AR067475A1 - Antagonistas no basico s del receptor de la hormona concentradora de melanina 1 - Google Patents

Antagonistas no basico s del receptor de la hormona concentradora de melanina 1

Info

Publication number
AR067475A1
AR067475A1 ARP080102936A ARP080102936A AR067475A1 AR 067475 A1 AR067475 A1 AR 067475A1 AR P080102936 A ARP080102936 A AR P080102936A AR P080102936 A ARP080102936 A AR P080102936A AR 067475 A1 AR067475 A1 AR 067475A1
Authority
AR
Argentina
Prior art keywords
alkyl
ring
cycloalkyl
lower alkyl
heteroaryl
Prior art date
Application number
ARP080102936A
Other languages
English (en)
Inventor
Sharon N Bisaha
Philip D Stein
William N Washburn
Khehyong Ngu
Saleem Ahmad
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR067475A1 publication Critical patent/AR067475A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos que incluyen todos los estereoisomeros, solvatos, profármacos y formas farmacéuticamente aceptables de los mismos de acuerdo con la formula (1). Además composiciones farmacéuticas que contienen al menos un compuesto de acuerdo con la formula (1) y opcionalmente al menos un agente terapéutico adicional y uso de dichos compuestos para preparar medicamentos utiles para tratar una enfermedad o trastorno modulado por MCHR-1 tal como, por ejemplo, obesidad, diabetes, depresion o ansiedad. Reivindicacion 1: Un compuesto de formula 1 o una sal farmacéuticamente aceptable del mismo caracterizado porque el anillo A es un anillo fenileno o un anillo heteroarilo que contiene uno o dos átomos de nitrogeno o un átomo de oxígeno; R1 es Z-Y-X-, donde X es O, S, >S(=O)-, o >S(=O)(=O); Y es un enlace, un cicloalquilo de 3 a 6 miembros o una cadena alquilo; y Z es arilo o heteroarilo; R2 es -E-G-(J)m, donde m es un numero entero de 1 a 3; E es O, S o un enlace; G es alquilo inferior, fenilalquilo, cicloalquilo, cicloalquilalquilo, alquilcicloalquilo, cicloalcoxi, alquilcicloalcoxi o cicloalcoxialquilo, y cada J es independientemente hidrogeno, hidroxilo, CN, -SO2R7, -SR7, -SOR7, alquilo inferior, alcoxi inferior, CF3, CF3O-, -COOR5 o CO-NR5aR6, donde cada uno de R5a y R6 se selecciona independientemente entre el grupo constituido por H, alquilo C1-3 y cicloalquilo, o R5a y R6 tomados juntos pueden ser propanodiilo, butanodiilo o pentanodiilo con el átomo de N al que están unidos para formar una amina cíclica de 4, 5 o 6 miembros que puede estar opcionalmente sustituida; R5 es H, alquilo C1-6 o cicloalquilo; R7 es alquilo inferior; y R3 es alquilo C1-6, cicloalquilo, alcoxi C1-6, halogeno, hidrogeno, -S-alquilo C1-6, CN, CF3O o CF3 y donde R2 y R3 pueden tomarse juntos para formar un anillo de 5 a 7 miembros que está saturado o parcialmente insaturado y puede incluir opcionalmente un heteroátomo E que es O o 0, 1 o 2 átomos de N, donde el anillo está sustituido con uno o dos grupos -O-G-(J)m, donde al menos un J es OH, y que puede estar opcionalmente sustituido con otros sustituyentes como los indicados para ôalquiloö o ôheteroariloö; con la condicion de que cuando el anillo A es un grupo fenileno, E-G y R3 no sean grupos alcoxi inferior no sustituidos iguales, y cuando G es alquilo inferior y J es H, R3 no sea hidrogeno; y cada uno de R8 y R9 es independientemente hidrogeno, halogeno o alquilo inferior, incluyendo ésteres de los mismos, profármacos de los mismos, solvatos de los mismos y todos los estereoisomeros de los mismos.
ARP080102936A 2007-07-06 2008-07-07 Antagonistas no basico s del receptor de la hormona concentradora de melanina 1 AR067475A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94821307P 2007-07-06 2007-07-06
US12/141,228 US20090011994A1 (en) 2007-07-06 2008-06-18 Non-basic melanin concentrating hormone receptor-1 antagonists and methods

Publications (1)

Publication Number Publication Date
AR067475A1 true AR067475A1 (es) 2009-10-14

Family

ID=40221936

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102936A AR067475A1 (es) 2007-07-06 2008-07-07 Antagonistas no basico s del receptor de la hormona concentradora de melanina 1

Country Status (16)

Country Link
US (3) US20090011994A1 (es)
EP (1) EP2173725A2 (es)
JP (1) JP2010532791A (es)
KR (1) KR20100044824A (es)
CN (1) CN101801938A (es)
AR (1) AR067475A1 (es)
AU (1) AU2008275207A1 (es)
BR (1) BRPI0813580A2 (es)
CA (1) CA2692671A1 (es)
CL (1) CL2008001994A1 (es)
CO (1) CO6270360A2 (es)
EA (1) EA201000157A1 (es)
PE (1) PE20090437A1 (es)
TW (1) TW200906413A (es)
WO (1) WO2009009501A2 (es)
ZA (1) ZA201000055B (es)

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KR20100044824A (ko) 2010-04-30
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US8012984B2 (en) 2011-09-06
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US20110144060A1 (en) 2011-06-16
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ZA201000055B (en) 2011-05-25

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