ES2530462T3 - Combinación terapia antitumoral - Google Patents

Combinación terapia antitumoral Download PDF

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Publication number
ES2530462T3
ES2530462T3 ES09751682T ES09751682T ES2530462T3 ES 2530462 T3 ES2530462 T3 ES 2530462T3 ES 09751682 T ES09751682 T ES 09751682T ES 09751682 T ES09751682 T ES 09751682T ES 2530462 T3 ES2530462 T3 ES 2530462T3
Authority
ES
Spain
Prior art keywords
antitumor therapy
combination antitumor
antimetabolite
combination
alkylating agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09751682T
Other languages
English (en)
Inventor
Jeffery Keene
Dennis Riley
Robert Beardsley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galera Therapeutics LLC
Original Assignee
Galera Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galera Therapeutics LLC filed Critical Galera Therapeutics LLC
Application granted granted Critical
Publication of ES2530462T3 publication Critical patent/ES2530462T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un agente alquilante antimetabolito y un mimético SOD selectivo para uso en un método para tratar el cáncer, en el que el agente alquilante antimetabolito es gemcitadina o sal derivada y el mimético SOD corresponde a la Fórmula (KM4419):
ES09751682T 2008-05-22 2009-05-22 Combinación terapia antitumoral Active ES2530462T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5541808P 2008-05-22 2008-05-22
PCT/US2009/045029 WO2009143454A2 (en) 2008-05-22 2009-05-22 Combination antitumor therapy

Publications (1)

Publication Number Publication Date
ES2530462T3 true ES2530462T3 (es) 2015-03-03

Family

ID=41340927

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09751682T Active ES2530462T3 (es) 2008-05-22 2009-05-22 Combinación terapia antitumoral

Country Status (6)

Country Link
US (1) US9198893B2 (es)
EP (2) EP2296645B1 (es)
CA (1) CA2724550C (es)
ES (1) ES2530462T3 (es)
HK (1) HK1155644A1 (es)
WO (1) WO2009143454A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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HUE044234T2 (hu) 2006-10-12 2019-10-28 Galera Labs Llc Eljárások szájnyálkahártya-gyulladás kezelésére
WO2013048965A1 (en) * 2011-09-26 2013-04-04 Galera Therapeutics, Llc Methods for treatment of diseases
US9446064B2 (en) 2013-03-14 2016-09-20 Epizyme, Inc. Combination therapy for treating cancer
JP2017527547A (ja) * 2014-08-13 2017-09-21 エピザイム，インコーポレイティド 癌を処置するための併用療法
JP2017532312A (ja) * 2014-09-17 2017-11-02 エピザイム，インコーポレイティド 癌を治療するための併用療法
CA2994845A1 (en) 2015-08-11 2017-02-16 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
EA201892510A3 (ru) * 2016-05-03 2019-09-30 ГАЛЕРА ЛЭБЗ, ЭлЭлСи Комбинированная терапия для лечения рака
CA3035766A1 (en) * 2016-09-01 2018-03-08 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound
WO2018152353A2 (en) 2017-02-15 2018-08-23 Galera Labs, Llc Pentaaza macrocyclic ring complexes for local intestinal delivery
CN110769837A (zh) * 2017-04-13 2020-02-07 加莱拉实验室有限责任公司 与五氮杂大环状环配合物的联合癌症免疫疗法
IL295620B2 (en) * 2017-04-13 2024-01-01 Galera Labs Llc Cancer immunotherapy combined with a macrocyclic ring pentase complex
EP3388082A1 (en) * 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
JP2019131508A (ja) * 2018-01-31 2019-08-08 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーＧａｌｅｒａ Ｌａｂｓ， Ｌｌｃ ペンタアザ大環状環複合体および白金を基にした抗癌剤による組み合わせ癌療法
CN111902147A (zh) * 2018-01-31 2020-11-06 加莱拉实验室有限责任公司 五氮杂大环状环配合物和基于铂的抗癌剂的组合癌症治疗
WO2021247009A1 (en) * 2020-06-02 2021-12-09 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and hormone therapy agent

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US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
TW197439B (es) 1991-04-04 1993-01-01 Ueno Pharmaceutics Applic Res Co Ltd
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AU4242993A (en) 1992-05-21 1993-12-13 Penn State Research Foundation, The Cultured (taxus) tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds
US5274137A (en) 1992-06-23 1993-12-28 Nicolaou K C Intermediates for preparation of taxols
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FR2696461B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent.
FR2696464B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2696462B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
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US5279949A (en) 1992-12-07 1994-01-18 Board Of Trustees Operating Michigan State University Process for the isolation and purification of taxol and taxanes from Taxus spp
US6204259B1 (en) 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5824701A (en) 1993-10-20 1998-10-20 Enzon, Inc. Taxane-based prodrugs
US5415869A (en) 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
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US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
NZ315505A (en) 1995-08-17 2000-01-28 Monsanto Co Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands
WO1998008833A1 (en) 1996-08-26 1998-03-05 Bristol-Myers Squibb Company Sulfenamide taxane derivatives
CA2264227A1 (en) 1996-09-27 1998-04-02 Raymond A. Firestone Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
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FR2863892B1 (fr) * 2003-12-18 2007-05-11 Univ Paris Descartes Utilisation de mimetiques de la superoxyde dismutase et de la glutathion reductase comme anti-cancereux
HUE044234T2 (hu) * 2006-10-12 2019-10-28 Galera Labs Llc Eljárások szájnyálkahártya-gyulladás kezelésére

Also Published As

Publication number Publication date
US20110136756A1 (en) 2011-06-09
HK1155644A1 (en) 2012-05-25
EP2859916A2 (en) 2015-04-15
EP2296645B1 (en) 2014-11-19
CA2724550A1 (en) 2009-11-26
EP2859916B1 (en) 2017-11-29
CA2724550C (en) 2017-01-03
WO2009143454A3 (en) 2010-03-04
EP2296645A4 (en) 2012-03-07
EP2296645A2 (en) 2011-03-23
WO2009143454A2 (en) 2009-11-26
EP2859916A3 (en) 2015-04-29
US9198893B2 (en) 2015-12-01

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