NZ518195A - Non-covalent inhibitors of urokinase and blood vessel formation - Google Patents

Non-covalent inhibitors of urokinase and blood vessel formation

Info

Publication number
NZ518195A
NZ518195A NZ51819501A NZ51819501A NZ518195A NZ 518195 A NZ518195 A NZ 518195A NZ 51819501 A NZ51819501 A NZ 51819501A NZ 51819501 A NZ51819501 A NZ 51819501A NZ 518195 A NZ518195 A NZ 518195A
Authority
NZ
New Zealand
Prior art keywords
hydroxyprolyl
compounds
urokinase
group
non
Prior art date
Application number
NZ51819501A
Inventor
Odile Esther Levy
Edwin L Madison
Joseph Edward Semple
Amir P Tamiz
Michael I Weinhouse
Original Assignee
Corvas Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US63748300A priority Critical
Priority to EP20000126874 priority patent/EP1182207B1/en
Priority to US09/733,645 priority patent/US6586405B2/en
Application filed by Corvas Int Inc filed Critical Corvas Int Inc
Priority to PCT/US2001/025337 priority patent/WO2002014349A2/en
Publication of NZ518195A publication Critical patent/NZ518195A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069Ser-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

Disclosed are compounds of formula (I), wherein: X is -S(O)2-, N(R)-S(O)2-, -(C=O)-, -OC(=O)-, -NH-C(=O)-, -P(O)(R')-, or a direct link, R1 is optionally substituted alkyl, cycloalkyl, heterocycloalkyl, heterocyclo, alkenyl, aryl, heteroaryl, aralkyl, heteroaralkyl, aralkenyl, hetroaralkenyl, C9-15fused carbocycle, difluoromethyl, perfluoroalkyl, perfluoroaryl, perfluoroaralkyl, or H, R2 is -CH2OH, -CH(CH3)OH, or selected to give a group at P3 of acyl or carbonate esters of D-seryl, R3 and R4 together give a group at P2 of prolyl, pipecolyl, azetidine-2-carbonyl, 4-hydroxyprolyl, 3-hydroxyprolyl, 3,4-methanoprolyl or 3,4-dehydroprolyl, R7 is H or alkyl, and the remaining substituents are defined herein. The compounds are used in the manufacture of medicaments for the treatment of conditions ameliorated by inhibiting or decreasing urokinase activity or angiogenesis in a mammal.
NZ51819501A 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation NZ518195A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US63748300A true 2000-08-11 2000-08-11
EP20000126874 EP1182207B1 (en) 2000-08-11 2000-12-07 Non-covalent inhibitors of urokinase and blood vessel formation
US09/733,645 US6586405B2 (en) 2000-08-11 2000-12-07 Non-covalent inhibitors of urokinase and blood vessel formation
PCT/US2001/025337 WO2002014349A2 (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NZ538572A NZ538572A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation

Publications (1)

Publication Number Publication Date
NZ518195A true NZ518195A (en) 2005-04-29

Family

ID=27223185

Family Applications (3)

Application Number Title Priority Date Filing Date
NZ51819501A NZ518195A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation
NZ538572A NZ538572A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation
NZ547626A NZ547626A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation

Family Applications After (2)

Application Number Title Priority Date Filing Date
NZ538572A NZ538572A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation
NZ547626A NZ547626A (en) 2000-08-11 2001-08-10 Non-covalent inhibitors of urokinase and blood vessel formation

Country Status (6)

Country Link
JP (1) JP2004506648A (en)
AU (2) AU785260B2 (en)
CA (1) CA2387002A1 (en)
IL (1) IL149042D0 (en)
NZ (3) NZ518195A (en)
WO (1) WO2002014349A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1364960A4 (en) * 2001-02-02 2005-05-18 Chugai Pharmaceutical Co Ltd Peptide derivatives
US7262211B2 (en) * 2001-12-04 2007-08-28 Dendreon Corporation Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation
WO2003053999A2 (en) * 2001-12-12 2003-07-03 Wilex Ag Selective arylguanidine peptides as urokinase inhibitors
DE50310038D1 (en) 2002-03-11 2008-08-07 Curacyte Ag Ingredients of urokinase, their preparation and use
DE10301300B4 (en) * 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Use of acylated 4-amidino- and 4-guanidinobenzylamines for the inhibition of plasma kallikrein
DE10323898A1 (en) 2003-05-26 2004-12-23 Wilex Ag Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors
DE10342108A1 (en) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basic substituted benzylamine analogs as coagulation factor Xa inhibitors, their preparation and use
JP2008543900A (en) 2005-06-24 2008-12-04 ヴィレックス アクチェンゲゼルシャフトWilex AG Use of urokinase inhibitors for the treatment and / or prevention of neuropathological diseases
WO2007025718A1 (en) * 2005-08-29 2007-03-08 Wilex Ag Oxadiazole compounds as urokinase inhibitors
DE102005044319A1 (en) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2- (Aminomethyl) -5-chloro-benzylamide derivatives and their use as inhibitors of coagulation factor Xa
DE102006050672A1 (en) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh New glycylglycine derivatives with a benzylsulfonylamido group and an amidino-organylamido group at the opposite chain ends, used in drugs for reducing loss of blood, e.g. in operations
GB0807828D0 (en) * 2008-04-29 2008-06-04 Vantia Ltd Aminopyridine derivatives
ES2483802T3 (en) 2010-07-07 2014-08-07 The Medicines Company (Leipzig) Gmbh Serine protease inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
AU1025795A (en) * 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
DE4443390A1 (en) * 1994-12-06 1996-06-13 Basf Ag New dipeptide p-Amidinobenzylamide with N-terminal sulfonyl or Aminosulfonylresten
AU706834B2 (en) * 1995-02-10 1999-06-24 Abbott Gmbh & Co. Kg Thrombin inhibitors
US6576613B1 (en) * 1998-07-24 2003-06-10 Corvas International, Inc. Title inhibitors of urokinase
JP4489976B2 (en) * 1999-04-09 2010-06-23 ビーエーエスエフ ソシエタス・ヨーロピアBasf Se Small molecule inhibitors of complement protease
DE10029015A1 (en) * 2000-06-15 2001-12-20 Curacyte Ag Coagulation Factor Xa inhibitor, useful for treatment, prophylaxis or diagnosis of thromboembolic disease, comprising acylated 3- or 4-amidino-benzylamine derivative
DE10029014A1 (en) * 2000-06-15 2001-12-20 Univ Schiller Jena Urokinase inhibitor, useful for treatment, prophylaxis or diagnosis of thromboembolic disease, comprising acylated 3- or 4-amidino-benzylamine derivative

Also Published As

Publication number Publication date
NZ547626A (en) 2007-10-26
IL149042D0 (en) 2002-11-10
WO2002014349A3 (en) 2002-10-03
AU785260B2 (en) 2006-12-07
NZ538572A (en) 2006-09-29
JP2004506648A (en) 2004-03-04
WO2002014349A2 (en) 2002-02-21
CA2387002A1 (en) 2002-02-21
AU2006235835A1 (en) 2006-11-30
AU2006235835B2 (en) 2009-06-25
AU8334701A (en) 2002-02-25

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Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
ASS Change of ownership

Owner name: DENDREON CORPORATION, US

Free format text: OLD OWNER(S): CORVAS INTERNATIONAL, INC.

ASS Change of ownership

Owner name: WILEX AG, DE

Free format text: OLD OWNER(S): DENDREON CORPORATION

RENW Renewal (renewal fees accepted)