PE20060014A1 - Taxanos con sustituyentes lactiloxilo en el c7 - Google Patents

Taxanos con sustituyentes lactiloxilo en el c7

Info

Publication number
PE20060014A1
PE20060014A1 PE2005000247A PE2005000247A PE20060014A1 PE 20060014 A1 PE20060014 A1 PE 20060014A1 PE 2005000247 A PE2005000247 A PE 2005000247A PE 2005000247 A PE2005000247 A PE 2005000247A PE 20060014 A1 PE20060014 A1 PE 20060014A1
Authority
PE
Peru
Prior art keywords
benzoxicarbonyl
taxane
lactyloxyl
furanil
diasteroisomers
Prior art date
Application number
PE2005000247A
Other languages
English (en)
Inventor
Robert A Holton
Hyeong Baik Kim
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of PE20060014A1 publication Critical patent/PE20060014A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE REFIERE A UNA PREPARACION FARMACEUTICA QUE COMPRENDE UN TAXANO CARACTERIZADO POR TENER UN SUSTITUYENTE LACTILOXILO EN EL C(7), DE FORMULA (I), EN DONDE X3 ES FURANILO, X5 ES T-BUTOXICARBONILO, Bz ES BENZOILO Y Ac ES ACETILO. ESTE TAXANO COMPRENDE UN CARBONO QUIRAL POR LO QUE PUEDEN ESTAR PRESENTES COMO DIASTEROISOMERO R O S, O UNA MEZCLA DE AMBOS DIASTEROISOMEROS: 7-((S)-(-)-2-HIDROXILOXIPROPIONIL)-2-FURANIL-DOCETAXEL Y 7-((R)-(+)-2-HIDROXILOXIPROPIONIL)-2-FURANIL-DOCETAXEL Y PUEDEN ESTAR PRESENTES EN UNA MEZCLA RACEMICA U OPTICAMENTE ACTIVA, CON UNA RELACION MOLAR DE LOS DIASTEROISOMEROS DE AL MENOS 5:1, 10:1, 20:1 DE UNO CON RELACION AL OTRO. ESTOS COMPUESTOS SE ENCUENTRAN EN FORMA CRISTALINA Y ES OBTENIDO MEDIANTE UN METODO QUE COMPRENDE LA CRISTALIZACION DEL TAXANO A PARTIR DE UNA SOLUCION. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA DE FORMA LIQUIDA O SOLIDA QUE LOS COMPRENDE, DE ADMINISTRACION POR VIA ORAL O PARENTERAL Y SON UTILES COMO AGENTES ANTITUMORALES
PE2005000247A 2004-03-05 2005-03-04 Taxanos con sustituyentes lactiloxilo en el c7 PE20060014A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55071204P 2004-03-05 2004-03-05

Publications (1)

Publication Number Publication Date
PE20060014A1 true PE20060014A1 (es) 2006-02-18

Family

ID=34975310

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000247A PE20060014A1 (es) 2004-03-05 2005-03-04 Taxanos con sustituyentes lactiloxilo en el c7

Country Status (11)

Country Link
US (1) US7160919B2 (es)
EP (1) EP1737444A4 (es)
JP (1) JP2007527432A (es)
CN (1) CN1960721A (es)
AR (1) AR048078A1 (es)
GT (1) GT200500041A (es)
PA (1) PA8625301A1 (es)
PE (1) PE20060014A1 (es)
SV (1) SV2006002036A (es)
TW (1) TW200540164A (es)
WO (1) WO2005087222A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104650109B (zh) * 2013-11-22 2019-01-01 江苏天士力帝益药业有限公司 紫杉烷类化合物
JP6942141B2 (ja) 2016-03-14 2021-09-29 ウイスコンシン アラムニ リサーチ ファンデーション 抗がん効能を高めたオリゴ乳酸複合体及びミセル

Family Cites Families (48)

* Cited by examiner, † Cited by third party
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US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
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CA2100808A1 (en) 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
KR100378612B1 (ko) 1992-12-23 2003-04-03 브리스톨-마이어스스퀴브컴파니 신규 측쇄-함유 탁산 및 그의 중간체 화합물
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IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
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Also Published As

Publication number Publication date
WO2005087222A1 (en) 2005-09-22
CN1960721A (zh) 2007-05-09
JP2007527432A (ja) 2007-09-27
TW200540164A (en) 2005-12-16
EP1737444A1 (en) 2007-01-03
EP1737444A4 (en) 2008-05-21
AR048078A1 (es) 2006-03-29
US20050209311A1 (en) 2005-09-22
US7160919B2 (en) 2007-01-09
GT200500041A (es) 2005-10-24
PA8625301A1 (es) 2006-06-02
SV2006002036A (es) 2006-03-16

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Legal Events

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FA Abandonment or withdrawal