AR037123A1 - Compuestos sustituidos de 1h-quinoxalin-2-ona; metodo de preparacion del compuesto y medicamento que lo contiene - Google Patents
Compuestos sustituidos de 1h-quinoxalin-2-ona; metodo de preparacion del compuesto y medicamento que lo contieneInfo
- Publication number
- AR037123A1 AR037123A1 ARP020104097A ARP020104097A AR037123A1 AR 037123 A1 AR037123 A1 AR 037123A1 AR P020104097 A ARP020104097 A AR P020104097A AR P020104097 A ARP020104097 A AR P020104097A AR 037123 A1 AR037123 A1 AR 037123A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- radical
- saturated
- unsaturated
- hydrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 229940126601 medicinal product Drugs 0.000 title 1
- 150000003254 radicals Chemical class 0.000 abstract 17
- -1 aliphatic radical Chemical class 0.000 abstract 16
- 229920006395 saturated elastomer Polymers 0.000 abstract 11
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000005418 aryl aryl group Chemical group 0.000 abstract 7
- 150000002431 hydrogen Chemical class 0.000 abstract 7
- 229910052757 nitrogen Inorganic materials 0.000 abstract 6
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- FFRYUAVNPBUEIC-UHFFFAOYSA-N quinoxalin-2-ol Chemical compound C1=CC=CC2=NC(O)=CN=C21 FFRYUAVNPBUEIC-UHFFFAOYSA-N 0.000 abstract 3
- 125000006413 ring segment Chemical group 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001033 ether group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000004987 o-phenylenediamines Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P23/00—Anaesthetics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
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- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
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- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
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- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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Abstract
Compuestos sustituidos de 1H-quinoxalin-2-ona, métodos para prepararlos a partir de o-fenilendiamina sustituida opcionalmente y un ácido 2-cetodicarboxílico o uno de sus ésteres; y medicamento que contiene el compuesto sustituido de 1H-quinoxalin-2-ona. Reivindicación 1: Compuestos caracterizados porque son compuestos sustituidos de 1H-quinoxalin-2-ona de la fórmula general (1) y sus tautómeros, donde R1, R2, R3 y R4 son iguales o diferentes y representan un radical alifático C1-10 lineal o ramificado, saturado o no saturado o un radical C3-7 cicloalifático saturado o no saturado, pudiendo estar unido cada uno de los radicales mencionados precedentemente por medio de un puente de éter, ó son hidrógeno, un halógeno o un grupo hidroxi; A es un puente de una de las siguientes fórmulas: -(CH2)n+2-, -(CH2)n-CH=CH-, -(CH2)nCOO-, -(CH2)n-CONH-, -(CH2)n+1O(CH2)pCO-, -(CH2)n+1O-, -(CH2)n+1NR1', -NH-(CH2)r-, donde n es 0, 1, 2 ó 3, p es 0 ó 1 y r es 0, 1 ó 2; R1' tiene el significado que se indica a continuación y la unión con el radical X siempre se menciona al final y donde la unión de los radicales X17 y X18 solamente es posible por medio de los tres puentes mencionados previamente y se exceptúa el enlace del radical X7 a través de un puente amida; y X es uno de los siguientes radicales de la fórmula general X1 hasta X18, donde la raya simboliza la unión con el puente A y X1 fórmula (2), X2 fórmula (3), X3 fórmula (4), X4 fórmula (5), X5 fórmula (6), X6 fórmula (7), X7 fórmula (8), X8 fórmula (9), X9 fórmula (10), X10 fórmula (11), X11 fórmula (12), X12 fórmula (13), X13 fórmula (14), X14 fórmula (15), X15 fórmula (16), X16 fórmula (17), X17 fórmula (18), X18 fórmula (19), donde R1' es hidrógeno, un radical alifático C1-10 lineal o ramificado, saturado o no saturado o un radical cicloalifático C3-7 saturado o no saturado, un radical arilo- o heteroarilo; R2' es un radical alifático C1-10 lineal o ramificado, saturado o no saturado, un radical cicloalifático C3-7 saturado o no saturado, un radical arilo- ó heteroarilo, pudiendo estar unidos todos los radicales mencionados, opcionalmente por medio de un puente de éter-, tioéter- ó SO2, o es hidrógeno, un halógeno, un grupo hidroxi-, tiol-, ciano- ó nitro o un grupo de la fórmula -CH2F, -CHF2, -CF3 ó -NR1'2, siendo los dos radicales R1' iguales o diferentes y tienen el significado indicado más arriba; R3' es un radical alifático C1-10 lineal o ramificado, saturado o no saturado, un radical cicloalifático C3-7 saturado o no saturado, un radical arilo- o heteroarilo, pudiendo estar unidos los radicales mencionados más arriba opcionalmente por medio de un puente éter o éster, es hidrógeno, un halógeno, un grupo hidroxi; R4' es hidrógeno, un radical arilo- o heteroarilo, pudiendo presentar el radical arilo- o heteroarilo por lo menos un sustituyente R2' con el significado que antecede, con excepción de hidrógeno; R5' es un radical de la fórmula -NR6'2, donde los dos radicales R6' pueden ser iguales o diferentes y tienen el siguiente significado o pueden formar juntos un anillo de 3-7 miembros con el átomo de nitrógeno que los une como miembro de anillo, el que puede contener opcionalmente por lo menos un átomo de oxígeno y/o al menos otro átomo de nitrógeno como átomo de anillo, pudiendo presentar el nitrógeno un sustituyente R10' que puede tener el siguiente significado; R6' es un radical alifático C1-10 lineal o ramificado, saturado o no saturado, un radical cicloalifático C3-7 saturado o no saturado, un radical arilo- o heteroarilo; R7' es un radical ciano-, amida- ó ácido carboxílico; R8' es un radical de la fórmula -NR9'2, pudiendo ser los dos radicales R9' iguales o diferentes y tienen el siguiente significado o pueden formar juntos un anillo de 3-7 miembros con el átomo de nitrógeno que los une como miembro de anillo, el que puede contener opcionalmente por lo menos un átomo de oxígeno y/o por lo menos otro átomo de nitrógeno como átomo de anillo; R9' es hidrógeno, un radical alifático C1-10 lineal o ramificado; R10' es hidrógeno, un radical alifático C1-10 lineal o ramificado, saturado o no saturado, un radical arilo- o heteroarilo y Z es por lo menos un átomo de oxígeno, azufre ó nitrógeno en calidad de átomo de anillo, opcionalmente presente, y q es 0, 1, 2 ó 3; opcionalmente en forma de sus racematos, sus estereoisómeros puros, sobre todo enantiómeros o diastereómeros, ó en forma de mezclas de estereoisómeros, sobre todo enantiómeros o diastereómeros, en cualquier relación de mezcla ó bien en forma de sus ácidos o sus bases ó en forma de sus sales, sobre todo las sales de tolerancia fisiológica, ó en forma de sus solvatos, sobre todo hidratos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10153345A DE10153345A1 (de) | 2001-10-29 | 2001-10-29 | Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen |
Publications (1)
Publication Number | Publication Date |
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AR037123A1 true AR037123A1 (es) | 2004-10-20 |
Family
ID=7704095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP020104097A AR037123A1 (es) | 2001-10-29 | 2002-10-29 | Compuestos sustituidos de 1h-quinoxalin-2-ona; metodo de preparacion del compuesto y medicamento que lo contiene |
Country Status (10)
Country | Link |
---|---|
US (1) | US20040224954A1 (es) |
EP (1) | EP1444212A1 (es) |
JP (1) | JP2005512986A (es) |
AR (1) | AR037123A1 (es) |
CA (1) | CA2465061A1 (es) |
DE (1) | DE10153345A1 (es) |
HU (1) | HUP0401829A3 (es) |
PE (1) | PE20030491A1 (es) |
PL (1) | PL369831A1 (es) |
WO (1) | WO2003037879A1 (es) |
Families Citing this family (10)
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WO2007150010A2 (en) | 2006-06-23 | 2007-12-27 | Abbott Laboratories | Cyclopropyl amine derivatives as histamin h3 receptor modulators |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
AU2007264030B2 (en) * | 2006-06-27 | 2012-04-05 | Sandoz Ag | New method for salt preparation |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
CN112759546B (zh) * | 2019-11-06 | 2022-08-26 | 复旦大学 | 3-(二甲氨基甲基)哌啶-4-醇衍生物及其制备方法和药物用途 |
CN112759587B (zh) * | 2019-11-06 | 2022-12-30 | 复旦大学 | 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途 |
CN112759545B (zh) * | 2019-11-06 | 2022-12-13 | 复旦大学 | 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途 |
US20230027752A1 (en) * | 2019-11-06 | 2023-01-26 | Fudan University | Opioid receptor agonist, preparation method therefor and pharmaceutical use thereof |
CN112759544B (zh) * | 2019-11-06 | 2022-08-26 | 复旦大学 | 3-(二甲氨基甲基)哌啶-4-醇衍生物制备方法和药物用途 |
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Publication number | Priority date | Publication date | Assignee | Title |
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BE610830A (es) * | 1960-12-01 | |||
GB1311580A (en) * | 1970-08-31 | 1973-03-28 | Upjohn Co | 4-substituted phenyl cyclohexylamines and the preparation thereof |
DD269620A1 (de) * | 1985-01-15 | 1989-07-05 | Inst F Pharmakologische Forsch | Verfahren zur herstellung von n-substituierten 2-(aminomethyl)chinoxalinen |
JPH0276860A (ja) * | 1987-10-05 | 1990-03-16 | Toyo Jozo Co Ltd | 6−置換アルコキシ−2−オキソ−1,2−ジヒドロキノキサリン誘導体 |
WO1992011245A1 (en) * | 1990-12-20 | 1992-07-09 | Warner-Lambert Company | 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity |
JPH05331151A (ja) * | 1992-05-28 | 1993-12-14 | Kyowa Hakko Kogyo Co Ltd | キノキサリン−2−オン誘導体 |
DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
GB9514417D0 (en) * | 1995-07-14 | 1995-09-13 | Iaf Biochem Int | Novel heterocyclic compounds for the treatment of pain and use thereof |
US6015800A (en) * | 1997-09-03 | 2000-01-18 | Warner-Lambert Company | Substituted quinoxaline-2-ones as glutamate receptor antagonists |
DE19826365A1 (de) * | 1998-06-12 | 1999-12-16 | Gruenenthal Gmbh | Verwendung von Benzomorphanderivaten als Analgetikum |
EP0982026B1 (en) * | 1998-08-18 | 2006-05-17 | F. Hoffmann-La Roche Ag | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers |
US6184236B1 (en) * | 1998-08-18 | 2001-02-06 | Hoffmann-La Roche Inc. | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative |
IL146871A0 (en) * | 1999-06-02 | 2002-08-14 | Nps Pharma Inc | Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases |
DE102004023332A1 (de) * | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
-
2001
- 2001-10-29 DE DE10153345A patent/DE10153345A1/de not_active Withdrawn
-
2002
- 2002-10-23 HU HU0401829A patent/HUP0401829A3/hu unknown
- 2002-10-23 WO PCT/EP2002/011832 patent/WO2003037879A1/de not_active Application Discontinuation
- 2002-10-23 JP JP2003540161A patent/JP2005512986A/ja active Pending
- 2002-10-23 EP EP02785285A patent/EP1444212A1/de not_active Withdrawn
- 2002-10-23 CA CA002465061A patent/CA2465061A1/en not_active Abandoned
- 2002-10-23 PL PL02369831A patent/PL369831A1/xx not_active Application Discontinuation
- 2002-10-28 PE PE2002001053A patent/PE20030491A1/es not_active Application Discontinuation
- 2002-10-29 AR ARP020104097A patent/AR037123A1/es unknown
-
2004
- 2004-04-26 US US10/832,205 patent/US20040224954A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2465061A1 (en) | 2003-05-08 |
DE10153345A1 (de) | 2003-05-08 |
US20040224954A1 (en) | 2004-11-11 |
JP2005512986A (ja) | 2005-05-12 |
WO2003037879A1 (de) | 2003-05-08 |
PE20030491A1 (es) | 2003-07-26 |
HUP0401829A3 (en) | 2005-06-28 |
EP1444212A1 (de) | 2004-08-11 |
HUP0401829A2 (hu) | 2005-01-28 |
PL369831A1 (en) | 2005-05-02 |
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