, Inc. Valved cartridge and system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922591A (en) * 1995-06-29 1999-07-13 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US20040063217A1 (en) * 2002-09-27 2004-04-01 Webster James Russell Miniaturized fluid delivery and analysis system
US20040209354A1 (en) * 2002-12-30 2004-10-21 The Regents Of The University Of California Fluid control structures in microfluidic devices

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Bo Zheng et al.A microfluidic approach for screening submcroliter volumes against multiple reagents by using preformed arrays of nanoliter plugs in a three phase liquid/liquid/gas flow.《Angew Chem Int Ed Engl》.2005,第44卷(第17期),第2520-2523页. *
Christopher J.Campbell et al.Microfluidic mixers: from microfabricated to self-assembling devices.《Phil.Trans.R.Soc.Lond.A》.2003,第1-18页. *
Julio M.Ottino et al.Introduction: mixing in microfluidics.《Phil.Trans.R.Soc.Lond.A》.2004,第362卷第923-935页. *
Timothy J. Johnson et al.Rapid microfluidic mixing.《Anal.Chem》.2002,第74卷第45-51页. *

Also Published As

Publication number Publication date
EP1979079A2 (en) 2008-10-15
US8476063B2 (en) 2013-07-02
US7745207B2 (en) 2010-06-29
US20080014576A1 (en) 2008-01-17
KR20080096567A (ko) 2008-10-30
JP5063616B2 (ja) 2012-10-31
US20160053314A1 (en) 2016-02-25
US9752185B2 (en) 2017-09-05
CA2641271A1 (en) 2008-03-13
CN101415813A (zh) 2009-04-22
US20110076735A1 (en) 2011-03-31
US20130344475A1 (en) 2013-12-26
WO2008030631A3 (en) 2008-10-02
JP2009525728A (ja) 2009-07-16
EP1979079A4 (en) 2012-11-28
WO2008030631A2 (en) 2008-03-13

Similar Documents

Publication Publication Date Title
CN101415813B (zh) 微流体装置
US8431340B2 (en) Methods for processing and analyzing nucleic acid samples
CN101990516B (zh) 多用试样准备系统及其在集成分析系统中的使用
EP3132073B1 (en) Portable nucleic acid analysis system and high-performance microfluidic electroactive polymer actuators
US8557518B2 (en) Microfluidic and nanofluidic devices, systems, and applications
CN102803147B (zh) 通用样品准备系统以及在一体化分析系统中的用途
US20120077260A1 (en) Reservoir-buffered mixers and remote valve switching for microfluidic devices

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130410

Termination date: 20140202