GT200500041A - Taxanos con sustituyente lactiloxilo en el c7 - Google Patents

Taxanos con sustituyente lactiloxilo en el c7

Info

Publication number
GT200500041A
GT200500041A GT200500041A GT200500041A GT200500041A GT 200500041 A GT200500041 A GT 200500041A GT 200500041 A GT200500041 A GT 200500041A GT 200500041 A GT200500041 A GT 200500041A GT 200500041 A GT200500041 A GT 200500041A
Authority
GT
Guatemala
Prior art keywords
taxanos
lactiloxilo
substitute
compounds
taxanes
Prior art date
Application number
GT200500041A
Other languages
English (en)
Inventor
Robert A Holton
Hyeong Baik Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200500041A publication Critical patent/GT200500041A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA QUE SE APRECIA EN EL PRESENTE RESUMEN EN EL QUE X3,X5,BZ,AC, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS CLASIFICADOS COMO TAXANOS SON DE UTILIDAD COMO AGENTES ANTINEOPLASICOS POR LO QUE SU UTILIZACION SE HACE IMPORTANTE EN CUADROS DE CANCER.
GT200500041A 2004-03-05 2005-03-04 Taxanos con sustituyente lactiloxilo en el c7 GT200500041A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55071204P 2004-03-05 2004-03-05

Publications (1)

Publication Number Publication Date
GT200500041A true GT200500041A (es) 2005-10-24

Family

ID=34975310

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200500041A GT200500041A (es) 2004-03-05 2005-03-04 Taxanos con sustituyente lactiloxilo en el c7

Country Status (11)

Country Link
US (1) US7160919B2 (es)
EP (1) EP1737444A4 (es)
JP (1) JP2007527432A (es)
CN (1) CN1960721A (es)
AR (1) AR048078A1 (es)
GT (1) GT200500041A (es)
PA (1) PA8625301A1 (es)
PE (1) PE20060014A1 (es)
SV (1) SV2006002036A (es)
TW (1) TW200540164A (es)
WO (1) WO2005087222A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104650109B (zh) * 2013-11-22 2019-01-01 江苏天士力帝益药业有限公司 紫杉烷类化合物
CA3017690C (en) 2016-03-14 2024-02-20 Wisconsin Alumni Research Foundation Oligolactic acid conjugates and micelles with enhanced anticancer efficacy

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
FR2679230B1 (fr) 1991-07-16 1993-11-19 Rhone Poulenc Rorer Sa Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
SG46582A1 (en) 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
ES2230790T3 (es) 1992-01-15 2005-05-01 E.R. SQUIBB & SONS, INC. Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos.
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
ATE181551T1 (de) 1992-04-17 1999-07-15 Abbott Lab Taxol-derivate
US5248796A (en) 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
US5319112A (en) 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
WO1994005282A1 (en) 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
CA2100808A1 (en) 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
WO1994014787A1 (en) 1992-12-23 1994-07-07 Bristol-Myers Squibb Company Novel sidechain-bearing taxanes and intermediates thereof
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
EP0690867B1 (en) * 1993-03-22 2003-02-19 Florida State University Taxanes having furyl or thienyl substituted side-chain
AU7138894A (en) 1993-06-11 1995-01-03 Pharmacia & Upjohn Company Delta 6,7--taxols antineoplastic use and pharmaceutical compositions containing them
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
FR2711369B1 (fr) 1993-10-20 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent.
US5415869A (en) 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
TW354293B (en) 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
CA2231837A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
US5767297A (en) 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
FR2745814B1 (fr) 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
IL126856A0 (en) 1996-05-06 1999-09-22 Univ Florida State 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
ES2151277T3 (es) 1996-05-22 2000-12-16 Protarga Inc Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US6136988A (en) 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same
US6146659A (en) 1998-07-01 2000-11-14 Neopharm, Inc. Method of administering liposomal encapsulated taxane
WO2000078707A1 (en) 1999-06-21 2000-12-28 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl(2r,3s)-3-phenylisoserine activated esters and methods for production thereof
US6348215B1 (en) 1999-10-06 2002-02-19 The Research Foundation Of State University Of New York Stabilization of taxane-containing dispersed systems
HUP0200651A3 (en) * 2000-02-02 2002-10-28 Univ Florida State Res Found C7 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them
WO2001057013A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. Taxane formulations having improved solubility
AR030188A1 (es) * 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
IT1319168B1 (it) 2000-03-17 2003-09-26 Indena Spa Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.
CA2354486A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C7 ester substituted taxanes

Also Published As

Publication number Publication date
US20050209311A1 (en) 2005-09-22
SV2006002036A (es) 2006-03-16
CN1960721A (zh) 2007-05-09
JP2007527432A (ja) 2007-09-27
TW200540164A (en) 2005-12-16
US7160919B2 (en) 2007-01-09
EP1737444A1 (en) 2007-01-03
EP1737444A4 (en) 2008-05-21
WO2005087222A1 (en) 2005-09-22
AR048078A1 (es) 2006-03-29
PE20060014A1 (es) 2006-02-18
PA8625301A1 (es) 2006-06-02

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