CN100351246C - 选择性衍生紫杉烷的方法 - Google Patents
选择性衍生紫杉烷的方法 Download PDFInfo
- Publication number
- CN100351246C CN100351246C CNB2005100641228A CN200510064122A CN100351246C CN 100351246 C CN100351246 C CN 100351246C CN B2005100641228 A CNB2005100641228 A CN B2005100641228A CN 200510064122 A CN200510064122 A CN 200510064122A CN 100351246 C CN100351246 C CN 100351246C
- Authority
- CN
- China
- Prior art keywords
- hydroxyl
- hydrocarbyl
- dab
- hydrogen
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Soil Working Implements (AREA)
- Fats And Perfumes (AREA)
- Percussion Or Vibration Massage (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5600097P | 1997-08-18 | 1997-08-18 | |
| US60/056,000 | 1997-08-18 | ||
| US8126598P | 1998-04-09 | 1998-04-09 | |
| US60/081,265 | 1998-04-09 | ||
| US09/063,477 US7288665B1 (en) | 1997-08-18 | 1998-04-20 | Process for selective derivatization of taxanes |
| US09/063,477 | 1998-04-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB98801341XA Division CN1205196C (zh) | 1997-08-18 | 1998-08-17 | 选择性衍生紫杉烷的方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101492418A Division CN1974563A (zh) | 1997-08-18 | 1998-08-17 | 选择性衍生紫杉烷的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1690053A CN1690053A (zh) | 2005-11-02 |
| CN100351246C true CN100351246C (zh) | 2007-11-28 |
Family
ID=27368950
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100641228A Expired - Fee Related CN100351246C (zh) | 1997-08-18 | 1998-08-17 | 选择性衍生紫杉烷的方法 |
| CNA2006101492418A Pending CN1974563A (zh) | 1997-08-18 | 1998-08-17 | 选择性衍生紫杉烷的方法 |
| CNB98801341XA Expired - Fee Related CN1205196C (zh) | 1997-08-18 | 1998-08-17 | 选择性衍生紫杉烷的方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101492418A Pending CN1974563A (zh) | 1997-08-18 | 1998-08-17 | 选择性衍生紫杉烷的方法 |
| CNB98801341XA Expired - Fee Related CN1205196C (zh) | 1997-08-18 | 1998-08-17 | 选择性衍生紫杉烷的方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US7288665B1 (enExample) |
| EP (6) | EP1671960A2 (enExample) |
| JP (1) | JP2001504864A (enExample) |
| KR (1) | KR100596989B1 (enExample) |
| CN (3) | CN100351246C (enExample) |
| AT (3) | ATE326455T1 (enExample) |
| AU (1) | AU744987B2 (enExample) |
| BR (1) | BR9806145A (enExample) |
| CA (2) | CA2268662A1 (enExample) |
| CY (1) | CY1105399T1 (enExample) |
| CZ (1) | CZ296580B6 (enExample) |
| DE (3) | DE69836072T2 (enExample) |
| DK (3) | DK0956284T3 (enExample) |
| ES (3) | ES2274579T3 (enExample) |
| HU (1) | HUP0300425A3 (enExample) |
| ID (1) | ID21654A (enExample) |
| IL (3) | IL129386A0 (enExample) |
| NO (4) | NO325139B1 (enExample) |
| NZ (1) | NZ335156A (enExample) |
| PL (3) | PL332723A1 (enExample) |
| PT (3) | PT1170293E (enExample) |
| RU (1) | RU2225402C2 (enExample) |
| SG (1) | SG97986A1 (enExample) |
| WO (1) | WO1999009021A1 (enExample) |
| ZA (1) | ZA987394B (enExample) |
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| IT1308636B1 (it) * | 1999-03-02 | 2002-01-09 | Indena Spa | Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii. |
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| ATE381328T1 (de) | 2000-02-02 | 2008-01-15 | Univ Florida State Res Found | Heterosubstituierte taxan-c10-acetate als antitumormittel |
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| US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| NZ514410A (en) | 2000-02-02 | 2005-01-28 | Univ Florida State Res Found | C7 carbamoyloxy substituted taxanes as antitumor agents |
| EP1165551B1 (en) | 2000-02-02 | 2008-07-16 | Florida State University Research Foundation, Inc. | C10 carbamoyloxy substituted taxanes as antitumor agents |
| HUP0200759A3 (en) | 2000-02-02 | 2002-10-28 | Univ Florida State Res Found | C10 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use |
| JP2003522170A (ja) | 2000-02-02 | 2003-07-22 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 抗腫瘍剤としてのc7カーボネート置換タキサン |
| US6362217B2 (en) * | 2000-03-17 | 2002-03-26 | Bristol-Myers Squibb Company | Taxane anticancer agents |
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| US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
| WO2004002468A1 (en) | 2002-06-26 | 2004-01-08 | Medigene Oncology Gmbh | Method of producing a cationic liposomal preparation comprising a lipophilic compound |
| CN101039957A (zh) | 2003-05-16 | 2007-09-19 | 因特缪恩公司 | 合成的趋化因子受体配体及其使用方法 |
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| CN101274924B (zh) * | 2007-03-27 | 2010-11-10 | 中国科学院大连化学物理研究所 | 一种制备紫杉醇及其衍生物的方法 |
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Citations (5)
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| US4924011A (en) * | 1988-04-06 | 1990-05-08 | Centre National De La Recherche Scientifique | Process for preparing taxol |
| US5578739A (en) * | 1991-07-10 | 1996-11-26 | Rhone-Poulenc Rorer S.A. | Process for the preparation of Baccatin III and 10-deacetylbaccatin III derivatives |
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- 1998-08-17 CN CNB2005100641228A patent/CN100351246C/zh not_active Expired - Fee Related
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