CO6341617A2 - 5-alquinil-pirimidinas - Google Patents
5-alquinil-pirimidinasInfo
- Publication number
- CO6341617A2 CO6341617A2 CO11009242A CO11009242A CO6341617A2 CO 6341617 A2 CO6341617 A2 CO 6341617A2 CO 11009242 A CO11009242 A CO 11009242A CO 11009242 A CO11009242 A CO 11009242A CO 6341617 A2 CO6341617 A2 CO 6341617A2
- Authority
- CO
- Colombia
- Prior art keywords
- alquinil
- pyrimidins
- medicine
- excessive
- prepare
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
La presente invención comprende compuestos de fórmula general (1)En la queR1 a R4 se definen como en la reivindicación 1, que son adecuados para el tratamiento adecuado de enfermedades caracterizadas por proliferación celular excesiva o anormal, y el uso de los mismos para preparar un medicamento que tiene las propiedades mencionadas anteriormente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08161369 | 2008-07-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6341617A2 true CO6341617A2 (es) | 2011-11-21 |
Family
ID=40202900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11009242A CO6341617A2 (es) | 2008-07-29 | 2011-01-27 | 5-alquinil-pirimidinas |
Country Status (25)
Country | Link |
---|---|
US (1) | US8916548B2 (es) |
EP (1) | EP2323992B1 (es) |
JP (1) | JP5599791B2 (es) |
KR (1) | KR20110041536A (es) |
CN (1) | CN102112450A (es) |
AR (1) | AR072845A1 (es) |
AU (1) | AU2009275957A1 (es) |
BR (1) | BRPI0916679A2 (es) |
CA (1) | CA2731909A1 (es) |
CL (1) | CL2011000195A1 (es) |
CO (1) | CO6341617A2 (es) |
DK (1) | DK2323992T3 (es) |
EA (1) | EA201100255A1 (es) |
EC (1) | ECSP11010786A (es) |
ES (1) | ES2597903T3 (es) |
HU (1) | HUE029837T2 (es) |
IL (1) | IL210343A0 (es) |
MA (1) | MA32505B1 (es) |
MX (1) | MX2011000729A (es) |
NZ (1) | NZ590558A (es) |
PE (1) | PE20110196A1 (es) |
PL (1) | PL2323992T3 (es) |
TW (1) | TW201010984A (es) |
UY (1) | UY32009A (es) |
WO (1) | WO2010012740A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20110041536A (ko) | 2008-07-29 | 2011-04-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 5-알키닐-피리미딘 |
CA2731919A1 (en) | 2008-07-29 | 2010-02-04 | Boehringer Ingelheim International Gmbh | New compounds |
AR076332A1 (es) * | 2009-04-21 | 2011-06-01 | Boehringer Ingelheim Int | Derivados heterociclicos de 5-alquinil-piridinas, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento y/o prevencion del cancer, procesos inflamatorios, autoinmunes, y/o infecciones. |
US8618111B2 (en) * | 2010-01-26 | 2013-12-31 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyrimidines |
US8633183B2 (en) | 2010-01-26 | 2014-01-21 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyrimidines |
US8466162B2 (en) * | 2011-01-26 | 2013-06-18 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyridines |
TW201245176A (en) * | 2011-01-26 | 2012-11-16 | Boehringer Ingelheim Int | New 5-alkynyl-pyridines |
US8912200B2 (en) * | 2011-07-28 | 2014-12-16 | Nerviano Medical Sciences S.R.L. | Alkynyl substituted pyrimidinyl-pyrroles active as kinases inhibitors |
UA110995C2 (uk) | 2011-10-07 | 2016-03-10 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як модулятори метаботропного глутаматного рецептора |
FI3080100T3 (fi) * | 2013-12-11 | 2023-03-15 | Celgene Quanticel Res Inc | Lysiinispesifisen demetylaasi-1:n estäjät |
BR112016025248B1 (pt) * | 2014-05-01 | 2022-12-13 | Celgene Quanticel Research, Inc | Compostos inibidores de demetilase lisina-específica-1, composição farmacêutica e seus usos |
BR112017004334A2 (pt) * | 2014-09-05 | 2018-08-07 | Celgene Quanticel Res Inc | inibidores de desmetilase específica de lisina-1. |
CN104744376A (zh) * | 2015-03-14 | 2015-07-01 | 长沙深橙生物科技有限公司 | 一种2-异丙基嘧啶衍生物的制备方法 |
CN104803921A (zh) * | 2015-03-14 | 2015-07-29 | 长沙深橙生物科技有限公司 | 一种苯取代嘧啶衍生物的制备方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3832570A1 (de) | 1988-09-24 | 1990-03-29 | Hoechst Ag | 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte |
AU5704594A (en) | 1992-12-18 | 1994-07-19 | Wellcome Foundation Limited, The | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
US5622954A (en) | 1994-05-11 | 1997-04-22 | Fmc Corporation | 5[W(substituted aryl)alkenylene and alkynylene]-2,4-diaminopyrimidines as pesticides |
IL150912A0 (en) | 2000-02-25 | 2003-02-12 | Hoffmann La Roche | Adenosine receptor modulators |
ATE469132T1 (de) | 2000-07-24 | 2010-06-15 | Krenitsky Pharmaceuticals Inc | Substituierte 5-alkinyl-pyrimidine mit neurotropher wirkung |
BRPI0411364A (pt) * | 2003-06-13 | 2006-07-25 | Zentaris Gmbh | compostos tendo atividade inibidora de fosfatidilinositol 3-cinase e métodos de uso dos mesmos |
EP1737462B1 (en) | 2003-12-24 | 2008-07-30 | AstraZeneca AB | Pyrimidines with tie2 (tek) activity |
SI2612862T1 (sl) * | 2004-05-13 | 2017-04-26 | Icos Corporation | Kinazolini kot inhibitorji humane fosfatidilinozitol 3-kinaze delta |
US7776869B2 (en) * | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
US20080146599A1 (en) | 2005-02-01 | 2008-06-19 | Astrazeneca Ab | Pyrimidine Compounds Having Tie-2 (Tek) Inhibitory Activity |
US20100048543A1 (en) | 2005-02-01 | 2010-02-25 | Astrazeneca Ab | Pyrimidine compounds having ties (tek) inhibitory activity |
US20070135437A1 (en) | 2005-03-04 | 2007-06-14 | Alsgen, Inc. | Modulation of neurodegenerative diseases |
WO2006106721A1 (ja) | 2005-03-30 | 2006-10-12 | Shionogi & Co., Ltd. | チロシンキナーゼ阻害作用を有するピリミジン誘導体 |
US20080194552A1 (en) | 2005-03-31 | 2008-08-14 | Astrazeneca Ab | Aminopyrimidine Derivatives With Tie2 Inhibiting Activity |
BRPI0617162B8 (pt) * | 2005-10-07 | 2021-05-25 | Exelixis Inc | compostos inibidores de fosfatidilinositol 3-quinase composições farmacêuticas que os contem e métodos de uso dos mesmos |
JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
JP2010501537A (ja) | 2006-08-24 | 2010-01-21 | アストラゼネカ アクチボラグ | 増殖性障害の治療に有用なモルホリノピリミジン誘導体 |
JP5283633B2 (ja) | 2006-12-29 | 2013-09-04 | テイボテク・フアーマシユーチカルズ | Hiv阻害性5,6−置換ピリミジン |
EP2022785A1 (en) | 2007-06-20 | 2009-02-11 | Bayer Schering Pharma Aktiengesellschaft | Alkynylpyrimidines as Tie2 kinase inhibitors |
KR20110041536A (ko) | 2008-07-29 | 2011-04-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 5-알키닐-피리미딘 |
US8633183B2 (en) | 2010-01-26 | 2014-01-21 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyrimidines |
-
2009
- 2009-07-28 KR KR1020117003951A patent/KR20110041536A/ko not_active Application Discontinuation
- 2009-07-28 CN CN2009801301499A patent/CN102112450A/zh active Pending
- 2009-07-28 TW TW098125388A patent/TW201010984A/zh unknown
- 2009-07-28 DK DK09781207.7T patent/DK2323992T3/en active
- 2009-07-28 EP EP09781207.7A patent/EP2323992B1/en active Active
- 2009-07-28 PE PE2011000088A patent/PE20110196A1/es not_active Application Discontinuation
- 2009-07-28 EA EA201100255A patent/EA201100255A1/ru unknown
- 2009-07-28 NZ NZ590558A patent/NZ590558A/xx not_active IP Right Cessation
- 2009-07-28 MX MX2011000729A patent/MX2011000729A/es unknown
- 2009-07-28 US US13/055,949 patent/US8916548B2/en active Active
- 2009-07-28 JP JP2011520491A patent/JP5599791B2/ja active Active
- 2009-07-28 WO PCT/EP2009/059763 patent/WO2010012740A1/en active Application Filing
- 2009-07-28 PL PL09781207T patent/PL2323992T3/pl unknown
- 2009-07-28 CA CA2731909A patent/CA2731909A1/en not_active Abandoned
- 2009-07-28 AR ARP090102873A patent/AR072845A1/es unknown
- 2009-07-28 UY UY0001032009A patent/UY32009A/es not_active Application Discontinuation
- 2009-07-28 BR BRPI0916679A patent/BRPI0916679A2/pt not_active IP Right Cessation
- 2009-07-28 AU AU2009275957A patent/AU2009275957A1/en not_active Abandoned
- 2009-07-28 HU HUE09781207A patent/HUE029837T2/en unknown
- 2009-07-28 ES ES09781207.7T patent/ES2597903T3/es active Active
-
2010
- 2010-12-29 IL IL210343A patent/IL210343A0/en unknown
-
2011
- 2011-01-26 MA MA33560A patent/MA32505B1/fr unknown
- 2011-01-27 EC EC2011010786A patent/ECSP11010786A/es unknown
- 2011-01-27 CO CO11009242A patent/CO6341617A2/es not_active Application Discontinuation
- 2011-01-28 CL CL2011000195A patent/CL2011000195A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2009275957A1 (en) | 2010-02-04 |
NZ590558A (en) | 2012-12-21 |
JP5599791B2 (ja) | 2014-10-01 |
CL2011000195A1 (es) | 2011-07-08 |
WO2010012740A1 (en) | 2010-02-04 |
ES2597903T3 (es) | 2017-01-24 |
KR20110041536A (ko) | 2011-04-21 |
DK2323992T3 (en) | 2016-10-31 |
MA32505B1 (fr) | 2011-07-03 |
AR072845A1 (es) | 2010-09-22 |
US20110281838A1 (en) | 2011-11-17 |
IL210343A0 (en) | 2011-03-31 |
PL2323992T3 (pl) | 2017-01-31 |
CA2731909A1 (en) | 2010-02-04 |
CN102112450A (zh) | 2011-06-29 |
UY32009A (es) | 2010-02-26 |
US8916548B2 (en) | 2014-12-23 |
TW201010984A (en) | 2010-03-16 |
BRPI0916679A2 (pt) | 2015-11-17 |
EA201100255A1 (ru) | 2011-08-30 |
EP2323992B1 (en) | 2016-07-20 |
HUE029837T2 (en) | 2017-04-28 |
PE20110196A1 (es) | 2011-04-03 |
ECSP11010786A (es) | 2011-02-28 |
JP2011529468A (ja) | 2011-12-08 |
MX2011000729A (es) | 2011-03-15 |
EP2323992A1 (en) | 2011-05-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn | ||
FC | Application refused |