AR071514A1 - Derivados de aminopiridina - Google Patents
Derivados de aminopiridinaInfo
- Publication number
- AR071514A1 AR071514A1 ARP090101507A ARP090101507A AR071514A1 AR 071514 A1 AR071514 A1 AR 071514A1 AR P090101507 A ARP090101507 A AR P090101507A AR P090101507 A ARP090101507 A AR P090101507A AR 071514 A1 AR071514 A1 AR 071514A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently selected
- alkoxy
- halo
- optionally substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Composiciones que comprenden tales compuestos; el uso de tales compuestos en terapia (como asma o EPOC); y métodos de tratamiento de pacientes con tales compuestos. Reivindicacion 1: Un compuesto de la formula (1) caracterizado porque R1 y R2 están seleccionados, de modo independiente, de H, OH, alquilo C1-10, alcoxi C1-6, alquenilo C2-6, cicloalquilo C3-10, heterocicloalquilo, arilo, heteroarilo, arilalquilo C1-4- y heteroarilalquilo C1-4-; R3 está seleccionado de H, alquilo C1-10 y alquenilo C2-6; R4 y R5 están seleccionados de H, alquilo C1-10, alquenilo C2-6, cicloalquilo C3-10, heterocicloalquilo, arilo, heteroarilo, arilalquilo C1-4- y heteroarilalquilo C1-4-; R6 y R7 están seleccionados de H, alquilo C1-10, alquenilo C2-6, cicloalquilo C3-10, heterocicloalquilo, arilo, heteroarilo, arilalquilo C1-4-, arilalquenilo C2-4-, heteroarilalquilo C1-4-, -SO2alquilo C1-6, - SO2ariIo y -SO2arilalquilo C1-4; o R6 y R7 junto con el átomo de nitrogeno al que están unidos, pueden formar un anillo de 4-7 miembros que contiene N, que opcionalmente contiene otro heteroátomo seleccionado de N, O y S, y que está opcionalmente sustituido con 1 o 2 sustituyentes seleccionados, de modo independiente, de alquilo C1-6, alcoxi C1-6, halo, CN e hidroxilo, dicho anillo que contiene N también puede estar opcionalmente fusionado con un grupo arilo; o R4 y R6 junto con los átomos a los que están unidos, pueden formar un anillo de 4-7 miembros saturado o parcialmente insaturado que contiene N, que opcionalmente contiene otro heteroátomo seleccionado de N, O y S, y que está opcionalmente sustituido en el carbono con 1 o 2 sustituyentes seleccionados, de modo independiente, de alquilo C1-6, alcoxi C1-6, halo, CN e hidroxilo; o R5 está ausente y R4 y R6 junto con los átomos a los que están unidos, pueden formar un anillo aromático mono- o bicíclico que contiene N de 5, 6, 9 o 10 miembros, que opcionalmente contiene otro heteroátomo seleccionado de N, O y S, y que está opcionalmente sustituido en el carbono con 1, 2 o 3 sustituyentes seleccionados, de modo independiente, de alquilo C1-6, alcoxi C1-6, halo, CN, arilo, COOR14 e hidroxilo; o R4 y R6 pueden formar juntos un grupo de acuerdo con la formula 2 o la formula 3, R8, R9 y R10 están seleccionados, de modo independiente, de H, alquilo C1-10, halo, hidroxilo y alcoxi C1-6; R11 está seleccionado de H y alquilo C1-6; R12 está seleccionado de H y alquilo C1-6; R13 está seleccionado de H, alquilo C1-6, alcoxi C1-6, OH, CN, CF3, COOR14, halo y NR14R15; R14 y R15 están seleccionados, de modo independiente, de H y alquilo C1-6; f y g están seleccionados, de modo independiente, de 0, 1, 2 y 3, de modo que f+g= 1, 2 o 3; h está seleccionado de 1 y 2; en donde: alquilo puede estar opcionalmente sustituido con 1 o 2 sustituyentes seleccionados, de modo independiente, de cicloalquilo C3-10, alcoxi C1-6, OH, CN, CF3, COOR14, halo y NR14R15; alquenilo puede estar opcionalmente sustituido con 1 o 2 sustituyentes seleccionados, de modo independiente, de cicloalquilo C3-10, alcoxi C1-6, OH, CN, CF3, COOR14, halo y NR14R15; alcoxi puede estar opcionalmente sustituido con 1 o 2 sustituyentes seleccionados, de modo independiente, de cicloalquilo C3-10, OH, CN, CF3, COOR14, halo y NR14R15; cicloalquilo es un anillo hidrocarbonado mono- o bicíclico no aromático, opcionalmente fusionado con un grupo arilo en donde dicho anillo cicloalquilo contiene opcionalmente, de ser posible, hasta dos enlaces dobles; y en donde, salvo que se establezca otra cosa, dicho cicloalquilo puede estar opcionalmente sustituido con 1 o 2 sustituyentes seleccionados, de modo independiente, de alquilo C1-6, alcoxi C1-6, OH, CN, CF3, COOR14, halo y NR14R15; heterocicloalquilo es un anillo mono- o bicíclico no aromático de 3 a 10 miembros unido a C o unido a N, en donde dicho anillo heterocicloalquilo contiene, de ser posible, 1, 2 o 3 heteroátomos seleccionados, de modo independiente, de N, NR14, S(O)q y O; y dicho anillo heterocicloalquilo contiene opcionalmente, de ser posible, 1 o 2 enlaces dobles, y está opcionalmente sustituido en el carbono con 1 o 2 sustituyentes seleccionados, de modo independiente, de alquilo C1-6, alcoxi C1-6, OH, CN, CF3, halo, COOR14, NR14R15 y arilo; arilo es un sistema de anillos aromáticos individuales o fusionados que contiene 6 o 10 átomos de carbono; en donde, salvo que se establezca otra cosa, cada aparicion de arilo puede estar opcionalmente sustituida con hasta 5 sustituyentes seleccionados, de modo independiente, de alquilo C1-6, alcoxi C1-6, OH, halo, CN, COOR14, CF3 y NR14R15; heteroarilo es un anillo aromático mono- o bicíclico de 5, 6, 9 o 10 miembros, que contiene 1 o 2 átomos de N y, opcionalmente, un átomo de NR14, o un átomo de NR14 y un átomo de S o de O, o un átomo de S, o un átomo de O; en donde, salvo que se establezca otra cosa, dicho heteroarilo puede estar opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados, de modo independiente, de alquilo C1-6, alcoxi C1-6, OH, halo, CN, COOR14, CF3 y NR14R15; q es 0, 1 o 2; y sus tautomeros, estereoisomeros, sales y solvatos farmacéuticamente aceptables.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7143108P | 2008-04-29 | 2008-04-29 | |
GBGB0807828.9A GB0807828D0 (en) | 2008-04-29 | 2008-04-29 | Aminopyridine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
AR071514A1 true AR071514A1 (es) | 2010-06-23 |
Family
ID=39522782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101507A AR071514A1 (es) | 2008-04-29 | 2009-04-28 | Derivados de aminopiridina |
Country Status (18)
Country | Link |
---|---|
US (1) | US20100076015A1 (es) |
EP (1) | EP2300428A1 (es) |
JP (1) | JP2011519845A (es) |
KR (1) | KR20110014161A (es) |
CN (1) | CN102076666A (es) |
AR (1) | AR071514A1 (es) |
AU (1) | AU2009241906A1 (es) |
BR (1) | BRPI0911443A2 (es) |
CA (1) | CA2722648A1 (es) |
CO (1) | CO6321287A2 (es) |
EC (1) | ECSP10010648A (es) |
GB (1) | GB0807828D0 (es) |
IL (1) | IL208812A0 (es) |
MX (1) | MX2010011896A (es) |
NZ (1) | NZ588635A (es) |
RU (1) | RU2010148420A (es) |
WO (1) | WO2009133348A1 (es) |
ZA (1) | ZA201007615B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009324479A1 (en) * | 2008-12-12 | 2011-06-30 | Vanderbilt Universtiy | 3.3.0 bicyclic GlyT1 inhibitors and methods of making and using same |
GB0918922D0 (en) * | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminopyridine derivatives |
US9290485B2 (en) | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
WO2018053446A1 (en) * | 2016-09-18 | 2018-03-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Yap1 inhibitors that target the interaction of yap1 with oct4 |
KR20210006334A (ko) | 2018-03-14 | 2021-01-18 | 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 | Yap1과 oct4의 상호작용을 표적으로 하는 yap1 저해제 |
JP2022552048A (ja) * | 2019-08-21 | 2022-12-15 | カルビスタ・ファーマシューティカルズ・リミテッド | 酵素阻害剤 |
US20230127046A1 (en) * | 2019-11-27 | 2023-04-27 | Riken | G9a INHIBITOR |
WO2022255399A1 (ja) * | 2021-06-01 | 2022-12-08 | 国立研究開発法人理化学研究所 | G9a阻害剤 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US5464820A (en) * | 1993-06-22 | 1995-11-07 | The University Hospital | Specific inhibitors of tissue kallikrein |
NZ518195A (en) * | 2000-08-11 | 2005-04-29 | Corvas Int Inc | Non-covalent inhibitors of urokinase and blood vessel formation |
FR2819254B1 (fr) * | 2001-01-08 | 2003-04-18 | Fournier Lab Sa | Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques |
FR2836143B1 (fr) * | 2002-02-21 | 2004-04-16 | Servier Lab | Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CA2557858A1 (en) * | 2004-03-02 | 2005-09-15 | Merck & Co., Inc. | Amino cyclopropane carboxamide derivatives as bradykinin antagonists |
EP1736465A4 (en) * | 2004-03-31 | 2009-06-17 | Ajinomoto Kk | ANILINE DERIVATIVES |
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2008
- 2008-04-29 GB GBGB0807828.9A patent/GB0807828D0/en not_active Ceased
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2009
- 2009-04-28 US US12/431,114 patent/US20100076015A1/en not_active Abandoned
- 2009-04-28 AU AU2009241906A patent/AU2009241906A1/en not_active Abandoned
- 2009-04-28 CN CN2009801248942A patent/CN102076666A/zh active Pending
- 2009-04-28 AR ARP090101507A patent/AR071514A1/es unknown
- 2009-04-28 JP JP2011506764A patent/JP2011519845A/ja active Pending
- 2009-04-28 MX MX2010011896A patent/MX2010011896A/es not_active Application Discontinuation
- 2009-04-28 NZ NZ588635A patent/NZ588635A/en not_active IP Right Cessation
- 2009-04-28 KR KR1020107026578A patent/KR20110014161A/ko not_active Application Discontinuation
- 2009-04-28 RU RU2010148420/04A patent/RU2010148420A/ru unknown
- 2009-04-28 CA CA2722648A patent/CA2722648A1/en not_active Abandoned
- 2009-04-28 WO PCT/GB2009/001062 patent/WO2009133348A1/en active Application Filing
- 2009-04-28 BR BRPI0911443A patent/BRPI0911443A2/pt not_active IP Right Cessation
- 2009-04-28 EP EP09738378A patent/EP2300428A1/en not_active Withdrawn
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2010
- 2010-10-19 IL IL208812A patent/IL208812A0/en unknown
- 2010-10-25 ZA ZA2010/07615A patent/ZA201007615B/en unknown
- 2010-10-25 CO CO10132210A patent/CO6321287A2/es not_active Application Discontinuation
- 2010-11-29 EC EC2010010648A patent/ECSP10010648A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN102076666A (zh) | 2011-05-25 |
RU2010148420A (ru) | 2012-06-10 |
KR20110014161A (ko) | 2011-02-10 |
BRPI0911443A2 (pt) | 2015-10-06 |
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AU2009241906A1 (en) | 2009-11-05 |
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