PT1773978E - Modelo de doença com células/tecidos tri-dimensionais perfundidos - Google Patents
Modelo de doença com células/tecidos tri-dimensionais perfundidos Download PDFInfo
- Publication number
- PT1773978E PT1773978E PT57797631T PT05779763T PT1773978E PT 1773978 E PT1773978 E PT 1773978E PT 57797631 T PT57797631 T PT 57797631T PT 05779763 T PT05779763 T PT 05779763T PT 1773978 E PT1773978 E PT 1773978E
- Authority
- PT
- Portugal
- Prior art keywords
- perfused
- tissue disease
- dimensional cell
- disease models
- models
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
- B01L3/50255—Multi-well filtration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/12—Well or multiwell plates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/40—Manifolds; Distribution pieces
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/14—Scaffolds; Matrices
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/0074—Biological products
- B01J2219/00743—Cells
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57258304P | 2004-05-19 | 2004-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1773978E true PT1773978E (pt) | 2014-05-29 |
Family
ID=35510334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT57797631T PT1773978E (pt) | 2004-05-19 | 2005-05-19 | Modelo de doença com células/tecidos tri-dimensionais perfundidos |
Country Status (9)
Country | Link |
---|---|
US (1) | US8318479B2 (pt) |
EP (1) | EP1773978B1 (pt) |
JP (2) | JP2007537759A (pt) |
CN (1) | CN101061213B (pt) |
DK (1) | DK1773978T3 (pt) |
ES (1) | ES2459367T3 (pt) |
PL (1) | PL1773978T3 (pt) |
PT (1) | PT1773978E (pt) |
WO (1) | WO2005123950A2 (pt) |
Families Citing this family (154)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0210809D0 (en) * | 2002-05-11 | 2002-06-19 | Univ Durham | Reactor |
WO2003096883A2 (en) | 2002-05-16 | 2003-11-27 | Barbara Ann Karmanos Cancer Institute | Combined diagnostic and therapeutic ultrasound system |
ATE439039T1 (de) * | 2003-01-16 | 2009-08-15 | Gen Hospital Corp | Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen |
US7854899B2 (en) * | 2004-08-26 | 2010-12-21 | The United States Of America As Represented By The Secretary Of Health And Human Services | Template methods and devices for preparing sample arrays |
US7767446B2 (en) * | 2004-09-16 | 2010-08-03 | Becton, Dickinson And Company | Perfusion bioreactors for culturing cells |
GB0512214D0 (en) | 2005-06-15 | 2005-07-27 | Capsant Neurotechnologies Ltd | Method |
US20060286003A1 (en) * | 2005-06-16 | 2006-12-21 | Desilets Kenneth G | Multi-well filter plate with shifted wells and U-bottom receiver plate |
US9637715B2 (en) | 2005-07-07 | 2017-05-02 | Emd Millipore Corporation | Cell culture and invasion assay method and system |
US9354156B2 (en) | 2007-02-08 | 2016-05-31 | Emd Millipore Corporation | Microfluidic particle analysis method, device and system |
EP1904619A4 (en) | 2005-07-07 | 2012-05-02 | Univ California | METHOD AND DEVICE FOR CELL CULTURE ARRAY |
US9388374B2 (en) | 2005-07-07 | 2016-07-12 | Emd Millipore Corporation | Microfluidic cell culture systems |
US8257964B2 (en) | 2006-01-04 | 2012-09-04 | Cell ASIC | Microwell cell-culture device and fabrication method |
US7745209B2 (en) * | 2005-07-26 | 2010-06-29 | Corning Incorporated | Multilayered cell culture apparatus |
WO2007035604A2 (en) * | 2005-09-16 | 2007-03-29 | Becton, Dickinson And Company | Scaffold carrier cartridge |
US8603806B2 (en) * | 2005-11-02 | 2013-12-10 | The Ohio State Universtiy Research Foundation | Materials and methods for cell-based assays |
US7820430B2 (en) * | 2005-11-28 | 2010-10-26 | Industrial Technology Research Institute | Micro device for cell culture |
WO2008030631A2 (en) | 2006-02-03 | 2008-03-13 | Microchip Biotechnologies, Inc. | Microfluidic devices |
KR100718158B1 (ko) | 2006-04-21 | 2007-05-14 | 삼성전자주식회사 | 세포 공동배양 장치 |
DE102006025011A1 (de) * | 2006-05-26 | 2007-11-29 | Rwth Aachen | Mikrotiterplatte und deren Verwendung |
US7745210B2 (en) * | 2006-06-30 | 2010-06-29 | Corning Incorporated | Fluid flow diverter for cell culture vessel |
US20100159590A1 (en) | 2006-10-05 | 2010-06-24 | Nanopoint, Inc. | Systems and methods for active microfluidic cell handling |
US7897379B2 (en) * | 2007-02-26 | 2011-03-01 | Corning Incorporated | Device and method for reducing bubble formation in cell culture |
US8870771B2 (en) | 2007-05-04 | 2014-10-28 | Barbara Ann Karmanos Cancer Institute | Method and apparatus for categorizing breast density and assessing cancer risk utilizing acoustic parameters |
US10201324B2 (en) | 2007-05-04 | 2019-02-12 | Delphinus Medical Technologies, Inc. | Patient interface system |
US9309491B2 (en) | 2007-05-29 | 2016-04-12 | Corning Incorporated | Cell culture apparatus for co-culture of cells |
EP2183353B1 (en) * | 2007-08-22 | 2015-04-29 | ProBioGen AG | Culture system and method for immunogenicity and immunofunction testing in vitro |
WO2009026931A2 (en) * | 2007-08-24 | 2009-03-05 | Smart Biosystems Aps | Mesoscale bioreactor platform for perfusion |
WO2009039378A2 (en) | 2007-09-19 | 2009-03-26 | The Charles Stark Draper Laboratory, Inc. | Microfluidic structures for biomedical applications |
EP2245453B1 (en) | 2008-01-03 | 2016-10-05 | EMD Millipore Corporation | Microfluidic cell culture array system for automated assays and methods of operation |
JP2011509686A (ja) * | 2008-01-25 | 2011-03-31 | コーニング インコーポレイテッド | アクセス制限された多層細胞培養システム |
DE102008017765A1 (de) * | 2008-04-03 | 2009-10-15 | Technische Universität Ilmenau | Mikrobioreaktor sowie CellChip-Mikrotiter-Platte |
CA2720261C (en) * | 2008-04-08 | 2020-09-22 | Massachusetts Institute Of Technology | Three-dimensional microfluidic platforms and methods of use thereof |
RU2517046C2 (ru) * | 2008-06-04 | 2014-05-27 | Тиссюз Гмбх | Устройство "орган-на-чипе" |
CA2730928C (en) | 2008-07-16 | 2023-06-20 | Children's Medical Center Corporation | Organ mimic device with microchannels and methods of use and manufacturing thereof |
PT104155B (pt) | 2008-08-06 | 2017-04-05 | Ass For The Advancement Of Tissue Eng And Cell Based Tech & Therapies (A4Tec) | Bioreactor multi-câmara com perfusão bidireccional integrado num sistema de cultura para aplicação em estratégias de engenharia de tecidos |
US20100178505A1 (en) * | 2008-12-17 | 2010-07-15 | Rutledge Gregory C | Fibers and fiber-based superstructures, their preparation and uses thereof |
US20110004304A1 (en) * | 2009-03-20 | 2011-01-06 | Tao Sarah L | Culturing retinal cells and tissues |
CN102449135B (zh) * | 2009-03-26 | 2014-07-09 | 新加坡科技研究局 | 用于细胞或组织培养的设备 |
SG176669A1 (en) | 2009-06-05 | 2012-01-30 | Integenx Inc | Universal sample preparation system and use in an integrated analysis system |
DE102009039868B4 (de) * | 2009-09-03 | 2020-12-31 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Anordnung zur Durchführung eines Verfahrens zur Untersuchung der Wirkung eines gasförmigen Mediums auf ein biologisches Prüfsystem unter Verwendung eines extrazellulären Metabolisierungssystems |
JP5594658B2 (ja) * | 2010-01-21 | 2014-09-24 | 一般財団法人生産技術研究奨励会 | 物質分布制御方法、デバイス、細胞培養方法、細胞分化制御方法 |
US9353342B2 (en) | 2010-01-21 | 2016-05-31 | Emd Millipore Corporation | Cell culture and gradient migration assay methods and devices |
US9144403B2 (en) | 2010-02-12 | 2015-09-29 | Delphinus Medical Technologies, Inc. | Method of characterizing the pathological response of tissue to a treatment plan |
WO2011100697A1 (en) | 2010-02-12 | 2011-08-18 | Delphinus Medical Technologies, Inc. | Method of characterizing tissue of a patient |
FR2957086B1 (fr) * | 2010-03-02 | 2014-11-28 | Univ Compiegne Tech | Boite multi-reacteurs pour culture cellulaire dynamique |
CA2791565C (fr) * | 2010-03-02 | 2018-08-28 | Universite Technologie De Compiegne - Utc | Boite multi-reacteurs pour culture cellulaire dynamique |
FR2957087B1 (fr) * | 2010-03-02 | 2014-11-28 | Univ Compiegne Tech | Boite multi-reacteurs pour culture cellulaire dynamique |
CN102234612B (zh) * | 2010-05-06 | 2014-01-29 | 同济大学 | 一种生物工程体外循环系统 |
JP5686310B2 (ja) * | 2010-05-25 | 2015-03-18 | 株式会社島津製作所 | 細胞培養デバイス、細胞培養システム、及び細胞培養方法 |
CN103026239B (zh) * | 2010-07-26 | 2015-04-15 | 恩普乐股份有限公司 | 微流路芯片和微分析系统 |
WO2012024658A2 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Integrated analysis system |
GB201100180D0 (en) * | 2011-01-06 | 2011-02-23 | Capsant Neurotechnologies Ltd | Tumour cell and tissue culture |
EP2484447A1 (en) * | 2011-02-07 | 2012-08-08 | Biocartis SA | Improved encoded microcarriers, assay system using them and method for performing an assay |
KR102117921B1 (ko) | 2011-02-28 | 2020-06-03 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 세포 배양 시스템 |
TWI438273B (zh) * | 2011-03-08 | 2014-05-21 | Univ Chang Gung | High-throughput perfusative microfluidic cell culture wafers for miniaturized three-dimensional cell culture |
WO2012126915A1 (en) * | 2011-03-22 | 2012-09-27 | Novartis Ag | Sensor |
US10526572B2 (en) | 2011-04-01 | 2020-01-07 | EMD Millipore Corporaticn | Cell culture and invasion assay method and system |
US20140137973A1 (en) * | 2011-06-14 | 2014-05-22 | Idex Health & Science Llc | Clog resistant fluid pathway |
CN104114280B (zh) * | 2011-09-30 | 2017-05-17 | 生命科技公司 | 用于生物分析的系统和方法 |
CN102337213B (zh) * | 2011-10-13 | 2013-06-05 | 西北工业大学 | 一种基于pdms的三维单细胞培养芯片及其可控制备方法 |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
JP6232383B2 (ja) | 2011-12-03 | 2017-11-15 | イー・エム・デイー・ミリポア・コーポレイシヨン | マイクロ流体の細胞培養のためのマイクロインキュベーションシステムおよび方法 |
WO2013086486A1 (en) | 2011-12-09 | 2013-06-13 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
WO2014018770A1 (en) | 2012-07-25 | 2014-01-30 | The Charles Stark Draper Laboratory, Inc. | Modular platform for multi-tissue integrated cell culture |
US9763641B2 (en) | 2012-08-30 | 2017-09-19 | Delphinus Medical Technologies, Inc. | Method and system for imaging a volume of tissue with tissue boundary detection |
US9932559B2 (en) * | 2012-11-16 | 2018-04-03 | The Johns Hopkins University | Platform for creating an artificial blood brain barrier |
WO2014100150A1 (en) * | 2012-12-20 | 2014-06-26 | Flir Detection, Inc. | Device and methods for detection of analytes including use of a clorimetric barcode |
CN104956226B (zh) | 2013-01-25 | 2018-02-02 | 艾克斯赛尔生物科学公司 | 用于选择性富集靶细胞的方法、组合物、试剂盒及系统 |
ES2734503T3 (es) | 2013-01-29 | 2019-12-10 | Charles Stark Draper Laboratory Inc | Plataforma modular para el cultivo celular integrado multitejido |
WO2014127250A1 (en) * | 2013-02-14 | 2014-08-21 | Cfd Research Corporation | Cell culture device with an array of microfluidic networks |
US10123770B2 (en) | 2013-03-13 | 2018-11-13 | Delphinus Medical Technologies, Inc. | Patient support system |
US9790465B2 (en) | 2013-04-30 | 2017-10-17 | Corning Incorporated | Spheroid cell culture well article and methods thereof |
US20160123960A1 (en) * | 2013-06-10 | 2016-05-05 | Millennium Pharmaceuticals, Inc. | Method for preparing three-dimensional, organotypic cell cultures and uses thereof |
DE202013103016U1 (de) | 2013-07-08 | 2013-07-15 | Bürkert Werke GmbH | Mikrofluiddosiereinheit und Testvorrichtung für Biomaterial |
WO2015004482A2 (en) * | 2013-07-12 | 2015-01-15 | Cn Bio Innovations Limited | Liver infection |
EP3024582A4 (en) | 2013-07-22 | 2017-03-08 | President and Fellows of Harvard College | Microfluidic cartridge assembly |
US10883083B2 (en) | 2013-08-02 | 2021-01-05 | The Trustees Of Columbia University In The City Of New York | Tissue-engineered three-dimensional model for tumor analysis |
KR102351838B1 (ko) | 2013-08-05 | 2022-01-18 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
DE102013109450B4 (de) | 2013-08-30 | 2015-04-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Expositionsapparat |
US10191071B2 (en) | 2013-11-18 | 2019-01-29 | IntegenX, Inc. | Cartridges and instruments for sample analysis |
CN103614297B (zh) * | 2013-11-20 | 2015-04-15 | 南方医科大学珠江医院 | 仿肝板结构肝细胞三维培养装置及其培养方法 |
CA2934662C (en) | 2013-12-20 | 2024-02-20 | President And Fellows Of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
US10039244B2 (en) * | 2014-03-04 | 2018-08-07 | Greenonyx Ltd | Systems and methods for cultivating and distributing aquatic organisms |
US10208332B2 (en) | 2014-05-21 | 2019-02-19 | Integenx Inc. | Fluidic cartridge with valve mechanism |
TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
JP6815985B2 (ja) | 2014-07-14 | 2021-01-20 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 流体システムおよびマイクロ流体システムの改善された性能のためのシステムおよび方法 |
US10285667B2 (en) | 2014-08-05 | 2019-05-14 | Delphinus Medical Technologies, Inc. | Method for generating an enhanced image of a volume of tissue |
CN107106983B (zh) | 2014-10-22 | 2021-04-16 | 尹特根埃克斯有限公司 | 用于样品制备、处理和分析的系统和方法 |
SG11201703500XA (en) | 2014-10-29 | 2017-05-30 | Corning Inc | Perfusion bioreactor platform |
DE102014119037B4 (de) | 2014-12-18 | 2023-12-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Expositionsvorrichtung |
WO2016126987A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Compositions and methods for synthetic gene assembly |
WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
EP3254008B1 (en) | 2015-02-04 | 2018-12-26 | The Charles Stark Draper Laboratory, Inc. | Actuated valve or pump for microfluidic devices |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
WO2016183231A1 (en) | 2015-05-12 | 2016-11-17 | Baker Group, LLP | Method and system for a bioartificial organ |
WO2017019542A1 (en) | 2015-07-24 | 2017-02-02 | President And Fellows Of Harvard College | Radial microfluidic devices and methods of use |
DK3341465T3 (da) | 2015-08-26 | 2023-11-20 | Emulate Inc | Perfusionsfordeleranordning |
CA2998169A1 (en) | 2015-09-18 | 2017-03-23 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
EP3353281A4 (en) * | 2015-09-21 | 2019-04-03 | Rutgers, The State University of New Jersey | MODIFIED BIOSENSOR WITH MAGNESIUM-ZINC OXIDE NANOSTRUCTURE AND MONITORING THE RESPONSE OF A POPULATION OF CELLS TO AN AGENT USING THE SAME |
WO2017053450A1 (en) | 2015-09-22 | 2017-03-30 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
ES2615512B1 (es) * | 2015-11-06 | 2018-03-15 | Universidad De Zaragoza | Dispositivo y sistema microfluídico para el estudio de cultivos celulares |
CA3006867A1 (en) | 2015-12-01 | 2017-06-08 | Twist Bioscience Corporation | Functionalized surfaces and preparation thereof |
WO2017176357A2 (en) | 2016-02-04 | 2017-10-12 | Massachusetts Institute Of Technology | Modular organ microphysiological system with integrated pumping, leveling, and sensing |
GB201604292D0 (en) * | 2016-03-14 | 2016-04-27 | Insphero Ag | 3D-tissue culture based method to assess mitochondrial impairment |
CN105754856B (zh) * | 2016-04-12 | 2018-06-22 | 中国航天员科研训练中心 | 一种抽屉式三维类血管化组织培养器官芯片及其构建方法 |
ITUA20163547A1 (it) * | 2016-05-18 | 2017-11-18 | Milano Politecnico | Dispositivo per la coltura cellulare |
CN107422119A (zh) * | 2016-05-23 | 2017-12-01 | 李榕生 | 典型六种肿瘤标志物联合检测用微流控芯片装置 |
CN107422120A (zh) * | 2016-05-23 | 2017-12-01 | 李榕生 | 普适型用于同时检测多种肿瘤标志物的微流控芯片装置 |
KR102308594B1 (ko) * | 2016-07-12 | 2021-10-05 | 에뮬레이트, 인크. | 마이크로유체 장치에서의 버블 제거 |
SG11201901563UA (en) | 2016-08-22 | 2019-03-28 | Twist Bioscience Corp | De novo synthesized nucleic acid libraries |
US20180057784A1 (en) | 2016-08-27 | 2018-03-01 | 3D Biotek, Llc | Bioreactor |
WO2018057526A2 (en) | 2016-09-21 | 2018-03-29 | Twist Bioscience Corporation | Nucleic acid based data storage |
CA3047128A1 (en) | 2016-12-16 | 2018-06-21 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
US20200040294A1 (en) * | 2017-01-18 | 2020-02-06 | Shinko Chemical Co., Ltd. | Device for evaluation of chemical substance and method for evaluation of chemical substance |
CN110892485B (zh) | 2017-02-22 | 2024-03-22 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
CN110913865A (zh) | 2017-03-15 | 2020-03-24 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
WO2018175478A2 (en) | 2017-03-21 | 2018-09-27 | Massachusetts Institute Of Technology | Modular organ microphysiological system with microbiome |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
US10696965B2 (en) | 2017-06-12 | 2020-06-30 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
US11767499B2 (en) | 2017-07-14 | 2023-09-26 | Corning Incorporated | Cell culture vessel |
CN111051494B (zh) | 2017-07-14 | 2024-03-29 | 康宁股份有限公司 | 用于手动或自动培养基交换的3d细胞培养容器 |
US11857970B2 (en) | 2017-07-14 | 2024-01-02 | Corning Incorporated | Cell culture vessel |
WO2019014610A1 (en) | 2017-07-14 | 2019-01-17 | Corning Incorporated | CELL CULTURE CONTAINER FOR 3D CULTURE AND METHODS OF CULTURING 3D CELLS |
CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
AU2019205269A1 (en) | 2018-01-04 | 2020-07-30 | Twist Bioscience Corporation | DNA-based digital information storage |
CN112041422A (zh) * | 2018-02-08 | 2020-12-04 | 佛罗里达大学研究基金会公司 | 具有灌注功能的生物反应器 |
US11680241B2 (en) | 2018-02-08 | 2023-06-20 | University Of Florida Research Foundation, Inc. | Perfusion enabled bioreactors |
US20190330584A1 (en) * | 2018-03-19 | 2019-10-31 | Massachusetts Institute Of Technology | Organ-on-chip platforms with reduced fluid volume |
US20210054319A1 (en) * | 2018-04-12 | 2021-02-25 | Technion Research & Development Foundation Limited | Flow bioreactor device for monitoring cellular dynamics |
WO2019213271A1 (en) | 2018-05-01 | 2019-11-07 | Massachusetts Institute Of Technology | Micropumps with electromagnetic actuator for organ-on-chip plattforms |
SG11202011467RA (en) | 2018-05-18 | 2020-12-30 | Twist Bioscience Corp | Polynucleotides, reagents, and methods for nucleic acid hybridization |
US20210201702A1 (en) * | 2018-05-22 | 2021-07-01 | The Regents Of The University Of California | Use of 3d-printed freestanding structures for ex vivo tissue |
JP7171695B2 (ja) | 2018-07-13 | 2022-11-15 | コーニング インコーポレイテッド | 液体培地送達面を含む側壁を有するマイクロキャビティ皿 |
EP3649227A1 (en) | 2018-07-13 | 2020-05-13 | Corning Incorporated | Fluidic devices including microplates with interconnected wells |
WO2020013845A1 (en) | 2018-07-13 | 2020-01-16 | Corning Incorporated | Cell culture vessels with stabilizer devices |
US20200116600A1 (en) | 2018-08-31 | 2020-04-16 | Lucid Scientific, Inc. | Measurement of a dynamic system |
WO2020172337A1 (en) * | 2019-02-19 | 2020-08-27 | Iontox, Llc | Methods to predict repeated dose toxicity using an integrated organ platform |
SG11202109283UA (en) | 2019-02-26 | 2021-09-29 | Twist Bioscience Corp | Variant nucleic acid libraries for antibody optimization |
EP3930753A4 (en) | 2019-02-26 | 2023-03-29 | Twist Bioscience Corporation | NUCLEIC ACID VARIANT BANKS FOR THE GLP1 RECEPTOR |
AU2020233887A1 (en) * | 2019-03-08 | 2021-10-07 | Advanced Solutions Life Sciences, Llc | Modular and expandable low flow pumping assemblies |
GB201903813D0 (en) | 2019-03-20 | 2019-05-01 | Cn Bio Innovations Ltd | Dual circulation microphysiological system |
US20220243156A1 (en) * | 2019-05-24 | 2022-08-04 | The Regents Of The University Of Michigan | Bioreactor assembly, bioreactor, and method of operating same |
WO2020252225A1 (en) | 2019-06-14 | 2020-12-17 | University Of Connecticut | Multigel tumor-on-a-chip system |
US11332738B2 (en) | 2019-06-21 | 2022-05-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
US11767498B2 (en) * | 2019-08-28 | 2023-09-26 | Massachusetts Institute Of Technology | In vitro tissue plate |
US20220105510A1 (en) | 2020-10-07 | 2022-04-07 | Massachusetts Institute Of Technology | Microfluidic cell culture devices |
CN112210496A (zh) * | 2020-10-19 | 2021-01-12 | 广州吉源生物科技有限公司 | 一种胚胎干细胞诱导分化仪器 |
CN112553072B (zh) * | 2020-12-10 | 2022-04-08 | 上海艾众生物科技有限公司 | 用于生物反应器罐外循环的微流道动力设备 |
US20220193674A1 (en) * | 2020-12-23 | 2022-06-23 | Imec Vzw | Microfluidic Device Unit |
EP4291630A1 (en) * | 2021-02-12 | 2023-12-20 | The Charles Stark Draper Laboratory, Inc. | Microchannel cell culture device and system |
US20220373462A1 (en) * | 2021-05-14 | 2022-11-24 | MBD Co., Ltd. | Measuring method of cell migration using the rate of cell invasion |
CN113846016B (zh) * | 2021-09-22 | 2023-06-02 | 清华大学 | 一种高通量多孔阵列芯片、装置、制备方法及应用 |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4033825A (en) | 1973-05-31 | 1977-07-05 | Instrumentation Laboratory, Inc. | Cell culture system |
US4060081A (en) | 1975-07-15 | 1977-11-29 | Massachusetts Institute Of Technology | Multilayer membrane useful as synthetic skin |
US4539716A (en) | 1981-03-19 | 1985-09-10 | Massachusetts Institute Of Technology | Fabrication of living blood vessels and glandular tissues |
US4546500A (en) | 1981-05-08 | 1985-10-15 | Massachusetts Institute Of Technology | Fabrication of living blood vessels and glandular tissues |
US4485096A (en) | 1982-02-26 | 1984-11-27 | Massachusetts Institute Of Technology | Tissue-equivalent and method for preparation thereof |
US4520821A (en) | 1982-04-30 | 1985-06-04 | The Regents Of The University Of California | Growing of long-term biological tissue correction structures in vivo |
IL68507A (en) | 1982-05-10 | 1986-01-31 | Univ Bar Ilan | System and methods for cell selection |
US4485097A (en) | 1982-05-26 | 1984-11-27 | Massachusetts Institute Of Technology | Bone-equivalent and method for preparation thereof |
US4734372A (en) | 1983-02-04 | 1988-03-29 | Brown University Research Foundation | Cell culturing methods and apparatus |
DE3600487A1 (de) * | 1986-01-10 | 1987-07-16 | Gebhardt Rolf | Perifusionsgeraet fuer die zuechtung lebender zellen und verfahren zur perifusions-kultivierung |
US5510254A (en) | 1986-04-18 | 1996-04-23 | Advanced Tissue Sciences, Inc. | Three dimensional cell and tissue culture system |
US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
JP2662215B2 (ja) | 1986-11-19 | 1997-10-08 | 株式会社日立製作所 | 細胞保持装置 |
US5595909A (en) | 1988-05-23 | 1997-01-21 | Regents Of The University Of Minnesota | Filter device |
US5605835A (en) | 1988-05-23 | 1997-02-25 | Regents Of The University Of Minnesota | Bioreactor device with application as a bioartificial liver |
US5155034A (en) | 1988-06-30 | 1992-10-13 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Three-dimensional cell to tissue assembly process |
JPH0292270A (ja) | 1988-09-30 | 1990-04-03 | Terumo Corp | 細胞培養装置 |
US5602026A (en) | 1988-10-14 | 1997-02-11 | The General Hospital Corporation | Culturing liver cells between two supports |
DE68922390T2 (de) | 1988-10-21 | 1995-10-05 | Molecular Devices Corp | Verfahren und apparat zur messung der effekte von zellwirksamen mitteln auf lebende zellen. |
US5521087A (en) | 1989-05-10 | 1996-05-28 | Massachusetts Institute Of Technology | Method for producing oriented connective tissue cells in a ligament configuration |
US5763266A (en) | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
DE3923279A1 (de) | 1989-07-14 | 1990-01-18 | Will W Prof Dr Minuth | Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren |
US5204055A (en) | 1989-12-08 | 1993-04-20 | Massachusetts Institute Of Technology | Three-dimensional printing techniques |
US5169601A (en) | 1990-04-27 | 1992-12-08 | Suzuki Motor Corporation | Immunological agglutination detecting apparatus with separately controlled supplementary light sources |
GB2244135B (en) | 1990-05-04 | 1994-07-13 | Gen Electric Co Plc | Sensor devices |
JPH04262780A (ja) | 1991-02-15 | 1992-09-18 | Hitachi Chem Co Ltd | 神経線維の成長方向を制御する素子及びその製造法 |
JPH04278080A (ja) | 1991-03-01 | 1992-10-02 | Hitachi Ltd | 神経回路の作製方法 |
US5650323A (en) | 1991-06-26 | 1997-07-22 | Costar Corporation | System for growing and manipulating tissue cultures using 96-well format equipment |
JP3067347B2 (ja) | 1991-10-30 | 2000-07-17 | 株式会社島津製作所 | ゲル状ビーズの選別装置 |
US5612188A (en) | 1991-11-25 | 1997-03-18 | Cornell Research Foundation, Inc. | Automated, multicompartmental cell culture system |
DE4206585C2 (de) | 1992-03-03 | 1994-11-24 | Augustinus Dr Med Bader | Vorrichtung zur Massenkultur von Zellen |
US5512474A (en) | 1992-05-29 | 1996-04-30 | Bsi Corporation | Cell culture support containing a cell adhesion factor and a positively-charged molecule |
US5639423A (en) | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor |
DK0671923T3 (da) | 1992-10-09 | 2001-08-13 | Advanced Tissue Sciences Inc | Leverreserveceller |
US5424209A (en) | 1993-03-19 | 1995-06-13 | Kearney; George P. | Automated cell culture and testing system |
US6176874B1 (en) | 1993-10-18 | 2001-01-23 | Masschusetts Institute Of Technology | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques |
US5518680A (en) | 1993-10-18 | 1996-05-21 | Massachusetts Institute Of Technology | Tissue regeneration matrices by solid free form fabrication techniques |
DK0725682T3 (da) | 1993-10-28 | 2002-07-15 | Houston Advanced Res Ct | Mikrofremstillet, porøst gennemløbsapparat til diskret påvisning af bindingsreaktioner |
US5451524A (en) | 1994-02-01 | 1995-09-19 | The Gillette Company | In vitro chamber for human organ tissue samples |
JPH09501324A (ja) | 1994-03-11 | 1997-02-10 | バクスター、インターナショナル、インコーポレイテッド | 細胞保持用の溝を備えた貫流バイオリアクター |
ATE198511T1 (de) | 1994-04-29 | 2001-01-15 | Perkin Elmer Corp | Verfahren und vorrichtung zur echtzeiterfassung der produkte von nukleinsäureamplifikation |
JP2570621B2 (ja) | 1994-06-27 | 1997-01-08 | 日本電気株式会社 | 細胞培養用基板とその作製方法および細胞配列形成方法 |
US5599788A (en) | 1994-07-01 | 1997-02-04 | Advanced Tissue Sciences | Method for accelerating skin wound healing with H3 protein |
JPH08154663A (ja) | 1994-12-06 | 1996-06-18 | Able Kk | 生体組織維持容器 |
BE1009306A5 (fr) | 1995-04-28 | 1997-02-04 | Baxter Int | Bioreacteur. |
US5602028A (en) | 1995-06-30 | 1997-02-11 | The University Of British Columbia | System for growing multi-layered cell cultures |
ATE192779T1 (de) | 1995-10-06 | 2000-05-15 | Microcloning Cccd Ab | Kompaktzellkulturscheibe |
GB9521775D0 (en) | 1995-10-24 | 1996-01-03 | Pa Consulting Services | Microwell plates |
EP0798844A1 (en) * | 1996-03-28 | 1997-10-01 | Tai-Her Yang | The combined power driven device having a three-layered electromechanical structure with common structures |
IT1291173B1 (it) | 1997-03-07 | 1998-12-29 | Ist Trentino Di Cultura | Sistema per il monitoraggio dell'attivita' metabolica di popolazioni cellulari viventi. |
US6548263B1 (en) * | 1997-05-29 | 2003-04-15 | Cellomics, Inc. | Miniaturized cell array methods and apparatus for cell-based screening |
WO1999047922A2 (en) | 1998-03-18 | 1999-09-23 | Massachusetts Institute Of Technology | Vascularized perfused microtissue/micro-organ arrays |
JP3686311B2 (ja) * | 2000-06-28 | 2005-08-24 | 三菱重工業株式会社 | 可変ターボチャージャ |
DE10041853C1 (de) * | 2000-08-25 | 2002-02-28 | Gmd Gmbh | Konfigurierbares Mikroreaktornetzwerk |
US7374906B2 (en) * | 2000-11-08 | 2008-05-20 | Surface Logix, Inc. | Biological assays using gradients formed in microfluidic systems |
US20020173033A1 (en) | 2001-05-17 | 2002-11-21 | Kyle Hammerick | Device and method or three-dimensional spatial localization and functional interconnection of different types of cells |
US20030215941A1 (en) * | 2002-03-12 | 2003-11-20 | Stewart Campbell | Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound |
AU2003282950A1 (en) * | 2002-10-22 | 2004-05-13 | Surface Logix, Inc. | Device and method for monitoring leukocyte migration |
EP1594694A4 (en) | 2002-12-30 | 2010-01-20 | Univ California | METHODS AND APPARATUS FOR DETECTION AND ANALYSIS OF PATHOGENIC AGENTS |
ATE432420T1 (de) * | 2003-03-10 | 2009-06-15 | Univ Michigan | Intergrierte mikrofluidische kontrollvorrichtung mit programmierbaren taktilen stellgliedern |
US7413712B2 (en) * | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
US7767446B2 (en) * | 2004-09-16 | 2010-08-03 | Becton, Dickinson And Company | Perfusion bioreactors for culturing cells |
-
2005
- 2005-05-19 PL PL05779763T patent/PL1773978T3/pl unknown
- 2005-05-19 DK DK05779763.1T patent/DK1773978T3/da active
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CN101061213B (zh) | 2012-12-19 |
US8318479B2 (en) | 2012-11-27 |
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PL1773978T3 (pl) | 2014-09-30 |
CN101061213A (zh) | 2007-10-24 |
EP1773978A4 (en) | 2010-01-13 |
WO2005123950A3 (en) | 2006-04-13 |
JP5538246B2 (ja) | 2014-07-02 |
JP2011072322A (ja) | 2011-04-14 |
ES2459367T3 (es) | 2014-05-09 |
EP1773978B1 (en) | 2014-04-02 |
US20050260745A1 (en) | 2005-11-24 |
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